Reactome | ABCE1 [mitochondrial matrix]

ABCE1 [mitochondrial matrix]

Stable Identifier

R-HSA-5216010

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

ATP-binding cassette sub-family E member 1, ABCE1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P61221 ABCE1

Gene Names

ABCE1, RLI, RNASEL1, RNASELI, RNS4I, OK/SW-cl.40

Chain

chain:1-599

Reference Genes

BioGPS Gene:6059 ABCE1

COSMIC (genes):ABCE1 ABCE1

CTD Gene:6059 ABCE1

dbSNP Gene:6059 ABCE1

ENSEMBL:ENSG00000164163 ABCE1

ENSEMBL_homo_sapiens_GENE:ENSG00000164163.11 ABCE1

HGNC:69 ABCE1

KEGG Gene (Homo sapiens):6059 ABCE1

Monarch:6059 ABCE1

NCBI Gene:6059 ABCE1

OMIM:601213 ABCE1

UCSC:P61221 ABCE1

Reference Transcript

Other Identifiers

11743804_at

11747858_a_at

11747859_s_at

11747860_x_at

11752588_s_at

16971139

201872_PM_s_at

201872_s_at

201873_PM_s_at

201873_s_at

2448887

2448888

2448889

2448890

2448891

2448892

2448893

2448894

2746026

2746027

2746028

2746029

2746030

2746031

2746033

2746034

2746036

2746037

2746038

2746041

2746042

2746044

2746046

2746048

2746050

2746054

2746055

2746056

2746057

2746058

2746059

3041566

3041568

3041569

39355_at

6059

8097647

A_23_P41380

GE60020

GO:0000054

GO:0000166

GO:0003824

GO:0003924

GO:0005506

GO:0005515

GO:0005524

GO:0005737

GO:0005739

GO:0005759

GO:0005829

GO:0005840

GO:0006413

GO:0006415

GO:0006417

GO:0006913

GO:0016020

GO:0016787

GO:0016887

GO:0017111

GO:0022626

GO:0032790

GO:0042254

GO:0043024

GO:0043226

GO:0043273

GO:0046872

GO:0051536

GO:0051539

GO:0060698

GO:0060702

GO:0072344

GO:0098772

GO:0140657

HMNXSV003036012

Hs.12013.0.A1_3p_a_at

ILMN_1676846

ILMN_2330267

PH_hs_0001128

TC04000709.hg

X74987_s_at

g4506558_3p_a_at

Participates

as a component of

ABCE1:RNASEL dimer [mitochondrial matrix] (Homo sapiens)

as an input of

ABCE1 binds RNASEL, inhibiting it (Homo sapiens)

Other forms of this molecule

ABCE1 [cytosol]

Inferred To

Abce1 [mitochondrial matrix] (Rattus norvegicus)

abce1 [mitochondrial matrix] (Xenopus tropicalis)

ABCE1 [mitochondrial matrix] (Bos taurus)

ABCE1 [mitochondrial matrix] (Canis familiaris)

ABCE1 [mitochondrial matrix] (Gallus gallus)

ABCE1 [mitochondrial matrix] (Mus musculus)

ABCE1 [mitochondrial matrix] (Sus scrofa)

Cross References

RefSeq

NP_002931.2, NP_001035809.1

OpenTargets

ENSG00000164163

GeneCards

P61221

HPA

ENSG00000164163-ABCE1

Ensembl

ENSP00000296577, ENSG00000164163, ENST00000296577

PRO

P61221

Pharos - Targets

P61221

PDB

6ZVJ, 6ZME, 7A09

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75822 EIF3J	1	EIF3J [cytosol] (R-HSA-72534)	0.666	4
UniProt:P03347-1 GAG			0.591	3
UniProt:Q9WH76 MATRX			0.581	3
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:Q8WV07 LTO1			0.527	2
UniProt:O15372 EIF3H	1	EIF3H [cytosol] (R-HSA-72544)	0.527	2
UniProt:P69479 PHOSP			0.499	3
UniProt:O75821 EIF3G	1	EIF3G [cytosol] (R-HSA-72538)	0.483	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	8

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