Reactome | CLTB [plasma membrane]

CLTB [plasma membrane]

Stable Identifier

R-HSA-2980617

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Clathrin light chain B, CLCB_HUMAN

Locations in the PathwayBrowser

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Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - EPH-Ephrin signaling (Homo sapiens)
      - EPH-ephrin mediated repulsion of cells (Homo sapiens)
        
        Clathrin internalises EPH:EFN complexes (Homo sapiens)
        
        Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin light chains [plasma membrane] (Homo sapiens)
        
        CLTB [plasma membrane] (Homo sapiens)
        
        EPHB:EFNB:F-actin:AP-2:Clathrrin:Dynamin [plasma membrane] (Homo sapiens)
        
        Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin light chains [plasma membrane] (Homo sapiens)
        
        CLTB [plasma membrane] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Gap junction trafficking and regulation (Homo sapiens)
    - Gap junction trafficking (Homo sapiens)
      - Gap junction degradation (Homo sapiens)
        
        Formation of annular gap junctions (Homo sapiens)
        
        Dab2 is recruited to the junctional plaques (Homo sapiens)
        
        planar gap junction plaques [plasma membrane] (Homo sapiens)
        
        Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin light chains [plasma membrane] (Homo sapiens)
        
        CLTB [plasma membrane] (Homo sapiens)
        
        planar gap junction plaques associated with Dab2 [plasma membrane] (Homo sapiens)
        
        planar gap junction plaques [plasma membrane] (Homo sapiens)
        
        Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin light chains [plasma membrane] (Homo sapiens)
        
        CLTB [plasma membrane] (Homo sapiens)
        
        Dynamin is recruited to the gap junction plaque (Homo sapiens)
        
        Planar gap junction plaques associated with Dab2 and Dynamin [plasma membrane] (Homo sapiens)
        
        planar gap junction plaques associated with Dab2 [plasma membrane] (Homo sapiens)
        
        planar gap junction plaques [plasma membrane] (Homo sapiens)
        
        Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin light chains [plasma membrane] (Homo sapiens)
        
        CLTB [plasma membrane] (Homo sapiens)
        
        planar gap junction plaques associated with Dab2 [plasma membrane] (Homo sapiens)
        
        planar gap junction plaques [plasma membrane] (Homo sapiens)
        
        Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin light chains [plasma membrane] (Homo sapiens)
        
        CLTB [plasma membrane] (Homo sapiens)
        
        Internalization of gap junction plaques (Homo sapiens)
        
        Planar gap junction plaques associated with Dab2 and Dynamin [plasma membrane] (Homo sapiens)
        
        planar gap junction plaques associated with Dab2 [plasma membrane] (Homo sapiens)
        
        planar gap junction plaques [plasma membrane] (Homo sapiens)
        
        Clathrin [plasma membrane] (Homo sapiens)
        
        Clathrin light chains [plasma membrane] (Homo sapiens)
        
        CLTB [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P09497 CLTB

Gene Names

CLTB

Chain

chain:1-229

Reference Genes

BioGPS Gene:1212 CLTB

COSMIC (genes):CLTB CLTB

CTD Gene:1212 CLTB

dbSNP Gene:1212 CLTB

ENSEMBL:ENSG00000175416 CLTB

HGNC:2091 CLTB

KEGG:hsa:1212 CLTB

Monarch:1212 CLTB

NCBI Gene:1212 CLTB

OMIM:118970 CLTB

UCSC:P09497 CLTB

Reference Transcript

Other Identifiers

11734975_a_at

1212

17003065

205172_PM_x_at

205172_x_at

206284_PM_x_at

206284_x_at

211043_PM_s_at

211043_s_at

216934_PM_at

216934_at

2888305

2888306

2888307

2888308

2888309

2888310

2888311

2888312

2888315

2888316

2888318

2888319

2888320

32522_f_at

32523_at

39307_s_at

39308_r_at

8115918

A_23_P252671

A_23_P60610

A_33_P3328666

GE57859

GO:0005198

GO:0005515

GO:0005802

GO:0005829

GO:0005886

GO:0005905

GO:0006886

GO:0016192

GO:0030118

GO:0030125

GO:0030130

GO:0030132

GO:0030659

GO:0030672

GO:0031410

GO:0032050

GO:0042277

GO:0043226

GO:0043231

GO:0045334

GO:0048488

GO:0060170

GO:0072583

GO:0098835

GO:0099631

HMNXSV003006181

HMNXSV003046638

Hs.73919.3.S1_3p_at

ILMN_1674609

ILMN_1709346

PH_hs_0018539

TC05002093.hg

X81637_at

g4502900_3p_s_at

Participates

as a candidate of

Clathrin light chains [plasma membrane] (Homo sapiens)

Other forms of this molecule

CLTB [cytosol]

CLTB [trans-Golgi network membrane]

CLTB [clathrin-coated endocytic vesicle membrane]

CLTB [lysosomal membrane]

Inferred To

Clc [plasma membrane] (Drosophila melanogaster)

CLC1 [plasma membrane] (Saccharomyces cerevisiae)

CLTB [plasma membrane] (Bos taurus)

CLTB [plasma membrane] (Canis familiaris)

CLTB [plasma membrane] (Gallus gallus)

CLTB [plasma membrane] (Sus scrofa)

clc [plasma membrane] (Dictyostelium discoideum)

cltb [plasma membrane] (Xenopus tropicalis)

Cltb [plasma membrane] (Mus musculus)

Cltb [plasma membrane] (Rattus norvegicus)

clic-1 [plasma membrane] (Caenorhabditis elegans)

clc1 [plasma membrane] (Schizosaccharomyces pombe)

Cross References

ENSEMBL

ENST00000345807, ENST00000310418, ENSP00000309415, ENSP00000310812, ENSG00000175416

OpenTargets

ENSG00000175416

GeneCards

CLTB

HPA

ENSG00000175416-CLTB

PRO

P09497

Pharos - Targets

P09497

GlyGen

P09497

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42566 EPS15	2	p-Y849 EPS15 [cytosol] (R-HSA-8867028) EPS15 [cytosol] (R-HSA-182920)	0.527	2
UniProt:Q14677 CLINT1	1	CLINT1 [cytosol] (R-HSA-429811)	0.527	2
UniProt:P55735 SEC13	4	SEC13 [cytosol] (R-HSA-203981) SEC13 [endoplasmic reticulum membrane] (R-HSA-203994) SEC13 [ER to Golgi transport vesicle membrane] (R-HSA-204012) SEC13 [lysosomal membrane] (R-HSA-9638246)	0.527	2
UniProt:O00443 PIK3C2A	3	PIK3C2A [cytosol] (R-HSA-1604624) PIK3C2A [cytoplasmic vesicle membrane] (R-HSA-432683) PIK3C2A [Golgi membrane] (R-HSA-432679)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	5