Reactome | CANX [endoplasmic reticulum lumen]

CANX [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-195906

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

calnexin

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P27824 CANX

Gene Names

CANX

Chain

signal peptide:1-20, chain:21-592

Reference Genes

BioGPS Gene:821 CANX

COSMIC (genes):CANX CANX

CTD Gene:821 CANX

dbSNP Gene:821 CANX

ENSEMBL:ENSG00000127022 CANX

ENSEMBL_homo_sapiens_GENE:ENSG00000127022.16 CANX

ENSEMBL_homo_sapiens_GENE:ENSG00000283777.2 CANX

HGNC:1473 CANX

KEGG Gene (Homo sapiens):821 CANX

Monarch:821 CANX

NCBI Gene:821 CANX

OMIM:114217 CANX

UCSC:P27824 CANX

Reference Transcript

Other Identifiers

11727421_a_at

11727422_s_at

11727423_a_at

11727424_s_at

11727425_s_at

11727426_a_at

11741127_s_at

11745457_a_at

16656823

16656825

16656827

16656829

16656831

16656833

16993397

18670177

18670178

18670179

18670180

18670181

18670182

18670183

18670184

18670185

18670186

18670187

18670189

18670190

18670192

18670193

18670194

18670195

18670196

18670197

18670199

18670200

18670201

18670202

200068_PM_s_at

200068_s_at

208852_PM_s_at

208852_s_at

208853_PM_s_at

208853_s_at

238034_PM_at

238034_at

238138_PM_at

238138_at

2844192

2844193

2844204

2844205

2844206

2844207

2844209

2844212

2844213

2844214

2844215

2844217

2844219

2844222

2844226

2844227

2844228

2844229

2844230

2844231

2844233

2844235

2844238

2844241

2844242

2844243

2844244

2844245

2844246

2844247

2844248

2844249

2844250

2844251

2844253

2844255

2844263

2844411

2844412

2844413

2844414

2844415

2844416

2844417

40125_at

53131_at

57826_at

7892514

7892972

7893103

7893270

7893272

7893345

7893632

7893641

7893642

7893880

7894074

7894674

7894687

7894725

7894878

7895017

7895188

7895276

7895283

7895334

7895475

7895547

7895693

7896020

7896050

7896136

7896308

7896387

7896430

7896644

8110522

821

83775_at

A_23_P147185

A_24_P345993

A_33_P3325131

GE57598

GE85806

GO:0003723

GO:0005509

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005635

GO:0005739

GO:0005783

GO:0005788

GO:0005789

GO:0006457

GO:0009306

GO:0016020

GO:0016192

GO:0019082

GO:0030163

GO:0030246

GO:0030433

GO:0031410

GO:0031965

GO:0031966

GO:0033162

GO:0034975

GO:0043226

GO:0044233

GO:0044322

GO:0046872

GO:0048488

GO:0051082

GO:0070062

GO:0072583

GO:0098553

GO:0098793

HMNXSV003013314

Hs.155560.0.S2_3p_a_at

Hs.157515.0.A1_3p_at

Hs.43679.0.A1_3p_at

ILMN_1762825

ILMN_2401057

L10284_at

PH_hs_0009368

TC05001050.hg

g179831_3p_a_at

g306480_3p_a_at

Participates

as an input of

as an output of

as a component of

as a member of

CALR,CANX [endoplasmic reticulum lumen] (Homo sapiens)

This entity regulates

Positively

Glycosylation and Folding of HA (Homo sapiens)

Other forms of this molecule

CANX [lumenal side of endoplasmic reticulum membrane]

Inferred To

CANX [endoplasmic reticulum lumen] (Bos taurus)

CANX [endoplasmic reticulum lumen] (Caenorhabditis elegans)

CANX [endoplasmic reticulum lumen] (Canis familiaris)

CANX [endoplasmic reticulum lumen] (Gallus gallus)

CANX [endoplasmic reticulum lumen] (Mus musculus)

CANX [endoplasmic reticulum lumen] (Rattus norvegicus)

CANX [endoplasmic reticulum lumen] (Saccharomyces cerevisiae)

CANX [endoplasmic reticulum lumen] (Schizosaccharomyces pombe)

CANX [endoplasmic reticulum lumen] (Sus scrofa)

