Reactome | PSMD14 [nucleoplasm]

PSMD14 [nucleoplasm]

Stable Identifier

R-HSA-174329

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

26S proteasome-associated pad1 homolog

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - G1/S DNA Damage Checkpoints (Homo sapiens)
    - p53-Independent G1/S DNA Damage Checkpoint (Homo sapiens)
      - Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A (Homo sapiens)
        
        Proteolytic degradation of ubiquitinated-Cdc25A (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP Lid Module 1 [nucleoplasm] (Homo sapiens)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
        
        PSMD14 [nucleoplasm] (Homo sapiens)
- Cell Cycle, Mitotic (Homo sapiens)
  - Mitotic G1 phase and G1/S transition (Homo sapiens)
    - G1/S Transition (Homo sapiens)
      - Cyclin E associated events during G1/S transition (Homo sapiens)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP Lid Module 1 [nucleoplasm] (Homo sapiens)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
        
        PSMD14 [nucleoplasm] (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP Lid Module 1 [nucleoplasm] (Homo sapiens)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
        
        PSMD14 [nucleoplasm] (Homo sapiens)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
        
        Degradation of multiubiquitinated Cdh1 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP Lid Module 1 [nucleoplasm] (Homo sapiens)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
        
        PSMD14 [nucleoplasm] (Homo sapiens)
  - S Phase (Homo sapiens)
    - Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
      - SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP Lid Module 1 [nucleoplasm] (Homo sapiens)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
        
        PSMD14 [nucleoplasm] (Homo sapiens)

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP Lid Module 1 [nucleoplasm] (Homo sapiens)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
        
        PSMD14 [nucleoplasm] (Homo sapiens)

Circadian clock (Homo sapiens)

- Degradation of CRY and PER proteins (Homo sapiens)
  - Proteolysis of K48polyUb,p-S-CRY1,2 (Homo sapiens)
    - 26S proteasome [nucleoplasm] (Homo sapiens)
      - 19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP Lid Module 1 [nucleoplasm] (Homo sapiens)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
        
        PSMD14 [nucleoplasm] (Homo sapiens)

DNA Replication (Homo sapiens)

- DNA Replication Pre-Initiation (Homo sapiens)
  - Assembly of the pre-replicative complex (Homo sapiens)
    - Ubiquitinated geminin is degraded by the proteasome (Homo sapiens)
      - 26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP Lid Module 1 [nucleoplasm] (Homo sapiens)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
        
        PSMD14 [nucleoplasm] (Homo sapiens)

Developmental Biology (Homo sapiens)

- Gastrulation (Homo sapiens)
  - Formation of paraxial mesoderm (Homo sapiens)
    - Somitogenesis (Homo sapiens)
      - RIPPLY2 binds TBX6 and recruits the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP Lid Module 1 [nucleoplasm] (Homo sapiens)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
        
        PSMD14 [nucleoplasm] (Homo sapiens)
        
        TBX6:RIPPLY2:26S proteasome [nucleoplasm] (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP Lid Module 1 [nucleoplasm] (Homo sapiens)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
        
        PSMD14 [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX2 (Homo sapiens)
      - Regulation of RUNX2 expression and activity (Homo sapiens)
        
        26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP Lid Module 1 [nucleoplasm] (Homo sapiens)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
        
        PSMD14 [nucleoplasm] (Homo sapiens)
    - Transcriptional regulation by RUNX3 (Homo sapiens)
      - Regulation of RUNX3 expression and activity (Homo sapiens)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP Lid Module 1 [nucleoplasm] (Homo sapiens)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
        
        PSMD14 [nucleoplasm] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Hedgehog (Homo sapiens)
  - Hedgehog 'on' state (Homo sapiens)
    - GLI2,3 are degraded by the proteasome (Homo sapiens)
      - 26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP Lid Module 1 [nucleoplasm] (Homo sapiens)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
        
        PSMD14 [nucleoplasm] (Homo sapiens)
- Signaling by NOTCH (Homo sapiens)
  - Signaling by NOTCH4 (Homo sapiens)
    - Negative regulation of NOTCH4 signaling (Homo sapiens)
      - Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP Lid Module 1 [nucleoplasm] (Homo sapiens)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
        
