Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PDHB [mitochondrial matrix]
Stable Identifier
R-HSA-69967
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
pyruvate dehydrogenase E1 beta apoprotein, ODPA_HUMAN, Pyruvate dehydrogenase E1 component beta subunit, mitochondrial precursor , PDHE1-B
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Pyruvate metabolism (Homo sapiens)
PDH complex synthesizes acetyl-CoA from PYR (Homo sapiens)
DLAT trimer transfers acetyl to CoA (Homo sapiens)
PDH complex [mitochondrial matrix] (Homo sapiens)
PDH E1 [mitochondrial matrix] (Homo sapiens)
PDHB [mitochondrial matrix] (Homo sapiens)
DLD dimer dehydrogenates dihydrolipoyl (Homo sapiens)
PDH complex [mitochondrial matrix] (Homo sapiens)
PDH E1 [mitochondrial matrix] (Homo sapiens)
PDHB [mitochondrial matrix] (Homo sapiens)
PDH E1 decarboxylates PYR, transferring acetyl to DLAT (Homo sapiens)
PDH E1 [mitochondrial matrix] (Homo sapiens)
PDHB [mitochondrial matrix] (Homo sapiens)
PDH complex [mitochondrial matrix] (Homo sapiens)
PDH E1 [mitochondrial matrix] (Homo sapiens)
PDHB [mitochondrial matrix] (Homo sapiens)
p-lipo-PDH [mitochondrial matrix] (Homo sapiens)
PDH E1 [mitochondrial matrix] (Homo sapiens)
PDHB [mitochondrial matrix] (Homo sapiens)
phosphorylated pyruvate dehydrogenase E1 complex [mitochondrial matrix] (Homo sapiens)
PDH E1 [mitochondrial matrix] (Homo sapiens)
PDHB [mitochondrial matrix] (Homo sapiens)
Regulation of pyruvate metabolism (Homo sapiens)
Regulation of pyruvate dehydrogenase (PDH) complex (Homo sapiens)
PDK isozymes phosphorylate PDHC subunit E1 (Homo sapiens)
PDH complex [mitochondrial matrix] (Homo sapiens)
PDH E1 [mitochondrial matrix] (Homo sapiens)
PDHB [mitochondrial matrix] (Homo sapiens)
p-lipo-PDH [mitochondrial matrix] (Homo sapiens)
PDH E1 [mitochondrial matrix] (Homo sapiens)
PDHB [mitochondrial matrix] (Homo sapiens)
phosphorylated pyruvate dehydrogenase E1 complex [mitochondrial matrix] (Homo sapiens)
PDH E1 [mitochondrial matrix] (Homo sapiens)
PDHB [mitochondrial matrix] (Homo sapiens)
PDP1,2 dephosphorylate p-lipo-PDH (Homo sapiens)
PDH complex [mitochondrial matrix] (Homo sapiens)
PDH E1 [mitochondrial matrix] (Homo sapiens)
PDHB [mitochondrial matrix] (Homo sapiens)
p-lipo-PDH [mitochondrial matrix] (Homo sapiens)
PDH E1 [mitochondrial matrix] (Homo sapiens)
PDHB [mitochondrial matrix] (Homo sapiens)
phosphorylated pyruvate dehydrogenase E1 complex [mitochondrial matrix] (Homo sapiens)
PDH E1 [mitochondrial matrix] (Homo sapiens)
PDHB [mitochondrial matrix] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Mitochondrial protein degradation (Homo sapiens)
CLPXP binds mitochondrial matrix proteins (Homo sapiens)
CLPXP:substrate protein (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)
PDHB [mitochondrial matrix] (Homo sapiens)
Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)
PDHB [mitochondrial matrix] (Homo sapiens)
CLPXP degrades mitochondrial matrix proteins (Homo sapiens)
CLPXP:substrate protein (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)
PDHB [mitochondrial matrix] (Homo sapiens)
LONP1 binds mitochondrial matrix proteins (Homo sapiens)
LONP1:substrate protein (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of LONP1 (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
PDHB [mitochondrial matrix] (Homo sapiens)
Substrate of LONP1 (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
PDHB [mitochondrial matrix] (Homo sapiens)
LONP1 degrades mitochondrial matrix proteins (Homo sapiens)
