Reactome | MPRIP(2-1015)-RAF1(279-648) fusion [cytosol]

MPRIP(2-1015)-RAF1(279-648) fusion [cytosol]

Stable Identifier

R-HSA-6802406

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
25204415	The landscape of kinase fusions in cancer Kim, JL, Schalm, S, Stransky, N, Lengauer, C, Cerami, E	Nat Commun	2014

External Reference Information

External Reference

UniProt:Q6WCQ1 MPRIP

Gene Names

MPRIP, KIAA0864, MRIP, RHOIP3

Chain

initiator methionine:, chain:2-1025

Reference Genes

BioGPS Gene:23164 MPRIP

COSMIC (genes):MPRIP MPRIP

CTD Gene:23164 MPRIP

dbSNP Gene:23164 MPRIP

ENSEMBL:ENSG00000133030 MPRIP

ENSEMBL_homo_sapiens_GENE:ENSG00000133030.22 MPRIP

HGNC:30321 MPRIP

KEGG Gene (Homo sapiens):23164 MPRIP

Monarch:23164 MPRIP

NCBI Gene:23164 MPRIP

OMIM:612935 MPRIP

UCSC:Q6WCQ1 MPRIP

Reference Transcript

Other Identifiers

11717546_s_at

11739524_a_at

16831562

212197_PM_x_at

212197_x_at

214694_PM_at

214694_at

214771_PM_x_at

214771_x_at

225896_PM_at

225896_at

23164

238328_PM_at

238328_at

2671507

2671508

2671509

2671510

2671512

2671513

2671514

2671515

2671519

2671520

2671550

3712364

3712365

3712376

3712378

3712397

3712400

3712404

3712405

3712406

3712408

3712413

3712417

3712418

3712419

3712422

3712423

3712427

3712428

3712429

3712431

3712432

3712449

3712450

3712452

3712453

3712455

3712456

3712457

3712459

3712461

3712463

3712464

3712471

3712472

3712473

3712474

3712475

3712476

3712484

3712485

3712486

38730_at

38731_at

51061_at

52146_at

8180362

8180363

A_19_P00317887

A_19_P00803575

A_19_P00811812

A_23_P15348

A_32_P105976

D23673_at

GE53547

GO:0003779

GO:0005515

GO:0005737

GO:0005829

GO:0005856

GO:0005925

GO:0008092

GO:0015629

GO:0043226

GO:0045296

GO:0051015

HMNXSV003006205

Hs.159336.0.A1_3p_at

Hs.46783.0.S1_3p_at

Hs.84883.0.A1_3p_a_at

ILMN_1678692

ILMN_1774547

ILMN_1836776

ILMN_1905780

PH_hs_0025217

TC17000194.hg

TC17002083.hg

TC17002084.hg

Participates

as a component of

MPRIP-RAF1 fusion dimer [cytosol] (Homo sapiens)

Other forms of this molecule

MPRIP(2-1015)-p-RAF1(279-648) fusion [cytosol]

Modified Residues

Name

Insertion of residues 279 to 648 at 1016 from UniProt:P04049 RAF1

Coordinate

1016

Name

O-phospho-L-serine at 621

Coordinate

621

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Disease

Name	Identifier	Synonyms
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer
skin melanoma	DOID:8923	malignant lip melanoma, malignant ear melanoma, malignant melanoma of ear and/or external auricular canal, cutaneous melanoma, malignant melanoma of skin of trunk except scrotum, malignant neck melanoma, malignant melanoma of skin of upper limb, malignant scalp melanoma, malignant upper limb melanoma, malignant lower limb melanoma, malignant melanoma of skin of lower limb, malignant trunk melanoma

Cross References

RefSeq

NP_958431.2, NP_055949.2

OpenTargets

ENSG00000133030

HPA

ENSG00000133030-MPRIP

GeneCards

Q6WCQ1

Ensembl

ENSP00000342379, ENST00000395811, ENST00000341712, ENSG00000133030, ENSP00000379156

PRO

Q6WCQ1

Pharos - Targets

Q6WCQ1

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.806	6
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.792	5
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	18
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.536	3
UniProt:P53350 PLK1	4	PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [cytosol] (R-HSA-164603)	0.527	2
UniProt:P61586 RHOA	6	RHOA [ficolin-1-rich granule membrane] (R-HSA-6804971) RHOA [secretory granule membrane] (R-HSA-6804980) RHOA [endoplasmic reticulum membrane] (R-HSA-5672082) RHOA [cytosol] (R-HSA-194866) RHOA [cell junction] (R-HSA-2134503) RHOA [plasma membrane] (R-HSA-194510)	0.499	3
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.483	3