Cnx99A [endoplasmic reticulum lumen] (Drosophila melanogaster)

canx [endoplasmic reticulum lumen] (Danio rerio)

canx [endoplasmic reticulum lumen] (Xenopus tropicalis)

cnxA [endoplasmic reticulum lumen] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001019820.1, XP_011532967.1, NP_001737.1

OpenTargets

ENSG00000127022

HPA

ENSG00000127022-CANX

GeneCards

P27824

Ensembl

ENST00000681476, ENST00000680042, ENSP00000424745, ENSP00000505526, ENSP00000505129, ENSP00000421434, ENST00000638425, ENSP00000424063, ENST00000680618, ENST00000452673, ENSP00000505013, ENSP00000506003, ENSP00000505202, ENSG00000283777, ENST00000681712, ENST00000680006, ENST00000681733, ENST00000681072, ENSP00000491760, ENST00000681674, ENST00000506654, ENST00000680092, ENST00000680013, ENST00000681168, ENSG00000127022, ENST00000639938, ENSP00000426555, ENST00000638706, ENSP00000492372, ENSP00000506568, ENST00000504734, ENSP00000506583, ENSP00000506021, ENST00000502296, ENSP00000506061, ENSP00000506509, ENST00000513246, ENST00000247461, ENSP00000506078, ENSP00000505960, ENSP00000492868, ENST00000680827, ENSP00000391646, ENSP00000247461, ENST00000509563, ENST00000681903, ENSP00000506051, ENSP00000421813

