Reactome | CLIP1(1-1083)-LTK(488-864) fusion [plasma membrane]

CLIP1(1-1083)-LTK(488-864) fusion [plasma membrane]

Stable Identifier

R-HSA-9842572

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

CAP-Gly domain-containing linker protein 1, CLIP1_HUMAN

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
34819663	The CLIP1-LTK fusion is an oncogenic driver in non-small-cell lung cancer Izumi, H, Matsumoto, S, Liu, J, Tanaka, K, Mori, S, Hayashi, K, Kumagai, S, Shibata, Y, Hayashida, T, Watanabe, K, Fukuhara, T, Ikeda, T, Yoh, K, Kato, T, Nishino, K, Nakamura, A, Nakachi, I, Kuyama, S, Furuya, N, Sakakibara-Konishi, J, Okamoto, I, Taima, K, Ebi, N, Daga, H, Yamasaki, A, Kodani, M, Udagawa, H, Kirita, K, Zenke, Y, Nosaki, K, Sugiyama, E, Sakai, T, Nakai, T, Ishii, G, Niho, S, Ohtsu, A, Kobayashi, SS, Goto, K	Nature	2021

External Reference Information

External Reference

UniProt:P30622 CLIP1

Gene Names

CLIP1, CYLN1, RSN

Chain

chain:1-1438

Reference Genes

BioGPS Gene:6249 CLIP1

COSMIC (genes):CLIP1 CLIP1

CTD Gene:6249 CLIP1

dbSNP Gene:6249 CLIP1

ENSEMBL:ENSG00000130779 CLIP1

HGNC:10461 CLIP1

KEGG:hsa:6249 CLIP1

Monarch:6249 CLIP1

NCBI Gene:6249 CLIP1

OMIM:179838 CLIP1

UCSC:P30622 CLIP1

Reference Transcript

Participates

as a component of

CLIP1(1-1083)-LTK(488-864) fusion dimer [plasma membrane] (Homo sapiens)

as an input of

CLIP1(1-1083)-LTK(488-864) fusion dimerizes (Homo sapiens)

Other forms of this molecule

CLIP1 [cytosol]

CLIP1(1-1083)-p-6Y LTK(488-864) fusion [plasma membrane]

Modified Residues

Name

Insertion of residues 488 to 864 at 1084 from UniProt:P29376 LTK

Coordinate

1084

Disease

Name	Identifier	Synonyms
non-small cell lung carcinoma	DOID:3908	Non-small cell lung cancer (disorder), NSCLC, NSCLC
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer

Cross References

RefSeq

NP_937883.1, NP_001234926.1, XP_047285272.1, XP_016875279.1, XP_047285273.1, XP_016875275.1, NP_002947.1, XP_047285266.1

OpenTargets

ENSG00000130779

ENSEMBL

ENSP00000303585, ENST00000537178, ENST00000302528, ENST00000358808, ENST00000620786, ENSP00000479322, ENSP00000351665, ENSG00000130779, ENSP00000445531

Mondo

0005233

HPA

ENSG00000130779-CLIP1

GeneCards

CLIP1

PRO

P30622

Pharos - Targets

P30622

Orphanet

CLIP1

GlyGen

P30622

PDB

8WHI, 2HQH, 3RDV, 2E3I, 2E3H, 3E2U, 2E4H, 8WHH, 2CP5, 2CP6, 2QK0

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15691 MAPRE1	1	MAPRE1 [cytosol] (R-HSA-376240)	0.751	4
UniProt:P68366 TUBA4A	9	TUBA4A [cytosol] (R-HSA-191694) TUBA4A [axonemal microtubule] (R-HSA-5610443) TUBA4A [extracellular region] (R-HSA-350734) Polyglutamyl-TUBA4A [cytosol] (R-HSA-8867386) L-isoglutamyl polyglycyl-TUBA4A [cytosol] (R-HSA-8867378) TUBA4A unfolded [cytosol] (R-HSA-392771) TUBA4A folding intermediate [cytosol] (R-HSA-392800) Ac K40 TUBA4A [axonemal microtubule] (R-HSA-5624859) AcK-TUBA4A [cytosol] (R-HSA-5618318)	0.618	3
UniProt:Q14203 DCTN1	7	DCTN1 [cytosol] (R-HSA-535580) DCTN1(1-1177)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711962) DCTN1(1-599)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711953) DCTN1(1-1065)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711959) DCTN1(1-1177)-ALK(1058-1620) fusion [cytosol] (R-HSA-9701997) DCTN1(1-599)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711960) DCTN1(1-1065)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711969)	0.595	3
UniProt:Q04864-2 REL			0.556	3
UniProt:P0DTC6 6	4	6 [nuclear envelope] (R-COV-9727279) 6 [cytosol] (R-COV-9708916) 6 [endoplasmic reticulum membrane] (R-COV-9727295) 6 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9705293)	0.547	2
UniProt:Q9BQQ3 GORASP1	4	GORASP1 [Golgi membrane] (R-HSA-6808767) p-S189,T216,S274,S373-GORASP1 [Golgi membrane] (R-HSA-2314415) GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-162984) p-T216,S274,S373-GORASP1 [Golgi membrane] (R-HSA-2172182)	0.527	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.483	4

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