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ZW10 [cytosol]
Stable Identifier
R-HSA-377880
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
Mitotic Spindle Checkpoint (Homo sapiens)
Amplification of signal from the kinetochores (Homo sapiens)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
ZW10 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
ZW10 [cytosol] (Homo sapiens)
MAD2 converted to an inhibitory state via interaction with Mad1 (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
ZW10 [cytosol] (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
ZW10 [cytosol] (Homo sapiens)
Mad1 binds kinetochore (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
ZW10 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
ZW10 [cytosol] (Homo sapiens)
Release of activated MAD2 from kinetochores (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
ZW10 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
ZW10 [cytosol] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Separation of Sister Chromatids (Homo sapiens)
ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
ZW10 [cytosol] (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
ZW10 [cytosol] (Homo sapiens)
Separation of sister chromatids (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
ZW10 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore:Microtubules [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
ZW10 [cytosol] (Homo sapiens)
Mitotic Prometaphase (Homo sapiens)
EML4 and NUDC in mitotic spindle formation (Homo sapiens)
EML4 recruits NUDC to mitotic spindle (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
ZW10 [cytosol] (Homo sapiens)
p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
ZW10 [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
ZW10 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
ZW10 [cytosol] (Homo sapiens)
Resolution of Sister Chromatid Cohesion (Homo sapiens)
CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
ZW10 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
ZW10 [cytosol] (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
ZW10 [cytosol] (Homo sapiens)
Kinetochore assembly (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
ZW10 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
ZW10 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
ZW10 [cytosol] (Homo sapiens)
PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
ZW10 [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
ZW10 [cytosol] (Homo sapiens)
Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
ZW10 [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
ZW10 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate Formins (Homo sapiens)
AURKB phosphorylates DIAPH2-2 at kinetochores (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
ZW10 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
ZW10 [cytosol] (Homo sapiens)
CDC42:GTP recruits DIAPH2-2 to kinetochores (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
ZW10 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
ZW10 [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
ZW10 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
ZW10 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
ZW10 [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Golgi-to-ER retrograde transport (Homo sapiens)
COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
COPI vesicle uncoating at the ER (Homo sapiens)
RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo:NBAS:RINT1:ZW10:STX18:USE1L:BNIP1 [endoplasmic reticulum membrane] (Homo sapiens)
NBAS:RINT1:ZW10 [cytosol] (Homo sapiens)
ZW10 [cytosol] (Homo sapiens)
Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Homo sapiens)
NBAS:RINT1:ZW10 [cytosol] (Homo sapiens)
ZW10 [cytosol] (Homo sapiens)
RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo:NBAS:RINT1:ZW10:STX18:USE1L:BNIP1 [endoplasmic reticulum membrane] (Homo sapiens)
NBAS:RINT1:ZW10 [cytosol] (Homo sapiens)
ZW10 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43264 ZW10
Gene Names
ZW10
Chain
initiator methionine:, chain:2-779
Reference Genes
BioGPS Gene:9183 ZW10
COSMIC (genes):ZW10 ZW10
CTD Gene:9183 ZW10
dbSNP Gene:9183 ZW10
ENSEMBL:ENSG00000086827 ZW10
ENSEMBL_homo_sapiens_GENE:ENSG00000086827.9 ZW10
HGNC:13194 ZW10
KEGG Gene (Homo sapiens):9183 ZW10
Monarch:9183 ZW10
NCBI Gene:9183 ZW10
OMIM:603954 ZW10
UCSC:O43264 ZW10
Reference Transcript
RefSeq:NM_004724.3 ZW10
Other Identifiers
11721684_a_at
16744501
204812_PM_at
204812_at
3391768
3391770
3391771
3391772
3391773
3391777
3391778
3391779
3391780
3391781
3391782
3391786
3391787
3391788
3391789
3391790
3391791
3391794
3391795
3391796
3391798
3391799
3391800
3391801
3391802
37854_at
69528_r_at
7951734
9183
A_23_P64204
GE59243
GO:0000070
GO:0000132
GO:0000278
GO:0000775
GO:0000776
GO:0000922
GO:0003677
GO:0005515
GO:0005634
GO:0005694
GO:0005737
GO:0005783
GO:0005789
GO:0005811
GO:0005819
GO:0005828
GO:0005829
GO:0005856
GO:0006888
GO:0006890
GO:0007010
GO:0007030
GO:0007049
GO:0007059
GO:0007080
GO:0007094
GO:0007096
GO:0007163
GO:0015031
GO:0016020
GO:0016192
GO:0019237
GO:0022414
GO:0023052
GO:0034501
GO:0043226
GO:0051301
GO:0051321
GO:0065003
GO:0070939
GO:0140014
GO:1990423
HMNXSV003003395
ILMN_1712556
PH_hs_0001304
TC11002305.hg
g4759343_3p_at
Participates
as a component of
NBAS:RINT1:ZW10 [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
Inferred To
Ghost homologue of ZW10 [cytosol]
(Schizosaccharomyces pombe)
zgc:55782 [cytosol]
(Danio rerio)
DSL1 [cytosol]
(Saccharomyces cerevisiae)
Zw10 [cytosol]
(Drosophila melanogaster)
Zw10 [cytosol]
(Mus musculus)
Zw10 [cytosol]
(Rattus norvegicus)
ZW10 [cytosol]
(Bos taurus)
ZW10 [cytosol]
(Canis familiaris)
ZW10 [cytosol]
(Dictyostelium discoideum)
ZW10 [cytosol]
(Gallus gallus)
ZW10 [cytosol]
(Sus scrofa)
czw-1 [cytosol]
(Caenorhabditis elegans)
zw10 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_004715.1
OpenTargets
ENSG00000086827
HPA
ENSG00000086827-ZW10
GeneCards
O43264
Ensembl
ENSP00000440879
,
ENST00000200135
,
ENST00000535142
,
ENSG00000086827
,
ENSP00000200135
PRO
O43264
Pharos - Targets
O43264
PDB
7QPG
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9P2W9 STX18
1
STX18 [endoplasmic reticulum membrane]
(R-HSA-2029079)
0.643
4
UniProt:Q9NZ43 USE1
1
USE1 [endoplasmic reticulum membrane]
(R-HSA-2193119)
0.643
6
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
12
UniProt:Q9P2Y5 UVRAG
2
UVRAG [cytosol]
(R-HSA-5668884)
UVRAG [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-9730510)
0.462
12
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