Reactome | PolyUb-LDHA [cytosol]

PolyUb-LDHA [cytosol]

Stable Identifier

R-HSA-9861549

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

lactate dehydrogenase A, L-lactate dehydrogenase A chain , LDH-A, LDH muscle subunit, LDH-M

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P00338 LDHA

Gene Names

LDHA, PIG19

Chain

initiator methionine:, chain:2-332

Reference Genes

BioGPS Gene:3939 LDHA

COSMIC (genes):LDHA LDHA

CTD Gene:3939 LDHA

dbSNP Gene:3939 LDHA

ENSEMBL:ENSG00000134333 LDHA

HGNC:6535 LDHA

KEGG:hsa:3939 LDHA

Monarch:3939 LDHA

NCBI Gene:3939 LDHA

OMIM:150000 LDHA

UCSC:P00338 LDHA

Reference Transcript

Other Identifiers

11733020_s_at

11733021_x_at

11742116_x_at

11756723_x_at

16722603

16722632

200650_PM_s_at

200650_s_at

2386590

2478578

2478586

2478587

3199613

3199615

3322776

3322777

3322778

3322779

3322780

3322781

3322782

3322783

3322784

3322785

3322786

3322787

3322788

3322789

3322790

3322791

3322792

3322793

3322794

3322795

3322797

3322798

3322799

3322800

3322801

3322802

3322803

3322804

3322805

3322806

3939

41485_at

7938777

A_23_P47565

GE59637

GE84963

GO:0003824

GO:0004459

GO:0005515

GO:0005634

GO:0005737

GO:0005739

GO:0005829

GO:0005975

GO:0006089

GO:0006090

GO:0006091

GO:0006096

GO:0016020

GO:0016491

GO:0016616

GO:0019752

GO:0021762

GO:0042802

GO:0043226

GO:0045296

GO:0048856

GO:0055086

GO:0070062

GO:1901135

GO:1990204

HMNXSV003023570

HMNXSV003053356

ILMN_1807106

PH_hs_0028715

TC11000240.hg

TC11002588.hg

X02152_at

g5031856_3p_a_at

p2667

Participates

as an output of

CTLH E3 ligase ubiquitinates LDHA (Homo sapiens)

This entity regulates

Negatively

Other forms of this molecule

LDHA [cytosol]

Inferred To

LOC490690 [cytosol] (Canis familiaris)

PolyUb-LDHA [cytosol] (Bos taurus)

PolyUb-LDHA [cytosol] (Caenorhabditis elegans)

PolyUb-LDHA [cytosol] (Danio rerio)

PolyUb-LDHA [cytosol] (Drosophila melanogaster)

PolyUb-LDHA [cytosol] (Gallus gallus)

PolyUb-LDHA [cytosol] (Mus musculus)

PolyUb-LDHA [cytosol] (Rattus norvegicus)

PolyUb-LDHA [cytosol] (Sus scrofa)

PolyUb-LDHA [cytosol] (Xenopus tropicalis)

Homologues of PolyUb-LDHA [cytosol] (Drosophila melanogaster)

Modified Residues

Name

ubiquitinylated lysine (polyubiquitin chain [cytosol]) at unknown position

Modification

polyubiquitin chain [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001158886.1, NP_001128711.1, NP_005557.1, NP_001158887.1, NP_001158888.1

OpenTargets

ENSG00000134333

ENSEMBL

ENSP00000499898, ENSP00000368722, ENSP00000499977, ENST00000430553, ENSP00000500603, ENST00000227157, ENSP00000500953, ENSP00000227157, ENSP00000500354, ENST00000396222, ENST00000671981, ENST00000672078, ENSP00000445331, ENST00000672996, ENSP00000395337, ENST00000673204, ENSP00000500284, ENST00000673007, ENST00000673083, ENSP00000379524, ENST00000542179, ENSP00000406172, ENSP00000500168, ENST00000379412, ENST00000422447, ENST00000672405

ZINC - Substances

LDHA_HUMAN

ZINC target

P00338

PRO

P00338

GlyGen

P00338

PDB

4M49, 5W8L, 4OJN, 7M2N, 6BAZ, 6BB3, 5IXY, 6Q13, 4L4R, 6BB2, 6Q0D, 5IXS, 6BAX, 6MVA, 6BAD, 4QO8, 6BB1, 6BAG, 6BB0, 4ZVV, 6ZZR, 5W8K, 5W8J, 5ZJD, 1I10, 8FW6, 4OKN, 5W8H, 4L4S, 4JNK, 5W8I, 4QSM, 4AJP, 4R68, 4RLS, 4QT0, 5ZJF, 5ZJE, 6MV8, 6SBU, 6SBV, 4QO7, 4R69

HPA

ENSG00000134333-LDHA

Pharos - Targets

P00338

Orphanet

LDHA

ZINC - Predictions - Purchasable

LDHA_HUMAN

HMDB Protein

HMDBP03579

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07195 LDHB	1	LDHB [cytosol] (R-HSA-70503)	0.804	5
UniProt:P07864 LDHC	1	LDHC [cytosol] (R-HSA-6807524)	0.708	6
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.706	20
UniProt:P00338 LDHA	2	LDHA [cytosol] (R-HSA-70502) PolyUb-LDHA [cytosol] (R-HSA-9861549)	0.668	3
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.639	4
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.569	5
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:P0DTD1-PRO_0000449630 REP			0.527	2
UniProt:P0DTD1-PRO_0000449627 REP			0.482	2
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE			0.462	2
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE			0.462	2

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