Reactome | ACSL4 [endoplasmic reticulum membrane]

ACSL4 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-548712

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Long-chain-fatty-acid--CoA ligase 4

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O60488 ACSL4

Gene Names

ACSL4, ACS4, FACL4, LACS4

Chain

chain:1-711

Reference Genes

BioGPS Gene:2182 ACSL4

COSMIC (genes):ACSL4 ACSL4

CTD Gene:2182 ACSL4

dbSNP Gene:2182 ACSL4

ENSEMBL:ENSG00000068366 ACSL4

HGNC:3571 ACSL4

KEGG:hsa:2182 ACSL4

Monarch:2182 ACSL4

NCBI Gene:2182 ACSL4

OMIM:300157 ACSL4

UCSC:O60488 ACSL4

Reference Transcript

Other Identifiers

11719042_s_at

11727317_at

11752258_a_at

17113293

202422_PM_s_at

202422_s_at

2182

220010_PM_at

220010_at

38099_r_at

4017799

4017807

4017808

4017809

4017811

4017812

4017813

4017814

4017815

4017816

4017819

4017820

4017821

4017822

4017823

4017825

4017829

4017831

4017832

4017834

4017835

4017836

4017837

4017838

4017839

4017840

4017841

4017848

4017849

4017869

4017870

51551_at

8174474

A_19_P00326531

A_23_P217564

A_23_P256641

A_23_P349267

GE54239

GE58479

GO:0000166

GO:0001676

GO:0003824

GO:0004467

GO:0005524

GO:0005737

GO:0005739

GO:0005741

GO:0005777

GO:0005778

GO:0005783

GO:0005789

GO:0005811

GO:0005886

GO:0006629

GO:0006631

GO:0006790

GO:0008610

GO:0016020

GO:0016874

GO:0022414

GO:0030154

GO:0030182

GO:0030307

GO:0031957

GO:0032024

GO:0032307

GO:0035336

GO:0035338

GO:0043226

GO:0044233

GO:0047676

GO:0055086

GO:0060136

GO:0070062

GO:0090433

GO:0140657

GO:1901135

HMNXSV003008120

HMNXSV003014027

HMNXSV003037274

HMNXSV003054504

ILMN_1683598

ILMN_1691714

ILMN_1711650

ILMN_2285506

ILMN_2391458

PH_hs_0008734

PH_hs_0023329

TC0X002336.hg

TC0X002337.hg

g12669908_3p_a_at

g6912441_3p_at

p17064

Participates

as a member of

ACSL3,4 [endoplasmic reticulum membrane] (Homo sapiens)

Other forms of this molecule

ACSL4 [mitochondrial outer membrane]

Inferred To

acsl4 [endoplasmic reticulum membrane] (Xenopus tropicalis)

acsl4a [endoplasmic reticulum membrane] (Danio rerio)

Acsl4 [endoplasmic reticulum membrane] (Mus musculus)

Acsl4 [endoplasmic reticulum membrane] (Rattus norvegicus)

Acsl [endoplasmic reticulum membrane] (Drosophila melanogaster)

acs-17 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

ACSL4 [endoplasmic reticulum membrane] (Bos taurus)

ACSL4 [endoplasmic reticulum membrane] (Canis familiaris)

ACSL4 [endoplasmic reticulum membrane] (Gallus gallus)

ACSL4 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

ACSL4 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

ACSL4 [endoplasmic reticulum membrane] (Sus scrofa)

Cross References

ENSEMBL

ENST00000672282, ENSP00000262835, ENSP00000500678, ENSP00000419171, ENSP00000500897, ENST00000348502, ENSP00000425408, ENSP00000499969, ENST00000502391, ENST00000671846, ENSP00000339787, ENST00000340800, ENST00000469796, ENST00000672401, ENSP00000500273, ENST00000673016

OpenTargets

ENSG00000068366

IntEnz

6.2.1.3

HPA

ENSG00000068366-ACSL4

PRO

O60488

Pharos - Targets

O60488

GlyGen

O60488

Orphanet

ACSL4

HMDB Protein

HMDBP00570

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.527	9

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