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Hyp-K50-EIF5A [cytosol]
Stable Identifier
R-HSA-3006310
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Eukaryotic translation initiation factor 5A, IF5A1_HUMAN, Hyp50
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Homo sapiens)
Hypusine synthesis from eIF5A-lysine (Homo sapiens)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Homo sapiens)
Hyp-K50-EIF5A [cytosol] (Homo sapiens)
Hyp-K50-EIF5A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P63241 EIF5A
Gene Names
EIF5A
Chain
initiator methionine:1, chain:2-154
Reference Genes
BioGPS Gene:1984 EIF5A
COSMIC (genes):EIF5A EIF5A
CTD Gene:1984 EIF5A
dbSNP Gene:1984 EIF5A
ENSEMBL:ENSG00000132507 EIF5A
ENSEMBL:ENSG00000132507.18 EIF5A
ENSEMBL:ENSG00000288145.1 EIF5A
HGNC:3300 EIF5A
KEGG Gene (Homo sapiens):1984 EIF5A
Monarch:1984 EIF5A
NCBI Gene:1984 EIF5A
OMIM:600187 EIF5A
UCSC:P63241 EIF5A
Reference Transcript
RefSeq:NM_001143760.1 EIF5A
RefSeq:NM_001143761.1 EIF5A
RefSeq:NM_001143762.1 EIF5A
RefSeq:NM_001970.4 EIF5A
RefSeq:XM_005256509.2 EIF5A
Other Identifiers
11737958_x_at
11744682_x_at
11753619_s_at
11758734_x_at
1984
201122_PM_x_at
201122_x_at
201123_PM_s_at
201123_s_at
213753_3p_x_at
213753_PM_x_at
213753_x_at
3253922
3253923
3253924
3253925
3253929
3253930
3253931
3253932
3297606
3297607
3297608
3297610
3708423
3708424
3708425
3708426
3708427
3708428
3708429
3708430
3708432
3708435
3708437
3708439
3708441
3708442
3708443
7928600
7928630
7934753
A_24_P31235
GE79692
GE88537
GO:0003723
GO:0003746
GO:0005515
GO:0005634
GO:0005635
GO:0005642
GO:0005643
GO:0005737
GO:0005783
GO:0005789
GO:0005829
GO:0006351
GO:0006355
GO:0006412
GO:0006414
GO:0012501
GO:0016020
GO:0017070
GO:0023052
GO:0033209
GO:0043022
GO:0043226
GO:0045182
GO:0045901
GO:0045905
GO:0045944
GO:0098586
GO:1902255
HMNXSV003008002
Hs.119140.1.S1_3p_x_at
ILMN_1794522
S72024_s_at
TC17000088.hg
g4503544_3p_a_at
Participates
as a member of
Hyp-K50-EIF5A [cytosol] (Homo sapiens)
Other forms of this molecule
EIF5A [cytosol]
Dhp-K50-EIF5A [cytosol]
Inferred To
eEF5 [cytosol]
(Drosophila melanogaster)
iff-2 [cytosol]
(Caenorhabditis elegans)
tif51a [cytosol]
(Schizosaccharomyces pombe)
Eif5a [cytosol]
(Mus musculus)
Eif5a [cytosol]
(Rattus norvegicus)
EIF5A [cytosol]
(Bos taurus)
ANB1 [cytosol]
(Saccharomyces cerevisiae)
Hyp-K50-EIF5A [cytosol]
(Canis familiaris)
Hyp-K50-EIF5A [cytosol]
(Gallus gallus)
Hyp-K50-EIF5A [cytosol]
(Plasmodium falciparum)
Hyp-K50-EIF5A [cytosol]
(Sus scrofa)
eif5a [cytosol]
(Danio rerio)
eif5a [cytosol]
(Dictyostelium discoideum)
eif5a [cytosol]
(Xenopus tropicalis)
Modified Residues
Name
hypusine at 50
Coordinate
50
PsiMod Name
hypusine [MOD:00125]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine.
Cross References
RefSeq
NP_001137234.1
,
XP_005256566.1
,
NP_001137233.1
,
NP_001137232.1
,
NP_001961.1
OpenTargets
ENSG00000132507
GeneCards
P63241
HPA
ENSG00000132507-EIF5A
Ensembl
ENSP00000500624
,
ENST00000673259
,
ENSP00000336702
,
ENSP00000500669
,
ENSP00000500847
,
ENST00000672765
,
ENSG00000288145
,
ENST00000672250
,
ENSG00000132507
,
ENST00000336458
,
ENST00000573542
,
ENST00000416016
,
ENST00000576930
,
ENST00000336452
,
ENST00000673304
,
ENST00000672755
,
ENSP00000390677
,
ENSP00000458269
,
ENSP00000459611
,
ENSP00000396073
,
ENSP00000459196
,
ENST00000571955
,
ENSP00000500414
,
ENSP00000336776
,
ENST00000673099
,
ENST00000419711
,
ENST00000673210
,
ENSP00000500717
,
ENSP00000499855
,
ENSP00000499995
PRO
P63241
Pharos - Targets
P63241
PDB
3CPF
,
5DLQ
HMDB Protein
HMDBP02415
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O00560 SDCBP
3
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [cytosol]
(R-HSA-373639)
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
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