Reactome | MCCC2 [cytosol]

MCCC2 [cytosol]

Stable Identifier

R-HSA-3323134

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

methylcrotonyl-CoA carboxylase beta chain

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Literature References

PubMed ID	Title	Journal	Year
16023992	Mitochondrial targeting signals and mature peptides of 3-methylcrotonyl-CoA carboxylase Holzinger, A, Anslinger, K, Röschinger, W, Roscher, AA, Herrmann, JM, Polanetz, R, Stadler, SC, Meier, S, Mayerhofer, PU	Biochem Biophys Res Commun	2005

External Reference Information

External Reference

UniProt:Q9HCC0 MCCC2

Gene Names

MCCC2, MCCB

Chain

transit peptide:1-22, chain:23-563

Reference Genes

BioGPS Gene:64087 MCCC2

COSMIC (genes):MCCC2 MCCC2

CTD Gene:64087 MCCC2

dbSNP Gene:64087 MCCC2

ENSEMBL:ENSG00000131844 MCCC2

HGNC:6937 MCCC2

KEGG:hsa:64087 MCCC2

Monarch:64087 MCCC2

NCBI Gene:64087 MCCC2

OMIM:609014 MCCC2

UCSC:Q9HCC0 MCCC2

Reference Transcript

Other Identifiers

11729236_at

11729237_a_at

1556345_PM_s_at

1556345_s_at

1560033_PM_at

1560033_at

16985911

209623_PM_at

209623_at

209624_PM_s_at

209624_s_at

233231_PM_at

233231_at

2814641

2814643

2814644

2814647

2814648

2814649

2814650

2814651

2814652

2814655

2814663

2814664

2814665

2814666

2814667

2814668

2814669

2814670

2814671

2814672

2814673

2814674

2814675

2814676

2814677

2814678

2814679

2814680

2814681

2814682

2814687

2814688

2814689

2814690

2814691

2814692

36432_at

43695_at

64087

72262_at

8106068

8177601

88457_at

A_14_P111147

A_14_P122432

A_23_P18887

GE56317

GE88197

GE905935

GO:0002169

GO:0003824

GO:0004485

GO:0005515

GO:0005524

GO:0005739

GO:0005759

GO:0005829

GO:0006520

GO:0006552

GO:0009083

GO:0015936

GO:0016874

GO:0043226

GO:0055086

GO:1901135

GO:1905202

HMNXSV003034390

Hs.167531.0.S2_3p_at

Hs.272240.0.S1_3p_at

Hs2.288415.1.S1_3p_at

Hs2.407347.1.S1_3p_s_at

PH_hs_0019391

PH_hs_0027271

PH_hs_0038535

TC05000334.hg

g10934058_3p_a_at

Participates

as a component of

Other forms of this molecule

A456V MCCC2 [mitochondrial matrix]

H190Y MCCC2 [mitochondrial matrix]

G352R MCCC2 [mitochondrial matrix]

V339M MCCC2 [mitochondrial matrix]

S173L MCCC2 [mitochondrial matrix]

E99Q MCCC2 [mitochondrial matrix]

MCCC2 [mitochondrial matrix]

Inferred To

mccc2 [cytosol] (Xenopus tropicalis)

mccb [cytosol] (Dictyostelium discoideum)

Mccc2 [cytosol] (Drosophila melanogaster)

Mccc2 [cytosol] (Mus musculus)

Mccc2 [cytosol] (Rattus norvegicus)

MCCC2 [cytosol] (Bos taurus)

MCCC2 [cytosol] (Caenorhabditis elegans)

MCCC2 [cytosol] (Canis familiaris)

MCCC2 [cytosol] (Gallus gallus)

MCCC2 [cytosol] (Sus scrofa)

Cross References

ENSEMBL

ENST00000683789, ENSP00000343657, ENSP00000507012, ENST00000340941

OpenTargets

ENSG00000131844

HPA

ENSG00000131844-MCCC2

PRO

Q9HCC0

Pharos - Targets

Q9HCC0

GlyGen

Q9HCC0

Orphanet

MCCC2

HMDB Protein

HMDBP00508

PDB

8J7D, 8J99, 8J4Z, 8J78, 8JAW, 8J73, 8JAK

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.519	5