PRO

P27824

Pharos - Targets

P27824

HMDB Protein

HMDBP07535

Interactors (165)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.888	27
UniProt:P43307 SSR1	1	SSR1 [endoplasmic reticulum membrane] (R-HSA-444588)	0.773	7
UniProt:Q9H5K3 POMK	1	POMK [endoplasmic reticulum membrane] (R-HSA-8879120)	0.725	5
UniProt:P61619 SEC61A1	2	SEC61A1 [endoplasmic reticulum membrane] (R-HSA-444591) SEC61A1 [phagocytic vesicle membrane] (R-HSA-1236813)	0.69	5
UniProt:Q8N766 EMC1			0.671	5
UniProt:P04844 RPN2	1	RPN2 [endoplasmic reticulum membrane] (R-HSA-264937)	0.671	5
UniProt:Q7LFX5 CHST15	1	CHST15 [Golgi membrane] (R-HSA-1971543)	0.669	3
UniProt:Q8TCJ2 STT3B			0.644	5
UniProt:Q9BTY2 FUCA2	4	FUCA2 [extracellular region] (R-HSA-6806227) FUCA2 [azurophil granule lumen] (R-HSA-6798772) p-FUCA2 [endoplasmic reticulum lumen] (R-HSA-8957005) FUCA2 [endoplasmic reticulum lumen] (R-HSA-8956727)	0.643	3
UniProt:Q9H741 SPRNG			0.643	3
UniProt:Q8NBL1 POGLUT1	1	POGLUT1 [endoplasmic reticulum lumen] (R-HSA-1464796)	0.643	5
UniProt:O94905 ERLIN2	3	ERLIN2 [endoplasmic reticulum membrane] (R-HSA-8866520) EML4(1-186)insVSLKRRIELTVEYPWRCGALSPTSNCRTG-p-8Y-FGFR1(1-822) [plasma membrane] (R-HSA-8853122) EML4(1-186)insVSLKRRIELTVEYPWRCGALSPTSNCRTG-FGFR1(1-822) [plasma membrane] (R-HSA-8853148)	0.643	3
UniProt:Q9UIQ6 LNPEP	3	LNPEP [cytoplasmic vesicle membrane] (R-HSA-1445121) LNPEP [early endosome lumen] (R-HSA-1236834) LNPEP [cytosol] (R-HSA-983098)	0.643	3
UniProt:Q14703 MBTPS1	4	MBTPS1 [Golgi membrane] (R-HSA-381108) MBTPS1 [endoplasmic reticulum membrane] (R-HSA-6797334) p-MBTPS1 [endoplasmic reticulum lumen] (R-HSA-8956924) MBTPS1 [endoplasmic reticulum lumen] (R-HSA-8956733)	0.643	3
UniProt:P54709 ATP1B3	1	ATP1B3 [plasma membrane] (R-HSA-375073)	0.643	3
UniProt:P16615 ATP2A2	2	ATP2A2 [platelet dense tubular network membrane] (R-HSA-427903) ATP2A2 [endoplasmic reticulum membrane] (R-HSA-391962)	0.643	3
UniProt:Q8NCH0 CHST14	9	CHST14 K69* [Golgi membrane] (R-HSA-3636891) CHST14 R135G [Golgi membrane] (R-HSA-3636924) CHST14 C289S [Golgi membrane] (R-HSA-3636925) CHST14 V49* [Golgi membrane] (R-HSA-3636926) CHST14 R213P [Golgi membrane] (R-HSA-3636894) CHST14 Y293C [Golgi membrane] (R-HSA-3636927) CHST14 P281L [Golgi membrane] (R-HSA-3636880) CHST14 L137Q [Golgi membrane] (R-HSA-5649488) CHST14 [Golgi membrane] (R-HSA-1971536)	0.643	3
UniProt:P04578 env	7	Surface protein gp120 (P04578) [cytosol] (R-HIV-189269) Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) ENV [viral envelope] (R-HIV-173439) Surface protein gp120 [viral envelope] (R-HIV-171211)	0.623	3
UniProt:Q9H3N1 TMX1			0.615	6
UniProt:P35610 SOAT1	1	SOAT1 [endoplasmic reticulum membrane] (R-HSA-8876490)	0.615	4
UniProt:O00115 DNASE2	2	DNASE2 [Golgi lumen] (R-HSA-434322) DNASE2 [lysosomal lumen] (R-HSA-429822)	0.589	2
UniProt:O95477 ABCA1	11	ABCA1 W590S [plasma membrane] (R-HSA-5682201) ABCA1 N935S [plasma membrane] (R-HSA-5682200) ABCA1 C1417R [plasma membrane] (R-HSA-5682190) ABCA1 S1446L [plasma membrane] (R-HSA-5682195) ABCA1 R587W [plasma membrane] (R-HSA-5682197) ABCA1 [plasma membrane] (R-HSA-194209) 4xPALM-C-p-2S-ABCA1 [plasma membrane] (R-HSA-5682069) 4xPALM-C-ABCA1 [endoplasmic reticulum membrane] (R-HSA-5682085) 4xPALM-C-ABCA1 [plasma membrane] (R-HSA-5682091) ABCA1 [endoplasmic reticulum membrane] (R-HSA-5682105) ABCA1 Q537R [plasma membrane] (R-HSA-5682199)	0.576	8
