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What is Reactome ?
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GNAS1 [plasma membrane]
Stable Identifier
R-HSA-8873940
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Guanine nucleotide-binding protein G, GNAS1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to mechanical stimuli (Homo sapiens)
Response of endothelial cells to shear stress (Homo sapiens)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Homo sapiens)
ADM:CALCRL:RAMP2 binds G(s):GDP:Gbeta:Ggamma heterotrimer (Homo sapiens)
ADM:CALCLR:RAMP2:G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
ADM:CALCRL:RAMP2:G-alpha(s):GDP:G-beta:G-gamma exchanges GDP for GTP (Homo sapiens)
ADM:CALCLR:RAMP2:G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
ADM:CALCRL:RAMP2:G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
ADM:CALCRL:RAMP2:G-alpha(s):GTP:G-beta:G-gamma dissociates (Homo sapiens)
ADM:CALCRL:RAMP2:G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
Activated Adenylate cyclase catalyses cAMP synthesis (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
G alpha (s) activates adenylate cyclase (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Leishmania parasite growth and survival (Homo sapiens)
Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
ADORA2B mediated anti-inflammatory cytokines production (Homo sapiens)
ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs (Homo sapiens)
ADORA2B:Ade-Rib:Heterotrimeric G-protein Gs:GTP [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs:GDP [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
ADORA2B:Ade-Rib binds heterometric G-protein Gs (Homo sapiens)
Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs:GDP [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
ADORA2B:Ade-Rib:GsGTP dissociates (Homo sapiens)
ADORA2B:Ade-Rib:Heterotrimeric G-protein Gs:GTP [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
G alpha (s) activates adenylate cyclase (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Prostacyclin signalling through prostacyclin receptor (Homo sapiens)
Activated prostacyclin receptor binds G-protein Gs (Homo sapiens)
Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
Prostacyclin:prostacyclin receptor:Gs (inactive) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
Dissociation of the Prostacyclin receptor:Gs complex (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
Prostacyclin:prostacyclin receptor:G-protein Gs (active) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
Gs activation by prostacyclin receptor (Homo sapiens)
Prostacyclin:prostacyclin receptor:G-protein Gs (active) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
Prostacyclin:prostacyclin receptor:Gs (inactive) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
Glucagon signaling in metabolic regulation (Homo sapiens)
G alpha (s) activates adenylate cyclase (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
G(s):GTP activates Adenylyl cyclase (Homo sapiens)
ADCY5,6,8:G-alpha(s):GTP [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
Glucagon:GCGR mediates GTP-GDP exchange (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
G-protein with G(s) alpha:GDP [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
PKA activation in glucagon signalling (Homo sapiens)
Activated Adenylate cyclase catalyses cAMP synthesis (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
Regulation of insulin secretion (Homo sapiens)
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (Homo sapiens)
Activated Adenylyl cyclase synthesizes cyclic AMP (Homo sapiens)
ADCY5,6,8:G-alpha(s):GTP [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
G(s):GTP activates Adenylyl cyclase (Homo sapiens)
ADCY5,6,8:G-alpha(s):GTP [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
GLP1R binds GLP1 (Homo sapiens)
