Reactome | ZC3HAV1(2-624)-BRAF(439-766) fusion [cytosol]

ZC3HAV1(2-624)-BRAF(439-766) fusion [cytosol]

Stable Identifier

R-HSA-6802506

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Literature References

PubMed ID	Title	Journal	Year
25204415	The landscape of kinase fusions in cancer Stransky, N, Cerami, E, Schalm, S, Kim, JL, Lengauer, C	Nat Commun	2014

External Reference Information

External Reference

UniProt:Q7Z2W4 ZC3HAV1

Gene Names

ZC3HAV1, ZC3HDC2, PRO1677

Chain

initiator methionine:1, chain:2-902

Reference Genes

BioGPS Gene:56829 ZC3HAV1

COSMIC - genes:ZC3HAV1 ZC3HAV1

CTD Gene:56829 ZC3HAV1

dbSNP Gene:56829 ZC3HAV1

ENSEMBL:ENSG00000105939 ZC3HAV1

HGNC:23721 ZC3HAV1

KEGG:hsa:56829 ZC3HAV1

Monarch:56829 ZC3HAV1

NCBI Gene:56829 ZC3HAV1

OMIM:607312 ZC3HAV1

UCSC:Q7Z2W4 ZC3HAV1

Reference Transcript

Participates

as a component of

ZC3HAV1-BRAF fusion dimer [cytosol] (Homo sapiens)

Other forms of this molecule

ZC3HAV1(2-624)-p-BRAF(439-766) fusion [cytosol]

Modified Residues

Name

Insertion of residues 439 to 766 at 625 from UniProt:P15056 BRAF

Coordinate

625

Name

O-phospho-L-serine at 446

Coordinate

446

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 729

Coordinate

729

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Disease

Name	Identifier	Synonyms
thyroid carcinoma	DOID:3963	head and neck cancer, Thyroid
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer

Cross References

RefSeq

NP_078901.3, NP_064504.2

OpenTargets

ENSG00000105939

ENSEMBL

ENSG00000105939, ENSP00000419855, ENST00000242351, ENSP00000242351, ENST00000471652

Mondo

0015075

HPA

ENSG00000105939-ZC3HAV1

GeneCards

ZC3HAV1

PRO

Q7Z2W4

Pharos - Targets

Q7Z2W4

GlyGen

Q7Z2W4

PDB

9BGL, 7TGQ, 6UEJ, 4X52, 2X5Y, 7KZH, 6UEI

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [extracellular region] (R-HSA-9017791) YBX1 [nucleoplasm] (R-HSA-72041)	0.564	4
UniProt:Q9NQT4 EXOSC5	3	EXOSC5 [cytosol] (R-HSA-429889) EXOSC5 [nucleoplasm] (R-HSA-6791550) EXOSC5 [nucleolus] (R-HSA-9935829)	0.536	2
UniProt:Q15646 OASL	1	OASL [cytosol] (R-HSA-1015678)	0.527	2
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-ESR1 [cytosol] (R-HSA-9632177) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.527	3
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	3
UniProt:P49711 CTCF	1	CTCF [nucleoplasm] (R-HSA-3782562)	0.527	2
UniProt:O95786 RIGI	4	DDX58 [cytosol] (R-HSA-168917) K63polyUb-DDX58 [cytosol] (R-HSA-918191) K48polyUb-DDX58 [cytosol] (R-HSA-3080568) PolyUb-DDX58 [cytosol] (R-HSA-6782770)	0.524	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.483	8
UniProt:Q8WYQ5 DGCR8	1	DGCR8 [nucleoplasm] (R-HSA-1482509)	0.483	3
UniProt:Q12906 ILF3	3	ILF3 [nucleoplasm] (R-HSA-9760401) ILF3 [cytosol] (R-HSA-450564) p-T188,T315-ILF3 [cytosol] (R-HSA-9836381)	0.483	2
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.483	2
UniProt:P62753 RPS6	4	RPS6 [cytosol] (R-HSA-72381) p-5S-RPS6 [cytosol] (R-HSA-165727) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) RPS6 [nucleoplasm] (R-HSA-6790606)	0.483	4

Cite Us!