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EIF4G1 [cytosol]
Stable Identifier
R-HSA-72584
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
eIF4G, eIF-4-gamma, eIF-4G, eukaryotic translation initiation factor 4 gamma, P220, Eukaryotic translation initiation factor 4 gamma, p220
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Regulation of expression of SLITs and ROBOs (Homo sapiens)
Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
ROBO3.2 mRNA:CBC:EIF4G1:PABPC1 [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
Translation of ROBO3.2 mRNA is negatively regulated by NMD (Homo sapiens)
Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
ROBO3.2 mRNA:CBC:EIF4G1:PABPC1 [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
ISG15 antiviral mechanism (Homo sapiens)
Competitive inhibition of translation initiation by ISGylated 4EHP (Homo sapiens)
EIF4F [cytosol] (Homo sapiens)
EIF4G [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
eIF4F:mRNA [cytosol] (Homo sapiens)
EIF4F [cytosol] (Homo sapiens)
EIF4G [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Deadenylation-dependent mRNA decay (Homo sapiens)
Deadenylation of mRNA (Homo sapiens)
CCR4-NOT complex deadenylates mRNA (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
Partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
PAN2-PAN3 complex partially deadenylates mRNA (Homo sapiens)
Partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
Translatable mRNA Complex [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
PARN deadenylates mRNA (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
Partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
ZCCHC6, ZCCHC11 are mRNA uridyltransferases (Homo sapiens)
Partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
Uridylated partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
Nonsense-Mediated Decay (NMD) (Homo sapiens)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
mRNA Cleaved by SMG6 [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
mRNA Cleaved by SMG6 [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
Regulation of mRNA stability by proteins that bind AU-rich elements (Homo sapiens)
AUF1 (hnRNP D0) binds and destabilizes mRNA (Homo sapiens)
AUF1 (hnRNP D0) is ubiquitinylated (Homo sapiens)
AUF1 Complexed with Translation and Heat Shock Proteins [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
AUF1 binds translation and heat shock proteins (Homo sapiens)
AUF1 Complexed with Translation and Heat Shock Proteins [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Homo sapiens)
Cap-bound mRNA is activated by helicases (Homo sapiens)
eIF4F:mRNP [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
Formation of the cap-binding eIF4F complex (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
Translation initiation complex formation (Homo sapiens)
Formation of translation initiation complexes containing mRNA that does not circularize (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
eIF4F binds to mRNP (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
eIF4F:mRNP [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
GTP hydrolysis and joining of the 60S ribosomal subunit (Homo sapiens)
eIF2:GTP is hydrolyzed, eIFs are released (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
Ribosomal scanning and start codon recognition (Homo sapiens)
Ribosomal scanning (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
Start codon recognition (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
L13a-mediated translational silencing of Ceruloplasmin expression (Homo sapiens)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MTOR signalling (Homo sapiens)
mTORC1-mediated signalling (Homo sapiens)
Phosphorylation and activation of eIF4G by activated S6K1 (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q04637 EIF4G1
Gene Names
EIF4G1, EIF4F, EIF4G, EIF4GI
Chain
initiator methionine:, chain:1-1599
Reference Genes
BioGPS Gene:1981 EIF4G1
COSMIC (genes):EIF4G1 EIF4G1
CTD Gene:1981 EIF4G1
dbSNP Gene:1981 EIF4G1
ENSEMBL:ENSG00000114867 EIF4G1
HGNC:3296 EIF4G1
KEGG Gene (Homo sapiens):1981 EIF4G1
Monarch:1981 EIF4G1
NCBI Gene:1981 EIF4G1
OMIM:600495 EIF4G1
UCSC:Q04637 EIF4G1
Reference Transcript
RefSeq:NM_182917.4 EIF4G1
RefSeq:NM_198242.2 EIF4G1
RefSeq:NM_198241.2 EIF4G1
RefSeq:NM_004953.4 EIF4G1
Other Identifiers
0000770164
0001190551
0005390035
11726566_a_at
11726567_a_at
11726568_x_at
1306_at
16948909
1981
208624_s_at
208625_3p_s_at
208625_s_at
2655689
2655690
2655691
2655692
2655693
2655695
2655696
2655697
2655698
2655699
2655700
2655701
2655702
2655704
2655705
2655706
2655707
2655708
2655709
2655711
2655712
2655713
2655714