GLP1:GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
GLP1R binds GLP1R agonists (Homo sapiens)
GLP1R:GLP1R agonists [plasma membrane] (Homo sapiens)
GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
GLP1R:GLP1 activates G(s) (Homo sapiens)
GLP-1:GLP-1R:Heterotrimeric G(s):GTP [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
GLP1:GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
Heterotrimeric G(s) complex dissociates (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
G alpha (s) activates adenylate cyclase (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
G alpha (s) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
G alpha (s):GTP:SRC catalyzes SRC to p-Y419-SRC (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
G alpha (s):GTP:SRC [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
G alpha (s):GTP:p-Y419-SRC [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
G alpha (s):GTP:SRC dissociates (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
G alpha (s):GTP:p-Y419-SRC [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
G protein alpha (s):GTP binds SRC (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
G alpha (s):GTP:SRC [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
GPER1 signaling (Homo sapiens)
Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s (Homo sapiens)
GPER1:Heterotrimeric G-protein Gs (active):ESTG [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
GPER1:Heterotrimeric G-protein Gs:ESTG [plasma membrane] (Homo sapiens)
GPER1:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
ESTG-stimulated dissociation of GPER:heterotrimeric G-protein (s) complex (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
GPER1:Heterotrimeric G-protein Gs (active):ESTG [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
G alpha (s) activates adenylate cyclase (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
GPER:Heterotrimeric G-protein Gs binds ESTG (Homo sapiens)
GPER1:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
GPER1:Heterotrimeric G-protein Gs:ESTG [plasma membrane] (Homo sapiens)
GPER1:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
Inactive G alpha (s) reassociates with G beta:gamma (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs:GDP [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
G alpha (z) signalling events (Homo sapiens)
Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class B/2 (Secretin family receptors) (Homo sapiens)
Glucagon-type ligand receptors (Homo sapiens)
GLP1R binds GLP1 (Homo sapiens)
GLP1:GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'off' state (Homo sapiens)
GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Aquaporin-mediated transport (Homo sapiens)
Vasopressin regulates renal water homeostasis via Aquaporins (Homo sapiens)
AVP:AVPR2 Complex binds inactive heterotrimeric G(s) complex (Homo sapiens)
AVPR2:AVP:G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Homo sapiens)
AVPR2:AVP:G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G alpha (s):GDP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
AVPR2:AVP:G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
Activated Adenylate cyclase catalyses cAMP synthesis (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
G alpha (s) activates adenylate cyclase (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
G alpha (s):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
Heterotrimeric G(s) complex dissociates (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
G alpha (s):GTP [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
GNAS [plasma membrane] (Homo sapiens)
GNAS1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q5JWF2 GNAS
Gene Names
GNAS, GNAS1, GSP
Chain
chain:1-1037
Reference Genes
BioGPS Gene:2778 GNAS
COSMIC (genes):GNAS GNAS
CTD Gene:2778 GNAS
dbSNP Gene:2778 GNAS
ENSEMBL:ENSG00000087460 GNAS
