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CAV1
Stable Identifier
R-HSA-5368451
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
early endosome membrane
Synonyms
caveolin-1
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (Homo sapiens)
WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Homo sapiens)
WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1 [early endosome membrane] (Homo sapiens)
CAV1 [early endosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q03135 CAV1
Gene Names
CAV1, CAV
Chain
initiator methionine:1, chain:2-178
Reference Genes
BioGPS Gene:857 CAV1
COSMIC (genes):CAV1 CAV1
CTD Gene:857 CAV1
dbSNP Gene:857 CAV1
ENSEMBL:ENSG00000105974 CAV1
HGNC:1527 CAV1
KEGG Gene (Homo sapiens):hsa:857 CAV1
Monarch:857 CAV1
NCBI Gene:857 CAV1
OMIM:601047 CAV1
UCSC:Q03135 CAV1
Reference Transcript
RefSeq:NM_001753.4 CAV1
Other Identifiers
0003140039
11715584_a_at
11745715_a_at
11745716_s_at
11757013_x_at
17050578
203065_s_at
212097_at
3020303
3020304
3020305
3020306
3020307
3020308
3020309
3020310
3020311
3020320
3020321
3020322
3020323
36119_at
3791
49326
8135594
857
A0A024R757
A_24_P12626
CAB003791
CAV1
CAV1-201
CAV1-202
CAV1-203
CAV1-205
CAV1-209
CCDS55156
CCDS5767
ENSG00000105974
ENSP00000339191
ENSP00000377110
ENSP00000377111
ENSP00000384348
ENSP00000479447
ENST00000341049
ENST00000393467
ENST00000393468
ENST00000405348
ENST00000614113
EntrezGene:857
g4580417_3p_s_at
GE54670
GO:0000122
GO:0000139
GO:0000165
GO:0000188
GO:0001525
GO:0001570
GO:0001666
GO:0001937
GO:0001960
GO:0002026
GO:0002080
GO:0002931
GO:0003057
GO:0005102
GO:0005113
GO:0005198
GO:0005515
GO:0005622
GO:0005768
GO:0005783
GO:0005789
GO:0005794
GO:0005811
GO:0005886
GO:0005887
GO:0005901
GO:0005925
GO:0005929
GO:0005938
GO:0006641
GO:0006816
GO:0006874
GO:0006940
GO:0007519
GO:0007595
GO:0008104
GO:0008285
GO:0009617
GO:0009968
GO:0010524
GO:0010608
GO:0010628
GO:0010952
GO:0015485
GO:0016020
GO:0016021
GO:0016032
GO:0016050
GO:0016504
GO:0019065
GO:0019217
GO:0019899
GO:0019901
GO:0019915
GO:0030193
GO:0030301
GO:0030512
GO:0030666
GO:0030674
GO:0030857
GO:0030879
GO:0031295
GO:0031397
GO:0031398
GO:0031410
GO:0031623
GO:0031901
GO:0032091
GO:0032092
GO:0032507
GO:0032570
GO:0032947
GO:0033137
GO:0033138
GO:0033484
GO:0034098
GO:0034141
GO:0042310
GO:0042532
GO:0042632
GO:0042802
GO:0043085
GO:0043234
GO:0043407
GO:0043409
GO:0043627
GO:0044325
GO:0044860
GO:0045019
GO:0045121
GO:0045907
GO:0046426
GO:0046982
GO:0048365
GO:0048471
GO:0048550
GO:0050900
GO:0050998
GO:0050999
GO:0051001
GO:0051117
GO:0051259
GO:0051260
GO:0051480
GO:0051592
GO:0051899
GO:0052547
GO:0055074
GO:0060056
GO:0060355
GO:0060546
GO:0061099
GO:0070320
GO:0070836
GO:0071360
GO:0071375
GO:0071455
GO:0071560
GO:0072584
GO:0086091
GO:0086098
GO:0090090
GO:0090263
GO:0097190
GO:0098903
GO:0098909
GO:0098911
GO:1900027
GO:1900085
GO:1901380
GO:1901844
GO:1903071
GO:1903361
GO:1903598
GO:1903609
GO:1904886
GO:2000286
GO:2000535
GO:2000811
GO:2001238
GO:2001244
HGNC:1527
HPA049326
Hs.74034
Hs.74034.1.S1_3p_at
ILMN_1687583
ILMN_2149226
MIM:601047
MIM:606721
MIM:612526
MIM:615343
NM_001172895
NM_001172896
NM_001172897
NM_001753
NP_001166366
NP_001166367
NP_001166368
NP_001744
PF01146