        PSMD14 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O00487 PSMD14

Gene Names

PSMD14, POH1

Chain

chain:1-310

Reference Genes

BioGPS Gene:10213 PSMD14

COSMIC (genes):PSMD14 PSMD14

CTD Gene:10213 PSMD14

dbSNP Gene:10213 PSMD14

ENSEMBL:ENSG00000115233 PSMD14

HGNC:16889 PSMD14

KEGG:hsa:10213 PSMD14

Monarch:10213 PSMD14

NCBI Gene:10213 PSMD14

OMIM:607173 PSMD14

UCSC:O00487 PSMD14

Reference Transcript

RefSeq:NM_005805.6 PSMD14

Other Identifiers

10213

11733918_a_at

11744362_a_at

16886919

212296_PM_at

212296_at

2512702

2512703

2512704

2512705

2512706

2512707

2512708

2512709

2512710

2512717

2512718

2512720

2512721

2512726

2512727

2512728

2512729

2512730

2512731

2512733

2512735

2512740

2512741

2512742

2512743

2512744

2512746

2512747

2512749

33247_at

43809_at

8045946

87461_at

A_23_P165691

GE59512

GE743596

GO:0000502

GO:0000724

GO:0005515

GO:0005576

GO:0005634

GO:0005654

GO:0005829

GO:0006281

GO:0006303

GO:0006310

GO:0006508

GO:0006511

GO:0006974

GO:0008233

GO:0008237

GO:0008541

GO:0016579

GO:0016787

GO:0022624

GO:0030163

GO:0031597

GO:0034774

GO:0043161

GO:0045471

GO:0046872

GO:0061133

GO:0061136

GO:0061578

GO:0070536

GO:0070628

GO:0098772

GO:0140492

GO:1904813

HMNXSV003017627

Hs.178761.0.S1_3p_at

ILMN_1737396

PH_hs_0010617

TC02000970.hg

U86782_at

p27462

Participates

as a component of

PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PSMD14 [cytosol]

PSMD14 [secretory granule lumen]

PSMD14 [extracellular region]

PSMD14 [ficolin-1-rich granule lumen]

Inferred To

psmd14 [nucleoplasm] (Danio rerio)

psmd14 [nucleoplasm] (Xenopus tropicalis)

PSMD14 [nucleoplasm] (Bos taurus)

PSMD14 [nucleoplasm] (Gallus gallus)

PSMD14 [nucleoplasm] (Plasmodium falciparum)

PSMD14 [nucleoplasm] (Sus scrofa)

psmD14 [nucleoplasm] (Dictyostelium discoideum)

Psmd14 [nucleoplasm] (Mus musculus)

Psmd14 [nucleoplasm] (Rattus norvegicus)

Rpn11 [nucleoplasm] (Drosophila melanogaster)

rpn-11 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of PSMD14 [nucleoplasm] (Canis familiaris)

Cross References

RefSeq

NP_005796.1

Guide to Pharmacology - Targets

2410

ENSEMBL

ENSP00000386541, ENST00000409682, ENSG00000115233

OpenTargets

ENSG00000115233

GeneCards

PSMD14

HPA

ENSG00000115233-PSMD14

PRO

O00487

Pharos - Targets

O00487

GlyGen

O00487

PDB

5T0H, 7W37, 5GJR, 9E8L, 9E8N, 5VGZ, 6WJN, 6MSG, 5VFP, 7QXX, 7QY7, 7W3C, 8K0G, 7W3F, 7QYA, 9E8G, 5T0I, 5VHS, 8JTI, 9E8K, 9E8I, 5T0C, 5L4K, 8USC, 8JRT, 6MSJ, 7W3B, 5VFS, 7W3A, 9E8Q, 7W3I, 7W39, 7QXU, 6MSB, 7W3G, 5VFQ, 6WJD, 5GJQ, 5T0G, 5LN3, 9E8O, 7QXW, 8JRI, 6MSE, 7QXP, 7QXN, 6MSD, 7W3M, 7W3K, 7QYB, 5VHH, 5T0J, 5M32, 5VHI, 8CVT, 9E8H, 9E8J, 8USB, 5VHF, 7W3J, 7W3H, 6MSK, 5VFT, 6MSH, 7W38, 5VFU, 5VFR