UniProt:Q9NZ01 TECR	1	TECR [endoplasmic reticulum membrane] (R-HSA-548663)	0.569	3
UniProt:P08069 IGF1R	3	IGF1R(741-1367) [plasma membrane] (R-HSA-2404180) IGF1R(31-736) [plasma membrane] (R-HSA-2404169) p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane] (R-HSA-2404172)	0.569	3
UniProt:P35606 COPB2	4	COPB2 [endoplasmic reticulum membrane] (R-HSA-6810957) COPB2 [Golgi membrane] (R-HSA-6808739) COPB2 [transport vesicle] (R-HSA-6808741) COPB2 [cytosol] (R-HSA-199972)	0.569	4
UniProt:P46977 STT3A	1	STT3A [endoplasmic reticulum membrane] (R-HSA-265023)	0.569	3
UniProt:P39656 DDOST	3	DDOST [azurophil granule membrane] (R-HSA-6799145) DDOST [plasma membrane] (R-HSA-879386) DDOST [endoplasmic reticulum membrane] (R-HSA-264963)	0.569	5
UniProt:Q96AG4 LRC59			0.569	4
UniProt:O14967 CLGN			0.569	3
UniProt:O00264 PGRMC1	2	PGRMC1 [plasma membrane] (R-HSA-6806314) PGRMC1 [specific granule membrane] (R-HSA-6799648)	0.569	4
UniProt:Q9H2J7 SLC6A15	1	SLC6A15 [plasma membrane] (R-HSA-352060)	0.569	3
UniProt:Q14739 LBR	4	LBR [nuclear envelope] (R-HSA-194637) p-S71,S86-LBR [nuclear envelope] (R-HSA-9624811) LBR [endoplasmic reticulum membrane] (R-HSA-9714334) LBR [endosome membrane] (R-HSA-9715094)	0.569	4
UniProt:Q9Y4L1 HYOU1	3	HYOU1 [extracellular region] (R-HSA-3221939) HYOU1 [endocytic vesicle lumen] (R-HSA-3221924) HYOU1 [endoplasmic reticulum lumen] (R-HSA-535542)	0.569	4
UniProt:P04843 RPN1	1	RPN1 [endoplasmic reticulum membrane] (R-HSA-264994)	0.569	4
UniProt:Q8NFQ8 TOIP2			0.569	3
UniProt:Q96GF1 RNF185	1	RNF185 [endoplasmic reticulum membrane] (R-HSA-8861819)	0.569	3
UniProt:Q07065 CKAP4	7	CKAP4 [endoplasmic reticulum lumen] (R-HSA-8956737) p-CKAP4 [endoplasmic reticulum lumen] (R-HSA-8956926) CKAP4 [azurophil granule membrane] (R-HSA-6799559) CKAP4 [plasma membrane] (R-HSA-5686306) CKAP4 [specific granule membrane] (R-HSA-6799552) PALM-C100-CKAP4 [plasma membrane] (R-HSA-5686280) PALM-C100-CKAP4 [lamellar body] (R-HSA-5686285)	0.569	3
UniProt:Q9P0L0 VAPA	4	VAPA [endoplasmic reticulum membrane] (R-HSA-429677) VAPA [azurophil granule membrane] (R-HSA-6799364) VAPA [plasma membrane] (R-HSA-6806269) VAPA [cytosol] (R-HSA-9609920)	0.569	5
UniProt:O75787 ATP6AP2	3	ATP6AP2 [plasma membrane] (R-HSA-2022356) ATP6AP2 [tertiary granule membrane] (R-HSA-6799717) ATP6AP2 [ficolin-1-rich granule membrane] (R-HSA-6800921)	0.569	4
UniProt:P05556 ITGB1	2	ITGB1 [endosome membrane] (R-HSA-9611157) ITGB1 [plasma membrane] (R-HSA-57596)	0.569	3
UniProt:P55011 SLC12A2	1	SLC12A2 [plasma membrane] (R-HSA-426146)	0.569	4
UniProt:Q9UBF2 COPG2	4	COPG2 [endoplasmic reticulum membrane] (R-HSA-6810962) COPG2 [Golgi membrane] (R-HSA-6808751) COPG2 [transport vesicle] (R-HSA-6808753) COPG2 [cytosol] (R-HSA-6807747)	0.569	3
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.569	3
UniProt:P35613 BSG	2	BSG [Golgi membrane] (R-HSA-204478) BSG [plasma membrane] (R-HSA-197673)	0.569	4
UniProt:Q15904 ATP6AP1	2	ATP6AP1 [endoplasmic reticulum membrane] (R-HSA-9714332) ATP6AP1 [endosome membrane] (R-HSA-5215981)	0.569	4