PH_hs_0004233
Q2TNI1
TC07003339.hg
uc003vif.3
uc003vig.3
uc003vih.4
uc010lkf.3
uc064hhd.1
UPI0000071F3D
UPI00001270ED
Z18951_at
Participant Of
hasComponent
WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1 [early endosome membrane]
Other forms of this molecule
CAV1 [plasma membrane]
CAV1 [lipid droplet]
CAV1 [endocytic vesicle membrane]
CAV1 [Golgi membrane]
Inferred To
Homologues of CAV1 [early endosome membrane] (Danio rerio)
Homologues of CAV1 [early endosome membrane] (Xenopus tropicalis)
CAV1 [early endosome membrane] (Bos taurus)
CAV1 [early endosome membrane] (Canis familiaris)
CAV1 [early endosome membrane] (Danio rerio)
CAV1 [early endosome membrane] (Gallus gallus)
CAV1 [early endosome membrane] (Mus musculus)
CAV1 [early endosome membrane] (Rattus norvegicus)
CAV1 [early endosome membrane] (Sus scrofa)
CAV1 [early endosome membrane] (Taeniopygia guttata)
CAV1 [early endosome membrane] (Xenopus tropicalis)
Cross References
RefSeq
NP_001744.2
GeneCards
Q03135
PRO
Q03135
Orphanet
17896
Interactors (30)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00533 EGFR
58
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.752
6
UniProt:P18031 PTPN1
1
PTPN1 [cytosol]
(R-HSA-210625)
0.697
5
UniProt:Q969G5 CAVN3
0.649
11
UniProt:P48995 TRPC1
2
TRPC1 [plasma membrane]
(R-HSA-2089937)
TRPC1 [plasma membrane]
(R-HSA-612168)
0.633
7
UniProt:Q16881 TXNRD1
1
TXNRD1 [cytosol]
(R-HSA-73531)
0.632
4
UniProt:P41134 ID1
1
ID1 [nucleoplasm]
(R-HSA-2534101)
0.602
6
UniProt:O95810 CAVN2
0.602
6
UniProt:P20936 RASA1
1
RASA1 [cytosol]
(R-HSA-186833)
0.59
2
UniProt:P51636 CAV2
0.564
2
UniProt:O75581 LRP6
8
p-S1490-LRP6 [plasma membrane]
(R-HSA-206156)
p-T1479,S1490,T1493-LRP6 [plasma membrane]
(R-HSA-205884)
LRP6 [early endosome membrane]
(R-HSA-5368481)
LRP6N [extracellular region]
(R-HSA-5334021)
LRP6 [plasma membrane]
(R-HSA-206252)
p-2S,S1490,2T-LRP6 [plasma membrane]
(R-HSA-1458894)
p-LRP6 [early endosome membrane]
(R-HSA-5368496)
p-4S,3T,T1479,S1490,T1493-LRP6 [plasma membrane]
(R-HSA-1458895)
0.556
3
UniProt:P52735-1 VAV2
0.544
3
UniProt:Q03160
1
GRB7 [cytosol]
(R-MMU-204819)
0.532
3
UniProt:P19174 PLCG1
6
p-Y771,Y783,Y1254-PLCG1 [cytosol]
(R-HSA-202357)
p-4Y-PLCG1 [plasma membrane]
(R-HSA-167679)
PLCG1 [cytosol]
(R-HSA-202320)
p-Y771,Y783-PLCG1 [plasma membrane]
(R-HSA-1169084)
PLCG1 [plasma membrane]
(R-HSA-167682)
p-Y-PLCG1 [plasma membrane]
(R-HSA-593686)
0.525
2
UniProt:P0DOE7 MATRX
0.524
2
UniProt:O00194 RAB27B
5
GGC-RAB27B [cytosol]
(R-HSA-8873786)
GGC-RAB27B [melanosome membrane]
(R-HSA-8877280)
RAB27B [cytosol]
(R-HSA-8873706)
RAB27B [plasma membrane]
(R-HSA-8862952)
RAB27B [platelet dense granule membrane]
(R-HSA-8862955)
0.524
2
UniProt:P01112 HRAS
8
Q61L HRAS [plasma membrane]
(R-HSA-6802452)
Q61R HRAS [plasma membrane]
(R-HSA-6802458)
Q61K HRAS [plasma membrane]
(R-HSA-6802442)
G12V HRAS [plasma membrane]
(R-HSA-6802350)
G13R HRAS [plasma membrane]
(R-HSA-6802368)
G12S HRAS [plasma membrane]
(R-HSA-6802343)
HRAS [cytosol]
(R-HSA-205771)
HRAS [plasma membrane]
(R-HSA-62717)
0.508
2
UniProt:P10586 PTPRF
1
PTPRF [plasma membrane]
(R-HSA-6786486)
0.499
2
UniProt:P63000 RAC1
6
RAC1 [secretory granule membrane]
(R-HSA-6804770)
