Reactome | ARPC1B [cytosol]

ARPC1B [cytosol]

Stable Identifier

R-HSA-6787770

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Actin-related protein 2/3 complex subunit 1B, ARC1B_HUMAN, p41-ARC

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - EPH-Ephrin signaling (Homo sapiens)
      - EPHB-mediated forward signaling (Homo sapiens)
        
        N-WASP binds ARP2/3 and G-actin (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ARPC1B [cytosol] (Homo sapiens)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ARPC1B [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O15143 ARPC1B

Gene Names

ARPC1B, ARC41

Chain

initiator methionine:, chain:2-372

Reference Genes

BioGPS Gene:10095 ARPC1B

COSMIC (genes):ARPC1B ARPC1B

CTD Gene:10095 ARPC1B

dbSNP Gene:10095 ARPC1B

ENSEMBL:ENSG00000130429 ARPC1B

ENSEMBL_homo_sapiens_GENE:ENSG00000130429.16 ARPC1B

HGNC:704 ARPC1B

KEGG Gene (Homo sapiens):10095 ARPC1B

Monarch:10095 ARPC1B

NCBI Gene:10095 ARPC1B

OMIM:604223 ARPC1B

UCSC:O15143 ARPC1B

Reference Transcript

Other Identifiers

10095

11744077_at

17048879

201954_PM_at

201954_at

3014715

3014716

3014717

3014718

3014719

3014720

3014722

3014724

3014726

3014729

3014730

3014731

3014732

3014734

3014736

3014738

3014739

39043_at

8134552

AF006084_at

A_23_P20196

GO:0003779

GO:0005198

GO:0005200

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005829

GO:0005856

GO:0005885

GO:0005925

GO:0007010

GO:0008092

GO:0015629

GO:0032355

GO:0034314

GO:0036284

GO:0043226

GO:0043627

GO:0044877

GO:0051015

GO:0070062

HMNXSV003056517

PH_hs_0020128

PH_hs_0035964

g5031600_3p_s_at

Participates

as a component of

ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)

Inferred To

ARPC1B [cytosol] (Bos taurus)

ARPC1B [cytosol] (Canis familiaris)

ARPC1B [cytosol] (Gallus gallus)

ARPC1B [cytosol] (Sus scrofa)

Arpc1 [cytosol] (Drosophila melanogaster)

Arpc1b [cytosol] (Mus musculus)

Arpc1b [cytosol] (Rattus norvegicus)

ARC40 [cytosol] (Saccharomyces cerevisiae)

arpc1b [cytosol] (Xenopus tropicalis)

arcA [cytosol] (Dictyostelium discoideum)

arx-3 [cytosol] (Caenorhabditis elegans)

arc1 [cytosol] (Schizosaccharomyces pombe)

arpc1a [cytosol] (Danio rerio)

Cross References

RefSeq

XP_006715889.1, NP_005711.1, XP_006715888.1

OpenTargets

ENSG00000130429

HPA

ENSG00000130429-ARPC1B

GeneCards

O15143

Ensembl

ENST00000645391, ENST00000414376, ENSP00000494033, ENSP00000496599, ENST00000458033, ENST00000427217, ENST00000455009, ENSP00000398110, ENST00000431816, ENST00000646101, ENSP00000388802, ENSG00000130429, ENSP00000403211, ENSP00000389631, ENSP00000410238, ENSP00000398620, ENST00000451682

PRO

O15143

Pharos - Targets

O15143

Orphanet

28501

PDB

6YW6, 6UHC

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42768 WAS	2	WAS [cytosol] (R-HSA-201879) p-Y291-WAS [cytosol] (R-HSA-2197668)	0.636	3
UniProt:O00401 WASL	4	N-WASP [cytosol] (R-HSA-201873) p-Y256-WASL [cytosol] (R-HSA-2197672) WASL [plasma membrane] (R-HSA-203010) WASL [endocytic vesicle membrane] (R-HSA-535012)	0.609	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	10

Cite Us!