Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
GGC-RAB5B [cytosol]
Stable Identifier
R-HSA-8870434
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Ras-related protein Rab-5B, RAB5B_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
RAB geranylgeranylation (Homo sapiens)
RGGT geranylgeranylates RAB proteins (Homo sapiens)
CHMs:GGC-RABs:GDP [cytosol] (Homo sapiens)
GGC-RABs:GDP [cytosol] (Homo sapiens)
GGC-RABs [cytosol] (Homo sapiens)
GGC-RAB5B [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Rab regulation of trafficking (Homo sapiens)
RAB GEFs exchange GTP for GDP on RABs (Homo sapiens)
RAB5 GEFs exchange GTP for GDP on RAB5 (Homo sapiens)
GGC-RAB5:GDP:GDIs,CHMs [cytosol] (Homo sapiens)
GGC-RAB5:GDP [cytosol] (Homo sapiens)
GGC-RAB5 [cytosol] (Homo sapiens)
GGC-RAB5B [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P61020 RAB5B
Gene Names
RAB5B
Chain
initiator methionine:1, chain:2-215
Reference Genes
BioGPS Gene:5869 RAB5B
COSMIC (genes):RAB5B RAB5B
CTD Gene:5869 RAB5B
dbSNP Gene:5869 RAB5B
ENSEMBL:ENSG00000111540 RAB5B
ENSEMBL:ENSG00000111540.16 RAB5B
HGNC:9784 RAB5B
KEGG Gene (Homo sapiens):5869 RAB5B
Monarch:5869 RAB5B
NCBI Gene:5869 RAB5B
OMIM:179514 RAB5B
UCSC:P61020 RAB5B
Reference Transcript
RefSeq:NM_001252036.1 RAB5B
RefSeq:NM_002868.3 RAB5B
RefSeq:XM_005269051.2 RAB5B
RefSeq:NM_001252037.1 RAB5B
RefSeq:XM_005269052.2 RAB5B
Other Identifiers
11717194_a_at
11717195_a_at
11751177_a_at
1221_at
16752322
201276_PM_at
201276_at
3417033
3417034
3417162
3417164
3417165
3417166
3417167
3417170
3417172
3417173
3417174
3417175
3417176
3417177
3417178
3417179
3417185
3417186
3417187
3417197
3417198
3417200
3635211
37362_at
5869
7956088
A_23_P410998
GE59798
GO:0000166
GO:0002376
GO:0003824
GO:0003924
GO:0003925
GO:0005515
GO:0005525
GO:0005576
GO:0005615
GO:0005768
GO:0005769
GO:0005886
GO:0006886
GO:0006897
GO:0007032
GO:0012505
GO:0015031
GO:0016020
GO:0016192
GO:0016787
GO:0019003
GO:0019882
GO:0030100
GO:0030139
GO:0030667
GO:0030672
GO:0030742
GO:0031410
GO:0031901
GO:0042470
GO:0043226
GO:0043231
GO:0048227
GO:0070062
GO:0098772
HMNXSV003020201
ILMN_1710682
ILMN_1752582
PH_hs_0004481
TC12000497.hg
X54871_at
g12006052_3p_at
g12006052_3p_x_at
Participates
as a candidate of
GGC-RAB5 [cytosol] (Homo sapiens)
GGC-RABs [cytosol] (Homo sapiens)
Other forms of this molecule
RAB5B [secretory granule membrane]
RAB5B [plasma membrane]
RAB5B [cytosol]
GGC-RAB5B [early endosome membrane]
RAB5B [early endosome membrane]
GGC-RAB5B [clathrin-coated endocytic vesicle membrane]
Inferred To
RAB5B [cytosol]
(Bos taurus)
Rab5b [cytosol]
(Rattus norvegicus)
rab-5 [cytosol]
(Caenorhabditis elegans)
RAB5C [cytosol]
(Sus scrofa)
GGC-RAB5B [cytosol]
(Canis familiaris)
GGC-RAB5B [cytosol]
(Danio rerio)
GGC-RAB5B [cytosol]
(Dictyostelium discoideum)
GGC-RAB5B [cytosol]
(Gallus gallus)
GGC-RAB5B [cytosol]
(Mus musculus)
GGC-RAB5B [cytosol]
(Plasmodium falciparum)
GGC-RAB5B [cytosol]
(Saccharomyces cerevisiae)
Rab5 [cytosol]
(Drosophila melanogaster)
Modified Residues
Name
S-geranylgeranyl-L-cysteine at 212
Coordinate
212
PsiMod Name
S-geranylgeranyl-L-cysteine [MOD:00113]
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine.
Name
S-geranylgeranyl-L-cysteine at 213
Coordinate
213
PsiMod Name
S-geranylgeranyl-L-cysteine [MOD:00113]
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine.
Cross References
RefSeq
NP_002859.1
,
NP_001238965.1
,
NP_001238966.1
,
XP_005269109.1
,
XP_005269108.1
OpenTargets
ENSG00000111540
GeneCards
P61020
HPA
ENSG00000111540-RAB5B
Ensembl
ENSP00000391319
,
ENSP00000450168
,
ENSG00000111540
,
ENST00000448789
,
ENST00000553116
,
ENST00000360299
,
ENSP00000353444
PRO
P61020
Pharos - Targets
P61020
PDB
2HEI
HMDB Protein
HMDBP08511
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.761
9
GTP [ChEBI:15996]
7
GTP [cilium]
(R-ALL-5617813)
GTP [early endosome membrane]
(R-ALL-2130170)
GTP [lysosomal membrane]
(R-ALL-2213216)
GTP [platelet dense granule lumen]
(R-ALL-114625)
GTP [cytoplasmic vesicle membrane]
(R-ALL-1996291)
GTP [ER to Golgi transport vesicle membrane]
(R-ALL-983318)
GTP [Golgi membrane]
(R-ALL-1806221)
0.558
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
© 2023
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text