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AARS [cytosol]
Stable Identifier
R-HSA-379666
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Alanyl-tRNA synthetase
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
tRNA Aminoacylation (Homo sapiens)
Cytosolic tRNA aminoacylation (Homo sapiens)
alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate (Homo sapiens)
AARS [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49588 AARS1
Gene Names
AARS1, AARS
Chain
chain:1-968
Reference Genes
BioGPS Gene:16 AARS1
COSMIC (genes):AARS AARS1
CTD Gene:16 AARS1
dbSNP Gene:16 AARS1
ENSEMBL:ENSG00000090861 AARS
HGNC:20 AARS1
Monarch:16 AARS1
NCBI Gene:16 AARS1
OMIM:601065 AARS1
UCSC:P49588 AARS1
Reference Transcript
RefSeq:NM_001605.2 AARS1
Other Identifiers
11716636_a_at
11735184_at
11746316_a_at
1553947_3p_at
1553947_PM_at
1553947_at
16
16827761
16827764
201000_PM_at
201000_at
36185_at
3697004
3697006
3697007
3697008
3697009
3697010
3697011
3697012
3697013
3697014
3697016
3697017
3697018
3697019
3697020
3697021
3697022
3697023
3697024
3697025
3697026
3697027
3697028
3697029
3697030
3697031
3697032
3697033
3697034
3697035
3697036
3697037
3697038
3697039
3697040
3697041
3697042
3697043
3697045
3697046
3697047
3697048
3697050
3697052
3697054
3697055
8002344
8002347
A_23_P100413
A_24_P172990
A_24_P39639
A_32_P121794
D32050_at
GE57174
GO:0000049
GO:0000166
GO:0002161
GO:0002196
GO:0003676
GO:0003723
GO:0003824
GO:0004812
GO:0004813
GO:0005524
GO:0005634
GO:0005737
GO:0005739
GO:0005829
GO:0006399
GO:0006400
GO:0006412
GO:0006418
GO:0006419
GO:0006520
GO:0008033
GO:0008270
GO:0012501
GO:0016020
GO:0016597
GO:0016787
GO:0016874
GO:0021680
GO:0035332
GO:0043039
GO:0043226
GO:0043524
GO:0046872
GO:0048856
GO:0050877
GO:0050885
GO:0050905
GO:0051402
GO:0070062
GO:0106074
GO:0140018
GO:0140098
GO:0140101
GO:0141207
GO:1901797
HMNXSV003009448
HMNXSV003020160
ILMN_1662364
ILMN_1670218
PH_hs_0020045
PH_hs_0023757
PH_hs_0040543
TC16001233.hg
TC16001234.hg
g4501840_3p_at
Cross References
ENSEMBL
ENST00000261772
,
ENST00000674691
,
ENSP00000502797
,
ENSP00000502247
,
ENST00000675643
,
ENSP00000261772
,
ENST00000674963
,
ENSP00000501924
OpenTargets
ENSG00000090861
IntEnz
6.1.1.7
HPA
ENSG00000090861-AARS1
ZINC - Substances
SYAC_HUMAN
ZINC target
P49588
PRO
P49588
Pharos - Targets
P49588
GlyGen
P49588
Orphanet
AARS1
HMDB Protein
HMDBP00625
PDB
5V59
,
4XEO
,
5T76
,
5KNN
,
4XEM
,
5T5S
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.527
4
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
6
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