Reactome | CCT2 [extracellular region]

CCT2 [extracellular region]

Stable Identifier

R-HSA-6806220

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

T-complex protein 1 subunit beta (TCP-1-beta)

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P78371 CCT2

Gene Names

CCT2, 99D8.1, CCTB

Chain

initiator methionine:1, chain:2-535

Reference Genes

BioGPS Gene:10576 CCT2

COSMIC (genes):CCT2 CCT2

CTD Gene:10576 CCT2

dbSNP Gene:10576 CCT2

ENSEMBL:ENSG00000166226.13 CCT2

HGNC:1615 CCT2

KEGG Gene (Homo sapiens):10576 CCT2

Monarch:10576 CCT2

NCBI Gene:10576 CCT2

OMIM:605139 CCT2

UCSC:P78371 CCT2

Reference Transcript

Other Identifiers

10576

11715420_a_at

11715421_a_at

16753964

201946_PM_s_at

201946_s_at

201947_PM_s_at

201947_s_at

3421631

3421632

3421633

3421634

3421635

3421636

3421637

3421638

3421640

3421643

3421644

3421645

3421650

3421652

3421653

3421654

3421655

3421656

3421657

3421658

3421661

3421666

3421667

3421668

3421669

35759_at

7957052

A_23_P105392

GE61414

GO:0000166

GO:0002199

GO:0003824

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005737

GO:0005764

GO:0005773

GO:0005829

GO:0005832

GO:0005856

GO:0005874

GO:0006457

GO:0007339

GO:0016787

GO:0016887

GO:0022414

GO:0031410

GO:0031625

GO:0032200

GO:0032212

GO:0035578

GO:0043226

GO:0044183

GO:0044297

GO:0050821

GO:0051082

GO:0051086

GO:0051131

GO:0051973

GO:0061077

GO:0065003

GO:0070062

GO:0090666

GO:0140657

GO:0140662

GO:1901998

GO:1904851

GO:1904871

GO:1904874

HMNXSV003028752

Hs.6456.0.S1_3p_a_at

ILMN_1679382

PH_hs_0022906

PH_hs_0040227

TC12000616.hg

U91327_at

g5453602_3p_a_at

g5453602_3p_x_at

Participates

as a member of

Azurophil granule lumen proteins [extracellular region] (Homo sapiens)

Other forms of this molecule

CCT2 [azurophil granule lumen]

CCT2 [cytosol]

Inferred To

Cct2 [extracellular region] (Mus musculus)

Cct2 [extracellular region] (Rattus norvegicus)

cct-2 [extracellular region] (Caenorhabditis elegans)

cct2 [extracellular region] (Dictyostelium discoideum)

cct2 [extracellular region] (Schizosaccharomyces pombe)

cct2 [extracellular region] (Xenopus tropicalis)

CCT2 [extracellular region] (Bos taurus)

CCT2 [extracellular region] (Canis familiaris)

CCT2 [extracellular region] (Drosophila melanogaster)

CCT2 [extracellular region] (Gallus gallus)

CCT2 [extracellular region] (Plasmodium falciparum)

CCT2 [extracellular region] (Saccharomyces cerevisiae)

CCT2 [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_001185771.1, NP_006422.1

OpenTargets

ENSG00000166226

GeneCards

P78371

HPA

ENSG00000166226-CCT2

Ensembl

ENST00000543146, ENSG00000166226, ENSP00000445471, ENSP00000299300, ENST00000299300

PRO

P78371

Pharos - Targets

P78371

PDB

7LUP, 6NRC, 7NVL, 6NR9, 7NVM, 6NRD, 7NVN, 6NRA, 7NVO, 6QB8, 6NR8, 6NRB, 7LUM

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.725	5
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.688	3
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.643	3
UniProt:Q9BUR4 WRAP53	2	WRAP53 [nucleoplasm] (R-HSA-418386) Unfolded WRAP53 [cytosol] (R-HSA-6813830)	0.597	4
UniProt:Q8IWZ6 BBS7	1	BBS7 [cytosol] (R-HSA-5617632)	0.597	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:O14744 PRMT5	3	p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300) PRMT5 [nucleoplasm] (R-HSA-5205609) PRMT5 [cytosol] (R-HSA-191876)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	6
UniProt:Q8N0U8 VKORC1L1	1	VKORC1L1 [endoplasmic reticulum membrane] (R-HSA-2980944)	0.556	3
UniProt:O43815 STRN	5	STRN [cytosol] (R-HSA-9037081) STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) p-11Y STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.527	2
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.527	2
UniProt:Q00535 CDK5	4	CDK5 [nucleoplasm] (R-HSA-8863586) p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249) CDK5 [cytosol] (R-HSA-180064) p-Y15-CDK5 [cytosol] (R-HSA-399809)	0.527	2
UniProt:Q92466 DDB2	3	DDB2 [nucleoplasm] (R-HSA-53491) PAR-DDB2 [nucleoplasm] (R-HSA-5696654) PolyUb-DDB2 [nucleoplasm] (R-HSA-6783035)	0.527	2
UniProt:Q9GZV5 WWTR1	3	p-S89-WWTR1 [cytosol] (R-HSA-2028665) WWTR1 [nucleoplasm] (R-HSA-1629775) WWTR1 [cytosol] (R-HSA-1629773)	0.499	2

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