Reactome | ZW10 [cytosol]

ZW10 [cytosol]

Stable Identifier

R-HSA-377880

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - Mitotic Spindle Checkpoint (Homo sapiens)
    - Amplification of signal from the kinetochores (Homo sapiens)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
        
        MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RZZ complex [cytosol] (Homo sapiens)
        
        ZW10 [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RZZ complex [cytosol] (Homo sapiens)
        
        ZW10 [cytosol] (Homo sapiens)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Homo sapiens)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RZZ complex [cytosol] (Homo sapiens)
        
        ZW10 [cytosol] (Homo sapiens)
        
        Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RZZ complex [cytosol] (Homo sapiens)
        
        ZW10 [cytosol] (Homo sapiens)
        
        Mad1 binds kinetochore (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RZZ complex [cytosol] (Homo sapiens)
        
        ZW10 [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RZZ complex [cytosol] (Homo sapiens)
        
        ZW10 [cytosol] (Homo sapiens)
        
        Release of activated MAD2 from kinetochores (Homo sapiens)
        
        Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RZZ complex [cytosol] (Homo sapiens)
        
        ZW10 [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RZZ complex [cytosol] (Homo sapiens)
        
        ZW10 [cytosol] (Homo sapiens)
- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Separation of Sister Chromatids (Homo sapiens)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RZZ complex [cytosol] (Homo sapiens)
        
        ZW10 [cytosol] (Homo sapiens)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RZZ complex [cytosol] (Homo sapiens)
        
        ZW10 [cytosol] (Homo sapiens)
        
        Separation of sister chromatids (Homo sapiens)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RZZ complex [cytosol] (Homo sapiens)
        
        ZW10 [cytosol] (Homo sapiens)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RZZ complex [cytosol] (Homo sapiens)
        
        ZW10 [cytosol] (Homo sapiens)
    - Mitotic Prometaphase (Homo sapiens)
      - EML4 and NUDC in mitotic spindle formation (Homo sapiens)
        
        EML4 recruits NUDC to mitotic spindle (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RZZ complex [cytosol] (Homo sapiens)
        
        ZW10 [cytosol] (Homo sapiens)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RZZ complex [cytosol] (Homo sapiens)
        
        ZW10 [cytosol] (Homo sapiens)
      - Kinetochore capture of astral microtubules (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RZZ complex [cytosol] (Homo sapiens)
        
        ZW10 [cytosol] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RZZ complex [cytosol] (Homo sapiens)
        
        ZW10 [cytosol] (Homo sapiens)
      - Resolution of Sister Chromatid Cohesion (Homo sapiens)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RZZ complex [cytosol] (Homo sapiens)
        
        ZW10 [cytosol] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RZZ complex [cytosol] (Homo sapiens)
        
        ZW10 [cytosol] (Homo sapiens)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RZZ complex [cytosol] (Homo sapiens)
        
        ZW10 [cytosol] (Homo sapiens)
        
        Kinetochore assembly (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RZZ complex [cytosol] (Homo sapiens)
        
        ZW10 [cytosol] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RZZ complex [cytosol] (Homo sapiens)
        
        ZW10 [cytosol] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RZZ complex [cytosol] (Homo sapiens)
        
        ZW10 [cytosol] (Homo sapiens)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RZZ complex [cytosol] (Homo sapiens)
        
        ZW10 [cytosol] (Homo sapiens)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RZZ complex [cytosol] (Homo sapiens)
        
        ZW10 [cytosol] (Homo sapiens)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RZZ complex [cytosol] (Homo sapiens)
        
        ZW10 [cytosol] (Homo sapiens)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        RZZ complex [cytosol] (Homo sapiens)
        