LONP1:substrate protein (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of LONP1 (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
PDHB [mitochondrial matrix] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
Signaling by Retinoic Acid (Homo sapiens)
PDK isozymes phosphorylate PDHC subunit E1 (Homo sapiens)
PDH complex [mitochondrial matrix] (Homo sapiens)
PDH E1 [mitochondrial matrix] (Homo sapiens)
PDHB [mitochondrial matrix] (Homo sapiens)
p-lipo-PDH [mitochondrial matrix] (Homo sapiens)
PDH E1 [mitochondrial matrix] (Homo sapiens)
PDHB [mitochondrial matrix] (Homo sapiens)
phosphorylated pyruvate dehydrogenase E1 complex [mitochondrial matrix] (Homo sapiens)
PDH E1 [mitochondrial matrix] (Homo sapiens)
PDHB [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:P11177 PDHB
Gene Names
PDHB, PHE1B
Chain
transit peptide:1-30, chain:31-359
Reference Genes
BioGPS Gene:5162 PDHB
COSMIC (genes):PDHB PDHB
CTD Gene:5162 PDHB
dbSNP Gene:5162 PDHB
ENSEMBL:ENSG00000168291 PDHB
HGNC:8808 PDHB
KEGG:hsa:5162 PDHB
Monarch:5162 PDHB
NCBI Gene:5162 PDHB
OMIM:179060 PDHB
UCSC:P11177 PDHB
Reference Transcript
RefSeq:NM_000925.3 PDHB
RefSeq:NM_001315536.1 PDHB
RefSeq:NM_001173468.1 PDHB
Other Identifiers
11725620_a_at
16955511
208911_PM_s_at
208911_s_at
211023_PM_at
211023_at
2678366
2678368
2678369
2678370
2678371
2678372
2678373
2678374
2678375
2678376
2678377
2678378
2678379
2678380
2678381
2678382
2678383
2678384
2678385
39160_at
5162
8088384
A_33_P3364884
D90086_at
GE57444
GO:0003824
GO:0004739
GO:0005515
GO:0005634
GO:0005654
GO:0005739
GO:0005759
GO:0005975
GO:0006006
GO:0006086
GO:0006099
GO:0006790
GO:0016491
GO:0034604
GO:0043226
GO:0045254
GO:0055086
GO:1901135
HMNXSV003005028
ILMN_1739274
PH_hs_0022756
TC03001499.hg
TC03002933.hg
g190791_3p_a_at
Participates
as a member of
Substrate of LONP1 (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)
as a component of
PDH E1 [mitochondrial matrix] (Homo sapiens)
Inferred To
pdhb [mitochondrial matrix]
(Xenopus tropicalis)
PDHB [mitochondrial matrix]
(Bos taurus)
PDHB [mitochondrial matrix]
(Caenorhabditis elegans)
PDHB [mitochondrial matrix]
(Canis familiaris)
PDHB [mitochondrial matrix]
(Dictyostelium discoideum)
PDHB [mitochondrial matrix]
(Drosophila melanogaster)
PDHB [mitochondrial matrix]
(Gallus gallus)
PDHB [mitochondrial matrix]
(Mus musculus)
PDHB [mitochondrial matrix]
(Rattus norvegicus)
PDHB [mitochondrial matrix]
(Saccharomyces cerevisiae)
PDHB [mitochondrial matrix]
(Schizosaccharomyces pombe)
PDHB [mitochondrial matrix]
(Sus scrofa)
Cross References
RefSeq
NP_001166939.1
,
NP_000916.2
,
NP_001302465.1
ENSEMBL
ENSP00000373220
,
ENST00000302746
,
ENST00000383714
,
ENSP00000307241
,
ENSP00000417267
,
ENST00000485460
OpenTargets
ENSG00000168291
HPA
ENSG00000168291-PDHB
PRO
P11177
Pharos - Targets
P11177
GlyGen
P11177
Orphanet
PDHB
HMDB Protein
HMDBP00012
PDB
6CFO
,
3EXI
,
3EXE
,
1NI4
,
6CER
,
3EXF
,
2OZL
,
3EXH
,
3EXG
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P10515 DLAT
4
Lipo-K259-DLAT [mitochondrial matrix]
(R-HSA-69969)
AcetyllipoH2-K132,K259-DLAT [mitochondrial matrix]
(R-HSA-9861594)
LipoH2-K259-DLAT [mitochondrial matrix]
(R-HSA-9861664)
DLAT [mitochondrial matrix]
(R-HSA-6792585)
0.667
8
UniProt:P42229 STAT5A
4
STAT5A [cytosol]
(R-HSA-380747)
p-Y694-STAT5A [cytosol]
(R-HSA-507936)
p-Y694-STAT5A [nucleoplasm]
(R-HSA-507995)
STAT5A [nucleoplasm]
(R-HSA-9701901)
0.527
3
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
6
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text