Reactome | KPNA5 [cytosol]

KPNA5 [cytosol]

Stable Identifier

R-HSA-1176062

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Importin subunit alpha-6, IMA6, IMA5_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O15131 KPNA5

Gene Names

KPNA5

Chain

chain:1-539

Reference Genes

BioGPS Gene:3841 KPNA5

COSMIC (genes):KPNA5 KPNA5

CTD Gene:3841 KPNA5

dbSNP Gene:3841 KPNA5

ENSEMBL:ENSG00000196911 KPNA5

ENSEMBL_homo_sapiens_GENE:ENSG00000196911.12 KPNA5

HGNC:6398 KPNA5

KEGG Gene (Homo sapiens):3841 KPNA5

Monarch:3841 KPNA5

NCBI Gene:3841 KPNA5

OMIM:604545 KPNA5

UCSC:O15131 KPNA5

Reference Transcript

Other Identifiers

11732203_at

17011992

206241_PM_at

206241_at

227934_PM_at

227934_at

229317_PM_at

229317_at

2922842

2922845

2922847

2922849

2922850

2922852

2922853

2922854

2922855

2922856

2922857

2922858

2922859

2922860

2922862

2922863

2922864

2922865

2922866

2922867

3841

48874_f_at

61342_at

65046_at

768_at

8121632

88308_at

AF005361_at

A_14_P121602

A_14_P129894

A_23_P156443

A_24_P476086

GE81137

GE88017

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006606

GO:0006607

GO:0006886

GO:0006913

GO:0008139

GO:0015031

GO:0042564

GO:0043226

GO:0061608

GO:0140104

HMNXSV003030515

HMNXSV003036504

HMNXSV003044936

Hs.24252.0.A1_3p_at

Hs.32615.0.A1_3p_at

Hs.32615.0.A1_3p_x_at

ILMN_1669700

PH_hs_0010792

TC06000925.hg

g4504902_3p_at

Participates

as a member of

Importin alpha [cytosol] (Homo sapiens)

Other forms of this molecule

KPNA5 [nucleoplasm]

Cross References

RefSeq

NP_002260.2, XP_016866329.1, XP_016866328.1

OpenTargets

ENSG00000196911

GeneCards

O15131

HPA

ENSG00000196911-KPNA5

Ensembl

ENST00000356348, ENSP00000357552, ENST00000368564, ENSP00000348704, ENSG00000196911

PRO

O15131

Pharos - Targets

O15131

PDB

4U2X

HMDB Protein

HMDBP08460

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P46527 CDKN1B	8	p-S10 CDKN1B [cytosol] (R-HSA-9632829) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-T157-CDKN1B [cytosol] (R-HSA-198629) CDKN1B [cytosol] (R-HSA-198622) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) CDKN1B [nucleoplasm] (R-HSA-182563) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808)	0.718	6
UniProt:P40692 MLH1	3	MLH1 S252* [nucleoplasm] (R-HSA-5444526) MLH1 H329P [nucleoplasm] (R-HSA-5444512) MLH1 [nucleoplasm] (R-HSA-912495)	0.556	3
UniProt:P07910 HNRNPC	3	HNRNPC [cytosol] (R-HSA-9715136) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [nucleoplasm] (R-HSA-71933)	0.556	3
UniProt:Q96C86 DCPS	1	DCPS [cytosol] (R-HSA-429988)	0.556	3
UniProt:P20700 LMNB1	8	LMNB1 [nucleoplasm] (R-HSA-264867) LMNB1(1-231) [nuclear envelope] (R-HSA-352244) LMNB1(232-586) [nuclear envelope] (R-HSA-352248) p-S395, S405-LMNB1 [nucleoplasm] (R-HSA-5228738) p-S23, S395, S405-LMNB1 [nucleoplasm] (R-HSA-5229018) LMNB1 [cytosol] (R-HSA-2995384) LMNB1(2-586) [nuclear envelope] (R-HSA-912402) p-S23,S393-LMNB1 [nucleoplasm] (R-HSA-8868341)	0.556	3
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:P43351 RAD52	3	monoSUMO1-K411,K412,K414-RAD52 [nucleoplasm] (R-HSA-4568909) RAD52 [nucleoplasm] (R-HSA-62639) p-Y104-RAD52 [nucleoplasm] (R-HSA-5686588)	0.556	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.547	4

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