Interactors (32)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P51665 PSMD7	5	PSMD7 [cytosol] (R-HSA-68806) PSMD7 [nucleoplasm] (R-HSA-174309) PSMD7 [secretory granule lumen] (R-HSA-6801008) PSMD7 [extracellular region] (R-HSA-6806488) PSMD7 [ficolin-1-rich granule lumen] (R-HSA-6800406)	0.904	16
UniProt:O00232 PSMD12	5	PSMD12 [cytosol] (R-HSA-68792) PSMD12 [nucleoplasm] (R-HSA-174339) PSMD12 [secretory granule lumen] (R-HSA-6800934) PSMD12 [extracellular region] (R-HSA-6806480) PSMD12 [ficolin-1-rich granule lumen] (R-HSA-6800416)	0.788	6
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.725	5
UniProt:Q16186 ADRM1	2	ADRM1 [cytosol] (R-HSA-5665939) ADRM1 [nucleoplasm] (R-HSA-9918361)	0.725	5
UniProt:Q9C005 DPY30	1	DPY30 [nucleoplasm] (R-HSA-5669104)	0.718	6
UniProt:Q9UNM6 PSMD13	5	PSMD13 [cytosol] (R-HSA-68794) PSMD13 [nucleoplasm] (R-HSA-174326) PSMD13 [secretory granule lumen] (R-HSA-6800983) PSMD13 [extracellular region] (R-HSA-6806469) PSMD13 [ficolin-1-rich granule lumen] (R-HSA-6800413)	0.669	4
UniProt:Q15008 PSMD6	5	PSMD6 [cytosol] (R-HSA-68804) PSMD6 [nucleoplasm] (R-HSA-174316) PSMD6 [secretory granule lumen] (R-HSA-6801036) PSMD6 [extracellular region] (R-HSA-6806486) PSMD6 [ficolin-1-rich granule lumen] (R-HSA-6800440)	0.669	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	7
UniProt:O00231 PSMD11	5	PSMD11 [cytosol] (R-HSA-68790) PSMD11 [nucleoplasm] (R-HSA-174327) PSMD11 [secretory granule lumen] (R-HSA-6800943) PSMD11 [extracellular region] (R-HSA-6806441) PSMD11 [ficolin-1-rich granule lumen] (R-HSA-6800436)	0.648	3
UniProt:P62195 PSMC5	2	PSMC5 [cytosol] (R-HSA-68780) PSMC5 [nucleoplasm] (R-HSA-174312)	0.643	4
UniProt:O43242 PSMD3	5	PSMD3 [cytosol] (R-HSA-68798) PSMD3 [nucleoplasm] (R-HSA-174328) PSMD3 [secretory granule lumen] (R-HSA-6800873) PSMD3 [extracellular region] (R-HSA-6806443) PSMD3 [ficolin-1-rich granule lumen] (R-HSA-6800408)	0.643	3
UniProt:P43686 PSMC4	2	PSMC4 [cytosol] (R-HSA-68777) PSMC4 [nucleoplasm] (R-HSA-174315)	0.643	3
UniProt:O75832 PSMD10	1	PSMD10 [cytosol] (R-HSA-68788)	0.643	4
UniProt:Q13200 PSMD2	5	PSMD2 [cytosol] (R-HSA-68796) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [secretory granule lumen] (R-HSA-6800919) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435)	0.643	3
UniProt:P50222 MEOX2			0.556	3
UniProt:Q8IZU0 FAM9B			0.556	3
UniProt:P62333 PSMC6	2	PSMC6 [cytosol] (R-HSA-68783) PSMC6 [nucleoplasm] (R-HSA-174319)	0.528	2
UniProt:P48556 PSMD8	2	PSMD8 [cytosol] (R-HSA-68808) PSMD8 [nucleoplasm] (R-HSA-174318)	0.527	2
UniProt:P55036 PSMD4	1	PSMD4 [cytosol] (R-HSA-68800)	0.527	3
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521)	0.527	4
UniProt:P35998 PSMC2	5	PSMC2 [cytosol] (R-HSA-68771) PSMC2 [nucleoplasm] (R-HSA-174332) PSMC2 [secretory granule lumen] (R-HSA-6800994) PSMC2 [extracellular region] (R-HSA-6806472) PSMC2 [ficolin-1-rich granule lumen] (R-HSA-6800421)	0.527	2
UniProt:P28065 PSMB9	3	PSMB9 [cytosol] (R-HSA-68765) pro-PSMB9 [cytosol] (R-HSA-9908136) PSMB9(1-20) [cytosol] (R-HSA-9908132)	0.527	3
UniProt:P49720 PSMB3	2	PSMB3 [cytosol] (R-HSA-68747) PSMB3 [nucleoplasm] (R-HSA-174341)	0.527	3
UniProt:P62191 PSMC1	2	PSMC1 [cytosol] (R-HSA-68768) PSMC1 [nucleoplasm] (R-HSA-174338)	0.527	3
UniProt:Q99460 PSMD1	4	PSMD1 [cytosol] (R-HSA-68786) PSMD1 [nucleoplasm] (R-HSA-174348) PSMD1 [azurophil granule lumen] (R-HSA-6798741) PSMD1 [extracellular region] (R-HSA-6806194)	0.527	2
UniProt:Q16401 PSMD5	1	PSMD5 [cytosol] (R-HSA-68802)	0.527	2
UniProt:P17980 PSMC3	5	PSMC3 [cytosol] (R-HSA-68774) PSMC3 [nucleoplasm] (R-HSA-174313) PSMC3 [secretory granule lumen] (R-HSA-6800917) PSMC3 [extracellular region] (R-HSA-6806496) PSMC3 [ficolin-1-rich granule lumen] (R-HSA-6800429)	0.527	2
UniProt:Q5JXX7 TMM31			0.527	3
UniProt:Q8NB90 AFG2A			0.527	2
UniProt:Q53HC0 CCD92			0.527	3
UniProt:Q96EN9 REX1B			0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.483	10