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PSMA7 [nucleoplasm]
Stable Identifier
R-HSA-174351
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Proteasome subunit alpha type 7 , Proteasome subunit RC6-1, Proteasome subunit XAPC7
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
20S core particle [nucleoplasm] (Homo sapiens)
20S CP outer ring [nucleoplasm] (Homo sapiens)
PSMA7 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
20S core particle [nucleoplasm] (Homo sapiens)
20S CP outer ring [nucleoplasm] (Homo sapiens)
PSMA7 [nucleoplasm] (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
20S core particle [nucleoplasm] (Homo sapiens)
20S CP outer ring [nucleoplasm] (Homo sapiens)
PSMA7 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
20S core particle [nucleoplasm] (Homo sapiens)
20S CP outer ring [nucleoplasm] (Homo sapiens)
PSMA7 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
20S core particle [nucleoplasm] (Homo sapiens)
20S CP outer ring [nucleoplasm] (Homo sapiens)
PSMA7 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
Ubiquitinated geminin is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
20S core particle [nucleoplasm] (Homo sapiens)
20S CP outer ring [nucleoplasm] (Homo sapiens)
PSMA7 [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Gastrulation (Homo sapiens)
Formation of paraxial mesoderm (Homo sapiens)
Somitogenesis (Homo sapiens)
RIPPLY2 binds TBX6 and recruits the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
20S core particle [nucleoplasm] (Homo sapiens)
20S CP outer ring [nucleoplasm] (Homo sapiens)
PSMA7 [nucleoplasm] (Homo sapiens)
TBX6:RIPPLY2:26S proteasome [nucleoplasm] (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
20S core particle [nucleoplasm] (Homo sapiens)
20S CP outer ring [nucleoplasm] (Homo sapiens)
PSMA7 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
20S core particle [nucleoplasm] (Homo sapiens)
20S CP outer ring [nucleoplasm] (Homo sapiens)
PSMA7 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
20S core particle [nucleoplasm] (Homo sapiens)
20S CP outer ring [nucleoplasm] (Homo sapiens)
PSMA7 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
20S core particle [nucleoplasm] (Homo sapiens)
20S CP outer ring [nucleoplasm] (Homo sapiens)
PSMA7 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
20S core particle [nucleoplasm] (Homo sapiens)
20S CP outer ring [nucleoplasm] (Homo sapiens)
PSMA7 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14818 PSMA7
Gene Names
PSMA7, HSPC
Chain
chain:1-248
Reference Genes
COSMIC (genes):PSMA7 PSMA7
dbSNP Gene:5688 PSMA7
ENSEMBL:ENSG00000101182 PSMA7
Participates
as a component of
20S CP outer ring [nucleoplasm] (Homo sapiens)
Other forms of this molecule
PSMA7 [cytosol]
Inferred To
Ghost homologue of PSMA7 [nucleoplasm]
(Danio rerio)
Prosalpha4 [nucleoplasm]
(Drosophila melanogaster)
PSMA7 [nucleoplasm]
(Bos taurus)
PSMA7 [nucleoplasm]
(Canis familiaris)
PSMA7 [nucleoplasm]
(Gallus gallus)
PSMA7 [nucleoplasm]
(Sus scrofa)
psma7 [nucleoplasm]
(Xenopus tropicalis)
pas-4 [nucleoplasm]
(Caenorhabditis elegans)
Psma7 [nucleoplasm]
(Mus musculus)
Psma7 [nucleoplasm]
(Rattus norvegicus)
psmA7 [nucleoplasm]
(Dictyostelium discoideum)
Interactors (36)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P25786 PSMA1
2
PSMA1 [cytosol]
(R-HSA-68724)
PSMA1 [nucleoplasm]
(R-HSA-174333)
0.948
22
UniProt:P25789 PSMA4
2
PSMA4 [cytosol]
(R-HSA-68730)
PSMA4 [nucleoplasm]
(R-HSA-174324)
0.884
12
UniProt:P60900 PSMA6
2
PSMA6 [cytosol]
(R-HSA-68734)
PSMA6 [nucleoplasm]
(R-HSA-174314)
0.85
13
UniProt:P25787 PSMA2
5
PSMA2 [cytosol]
(R-HSA-68726)
PSMA2 [nucleoplasm]
(R-HSA-174345)
