Reactome | IQGAP3 [cytosol]

IQGAP3 [cytosol]

Stable Identifier

R-HSA-5625977

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ras GTPase-activating-like protein IQGAP3

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q86VI3 IQGAP3

Gene Names

IQGAP3

Chain

chain:1-1631

Reference Genes

BioGPS Gene:128239 IQGAP3

COSMIC (genes):IQGAP3 IQGAP3

CTD Gene:128239 IQGAP3

dbSNP Gene:128239 IQGAP3

ENSEMBL:ENSG00000183856 IQGAP3

ENSEMBL_homo_sapiens_GENE:ENSG00000183856.11 IQGAP3

ENSEMBL_homo_sapiens_GENE:ENSG00000291754.1 IQGAP3

HGNC:20669 IQGAP3

KEGG Gene (Homo sapiens):128239 IQGAP3

Monarch:128239 IQGAP3

NCBI Gene:128239 IQGAP3

UCSC:Q86VI3 IQGAP3

Reference Transcript

RefSeq:NM_178229.4 IQGAP3

Other Identifiers

11728997_at

11756753_a_at

128239

1569061_PM_at

1569061_at

1569062_PM_s_at

1569062_s_at

16694617

229538_PM_s_at

229538_s_at

241939_3p_at

241939_PM_at

241939_at

2438283

2438284

2438285

2438286

2438287

2438288

2438289

2438290

2438291

2438292

2438293

2438294

2438295

2438298

2438301

2438302

2438305

2438306

2438307

2438308

2438311

2438312

2438313

2438314

2438315

2438317

2438318

2438320

2438321

2438322

2438324

2438325

2438326

2438327

2438328

2438329

2438330

2438333

2438334

2438335

2438336

2438337

2438338

2438339

7921033

91873_s_at

A_23_P329335

A_33_P3321293

GE772511

GO:0000082

GO:0000278

GO:0000910

GO:0001934

GO:0005096

GO:0005515

GO:0005516

GO:0005737

GO:0005829

GO:0005886

GO:0005911

GO:0005938

GO:0007010

GO:0007265

GO:0008092

GO:0008361

GO:0010467

GO:0010628

GO:0010629

GO:0016328

GO:0023052

GO:0031267

GO:0033598

GO:0033601

GO:0036211

GO:0043087

GO:0043410

GO:0048856

GO:0051015

GO:0070371

GO:0070856

GO:0071310

GO:0098772

GO:0110165

GO:1903479

HMNXSV003016460

Hs.122487.0.A1_3p_at

Hs.122487.0.A1_3p_s_at

Hs.133294.1.S1_3p_a_at

Hs2.133294.1.A1_3p_s_at

ILMN_1695418

PH_hs_0008016

TC01003343.hg

Participates

as a component of

IQGAP3 dimer [cytosol] (Homo sapiens)

Inferred To

IQG1 [cytosol] (Saccharomyces cerevisiae)

rng2 [cytosol] (Schizosaccharomyces pombe)

IQGAP3 [cytosol] (Bos taurus)

IQGAP3 [cytosol] (Canis familiaris)

IQGAP3 [cytosol] (Danio rerio)

IQGAP3 [cytosol] (Gallus gallus)

IQGAP3 [cytosol] (Schizosaccharomyces pombe)

IQGAP3 [cytosol] (Sus scrofa)

pes-7 [cytosol] (Caenorhabditis elegans)

gapA [cytosol] (Dictyostelium discoideum)

rgaA [cytosol] (Dictyostelium discoideum)

Iqgap3 [cytosol] (Mus musculus)

Iqgap3 [cytosol] (Rattus norvegicus)

Homologues of IQGAP3 [cytosol] (Dictyostelium discoideum)

Homologues of IQGAP3 [cytosol] (Schizosaccharomyces pombe)

iqgap3 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_839943.2

OpenTargets

ENSG00000183856

GeneCards

Q86VI3

HPA

ENSG00000183856-IQGAP3

Ensembl

ENST00000361170, ENSG00000183856, ENSP00000354451

PRO

Q86VI3

Pharos - Targets

Q86VI3

PDB

3ISU

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06396 GSN	7	GSN(200-270) [extracellular region] (R-HSA-976940) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275)	0.556	3
UniProt:P63000 RAC1	6	RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.508	2
UniProt:Q92845 KIFAP3	3	KIFAP3 [cytosol] (R-HSA-984736) KIFAP3 [cilium] (R-HSA-5624882) KIFAP3 [ciliary tip] (R-HSA-5625382)	0.508	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	6