Reactome | COPA [Golgi membrane]

COPA [Golgi membrane]

Stable Identifier

R-HSA-6808731

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

Coatomer alpha subunit

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        COPI vesicle uncoating (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [Golgi membrane] (Homo sapiens)
        
        coatomer [Golgi membrane] (Homo sapiens)
        
        trimeric coatomer complex [Golgi membrane] (Homo sapiens)
        
        COPA [Golgi membrane] (Homo sapiens)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [Golgi membrane] (Homo sapiens)
        
        coatomer [Golgi membrane] (Homo sapiens)
        
        trimeric coatomer complex [Golgi membrane] (Homo sapiens)
        
        COPA [Golgi membrane] (Homo sapiens)
        
        cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [Golgi membrane] (Homo sapiens)
        
        coatomer [Golgi membrane] (Homo sapiens)
        
        trimeric coatomer complex [Golgi membrane] (Homo sapiens)
        
        COPA [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [Golgi membrane] (Homo sapiens)
        
        coatomer [Golgi membrane] (Homo sapiens)
        
        trimeric coatomer complex [Golgi membrane] (Homo sapiens)
        
        COPA [Golgi membrane] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPI-mediated anterograde transport (Homo sapiens)
      - COPI vesicle uncoating (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [Golgi membrane] (Homo sapiens)
        
        coatomer [Golgi membrane] (Homo sapiens)
        
        trimeric coatomer complex [Golgi membrane] (Homo sapiens)
        
        COPA [Golgi membrane] (Homo sapiens)
      - Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [Golgi membrane] (Homo sapiens)
        
        coatomer [Golgi membrane] (Homo sapiens)
        
        trimeric coatomer complex [Golgi membrane] (Homo sapiens)
        
        COPA [Golgi membrane] (Homo sapiens)
      - cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [Golgi membrane] (Homo sapiens)
        
        coatomer [Golgi membrane] (Homo sapiens)
        
        trimeric coatomer complex [Golgi membrane] (Homo sapiens)
        
        COPA [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [Golgi membrane] (Homo sapiens)
        
        coatomer [Golgi membrane] (Homo sapiens)
        
        trimeric coatomer complex [Golgi membrane] (Homo sapiens)
        
        COPA [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P53621 COPA

Gene Names

COPA

Chain

chain:1-1224, peptide:1-35, peptide:1-25

Reference Genes

BioGPS Gene:1314 COPA

COSMIC (genes):COPA COPA

CTD Gene:1314 COPA

dbSNP Gene:1314 COPA

ENSEMBL:ENSG00000122218 COPA

HGNC:2230 COPA

KEGG:hsa:1314 COPA

Monarch:1314 COPA

NCBI Gene:1314 COPA

OMIM:601924 COPA

UCSC:P53621 COPA

Reference Transcript

Other Identifiers

11732125_s_at

11751927_x_at

1314

16695345

208684_PM_at

208684_at

214336_PM_s_at

214336_s_at

214337_PM_at

214337_at

2440137

2440138

2440139

2440140

2440142

2440144

2440145

2440146

2440147

2440148

2440149

2440150

2440151

2440152

2440153

2440154

2440155

2440156

2440157

2440158

2440159

2440160

2440161

2440162

2440163

2440164

2440165

2440166

2440167

2440169

2440170

2440171

2440172

2440173

2440174

2440175

2440179

2440180

2440181

2440183

2440184

2440185

2440186

2440187

2440188

2440189

2440190

2440191

2440192

2440193

2440194

2440195

2440196

2440197

2440198

2440199

2440200

2440206

2440207

2440210

2440215

2440216

2440217

2440218

2440219

2440220

2440221

2440222

2440223

2440224

2440225

2440226

2440227

2440228

2440229

2440231

2440232

2440233

36962_at

45020_r_at

7921583

A_23_P325932

A_24_P28367

A_32_P20454

GE58333

GE702928

GO:0000139

GO:0005179

GO:0005198

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005789

GO:0005794

GO:0005829

GO:0006886

GO:0006888

GO:0006890

GO:0006891

GO:0007165

GO:0015031

GO:0016020

GO:0016192

GO:0022600

GO:0030117

GO:0030126

GO:0030133

GO:0030157

GO:0030426

GO:0030663

GO:0031410

GO:0043226

GO:0048018

GO:0070062

GO:0098772

HMNXSV003001860

Hs.75887.1.A1_3p_a_at

ILMN_1811615

PH_hs_0026462

PH_hs_0031935

TC01003400.hg

U24105_at

g1638873_3p_x_at

Participates

as a component of

trimeric coatomer complex [Golgi membrane] (Homo sapiens)

Other forms of this molecule

COPA [endoplasmic reticulum membrane]

COPA [transport vesicle]

COPA [cytosol]

Inferred To

COPA [Golgi membrane] (Bos taurus)

COPA [Golgi membrane] (Canis familiaris)

COPA [Golgi membrane] (Gallus gallus)

COPA [Golgi membrane] (Schizosaccharomyces pombe)

COPA [Golgi membrane] (Sus scrofa)

alphaCOP [Golgi membrane] (Drosophila melanogaster)

copa [Golgi membrane] (Dictyostelium discoideum)

copa [Golgi membrane] (Xenopus tropicalis)

Copa [Golgi membrane] (Mus musculus)

Copa [Golgi membrane] (Rattus norvegicus)

copa-1 [Golgi membrane] (Caenorhabditis elegans)

Cross References

ENSEMBL

ENST00000241704, ENSP00000357048, ENST00000368069, ENSP00000241704

OpenTargets

ENSG00000122218

HPA

ENSG00000122218-COPA

PRO

P53621

Pharos - Targets

P53621

GlyGen

P53621

Orphanet

COPA

HMDB Protein

HMDBP08329

PDB

6U3V, 6TZT, 6PBG

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	16
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	4
UniProt:Q9NTJ5 SACM1L	2	SACM1L [endoplasmic reticulum membrane] (R-HSA-1604637) SACM1L [Golgi membrane] (R-HSA-1806242)	0.527	2
UniProt:Q8WUJ3 CEMIP	1	CEMIP [extracellular region] (R-HSA-5693352)	0.499	2

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