polySUMO2,3-K203,K486-PARP1 [nucleoplasm]

Stable Identifier
R-HSA-4551617
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
Poly (ADP-ribose) polymerase 1
polySUMO2,3-K203,K486-PARP1 [nucleoplasm] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
24782567 Proteome-wide identification of SUMO2 modification sites

Tatham, MH, Hay, RT, Tammsalu, T, Ibrahim, AF, Jaffray, EG, Matic, I

Sci Signal 2014
25218447 Uncovering global SUMOylation signaling networks in a site-specific manner

Yang, B, Hendriks, IA, Verlaan-de Vries, M, Vertegaal, AC, D'Souza, RC, Mann, M

Nat. Struct. Mol. Biol. 2014
23750026 Targeted identification of SUMOylation sites in human proteins using affinity enrichment and paralog-specific reporter ions

Zerweck, J, Wenshuk, H, Wildemann, D, Durette, C, Bonneil, E, Lamoliatte, F, Caron-Lizotte, O, Thibault, P

Mol. Cell Proteomics 2013
External Reference Information
External Reference
Gene Names
PARP1, ADPRT, PPOL
Chain
initiator methionine:, chain:2-1014, chain:2-214, chain:215-1014
Reference Transcript
Other Identifiers
11726247_s_at
11726248_x_at
11726249_a_at
11745950_a_at
1287_at
142
16699739
208644_PM_at
208644_at
2458786
2458787
2458788
2458789
2458790
2458791
2458792
2458796
2458797
2458801
2458803
2458805
2458806
2458808
2458810
2458813
2458816
2458817
2458818
2458819
2458820
2458821
2458823
2458825
2458827
2458828
2458829
2458832
2458838
2458839
2458840
3501577
3501611
3539486
3539490
3539492
3539496
41146_at
7924733
A_33_P3236921
A_33_P3290338
GE81045
GO:0000122
GO:0000228
GO:0000723
GO:0000781
GO:0000785
GO:0002376
GO:0003012
GO:0003677
GO:0003682
GO:0003684
GO:0003723
GO:0003824
GO:0003950
GO:0005515
GO:0005634
GO:0005635
GO:0005654
GO:0005667
GO:0005694
GO:0005730
GO:0005737
GO:0005739
GO:0005829
GO:0005975
GO:0006260
GO:0006281
GO:0006302
GO:0006310
GO:0006351
GO:0006355
GO:0006366
GO:0006915
GO:0006974
GO:0007005
GO:0007179
GO:0008047
GO:0008152
GO:0008270
GO:0010332
GO:0010613
GO:0010990
GO:0012501
GO:0016020
GO:0016051
GO:0016540
GO:0016604
GO:0016740
GO:0016757
GO:0016779
GO:0019899
GO:0019901
GO:0022414
GO:0023019
GO:0023052
GO:0030154
GO:0030225
GO:0030331
GO:0030592
GO:0031491
GO:0031625
GO:0032042
GO:0032200
GO:0032786
GO:0032869
GO:0032880
GO:0032991
GO:0032993
GO:0033148
GO:0034244
GO:0034599
GO:0034644
GO:0035861
GO:0036211
GO:0042802
GO:0042803
GO:0042826
GO:0043123
GO:0043226
GO:0043504
GO:0043596
GO:0044030
GO:0045087
GO:0045188
GO:0045824
GO:0045892
GO:0045944
GO:0046332
GO:0046697
GO:0046872
GO:0048856
GO:0050790
GO:0051052
GO:0051287
GO:0051604
GO:0051901
GO:0055086
GO:0060391
GO:0060545
GO:0061629
GO:0065003
GO:0070212
GO:0070213
GO:0070412
GO:0071168
GO:0071294
GO:0071560
GO:0071932
GO:0090734
GO:0098542
GO:0098772
GO:0140096
GO:0140294
GO:0140805
GO:0140806
GO:0140807
GO:0140808
GO:0140815
GO:0140816
GO:0140817
GO:0140822
GO:1900182
GO:1901135
GO:1901216
GO:1903376
GO:1903518
GO:1904044
GO:1904178
GO:1904357
GO:1904646
GO:1904762
GO:1905051
GO:1905168
GO:1990090
GO:1990404
GO:1990966
GO:2000679
GO:2001170
HMNXSV003052846
J03473_at
PH_hs_0010559
TC01003876.hg
g190266_3p_at
Participates
Other forms of this molecule
Inferred To
Modified Residues
Name
sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 203
Coordinate
203
Modification
polySUMO2,3 [nucleoplasm]
PsiMod Name
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Name
sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 486
Coordinate
486
Modification
polySUMO2,3 [nucleoplasm]
PsiMod Name
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
ZINC - Investigational
ZINC - Metabolites
IntEnz
GeneCards
Pharos - Targets
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (42)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P13010 XRCC5  4 0.839 9
 UniProt:Q8IW19 APLF      0.837 8
 UniProt:P16104 H2AFX  7 0.798 10
 UniProt:P12956 XRCC6  5 0.757 7
 UniProt:P04637 TP53  20 0.75 5
 UniProt:Q14191 WRN  2 0.739 8
 UniProt:Q7Z2E3 APTX      0.706 9
 UniProt:P18887 XRCC1  1 0.669 6
 UniProt:P46063 RECQ1      0.669 8
 UniProt:P09874 PARP1  4 0.623 3
 UniProt:P42574 CASP3  5 0.623 2
 UniProt:Q01094 E2F1  2 0.609 3
 UniProt:Q9Y530 OARD1      0.602 5
 UniProt:Q8N2W9 PIAS4  2 0.602 5
 UniProt:Q9NQB0 TCF7L2  4 0.597 6
 IntAct:EBI-22028558 HTR1A-PROMOTER      0.591 3
 UniProt:BRCA2 ENSG00000139618      0.591 3
 UniProt:Q86WJ1-1 CHD1L      0.591 3
 UniProt:Q14684-1 RRP1B      0.584 4
 UniProt:P11308 ERG      0.558 7
 UniProt:P22415 USF1  1 0.558 3
 UniProt:Q9NTX7 RNF146  1 0.558 4
 ChEBI:62878 XAV939      0.544 3
 UniProt:Q02085 Snai1  1 0.544 3
 UniProt:P26358 DNMT1  2 0.537 6
 UniProt:Q14684 RRP1B      0.527 2
 UniProt:Q01831 XPC  5 0.527 2
 UniProt:P78527 PRKDC  4 0.527 5
 UniProt:P0CG48 UBC  20 0.524 2
 UniProt:P54577 YARS1  1 0.524 5
 IntAct:EBI-11426955 1082A      0.524 3
 UniProt:Q13007 IL24  1 0.508 2
 UniProt:P49715 CEBPA  1 0.499 2
 UniProt:P09429 HMGB1  5 0.499 2
 UniProt:P68431 HIST1H3G  20 0.483 3
 UniProt:P13569 CFTR  17 0.483 7
 UniProt:O95863 SNAI1  1 0.463 10
 UniProt:Q5T7N2 LITD1      0.462 5
 UniProt:P11388 TOP2A  3 0.462 2
 UniProt:P51858 HDGF  1 0.462 3
 UniProt:P03372 ESR1  8 0.462 2
 UniProt:P11387 TOP1  2 0.462 3
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