2655715
2655716
2655717
2655718
2655719
2655720
2655721
2655722
2655723
2655725
2655727
2655728
2655729
2655730
2655731
2655732
2655733
2655734
2655735
2655737
2655738
2655739
2655741
2655743
2655745
2655747
2655750
2655751
2655752
2655753
2655754
2655756
32844_at
57332_r_at
69222_at
8084439
A_23_P218892
GE62301
GO:0000184
GO:0000278
GO:0001662
GO:0002191
GO:0003674
GO:0003723
GO:0003729
GO:0003743
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005829
GO:0005844
GO:0006412
GO:0006413
GO:0006417
GO:0006446
GO:0006464
GO:0006914
GO:0006950
GO:0007049
GO:0008135
GO:0008150
GO:0008190
GO:0008219
GO:0009056
GO:0009058
GO:0010494
GO:0010507
GO:0010801
GO:0010942
GO:0016020
GO:0016032
GO:0016281
GO:0022607
GO:0030154
GO:0030307
GO:0031369
GO:0031669
GO:0032270
GO:0032502
GO:0032991
GO:0033138
GO:0034330
GO:0034641
GO:0034645
GO:0034655
GO:0036493
GO:0040007
GO:0042592
GO:0042802
GO:0043167
GO:0043226
GO:0043488
GO:0044403
GO:0045666
GO:0048856
GO:0060090
GO:0060964
GO:0065003
GO:0080135
GO:0097009
GO:1900087
GO:1901215
GO:1905537
GO:1905606
GO:1905612
GO:1905618
GO:1905696
Hs.211568.1.A1_3p_a_at
ILMN_1657066
ILMN_1672902
ILMN_1678244
ILMN_1768470
ILMN_2370772
PH_hs_0030188
TC03001000.hg
TC03002693.hg
g3941723_3p_s_at
Participant Of
hasComponent
AUF1 Complexed with Translation and Heat Shock Proteins [cytosol]
eIF4F [cytosol]
mRNA Cleaved by SMG6 [cytosol]
mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol]
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol]
Partially Deadenylated mRNA Complex [cytosol]
ROBO3.2 mRNA:CBC:EIF4G1:PABPC1 [cytosol]
Translatable mRNA Complex [cytosol]
Uridylated partially Deadenylated mRNA Complex [cytosol]
input
AUF1 binds translation and heat shock proteins
Formation of the cap-binding eIF4F complex
Phosphorylation and activation of eIF4G by activated S6K1
Translation of ROBO3.2 mRNA initiates NMD
output
CCR4-NOT complex deadenylates mRNA
Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex
eIF2:GTP is hydrolyzed, eIFs are released
PARN deadenylates mRNA
hasMember
EIF4G [cytosol]
Other forms of this molecule
p-S1108,S1148,S1192-EIF4G1 [cytosol]
Inferred To
eif4g1a [cytosol] (Danio rerio)
Eif4g1 [cytosol] (Mus musculus)
Eif4g1 [cytosol] (Rattus norvegicus)
eIF4G1 [cytosol] (Drosophila melanogaster)
fndc3a [cytosol] (Xenopus tropicalis)
ifg-1 [cytosol] (Caenorhabditis elegans)
eIF4G2 [cytosol] (Drosophila melanogaster)
eif4g [cytosol] (Dictyostelium discoideum)
EIF4G1 [cytosol] (Canis familiaris)
EIF4G1 [cytosol] (Gallus gallus)
EIF4G1 [cytosol] (Plasmodium falciparum)
EIF4G1 [cytosol] (Sus scrofa)
TIF4631 [cytosol] (Saccharomyces cerevisiae)
Homologues of EIF4G1 [cytosol] (Drosophila melanogaster)
Homologues of EIF4G1 [cytosol] (Saccharomyces cerevisiae)
TIF4632 [cytosol] (Saccharomyces cerevisiae)
Ghost homologue of EIF4G1 [cytosol] (Bos taurus)
tif471 [cytosol] (Schizosaccharomyces pombe)
Cross References
RefSeq
NP_004944.3
,
NP_937884.1
,
NP_937885.1
,
NP_886553.3
OpenTargets
ENSG00000114867
GeneCards
Q04637
HPA
ENSG00000114867-EIF4G1
Ensembl
ENSP00000371767
,
ENSP00000343450
,
ENSP00000316879
,
ENSP00000317600
,
ENST00000342981
,
ENST00000350481
,
ENSP00000338020
,
ENST00000424196
,
ENSP00000416255
,
ENST00000435046
,
ENST00000382330
,
ENST00000392537
,
ENST00000346169
,
ENST00000414031
,
ENST00000434061
,
ENSP00000411826
,
ENST00000352767
,
ENSG00000114867
,
ENSP00000404754
,
ENSP00000391935
,
ENSP00000376320
PRO
Q04637
Orphanet
20634
PDB
5T46
,
4F02
,
5EI3
,
1UG3
,
4AZA
,
2W97
,
1LJ2
,
5EIR
,
5EHC
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P60842 EIF4A1
1
EIF4A1 [cytosol]
(R-HSA-72573)
0.961
15
UniProt:P06730 EIF4E
1
EIF4E [cytosol]
(R-HSA-72578)
0.915
10
UniProt:P11940 PABPC1
1
PABPC1 [cytosol]
(R-HSA-156803)
0.835
6
UniProt:Q14240 EIF4A2
1
EIF4A2 [cytosol]
(R-HSA-72575)
0.656
4
UniProt:Q9BWF3-1 RBM4
0.591
4
UniProt:Q9UGR2 Z3H7B
0.567
3
UniProt:P23116
1
Eif3a [cytosol]
(R-MMU-72546)
0.564
2
UniProt:O00571 DDX3X
3
DDX3X [extracellular region]
(R-HSA-6806507)
DDX3X [ficolin-1-rich granule lumen]
(R-HSA-6801273)
DDX3X [secretory granule lumen]
(R-HSA-6801275)
0.557
3
UniProt:Q04637 EIF4G1
2
EIF4G1 [cytosol]
(R-HSA-72584)
p-S1108,S1148,S1192-EIF4G1 [cytosol]
(R-HSA-165762)
0.544
2
UniProt:P03372 ESR1
8
SUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.527
3
UniProt:O75822 EIF3J
1
EIF3J [cytosol]
(R-HSA-72534)
0.524
2
UniProt:Q9J0X9 Q9J0X9
0.499
3
UniProt:Q14103-4 HNRNPD
2
HNRNPD-4 [cytosol]
(R-HSA-450442)
Ub-HNRNPD-4 [cytosol]
(R-HSA-451232)
0.499
3
UniProt:Q13283 G3BP1
0.491
2
UniProt:Q00721 NSP3
0.482
2
UniProt:Q09161 NCBP1
2
NCBP1 [cytosol]
(R-HSA-162459)
NCBP1 [nucleoplasm]
(R-HSA-51469)
0.462
2
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