RAC1 [ficolin-1-rich granule membrane]
(R-HSA-6804802)
RAC1 [endoplasmic reticulum membrane]
(R-HSA-5672076)
GGC-PalmC-RAC1 [plasma membrane]
(R-HSA-2316446)
RAC1 [plasma membrane]
(R-HSA-351141)
RAC1 [cytosol]
(R-HSA-442615)
0.499
2
UniProt:Q6NZI2 CAVIN1
1
PTRF [nucleoplasm]
(R-HSA-74981)
0.499
8
UniProt:Q06124 PTPN11
4
PTPN11 [nucleoplasm]
(R-HSA-8937745)
p-Y546-PTPN11 [cytosol]
(R-HSA-1369081)
PTPN11 [cytosol]
(R-HSA-162563)
p-Y546,Y584-PTPN11 [cytosol]
(R-HSA-162573)
0.499
2
UniProt:P29350 PTPN6
5
PTPN6 [extracellular region]
(R-HSA-6806315)
PTPN6 [specific granule lumen]
(R-HSA-6799641)
PTPN6 [tertiary granule lumen]
(R-HSA-6800952)
PTPN6 [nucleoplasm]
(R-HSA-9008911)
PTPN6 [cytosol]
(R-HSA-197938)
0.499
2
UniProt:P60484 PTEN
41
PTEN [nucleoplasm]
(R-HSA-5690148)
K48polyUb-PTEN [cytosol]
(R-HSA-8874327)
PolyUb-PTEN [nucleoplasm]
(R-HSA-6782515)
PTEN H93R [cytosol]
(R-HSA-2318524)
PTEN C124R [cytosol]
(R-HSA-2317439)
PTEN H93Y [cytosol]
(R-HSA-2318520)
PTEN R130G [cytosol]
(R-HSA-2317339)
PTEN H93D [cytosol]
(R-HSA-2318550)
PTEN R130L [cytosol]
(R-HSA-2317430)
PTEN H93A [cytosol]
(R-HSA-2318544)
PTEN G129E [cytosol]
(R-HSA-2318509)
PTEN S170N [cytosol]
(R-HSA-2318408)
PTEN R173P [cytosol]
(R-HSA-2317480)
PTEN R130Q [cytosol]
(R-HSA-2317416)
PTEN H93Q [cytosol]
(R-HSA-2318565)
PTEN G129R [cytosol]
(R-HSA-2318501)
PTEN H123Y [cytosol]
(R-HSA-2318469)
PTEN S170R [cytosol]
(R-HSA-2318437)
PTEN R173C [cytosol]
(R-HSA-2317478)
PTEN R173H [cytosol]
(R-HSA-2317473)
PTEN C124S [cytosol]
(R-HSA-2317379)
PTEN C124Y [cytosol]
(R-HSA-2317464)
PTEN R130P [cytosol]
(R-HSA-2317432)
PTEN C124F [cytosol]
(R-HSA-2317461)
PTEN G129V [cytosol]
(R-HSA-2318503)
PTEN S170I [cytosol]
(R-HSA-2318455)
PTEN S170G [cytosol]
(R-HSA-2318465)
PTEN R233* [cytosol]
(R-HSA-2318573)
PTEN R335* [cytosol]
(R-HSA-2318568)
PTEN R130* [cytosol]
(R-HSA-2318571)
p-Y336-PTEN [cytosol]
(R-HSA-8847980)
K27polyUb-PTEN [cytosol]
(R-HSA-8851009)
RibC-E40,E150,D326-PTEN [cytosol]
(R-HSA-8948798)
PolyUb-PTEN [cytosol]
(R-HSA-6807280)
PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN [cytosol]
(R-HSA-8948841)
p-3S,2T-PTEN [cytosol]
(R-HSA-8850936)
PTEN [cytosol]
(R-HSA-199420)
PTEN [nucleoplasm]
(R-HSA-6807273)
MonoUb-K13,K289-PTEN [nucleoplasm]
(R-HSA-6807264)
MonoUb-K13,K289-PTEN [cytosol]
(R-HSA-6807247)
K48polyUb-K289-PTEN [cytosol]
(R-HSA-8948777)
0.499
2
UniProt:P52735 VAV2
2
p-Y172-VAV2 [cytosol]
(R-HSA-442307)
VAV2 [cytosol]
(R-HSA-195012)
0.499
2
UniProt:P22307 SCP2
4
SCP2(1-424) [peroxisomal matrix]
(R-HSA-9033486)
SCP2(425-547) [peroxisomal matrix]
(R-HSA-9033522)
SCP2 [cytosol]
(R-HSA-9033130)
SCP2 [peroxisomal matrix]
(R-HSA-2046067)
0.482
3
UniProt:Q07820 MCL1
1
MCL1 [cytosol]
(R-HSA-5661490)
0.463
3
UniProt:P25445 FAS
1
FAS [plasma membrane]
(R-HSA-66248)
0.463
3
UniProt:O70239 AXIN1
0.463
5
UniProt:O15118 NPC1
1
NPC1 [lysosomal membrane]
(R-HSA-5216153)
0.463
3
UniProt:Q12933 TRAF2
5
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.463
3
UniProt:P55957 BID
4
BID(62-195) [cytosol]
(R-HSA-139953)
BID(1-195) [cytosol]
(R-HSA-50825)
MYS-BID(62-195) [cytosol]
(R-HSA-141373)
MYS-BID(62-195) [mitochondrial outer membrane]
(R-HSA-114266)
0.463
3
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