PSMA2 [secretory granule lumen]
(R-HSA-6803329)
PSMA2 [extracellular region]
(R-HSA-6806506)
PSMA2 [ficolin-1-rich granule lumen]
(R-HSA-6803285)
0.85
9
UniProt:P25788 PSMA3
2
PSMA3 [cytosol]
(R-HSA-68728)
PSMA3 [nucleoplasm]
(R-HSA-174323)
0.835
7
UniProt:P49721 PSMB2
2
PSMB2 [cytosol]
(R-HSA-68744)
PSMB2 [nucleoplasm]
(R-HSA-174335)
0.788
6
UniProt:P49720 PSMB3
2
PSMB3 [cytosol]
(R-HSA-68747)
PSMB3 [nucleoplasm]
(R-HSA-174341)
0.768
7
UniProt:P28066 PSMA5
5
PSMA5 [cytosol]
(R-HSA-68732)
PSMA5 [nucleoplasm]
(R-HSA-174340)
PSMA5 [secretory granule lumen]
(R-HSA-6803316)
PSMA5 [extracellular region]
(R-HSA-6806459)
PSMA5 [ficolin-1-rich granule lumen]
(R-HSA-6803328)
0.744
6
UniProt:P28070 PSMB4
4
PSMB4 [cytosol]
(R-HSA-68750)
PSMB4 [nucleoplasm]
(R-HSA-174343)
pro-PSMB4 [cytosol]
(R-HSA-9908138)
PSMB4(1-45) [cytosol]
(R-HSA-9908122)
0.725
5
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
13
UniProt:Q92530 PSMF1
1
PSMF1 [cytosol]
(R-HSA-68818)
0.659
3
UniProt:P28072 PSMB6
4
PSMB6 [cytosol]
(R-HSA-68756)
PSMB6 [nucleoplasm]
(R-HSA-174342)
pro-PSMB6 [cytosol]
(R-HSA-9908130)
PSMB6(1-34) [cytosol]
(R-HSA-9908141)
0.643
3
UniProt:P20618 PSMB1
7
PSMB1 [cytosol]
(R-HSA-68738)
PSMB1 [nucleoplasm]
(R-HSA-174347)
PSMB1 [secretory granule lumen]
(R-HSA-6803287)
PSMB1 [extracellular region]
(R-HSA-6806477)
PSMB1 [ficolin-1-rich granule lumen]
(R-HSA-6803340)
pro-PSMB1 [cytosol]
(R-HSA-9908139)
PSMB1(1-28) [cytosol]
(R-HSA-9908143)
0.643
4
UniProt:P28065 PSMB9
3
pro-PSMB9 [cytosol]
(R-HSA-9908136)
PSMB9 [cytosol]
(R-HSA-68765)
PSMB9(1-20) [cytosol]
(R-HSA-9908132)
0.643
5
UniProt:Q99436 PSMB7
7
PSMB7 [cytosol]
(R-HSA-68759)
PSMB7 [nucleoplasm]
(R-HSA-174331)
PSMB7 [secretory granule lumen]
(R-HSA-6803279)
PSMB7 [extracellular region]
(R-HSA-6806449)
PSMB7 [ficolin-1-rich granule lumen]
(R-HSA-6803312)
pro-PSMB7 [cytosol]
(R-HSA-9908145)
PSMB7(1-43) [cytosol]
(R-HSA-9908129)
0.643
4
UniProt:P62333 PSMC6
2
PSMC6 [cytosol]
(R-HSA-68783)
PSMC6 [nucleoplasm]
(R-HSA-174319)
0.638
3
UniProt:O14818 PSMA7
2
PSMA7 [nucleoplasm]
(R-HSA-174351)
PSMA7 [cytosol]
(R-HSA-68736)
0.635
3
UniProt:Q9Y244 POMP
1
POMP [cytosol]
(R-HSA-9908067)
0.613
3
UniProt:Q9UNM6 PSMD13
5
PSMD13 [cytosol]
(R-HSA-68794)
PSMD13 [nucleoplasm]
(R-HSA-174326)
PSMD13 [secretory granule lumen]
(R-HSA-6800983)
PSMD13 [extracellular region]
(R-HSA-6806469)
PSMD13 [ficolin-1-rich granule lumen]
(R-HSA-6800413)
0.564
2
UniProt:P55036 PSMD4
1
PSMD4 [cytosol]
(R-HSA-68800)
0.564
2
UniProt:Q7L775 EPMIP
0.556
3
UniProt:Q5VVQ6 YOD1
1
YOD1 [cytosol]
(R-HSA-6781909)
0.556
5
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:Q16665 HIF1A
7
HIF1A [nucleoplasm]
(R-HSA-1234135)
HIF1A [cytosol]
(R-HSA-1234102)
p-Y565-HIF1A [cytosol]
(R-HSA-8857584)
p-Y565,S797-HIF1A [cytosol]
(R-HSA-9634700)
2xHP-HIF1A [cytosol]
(R-HSA-1234131)
2xHP-HIF1A [nucleoplasm]
(R-HSA-1234105)
HN-HIF1A [cytosol]
(R-HSA-1234110)
0.544
2
UniProt:Q06323 PSME1
1
PSME1 [cytosol]
(R-HSA-68812)
0.527
2
UniProt:Q969U7 PSMG2
1
PSMG2 [cytosol]
(R-HSA-9908053)
0.527
3
UniProt:P61289 PSME3
1
PSME3 [cytosol]
(R-HSA-68816)
0.527
2
UniProt:Q9BT73 PSMG3
1
PSMG3 [cytosol]
(R-HSA-9908033)
0.527
2
UniProt:O95456 PSMG1
1
PSMG1 [cytosol]
(R-HSA-9908050)
0.527
2
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [cytosol]
(R-HSA-1629778)
UCHL5 [nucleoplasm]
(R-HSA-5689584)
0.527
3
UniProt:Q14997 PSME4
1
PSME4 [cytosol]
(R-HSA-947606)
0.527
2
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.527
4
UniProt:Q19T08 ECSCR
0.508
3
UniProt:Q96G75 RMND5B
1
RMND5B [cytosol]
(R-HSA-9861550)
0.508
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
8
UniProt:A0A0F6B1Q8 A0A0F6B1Q8
0.462
2
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