HGNC:4392 GNAS
Monarch:2778 GNAS
NCBI Gene:2778 GNAS
OMIM:139320 GNAS
UCSC:Q5JWF2 GNAS
Reference Transcript
RefSeq:NM_001309883.1 GNAS
RefSeq:NM_080425.3 GNAS
RefSeq:XM_017027813.1 GNAS
Other Identifiers
11717596_s_at
11717597_x_at
11746698_a_at
11753828_x_at
11754007_x_at
200780_PM_x_at
200780_x_at
200981_PM_x_at
200981_x_at
211858_PM_x_at
211858_x_at
212273_PM_x_at
212273_x_at
214157_PM_at
214157_at
214548_PM_x_at
214548_x_at
217057_PM_s_at
217057_s_at
228173_PM_at
228173_at
229274_PM_at
229274_at
2350846
242816_PM_at
242816_at
242975_PM_s_at
242975_s_at
2778
31604_at
37448_s_at
37449_i_at
37450_r_at
3891164
3891165
3891166
3891167
3891168
3891169
3891171
3891177
3891178
3891179
3891180
3891181
3891182
3891183
3891184
3891185
3891186
3891187
3891188
3891189
3891190
3891191
3891198
3891199
3891200
3891201
3891202
3891203
3891204
3891205
3891207
3891208
3891209
3891210
3891211
3891212
3891213
3891214
3891215
3891216
3891217
3891218
3891219
3891220
3891221
3891223
3891224
3891226
3891227
3891230
3891231
3891232
3891233
3891234
3891235
3891236
3891237
3891238
3891239
3891240
3891241
3891242
3891243
3891244
3891245
3891246
3891247
3891248
3891249
3891250
3891251
3891252
3891253
3891254
3891255
3891256
3891257
3891258
45630_at
46156_at
79959_r_at
8063668
81444_at
A_14_P103340
A_14_P112054
A_24_P168574
A_24_P168581
A_24_P273666
A_24_P418809
A_24_P53595
A_24_P926617
GE61326
GO:0002862
GO:0003014
GO:0003091
GO:0003674
GO:0003824
GO:0003924
GO:0003925
GO:0005159
GO:0005515
GO:0005525
GO:0005576
GO:0005634
GO:0005737
GO:0005829
GO:0005834
GO:0005886
GO:0007155
GO:0007165
GO:0007186
GO:0007189
GO:0007190
GO:0007191
GO:0007192
GO:0007565
GO:0007606
GO:0007608
GO:0009306
GO:0010854
GO:0010856
GO:0016020
GO:0016324
GO:0016787
GO:0019001
GO:0022414
GO:0030133
GO:0031410
GO:0031683
GO:0031698
GO:0031748
GO:0031852
GO:0032588
GO:0034695
GO:0035255
GO:0040015
GO:0043226
GO:0046872
GO:0046907
GO:0048471
GO:0048589
GO:0048856
GO:0050796
GO:0050877
GO:0050890
GO:0051430
GO:0060348
GO:0060789
GO:0070062
GO:0070527
GO:0071107
GO:0071377
GO:0071380
GO:0071870
GO:0071880
GO:0098772
GO:0120162
HMNXSV003047431
HMNXSV003050994
Hs.113368.3.A1_3p_a_at
Hs.113368.3.A1_3p_x_at
Hs.157307.0.A1_3p_at
Hs.159354.1.A1_3p_at
Hs.273385.1.A1_3p_s_at
Hs.273385.2.A1_3p_s_at
Hs.38057.0.A1_3p_at
Hs.46853.0.A1_3p_at
ILMN_1769191
ILMN_1785637
ILMN_1804283
M21142_cds2_s_at
PH_hs_0027894
TC20001320.hg
g3552031_3p_a_at
g3552031_3p_s_at
p26155
Participates
as a candidate of
GNAS [plasma membrane] (Homo sapiens)
Inferred To
GNAS [plasma membrane]
(Canis familiaris)
GNAS [plasma membrane]
(Sus scrofa)
GNAS1 [plasma membrane]
(Drosophila melanogaster)
GNAS1 [plasma membrane]
(Mus musculus)
GNAS1 [plasma membrane]
(Rattus norvegicus)
GNASXL [plasma membrane]
(Gallus gallus)
gsa-1 [plasma membrane]
(Caenorhabditis elegans)
Homologues of GNAS1 [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
XP_016883302.1
,
NP_536350.2
,
NP_001296812.1
ENSEMBL
ENST00000371100
,
ENSP00000360141
,
ENST00000371102
,
ENSP00000360143
,
ENSP00000499644
,
ENST00000481768
OpenTargets
ENSG00000087460
PRO
Q5JWF2
Pharos - Targets
Q5JWF2
GlyGen
Q5JWF2
HMDB Protein
HMDBP10759
PDB
8JHI
,
8WW2
,
8I2G
,
9BKK
,
8JHB
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49407 ARRB1
6
ARRB1 [cytosol]
(R-HSA-264470)
PolyUb-ARRB1 [cytosol]
(R-HSA-6783186)
ARRB1 [endocytic vesicle membrane]
(R-HSA-9910882)
ARRB1 [lysosomal membrane]
(R-HSA-432701)
ARRB1 [Golgi membrane]
(R-HSA-350831)
ARRB1 [cytoplasmic vesicle membrane]
(R-HSA-351187)
0.639
5
UniProt:P52333 JAK3
6
JAK3 [cytosol]
(R-HSA-451893)
p-Y-JAK3 [cytosol]
(R-HSA-9006854)
p-JAK3 [cytosol]
(R-HSA-8982856)
JAK3 [endosome]
(R-HSA-8983184)
p-Y904,939-JAK3 [plasma membrane]
(R-HSA-8985978)
p-Y980 JAK3 [cytosol]
(R-HSA-9701438)
0.527
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
3
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