Reactome | ZC3HAV1(2-624)-p-BRAF(439-766) fusion [cytosol]

ZC3HAV1(2-624)-p-BRAF(439-766) fusion [cytosol]

Stable Identifier

R-HSA-6802557

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
25204415	The landscape of kinase fusions in cancer Kim, JL, Schalm, S, Stransky, N, Lengauer, C, Cerami, E	Nat Commun	2014

External Reference Information

External Reference

UniProt:Q7Z2W4 ZC3HAV1

Gene Names

ZC3HAV1, ZC3HDC2, PRO1677

Chain

initiator methionine:, chain:2-902

Reference Genes

BioGPS Gene:56829 ZC3HAV1

COSMIC (genes):ZC3HAV1 ZC3HAV1

CTD Gene:56829 ZC3HAV1

dbSNP Gene:56829 ZC3HAV1

ENSEMBL:ENSG00000105939 ZC3HAV1

ENSEMBL_homo_sapiens_GENE:ENSG00000105939.14 ZC3HAV1

HGNC:23721 ZC3HAV1

KEGG Gene (Homo sapiens):56829 ZC3HAV1

Monarch:56829 ZC3HAV1

NCBI Gene:56829 ZC3HAV1

OMIM:607312 ZC3HAV1

UCSC:Q7Z2W4 ZC3HAV1

Reference Transcript

Other Identifiers

11717366_at

11717367_at

11717368_x_at

11756839_x_at

17063428

213051_PM_at

213051_at

220104_PM_at

220104_at

225634_PM_at

225634_at

2995180

3075567

3075568

3075569

3075570

3075572

3075573

3075575

3075576

3075577

3075583

3075584

3075588

3075589

3075590

3075592

3075593

3075594

3075597

3075598

3075599

3075600

3075601

3075609

3075610

35682_at

56525_at

56829

69142_at

8143279

A_23_P20122

A_23_P425224

A_24_P341938

A_33_P3397418

GE82494

GE88728

GO:0002376

GO:0003723

GO:0003824

GO:0003950

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0009615

GO:0016071

GO:0016740

GO:0023052

GO:0032481

GO:0032727

GO:0032728

GO:0043123

GO:0043226

GO:0045071

GO:0045087

GO:0045296

GO:0046872

GO:0051607

GO:0061014

GO:0098542

GO:1900246

HMNXSV003015407

HMNXSV003024895

Hs.325568.0.A1_3p_at

Hs.35254.1.S1_3p_at

ILMN_1667068

ILMN_1724837

ILMN_1729973

PH_hs_0022101

TC07001910.hg

g9910221_3p_at

Participates

as a component of

p-ZC3HAV1-BRAF fusion dimer [cytosol] (Homo sapiens)

Other forms of this molecule

ZC3HAV1(2-624)-BRAF(439-766) fusion [cytosol]

Modified Residues

Name

Insertion of residues 439 to 766 at 625 from UniProt:P15056 BRAF

Coordinate

625

Name

O-phospho-L-serine at 446

Coordinate

446

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 729

Coordinate

729

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 599

Coordinate

599

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 602

Coordinate

602

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Disease

Name	Identifier	Synonyms
thyroid carcinoma	DOID:3963	head and neck cancer, Thyroid
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer

Cross References

RefSeq

NP_078901.3, NP_064504.2

OpenTargets

ENSG00000105939

HPA

ENSG00000105939-ZC3HAV1

GeneCards

Q7Z2W4

Ensembl

ENST00000242351, ENSP00000419855, ENST00000471652, ENSG00000105939, ENSP00000242351

PRO

Q7Z2W4

Pharos - Targets

Q7Z2W4

PDB

4X52, 7TGQ, 6UEJ, 6UEI, 2X5Y, 7KZH

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.564	4
UniProt:Q9NQT4 EXOSC5	2	EXOSC5 [cytosol] (R-HSA-429889) EXOSC5 [nucleoplasm] (R-HSA-6791550)	0.536	2
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.527	3
UniProt:Q15646 OASL	1	OASL [cytosol] (R-HSA-1015678)	0.527	2
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	3
UniProt:O95786 RIGI	4	PolyUb-DDX58 [cytosol] (R-HSA-6782770) K48polyUb-DDX58 [cytosol] (R-HSA-3080568) K63polyUb-DDX58 [cytosol] (R-HSA-918191) DDX58 [cytosol] (R-HSA-168917)	0.524	3
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.483	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	8
UniProt:Q8WYQ5 DGCR8	1	DGCR8 [nucleoplasm] (R-HSA-1482509)	0.483	3
UniProt:Q12906 ILF3	3	p-T188,T315-ILF3 [cytosol] (R-HSA-9836381) ILF3 [cytosol] (R-HSA-450564) ILF3 [nucleoplasm] (R-HSA-9760401)	0.483	2
UniProt:P62753 RPS6	4	RPS6 [nucleoplasm] (R-HSA-6790606) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) p-5S-RPS6 [cytosol] (R-HSA-165727) RPS6 [cytosol] (R-HSA-72381)	0.483	4