UniProt:Q9NZC7 WWOX	1	WWOX [cytosol] (R-HSA-1253335)	0.569	3
UniProt:O15173 PGRMC2	4	PGRMC2 [nuclear envelope] (R-HSA-9707674) PGRMC2 [nucleoplasm] (R-HSA-9707859) PGRMC2 [endoplasmic reticulum membrane] (R-HSA-9714349) PGRMC2 [endosome membrane] (R-HSA-9715090)	0.569	4
UniProt:Q9Y5M8 SRPRB	1	SRPRB [endoplasmic reticulum membrane] (R-HSA-265002)	0.569	4
UniProt:Q921T2	1	Tor1aip1 [cytosol] (R-MMU-9715083)	0.564	2
UniProt:P00387 CYB5R3	3	MyrG-CYB5R3(2-301) [mitochondrial outer membrane] (R-HSA-198771) CYB5R3(27-301) [extracellular region] (R-HSA-6806205) CYB5R3(27-301) [azurophil granule lumen] (R-HSA-6799217)	0.564	2
UniProt:Q8NBM8 PCYOX1L	2	PCYOX1L [extracellular region] (R-HSA-8862953) PCYOX1L [platelet alpha granule lumen] (R-HSA-8862980)	0.527	2
UniProt:Q9Y2A9 B3GNT3	1	B3GNT3 [Golgi membrane] (R-HSA-916819)	0.527	3
UniProt:P36897 TGFBR1	13	Ub-TGFBR1 [plasma membrane] (R-HSA-8869461) p-4S,T185,T186-TGFBR1 W242* [plasma membrane] (R-HSA-3656504) p-4S,T185,T186-TGFBR1 P327Qfs8 [plasma membrane] (R-HSA-3656505) p-4S,T185,T186-TGFBR1 L354Nfs4 [plasma membrane] (R-HSA-3656506) p-4S,T185,T186-TGFBR1 R414* [plasma membrane] (R-HSA-3656508) p-4S,T185,T186-TGFBR1 D269_Q324del [plasma membrane] (R-HSA-3656509) TGFBR1 G52R [plasma membrane] (R-HSA-3656368) TGFBR1 C41Y [plasma membrane] (R-HSA-3656328) TGFBR1 N45S [plasma membrane] (R-HSA-3656348) TGFBR1 P83L [plasma membrane] (R-HSA-3656341) TGFBR1 P83S [plasma membrane] (R-HSA-3656326) TGFBR1 [plasma membrane] (R-HSA-170839) p-4S,T185,T186-TGFBR1 [plasma membrane] (R-HSA-170849)	0.527	2
UniProt:Q15165 PON2	1	PON2 [extracellular region] (R-HSA-8932636)	0.527	2
UniProt:O60512 B4GALT3	1	B4GALT3 [Golgi membrane] (R-HSA-975922)	0.527	2
UniProt:P42892 ECE1	1	ECE1 [plasma membrane] (R-HSA-8876866)	0.527	2
UniProt:P06280 GLA	3	GLA [extracellular region] (R-HSA-6806179) GLA [azurophil granule lumen] (R-HSA-6798777) GLA [lysosomal lumen] (R-HSA-1605763)	0.527	2
UniProt:Q8WTV0 SCARB1			0.527	2
UniProt:Q6UWY0 ARSK	2	OxA-ARSK [endoplasmic reticulum lumen] (R-HSA-1614364) ARSK [endoplasmic reticulum lumen] (R-HSA-1609684)	0.527	3
UniProt:Q9UNL2 SSR3	1	SSR3 [endoplasmic reticulum membrane] (R-HSA-264973)	0.527	2
UniProt:Q9H1A3 METL9			0.527	2
UniProt:P45880 VDAC2	6	p-S65-Ub:VDAC2 [mitochondrial outer membrane] (R-HSA-9834982) K63polyUb-VDAC2 [mitochondrial outer membrane] (R-HSA-9843314) K48polyUb-VDAC2 [mitochondrial outer membrane] (R-HSA-9843321) Ub-VDAC2 [mitochondrial outer membrane] (R-HSA-9835025) VDAC2 [mitochondrial outer membrane] (R-HSA-5696880) PolyUb-VDAC2 [mitochondrial outer membrane] (R-HSA-6783185)	0.527	2
UniProt:Q14982 OPCML	2	cleaved GPI-OPCML [extracellular region] (R-HSA-8941075) GPI-OPCML [plasma membrane] (R-HSA-8940828)	0.527	2
UniProt:Q9Y320 TMX2			0.527	3
UniProt:P08195 SLC3A2	1	SLC3A2 [plasma membrane] (R-HSA-352179)	0.527	2
UniProt:P40126 DCT	1	DCT [melanosome membrane] (R-HSA-5662685)	0.527	3
UniProt:Q8IWF2 FXRD2			0.527	3
UniProt:Q9NV96 TMEM30A	3	TMEM30A [specific granule membrane] (R-HSA-6799526) TMEM30A [plasma membrane] (R-HSA-6806278) TMEM30A [azurophil granule membrane] (R-HSA-6799504)	0.527	2