        ZW10 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O43264 ZW10

Gene Names

ZW10

Chain

initiator methionine:, chain:2-779

Reference Genes

BioGPS Gene:9183 ZW10

COSMIC (genes):ZW10 ZW10

CTD Gene:9183 ZW10

dbSNP Gene:9183 ZW10

ENSEMBL:ENSG00000086827 ZW10

HGNC:13194 ZW10

KEGG:hsa:9183 ZW10

Monarch:9183 ZW10

NCBI Gene:9183 ZW10

OMIM:603954 ZW10

UCSC:O43264 ZW10

Reference Transcript

RefSeq:NM_004724.3 ZW10

Other Identifiers

11721684_a_at

16744501

204812_PM_at

204812_at

3391768

3391770

3391771

3391772

3391773

3391777

3391778

3391779

3391780

3391781

3391782

3391786

3391787

3391788

3391789

3391790

3391791

3391794

3391795

3391796

3391798

3391799

3391800

3391801

3391802

37854_at

69528_r_at

7951734

9183

A_23_P64204

GE59243

GO:0000070

GO:0000132

GO:0000278

GO:0000775

GO:0000776

GO:0000922

GO:0003677

GO:0005515

GO:0005634

GO:0005694

GO:0005737

GO:0005783

GO:0005789

GO:0005811

GO:0005819

GO:0005828

GO:0005829

GO:0005856

GO:0006888

GO:0006890

GO:0007010

GO:0007030

GO:0007059

GO:0007080

GO:0007094

GO:0007096

GO:0015031

GO:0016020

GO:0016192

GO:0019237

GO:0022414

GO:0034501

GO:0043226

GO:0051301

GO:0051321

GO:0051988

GO:0065003

GO:0070939

GO:1990423

HMNXSV003003395

ILMN_1712556

PH_hs_0001304

TC11002305.hg

g4759343_3p_at

Participates

as a component of

Inferred To

Ghost homologue of ZW10 [cytosol] (Schizosaccharomyces pombe)

DSL1 [cytosol] (Saccharomyces cerevisiae)

Zw10 [cytosol] (Drosophila melanogaster)

Zw10 [cytosol] (Mus musculus)

Zw10 [cytosol] (Rattus norvegicus)

ZW10 [cytosol] (Bos taurus)

ZW10 [cytosol] (Canis familiaris)

ZW10 [cytosol] (Dictyostelium discoideum)

ZW10 [cytosol] (Gallus gallus)

ZW10 [cytosol] (Sus scrofa)

czw-1 [cytosol] (Caenorhabditis elegans)

zw10 [cytosol] (Danio rerio)

zw10 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_004715.1

ENSEMBL

ENSG00000086827, ENSP00000440879, ENST00000535142, ENST00000200135, ENSP00000200135

OpenTargets

ENSG00000086827

GeneCards

ZW10

HPA

ENSG00000086827-ZW10

PRO

O43264

Pharos - Targets

O43264

GlyGen

O43264

PDB

7QPG

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9P2W9 STX18	1	STX18 [endoplasmic reticulum membrane] (R-HSA-2029079)	0.788	7
UniProt:Q9NZ43 USE1	1	USE1 [endoplasmic reticulum membrane] (R-HSA-2193119)	0.723	8
UniProt:O75396 SEC22B	6	SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688566) SEC22B [phagocytic vesicle membrane] (R-HSA-8863938) SEC22B [endoplasmic reticulum membrane] (R-HSA-5688150) SEC22B [ER to Golgi transport vesicle membrane] (R-HSA-5688565) SEC22B [transport vesicle] (R-HSA-6810994) SEC22B [Golgi membrane] (R-HSA-6810993)	0.643	4
UniProt:P54920 NAPA	1	NAPA [cytosol] (R-HSA-264469)	0.527	2
UniProt:P08173 CHRM4	1	CHRM4 [plasma membrane] (R-HSA-390693)	0.527	2
UniProt:Q12981 BNIP1	1	BNIP1 [endoplasmic reticulum membrane] (R-HSA-6810950)	0.527	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	12
UniProt:Q9P2Y5 UVRAG	2	UVRAG [cytosol] (R-HSA-5668884) UVRAG [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9730510)	0.462	12

Cite Us!