Reactome | p-HSP90B1 [endoplasmic reticulum lumen]

p-HSP90B1 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-8957016

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

HSP90B1, Endoplasmin, ENPL_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P14625 HSP90B1

Gene Names

HSP90B1, GPR94, GRP94, TRA1

Chain

signal peptide:1-21, chain:22-803

Reference Genes

BioGPS Gene:7184 HSP90B1

COSMIC (genes):HSP90B1 HSP90B1

CTD Gene:7184 HSP90B1

dbSNP Gene:7184 HSP90B1

ENSEMBL:ENSG00000166598 HSP90B1

ENSEMBL_homo_sapiens_GENE:ENSG00000166598.16 HSP90B1

HGNC:12028 HSP90B1

KEGG Gene (Homo sapiens):7184 HSP90B1

Monarch:7184 HSP90B1

NCBI Gene:7184 HSP90B1

OMIM:191175 HSP90B1

Reference Transcript

RefSeq:NM_003299.2 HSP90B1

Other Identifiers

11741912_a_at

11741913_s_at

11752967_x_at

11753260_x_at

11754606_a_at

11754607_s_at

11754608_x_at

16756078

200598_PM_s_at

200598_s_at

200599_PM_s_at

200599_s_at

216449_3p_x_at

216449_PM_x_at

216449_x_at

2346499

2346503

3429313

3429314

3429316

3429318

3429319

3429320

3429323

3429325

3429326

3429327

3429329

3429330

3429331

3429332

3429335

3429339

3429341

3429343

3429344

3429346

3429347

3429348

3611056

3611061

3611062

3611065

442_at

7184

7958130

A_23_P2601

GE79080

GO:0000166

GO:0001666

GO:0003723

GO:0003824

GO:0005509

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005783

GO:0005788

GO:0005789

GO:0005790

GO:0005829

GO:0005886

GO:0005925

GO:0006457

GO:0006886

GO:0007010

GO:0012501

GO:0015031

GO:0016020

GO:0016529

GO:0016787

GO:0016887

GO:0019903

GO:0030163

GO:0030312

GO:0030433

GO:0030496

GO:0030970

GO:0031012

GO:0031247

GO:0031410

GO:0032991

GO:0033018

GO:0034663

GO:0034975

GO:0034976

GO:0036211

GO:0042470

GO:0043066

GO:0043226

GO:0043666

GO:0044183

GO:0048471

GO:0050750

GO:0051082

GO:0051208

GO:0055065

GO:0062023

GO:0070062

GO:0071287

GO:0071318

GO:0071682

GO:0097524

GO:0140657

GO:0140662

HMNXSV003014483

HMNXSV003050728

Hs.288528.0.S1_3p_s_at

Hs.82689.0.S1_3p_a_at

ILMN_2096116

PH_hs_0022928

TC12000803.hg

X15187_at

g4507676_3p_a_at

Participates

as a member of

FAM20C products [endoplasmic reticulum lumen] (Homo sapiens)

Other forms of this molecule

HSP90B1 [endocytic vesicle lumen]

HSP90B1 [extracellular region]

HSP90B1 [endoplasmic reticulum lumen]

Inferred To

phospho-HSP90B1 [endoplasmic reticulum lumen] (Gallus gallus)

phospho-HSP90B1 [endoplasmic reticulum lumen] (Sus scrofa)

phospho-Gp93 [endoplasmic reticulum lumen] (Drosophila melanogaster)

phospho-p-HSP90B1 [endoplasmic reticulum lumen] (Bos taurus)

phospho-p-HSP90B1 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

phospho-p-HSP90B1 [endoplasmic reticulum lumen] (Canis familiaris)

phospho-p-HSP90B1 [endoplasmic reticulum lumen] (Mus musculus)

phospho-p-HSP90B1 [endoplasmic reticulum lumen] (Rattus norvegicus)

phospho-hsp90b1 [endoplasmic reticulum lumen] (Xenopus tropicalis)

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

RefSeq

NP_003290.1

Guide to Pharmacology - Targets

2904

OpenTargets

ENSG00000166598

ZINC - Substances

ENPL_HUMAN

ZINC target

P14625

PRO

P14625

PDB

7ULL, 4NH9

ZINC - Investigational

ENPL_HUMAN

HPA

ENSG00000166598-HSP90B1

GeneCards

P14625

Ensembl

ENST00000299767, ENSG00000166598, ENSP00000299767

Pharos - Targets

P14625

ZINC - Predictions - Purchasable

ENPL_HUMAN

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13438 OS9	1	OS9 [endoplasmic reticulum membrane] (R-HSA-1022132)	0.643	5
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.623	5
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	20
UniProt:Q00597 FANCC	2	FANCC [cytosol] (R-HSA-420801) FANCC [nucleoplasm] (R-HSA-419530)	0.581	4
ChEBI:28304 HEPARIN			0.564	4
UniProt:P11021 HSPA5	6	HSPA5 [extracellular region] (R-HSA-351322) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498)	0.564	2
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:P02452 COL1A1	20	3x4Hyp-3Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023648) 3x4Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023667) GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023604) GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022999) 3x4Hyp-3Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023559) 3x4Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023582) COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1650777) 3x4Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985659) 3x4Hyp-3Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022446) 3x4Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022951) 3x4Hyp-3Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022954) 5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985663) Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396137) Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396440) Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396471) Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396464) Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396068) Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396388) Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396315) Dehydrolysinonorlysyl 4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396441)	0.499	2
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.483	2

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