Reactome | MAT2A [cytosol]

MAT2A [cytosol]

Stable Identifier

R-HSA-174363

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

MAT II

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P31153 MAT2A

Gene Names

MAT2A, AMS2, MATA2

Chain

chain:1-395

Reference Genes

BioGPS Gene:4144 MAT2A

COSMIC (genes):MAT2A MAT2A

CTD Gene:4144 MAT2A

dbSNP Gene:4144 MAT2A

ENSEMBL:ENSG00000168906 MAT2A

HGNC:6904 MAT2A

KEGG:hsa:4144 MAT2A

Monarch:4144 MAT2A

NCBI Gene:4144 MAT2A

OMIM:601468 MAT2A

UCSC:P31153 MAT2A

Reference Transcript

RefSeq:NM_005911.5 MAT2A

Other Identifiers

11734751_x_at

11751134_x_at

11751457_a_at

11756985_a_at

11757376_s_at

11760938_a_at

16882258

17123316

200768_PM_s_at

200768_s_at

200769_PM_s_at

200769_s_at

2491623

2491624

2491625

2491626

2491627

2491629

2491630

2491631

2491632

2491633

2491634

2491635

2491636

2491637

2491638

2491639

2491640

2491641

2491642

2491643

2491644

2491645

2491646

2491647

2491648

2491649

2491650

2491651

2491652

2491654

2491656

2688877

2688878

2688879

2688880

2688881

32571_at

3426023

3426028

4144

80415_at

8043187

A_14_P131822

A_23_P401568

A_32_P87703

A_33_P3403044

A_33_P3403048

GE59950

GO:0003824

GO:0004478

GO:0005515

GO:0005524

GO:0005829

GO:0006556

GO:0006730

GO:0006790

GO:0016740

GO:0034214

GO:0036094

GO:0042802

GO:0046872

GO:0048269

GO:0051291

GO:0061431

GO:0065003

GO:1904263

GO:1990830

HMNXSV003001312

HMNXSV003025543

ILMN_1737298

PH_hs_0027696

TC02000511.hg

X68836_at

g12804546_3p_at

g12804546_3p_s_at

g5174528_3p_a_at

Participates

as a component of

MAT2A:K+:2Mg2+ [cytosol] (Homo sapiens)

Inferred To

MAT1A [cytosol] (Dictyostelium discoideum)

mat2a [cytosol] (Xenopus tropicalis)

mat2aa [cytosol] (Danio rerio)

MAT2L [cytosol] (Gallus gallus)

MAT2A [cytosol] (Bos taurus)

MAT2A [cytosol] (Canis familiaris)

MAT2A [cytosol] (Mus musculus)

MAT2A [cytosol] (Rattus norvegicus)

MAT2A [cytosol] (Sus scrofa)

Cross References

OpenTargets

ENSG00000168906

ENSEMBL

ENSP00000386353, ENSP00000303147, ENST00000409017, ENST00000306434

IntEnz

2.5.1.6

HPA

ENSG00000168906-MAT2A

PRO

P31153

Pharos - Targets

P31153

Orphanet

MAT2A

GlyGen

P31153

HMDB Protein

HMDBP00405

PDB

6FAJ, 6P9V, 6FWB, 6FBN, 7RW7, 6G6R, 8QE2, 7LNH, 7L1A, 7KDB, 8QE3, 2P02, 7RWH, 7BHS, 7BHX, 7RXV, 7BHR, 7BHU, 6FCB, 7BHW, 8P1T, 5UGH, 8P1V, 8AXZ, 5A19, 7KCC, 7RW5, 6WKB, 6FBO, 6FBP, 8QE0, 5A1I, 8QDZ, 8QE1, 8QDY, 7KDA, 5A1G, 7RWG, 7RXX, 7BHV, 7BHT, 8OOG, 6FCD, 7RXW, 8P4H, 4KTT, 7KCF, 8P1W, 4NDN, 8XAM, 7KCE, 4KTV

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	14
UniProt:P02795 MT2A	1	MT2A [cytosol] (R-HSA-1031707)	0.556	3
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.556	3
UniProt:Q9UIH9 KLF15	1	KLF15 [nucleoplasm] (R-HSA-8878735)	0.556	3
UniProt:O43663 PRC1	1	PRC1 [cytosol] (R-HSA-264441)	0.556	3

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