Reactome | TMOD3 [cytosol]

TMOD3 [cytosol]

Stable Identifier

R-HSA-217354

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tmod3

Locations in the PathwayBrowser

Expand all

Muscle contraction (Homo sapiens)

- Striated Muscle Contraction (Homo sapiens)
  - ATP Hydrolysis By Myosin (Homo sapiens)
    - ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Tropomodulin [cytosol] (Homo sapiens)
        
        TMOD3 [cytosol] (Homo sapiens)
    - ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Tropomodulin [cytosol] (Homo sapiens)
        
        TMOD3 [cytosol] (Homo sapiens)
  - Calcium Binds Troponin-C (Homo sapiens)
    - Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Tropomodulin [cytosol] (Homo sapiens)
        
        TMOD3 [cytosol] (Homo sapiens)
    - Inactive Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament [cytosol] (Homo sapiens)
        
        Tropomodulin [cytosol] (Homo sapiens)
        
        TMOD3 [cytosol] (Homo sapiens)
  - Myosin Binds ATP (Homo sapiens)
    - ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Tropomodulin [cytosol] (Homo sapiens)
        
        TMOD3 [cytosol] (Homo sapiens)
    - Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Tropomodulin [cytosol] (Homo sapiens)
        
        TMOD3 [cytosol] (Homo sapiens)
  - Release Of ADP From Myosin (Homo sapiens)
    - ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Tropomodulin [cytosol] (Homo sapiens)
        
        TMOD3 [cytosol] (Homo sapiens)
    - Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Tropomodulin [cytosol] (Homo sapiens)
        
        TMOD3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NYL9 TMOD3

Gene Names

TMOD3

Chain

chain:1-352

Reference Genes

BioGPS Gene:29766 TMOD3

COSMIC (genes):TMOD3 TMOD3

CTD Gene:29766 TMOD3

dbSNP Gene:29766 TMOD3

ENSEMBL:ENSG00000138594 TMOD3

HGNC:11873 TMOD3

Monarch:29766 TMOD3

NCBI Gene:29766 TMOD3

OMIM:605112 TMOD3

UCSC:Q9NYL9 TMOD3

Reference Transcript

Other Identifiers

11743613_a_at

11761864_a_at

16801143

220800_PM_s_at

220800_s_at

223077_PM_at

223077_at

223078_PM_s_at

223078_s_at

242316_PM_at

242316_at

29766

3594067

3594074

3594075

3594076

3594077

3594081

3594084

3594085

3594086

3594087

3594089

3594090

3594094

3594095

3594096

3594097

3594098

3594099

3594100

3594101

3594102

3594103

3594104

3594105

3594106

3594107

3594108

3594109

3594110

3594111

3594112

3594114

3594115

3594116

3594117

3594120

43032_at

46199_at

47605_at

54391_at

59816_i_at

59817_r_at

7983744

80553_at

A_14_P126711

A_14_P139353

A_19_P00321606

A_23_P65674

A_24_P923113

GE56746

GE79026

GO:0003012

GO:0003779

GO:0005515

GO:0005523

GO:0005737

GO:0005856

GO:0005865

GO:0005912

GO:0006936

GO:0007010

GO:0007015

GO:0007155

GO:0008092

GO:0030016

GO:0030036

GO:0030239

GO:0043226

GO:0044772

GO:0048821

GO:0048856

GO:0051694

GO:0098609

GO:0098631

GO:0098641

GO:1901992

HMNXSV003000561

HMNXSV003030991

Hs.149419.0.A1_3p_at

Hs.22826.1.S2_3p_at

ILMN_1687865

ILMN_1809484

PH_hs_0001998

TC15000412.hg

TC15000415.hg

g6934243_3p_a_at

g7657648_3p_a_at

Participates

as a candidate of

Inferred To

Tmod3 [cytosol] (Mus musculus)

Tmod3 [cytosol] (Rattus norvegicus)

TMOD3 [cytosol] (Bos taurus)

TMOD3 [cytosol] (Canis familiaris)

TMOD3 [cytosol] (Gallus gallus)

TMOD3 [cytosol] (Sus scrofa)

tmod3 [cytosol] (Xenopus tropicalis)

tmod [cytosol] (Drosophila melanogaster)

tmod2 [cytosol] (Danio rerio)

Cross References

ENSEMBL

ENST00000308580, ENSP00000308753

OpenTargets

ENSG00000138594

HPA

ENSG00000138594-TMOD3

PRO

Q9NYL9

Pharos - Targets

Q9NYL9

GlyGen

Q9NYL9

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.706	21
UniProt:P60709 ACTB	5	ACTB [plasma membrane] (R-HSA-196016) ACTB [lysosomal membrane] (R-HSA-196160) ACTB [cytosol] (R-HSA-201861) ACTB [nucleoplasm] (R-HSA-3321990) Unfolded ACTB [cytosol] (R-HSA-390462)	0.643	4
UniProt:P13196 ALAS1	2	PXLP-ALAS1 [mitochondrial matrix] (R-HSA-1022086) ALAS1 [mitochondrial matrix] (R-HSA-189438)	0.527	2
UniProt:P62736 ACTA2	1	ACTA2 [cytosol] (R-HSA-445792)	0.527	3
UniProt:P0DTC2 S	20	S(686-815) [plasma membrane] (R-COV-9770188) Spike S2' Fragment [plasma membrane] (R-COV-9770189) S1 [plasma membrane] (R-COV-9769950) fully glycosylated Spike [plasma membrane] (R-COV-9733472) nascent Spike [endoplasmic reticulum lumen] (R-COV-9694796) 14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9694459) Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696892) high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696875) high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (R-COV-9696880) high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9766369) high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696943) di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696920) complex N-glycan-PALM-Spike S1 Fragment [virion membrane] (R-COV-9694638) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9694791) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9694343) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9694745) fully glycosylated Spike [virion membrane] (R-COV-9698327) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698330) complex N-glycan-PALM-Spike S2 Fragment [plasma membrane] (R-COV-9769952) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696997)	0.527	2

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