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HK1 [cytosol]
Stable Identifier
R-HSA-70395
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
hexokinase 1, hexokinase type 1, hexokinase brain form, HXK1_HUMAN, Hexokinase, type I , HK I, Brain form hexokinase
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glucose metabolism (Homo sapiens)
Glycolysis (Homo sapiens)
HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Homo sapiens)
glucokinase and hexokinases [cytosol] (Homo sapiens)
HK1 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
Synthesis of GDP-mannose (Homo sapiens)
HK1 phosphorylates Mannose to Man6P (Homo sapiens)
HK1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P19367 HK1
Gene Names
HK1
Chain
chain:1-917
Reference Genes
BioGPS Gene:3098 HK1
COSMIC (genes):HK1 HK1
CTD Gene:3098 HK1
dbSNP Gene:3098 HK1
ENSEMBL:ENSG00000156515 HK1
HGNC:4922 HK1
KEGG:hsa:3098 HK1
Monarch:3098 HK1
NCBI Gene:3098 HK1
OMIM:142600 HK1
UCSC:P19367 HK1
Reference Transcript
RefSeq:NM_033497.2 HK1
RefSeq:NM_000188.2 HK1
RefSeq:NM_033496.2 HK1
RefSeq:NM_033500.2 HK1
RefSeq:NM_033498.2 HK1
RefSeq:NM_001322364.1 HK1
RefSeq:XM_011539732.1 HK1
Other Identifiers
11718291_a_at
11718292_s_at
11731491_a_at
11752103_a_at
16705577
200697_PM_at
200697_at
3098
3250279
3250280
3250281
3250282
3250284
3250285
3250288
3250289
3250290
3250294
3250295
3250296
3250297
3250298
3250302
3250303
3250304
3250307
3250308
3250309
3250310
3250311
3250312
3250313
3250314
3250323
3250324
3250325
3250326
3250327
3250329
3250331
3250341
3250342
3250343
3250344
3250346
3250347
3250348
3250349
3250350
3250351
3250352
3250353
3250354
3250356
3250357
3250359
3250360
3250361
47648_at
7928019
A_14_P123703
A_23_P217958
A_24_P367965
GE58076
GE60467
GE862261
GO:0001678
GO:0002376
GO:0002720
GO:0003824
GO:0004340
GO:0004396
GO:0005515
GO:0005524
GO:0005536
GO:0005737
GO:0005739
GO:0005741
GO:0005829
GO:0005975
GO:0006002
GO:0006006
GO:0006013
GO:0006091
GO:0006096
GO:0006954
GO:0008865
GO:0009298
GO:0016301
GO:0016740
GO:0016773
GO:0019158
GO:0019318
GO:0032731
GO:0042834
GO:0043226
GO:0045087
GO:0045121
GO:0046835
GO:0047931
GO:0051156
GO:0055086
GO:0061621
GO:0072655
GO:0072656
GO:0098542
GO:1901135
HMNXSV003053862
ILMN_1755548
ILMN_1761829
ILMN_2382990
M75126_at
PH_hs_0006537
TC10000419.hg
TC10002109.hg
U38227_s_at
g4504390_3p_at
Participates
as a member of
glucokinase and hexokinases [cytosol] (Homo sapiens)
Other forms of this molecule
HK1 L529S [cytosol]
HK1 H577_C672del [cytosol]
HK1 T680S [cytosol]
Inferred To
HK1 [cytosol]
(Bos taurus)
HK1 [cytosol]
(Canis familiaris)
HK1 [cytosol]
(Drosophila melanogaster)
HK1 [cytosol]
(Gallus gallus)
HK1 [cytosol]
(Mus musculus)
HK1 [cytosol]
(Plasmodium falciparum)
HK1 [cytosol]
(Rattus norvegicus)
HK1 [cytosol]
(Saccharomyces cerevisiae)
HK1 [cytosol]
(Schizosaccharomyces pombe)
HK1 [cytosol]
(Sus scrofa)
Hex-A [cytosol]
(Drosophila melanogaster)
hxk-1 [cytosol]
(Caenorhabditis elegans)
