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PSMA7 [nucleoplasm]
Stable Identifier
R-HSA-174351
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Proteasome subunit alpha type 7 , Proteasome subunit RC6-1, Proteasome subunit XAPC7
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA7 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA7 [nucleoplasm] (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA7 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA7 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA7 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
Ubiquitinated geminin is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA7 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA7 [nucleoplasm] (Homo sapiens)
Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA7 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA7 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA7 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA7 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14818 PSMA7
Gene Names
PSMA7, HSPC
Chain
chain:1-248
Reference Genes
BioGPS Gene:5688 PSMA7
COSMIC (genes):PSMA7 PSMA7
CTD Gene:5688 PSMA7
dbSNP Gene:5688 PSMA7
ENSEMBL:ENSG00000101182 PSMA7
HGNC:9536 PSMA7
KEGG Gene (Homo sapiens):5688 PSMA7
Monarch:5688 PSMA7
NCBI Gene:5688 PSMA7
OMIM:606607 PSMA7
UCSC:O14818 PSMA7
Reference Transcript
RefSeq:NM_002792.3 PSMA7
Other Identifiers
0001450301
0003780402
11734682_a_at
16920910
201114_PM_x_at
201114_x_at
216088_PM_s_at
216088_s_at
33449_at
3912862
3912863
3912864
3912865
3912867
3912870
3912872
3912873
3912874
3912875
3912876
3912877
3912879
3912883
3912885
3912886
8067382
A_23_P91468
GE561832
GE62892
GO:0000165
GO:0000209
GO:0000278
GO:0000502
GO:0002223
GO:0002376
GO:0002479
GO:0003674
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005839
GO:0006464
GO:0006511
GO:0006520
GO:0006521
GO:0006810
GO:0006950
GO:0007049
GO:0007165
GO:0007267
GO:0008150
GO:0009056
GO:0009058
GO:0010498
GO:0010972
GO:0016579
GO:0019773
GO:0022607
GO:0030154
GO:0031145
GO:0031146
GO:0032991
GO:0033209
GO:0034641
GO:0034655
GO:0036388
GO:0038061
GO:0038095
GO:0042802
GO:0043161
GO:0043226
GO:0043488
GO:0043687
GO:0044281
GO:0048856
GO:0050852
GO:0051603
GO:0055085
GO:0060071
GO:0061418
GO:0065003
GO:0070062
GO:0070498
GO:0090090
GO:0090263
GO:0098794
GO:1902036
HMNXSV003028165
Hs.233952.3.S1_3p_a_at
ILMN_1701962
PH_hs_0012783
PH_hs_0035712
TC20001005.hg
Participates
as a component of
26S proteasome [nucleoplasm] (Homo sapiens)
Other forms of this molecule
PSMA7 [cytosol]
Inferred To
Prosalpha4T2 [nucleoplasm]
(Drosophila melanogaster)
Ghost homologue of PSMA7 [nucleoplasm]
(Danio rerio)
Prosalpha4 [nucleoplasm]
(Drosophila melanogaster)
PSMA7 [nucleoplasm]
(Bos taurus)
PSMA7 [nucleoplasm]
(Canis familiaris)
PSMA7 [nucleoplasm]
(Gallus gallus)
PSMA7 [nucleoplasm]
(Sus scrofa)
psma7 [nucleoplasm]
(Xenopus tropicalis)
pas-4 [nucleoplasm]
(Caenorhabditis elegans)
Psma7 [nucleoplasm]
(Mus musculus)
Psma7 [nucleoplasm]
(Rattus norvegicus)
psmA7 [nucleoplasm]
(Dictyostelium discoideum)
Homologues of PSMA7 [nucleoplasm]
(Drosophila melanogaster)
Prosalpha4T1 [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_002783.1
OpenTargets
ENSG00000101182
HPA
ENSG00000101182-PSMA7
GeneCards
O14818
Ensembl
ENSG00000101182
,
ENSP00000359910
,
ENSP00000359898
,
ENSP00000359895
,
ENST00000370873
,
ENST00000370858
,
ENST00000370861
PRO
O14818
Pharos - Targets
O14818
PDB
7NHT
,
5L4G
,
6WJD
,
5LE5
,
5VFO
,
5VFU
,
7LXV
,
5LEX
,
7AWE
,
4R67
,
6MSK
,
5LF6
,
5GJR
,
5VFS
,
5LF7
,
4R3O
,
6RGQ
,
5A0Q
,
5LF3
,
6WJN
,
7PG9
,
5T0J
,
6MSB
,
6E5B
,
5LF4
,
7V5M
,
6KWY
,
5LF0
,
5LEZ
,
5T0H
,
5LF1
,
7V5G
,
6R70
,
5T0I
,
6XMJ
,
6MSH
,
5LEY
,
5T0G
,
6MSJ
,
6MSG
,
6AVO
,
5VFR
,
5M32
,
5T0C
,
5VFT
,
6REY
,
5LN3
,
5VFP
,
6MSD
,
6MSE
,
5GJQ
,
5VFQ
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
13
UniProt:Q5VVQ6 YOD1
1
YOD1 [cytosol]
(R-HSA-6781909)
0.556
5
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:Q16665 HIF1A
7
2xHP-HIF1A [cytosol]
(R-HSA-1234131)
2xHP-HIF1A [nucleoplasm]
(R-HSA-1234105)
HN-HIF1A [cytosol]
(R-HSA-1234110)
p-Y565,S797-HIF1A [cytosol]
(R-HSA-9634700)
p-Y565-HIF1A [cytosol]
(R-HSA-8857584)
HIF1A [cytosol]
(R-HSA-1234102)
HIF1A [nucleoplasm]
(R-HSA-1234135)
0.544
2
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [nucleoplasm]
(R-HSA-5689584)
UCHL5 [cytosol]
(R-HSA-1629778)
0.527
3
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