Reactome | PFKL [cytosol]

PFKL [cytosol]

Stable Identifier

R-HSA-70459

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

6-phosphofructokinase, liver type , Phosphofructokinase 1, Phosphohexokinase, Phosphofructo-1-kinase isozyme B, PFK-B

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P17858 PFKL

Gene Names

PFKL

Chain

initiator methionine:, chain:2-780

Reference Genes

BioGPS Gene:5211 PFKL

COSMIC (genes):PFKL PFKL

CTD Gene:5211 PFKL

dbSNP Gene:5211 PFKL

ENSEMBL:ENSG00000141959 PFKL

ENSEMBL_homo_sapiens_GENE:ENSG00000141959.17 PFKL

HGNC:8876 PFKL

KEGG Gene (Homo sapiens):5211 PFKL

Monarch:5211 PFKL

NCBI Gene:5211 PFKL

OMIM:171860 PFKL

UCSC:P17858 PFKL

Reference Transcript

Other Identifiers

11730211_x_at

11744335_x_at

11752746_a_at

16922993

201102_3p_s_at

201102_PM_s_at

201102_s_at

211065_3p_x_at

211065_PM_x_at

211065_x_at

3923634

3923635

3923646

3923648

3923650

3923651

3923652

3923653

3923654

3923655

3923660

3923661

3923664

3923665

3923668

3923672

3923673

3923674

3923676

3923679

3923680

3923682

3923684

3923685

3923686

3923687

40116_at

5211

8069057

A_23_P29081

GE59729

GO:0000166

GO:0003824

GO:0003872

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005737

GO:0005829

GO:0005945

GO:0005975

GO:0006002

GO:0006091

GO:0006096

GO:0008152

GO:0009749

GO:0016020

GO:0016208

GO:0016301

GO:0016310

GO:0016740

GO:0019900

GO:0023052

GO:0030388

GO:0031410

GO:0034774

GO:0042802

GO:0043226

GO:0046676

GO:0046872

GO:0048029

GO:0055086

GO:0061615

GO:0061621

GO:0070061

GO:0070062

GO:0070095

GO:1901135

GO:1904813

HMNXSV003005798

ILMN_1713037

PH_hs_0024080

TC21000768.hg

X15573_at

g13623608_3p_s_at

g4505746_3p_s_at

Participates

as a component of

Other forms of this molecule

PFKL [secretory granule lumen]

PFKL [extracellular region]

PFKL [ficolin-1-rich granule lumen]

Inferred To

Homologues of PFKL [cytosol] (Caenorhabditis elegans)

Homologues of PFKL [cytosol] (Saccharomyces cerevisiae)

PFKL [cytosol] (Bos taurus)

PFKL [cytosol] (Caenorhabditis elegans)

PFKL [cytosol] (Canis familiaris)

PFKL [cytosol] (Drosophila melanogaster)

PFKL [cytosol] (Gallus gallus)

PFKL [cytosol] (Mus musculus)

PFKL [cytosol] (Rattus norvegicus)

PFKL [cytosol] (Saccharomyces cerevisiae)

PFKL [cytosol] (Schizosaccharomyces pombe)

PFKL [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_002617.3, NP_001002021.2

OpenTargets

ENSG00000141959

GeneCards

P17858

HPA

ENSG00000141959-PFKL

Ensembl

ENSG00000141959, ENST00000349048, ENSP00000269848

PRO

P17858

Pharos - Targets

P17858

PDB

7LW1

HMDB Protein

HMDBP00758

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	16
UniProt:Q969Y2 GTPBP3	1	GTPBP3 [mitochondrial matrix] (R-HSA-6787414)	0.556	3

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