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UBE2L3 [nucleoplasm]
Stable Identifier
R-HSA-8852056
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Ubiquitin-conjugating enzyme E2 L3 ecNumber evidence="18"2.3.2.23/ecNumber, UB2L3_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Protein ubiquitination (Homo sapiens)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Homo sapiens)
UBA1 conjugates ubiquitin to nuclear E2 enzymes (Homo sapiens)
E2 ubiquitin conjugating enzyme (UBA1 substrate) [nucleoplasm] (Homo sapiens)
UBE2L3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P68036 UBE2L3
Gene Names
UBE2L3, UBCE7, UBCH7
Chain
chain:1-154
Reference Genes
BioGPS Gene:7332 UBE2L3
COSMIC (genes):UBE2L3 UBE2L3
CTD Gene:7332 UBE2L3
dbSNP Gene:7332 UBE2L3
ENSEMBL:ENSG00000185651 UBE2L3
HGNC:12488 UBE2L3
KEGG:hsa:7332 UBE2L3
Monarch:7332 UBE2L3
NCBI Gene:7332 UBE2L3
OMIM:603721 UBE2L3
UCSC:P68036 UBE2L3
Reference Transcript
RefSeq:NM_003347.3 UBE2L3
RefSeq:NM_001256356.1 UBE2L3
RefSeq:NM_001256355.1 UBE2L3
Other Identifiers
11718508_at
11718509_s_at
11718510_a_at
11718511_s_at
11749192_s_at
11749193_x_at
11754929_s_at
16927615
200676_PM_s_at
200676_s_at
200682_PM_s_at
200682_s_at
200683_PM_s_at
200683_s_at
200684_PM_s_at
200684_s_at
223_at
3483952
3483953
3536774
3536775
3536776
3536777
3820148
38701_at
3938176
3938177
3938178
3938183
3938188
3938191
3938192
3938197
3938198
3938199
3938200
3938201
3938202
3938203
3938204
3938205
3938206
3938207
64361_s_at
7332
7968331
8071547
A_21_P0000566
A_23_P166353
GE55131
GO:0000151
GO:0000209
GO:0003713
GO:0003723
GO:0003824
GO:0004842
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006355
GO:0006511
GO:0008283
GO:0016567
GO:0016740
GO:0019787
GO:0019899
GO:0031398
GO:0031625
GO:0032446
GO:0036211
GO:0043226
GO:0044770
GO:0045893
GO:0051443
GO:0060090
GO:0061631
GO:0070979
GO:0071383
GO:0071385
GO:0097027
GO:0098772
GO:0098793
GO:0140096
GO:0140110
GO:1903955
HMNXSV003027099
Hs.108104.0.S1_3p_a_at
Hs.108104.0.S2_3p_a_at
Hs.108104.0.S3_3p_a_at
ILMN_1677877
ILMN_1796830
PH_hs_0029083
S81003_at
TC22000092.hg
TC22000993.hg
g4507788_3p_x_at
Participates
as a member of
E2 ubiquitin conjugating enzyme (UBA1 substrate) [nucleoplasm] (Homo sapiens)
Other forms of this molecule
Ub-C86-UBE2L3 [cytosol]
UBE2L3 [cytosol]
Ub-C86-UBE2L3 [nucleoplasm]
Inferred To
Ube2l3 [nucleoplasm]
(Mus musculus)
Ube2l3 [nucleoplasm]
(Rattus norvegicus)
ube2l3 [nucleoplasm]
(Xenopus tropicalis)
UBE2L3 [nucleoplasm]
(Bos taurus)
UBE2L3 [nucleoplasm]
(Canis familiaris)
UBE2L3 [nucleoplasm]
(Dictyostelium discoideum)
UBE2L3 [nucleoplasm]
(Gallus gallus)
UBE2L3 [nucleoplasm]
(Sus scrofa)
ubc-18 [nucleoplasm]
(Caenorhabditis elegans)
ube2l3a [nucleoplasm]
(Danio rerio)
Ubc10 [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_003338.1
,
NP_001243285.1
,
NP_001243284.1
OpenTargets
ENSG00000185651
ENSEMBL
ENST00000545681
,
ENSP00000445931
,
ENSP00000400906
,
ENSP00000344259
,
ENST00000458578
,
ENST00000342192
IntEnz
2.3.2.23
HPA
ENSG00000185651-UBE2L3
PRO
P68036
Pharos - Targets
P68036
Orphanet
UBE2L3
GlyGen
P68036
HMDB Protein
HMDBP00601
PDB
3SQV
,
7B5N
,
4Q5H
,
8EAZ
,
5UDH
,
7B5L
,
6XXU
,
5HPT
,
1C4Z
,
6DJX
,
6N13
,
1FBV
,
6DJW
,
8EB0
,
7OIK
,
7V8F
,
6CP2
,
5TTE
,
4Q5E
,
3SY2
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O95376 ARIH2
1
ARIH2 [cytosol]
(R-HSA-975987)
0.884
12
UniProt:Q9BYM8 RBCK1
1
RBCK1 [cytosol]
(R-HSA-976018)
0.666
4
UniProt:P50876 RNF144A
1
RNF144A [endosome membrane]
(R-HSA-8938771)
0.666
4
UniProt:O15344 MID1
1
MID1 [cytosol]
(R-HSA-976027)
0.666
4
UniProt:Q9Y4X5 ARIH1
1
ARIH1 [cytosol]
(R-HSA-1678825)
0.643
7
UniProt:Q99PZ6 OSPG
0.558
3
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.556
3
UniProt:Q9NWF9 RNF216
1
RNF216 [cytosol]
(R-HSA-936043)
0.556
3
UniProt:O60260-5 PRKN
0.556
3
IntAct:EBI-23192465 CCSB ORF ID
0.556
3
UniProt:Q8N6D2 RNF182
1
RNF182 [cytosol]
(R-HSA-976010)
0.556
3
UniProt:O94941 UBOX5
1
UBOX5 [cytosol]
(R-HSA-976034)
0.547
2
UniProt:Q6ZMZ0 RNF19B
1
RNF19B [cytosol]
(R-HSA-975969)
0.524
2
UniProt:Q96EQ8 RNF125
2
RNF125 [cytosol]
(R-HSA-918184)
K48polyUb-RNF125 [cytosol]
(R-HSA-3080560)
0.488
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
6
UniProt:Q9NPC3 CIP1
0.482
2
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