hxk-2 [cytosol]
(Caenorhabditis elegans)
Hex-C [cytosol]
(Drosophila melanogaster)
hxk-3 [cytosol]
(Caenorhabditis elegans)
hk1 [cytosol]
(Danio rerio)
hk1 [cytosol]
(Xenopus tropicalis)
Homologues of HK1 [cytosol]
(Caenorhabditis elegans)
Homologues of HK1 [cytosol]
(Drosophila melanogaster)
Homologues of HK1 [cytosol]
(Saccharomyces cerevisiae)
Homologues of HK1 [cytosol]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_000179.2
,
NP_277035.2
,
XP_011538034.1
,
NP_001309293.1
,
NP_277033.1
,
NP_277031.1
,
NP_277032.1
OpenTargets
ENSG00000156515
ENSEMBL
ENSP00000494664
,
ENST00000436817
,
ENSP00000298649
,
ENST00000359426
,
ENSP00000352398
,
ENST00000298649
,
ENSP00000415949
,
ENST00000643399
HPA
ENSG00000156515-HK1
PRO
P19367
Pharos - Targets
P19367
Orphanet
HK1
GlyGen
P19367
HMDB Protein
HMDBP00215
PDB
1DGK
,
4F9O
,
4FPA
,
4FOE
,
4FPB
,
1HKB
,
1HKC
,
1QHA
,
1CZA
,
4FOI
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05480 Src
13
SRC-2 [cytosol]
(R-MMU-191648)
phospho-MyrG-p-Y419-SRC [plasma membrane]
(R-MMU-1810408)
SRC-1 [plasma membrane]
(R-MMU-65043)
phospho-MyrG,p-Y530-SRC [plasma membrane]
(R-MMU-377598)
phospho-p-Y419-SRC [cytosol]
(R-MMU-377592)
Src [cytosol]
(R-MMU-418782)
phospho-p-Y419-SRC-1 [plasma membrane]
(R-MMU-112331)
MyrG-SRC [plasma membrane]
(R-MMU-8876922)
phospho-p-Y419-SRC [cytosol]
(R-MMU-8964276)
SRC [cytosol]
(R-MMU-9628701)
MyrG-p-Y424-Src [plasma membrane]
(R-MMU-9011258)
Activated Src [nucleoplasm]
(R-MMU-8937700)
p-Y416-Src [cytosol]
(R-MMU-8964306)
0.644
8
UniProt:P15336 ATF2
2
p-T69,T71-ATF2 [nucleoplasm]
(R-HSA-450243)
ATF2 [nucleoplasm]
(R-HSA-450336)
0.576
4
UniProt:P21796 VDAC1
7
p-S65-Ub:VDAC1 [mitochondrial outer membrane]
(R-HSA-9834991)
K63polyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-9834037)
K48polyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-5205624)
Ub-VDAC1 [mitochondrial outer membrane]
(R-HSA-9834989)
VDAC1 [mitochondrial outer membrane]
(R-HSA-1267988)
VDAC1 [mitochondrial intermembrane space]
(R-HSA-1267960)
PolyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-6783079)
0.564
3
UniProt:P19367 HK1
4
HK1 [cytosol]
(R-HSA-70395)
HK1 L529S [cytosol]
(R-HSA-5621861)
HK1 H577_C672del [cytosol]
(R-HSA-5621873)
HK1 T680S [cytosol]
(R-HSA-5621880)
0.536
2
UniProt:P12931 SRC
6
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
p-Y419-SRC [cytosol]
(R-HSA-8964276)
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
0.524
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.519
5
UniProt:Q15388 TOMM20
6
PolyUb-TOMM20 [mitochondrial outer membrane]
(R-HSA-6783144)
TOMM20 [mitochondrial outer membrane]
(R-HSA-1252091)
Ub-TOMM20 [mitochondrial outer membrane]
(R-HSA-9834976)
K48polyUb-TOMM20 [mitochondrial outer membrane]
(R-HSA-9843324)
K63polyUb-TOMM20 [mitochondrial outer membrane]
(R-HSA-9843313)
p-S65-Ub:TOMM20 [mitochondrial outer membrane]
(R-HSA-9834948)
0.483
2
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