UniProt:Q96EG1 ARSG	2	OxA-ARSG [endoplasmic reticulum lumen] (R-HSA-1614304) ARSG [endoplasmic reticulum lumen] (R-HSA-1614361)	0.527	2
UniProt:Q9Y2B1 RXLT1			0.527	2
UniProt:P54802 NAGLU	5	NAGLU R674C [lysosomal lumen] (R-HSA-2219558) NAGLU R674H [lysosomal lumen] (R-HSA-2219557) NAGLU R626* [lysosomal lumen] (R-HSA-2219568) NAGLU R297* [lysosomal lumen] (R-HSA-2219553) NAGLU(59-743) [lysosomal lumen] (R-HSA-1678772)	0.527	2
UniProt:P56704 WNT3A	10	N4GlycoAsn-PalmS WNT3A [plasma membrane] (R-HSA-3247807) N4GlycoAsn-PalmS WNT3A [extracellular region] (R-HSA-3247784) N4GlycoAsn-PalmS WNT3A [Golgi lumen] (R-HSA-3247832) N4GlycoAsn-PalmS WNT3A [endoplasmic reticulum lumen] (R-HSA-3238344) N4GlycoAsn-WNT3A [endoplasmic reticulum lumen] (R-HSA-3238231) WNT3A [endoplasmic reticulum lumen] (R-HSA-3238292) N4GlycoAsn-PalmS WNT3A [early endosome membrane] (R-HSA-5368483) N4GlycoAsn-PalmS WNT3A [endocytic vesicle membrane] (R-HSA-3781944) N4GlycoAsn-PalmS WNT3A [extracellular exosome] (R-HSA-3781968) WNT3A [extracellular region] (R-HSA-201710)	0.527	3
UniProt:Q9Y5X9 LIPG	1	LIPG [extracellular region] (R-HSA-6789318)	0.527	2
UniProt:Q86YC3 LRC33			0.527	2
UniProt:Q6PK18 OGFD3			0.527	3
UniProt:Q8NE01 CNNM3			0.527	2
UniProt:Q8TCT7 SPPL2B	1	SPPL2B [plasma membrane] (R-HSA-8863116)	0.527	2
UniProt:Q16880 UGT8	1	UGT8 [endoplasmic reticulum membrane] (R-HSA-9844570)	0.527	2
UniProt:Q96MM7 HS6ST2	1	HS6ST2 [Golgi membrane] (R-HSA-2076353)	0.527	2
UniProt:Q6UWB1 IL27RA	4	IL27RA [plasma membrane] (R-HSA-448478) p-Y611-IL27RA [plasma membrane] (R-HSA-8950330) sIL27RA [extracellular region] (R-HSA-8950454) sIL27RA [cytoplasm] (R-HSA-8950653)	0.527	2
UniProt:P49286 MTNR1B	1	MTNR1B [plasma membrane] (R-HSA-419349)	0.527	2
UniProt:Q9UKU6 TRHDE			0.527	2
UniProt:Q8N5K1 CISD2			0.527	2
UniProt:P18507 GABRG2	1	GABRG2 [plasma membrane] (R-HSA-975350)	0.527	2
UniProt:Q17R55 F187B			0.527	2
UniProt:P04062 GBA1	2	Unfolded GBA [cytosol] (R-HSA-6813790) GBA1 [lysosomal membrane] (R-HSA-1605775)	0.527	2
UniProt:Q99999 GAL3ST1	1	GAL3ST1 [Golgi membrane] (R-HSA-1631586)	0.527	3
UniProt:P10909 CLU	4	CLU(23-449) [extracellular region] (R-HSA-349732) CLU(23-449) [platelet alpha granule lumen] (R-HSA-349733) CLU(228-449) [extracellular region] (R-HSA-6810626) CLU(23-227) [extracellular region] (R-HSA-6810660)	0.527	2
UniProt:Q86T26 TM11B			0.527	2
UniProt:Q9UKJ8 ADAM21	1	ADAM21 [plasma membrane] (R-HSA-1297340)	0.527	3
UniProt:P48039 MTNR1A	1	MTNR1A [plasma membrane] (R-HSA-419316)	0.527	2
UniProt:O14656 TOR1A	1	TOR1A [cytosol] (R-HSA-8862858)	0.527	3
UniProt:Q9C0B6 BRNP2			0.527	3
UniProt:Q16842 ST3GAL2	1	ST3GAL2 [Golgi membrane] (R-HSA-981482)	0.527	2
UniProt:P11021 HSPA5	6	HSPA5 [extracellular region] (R-HSA-351322) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498)	0.527	2
UniProt:P51172 SCNN1D	1	SCNN1D [plasma membrane] (R-HSA-2671902)	0.527	2
UniProt:Q96JJ7 TMX3	2	TMX3 [plasma membrane] (R-HSA-8848896) TMX3 [platelet alpha granule membrane] (R-HSA-8848889)	0.527	3
UniProt:Q92820 GGH	4	GGH [specific granule lumen] (R-HSA-6799639) GGH [tertiary granule lumen] (R-HSA-6800911) GGH [extracellular region] (R-HSA-6799679) GGH [azurophil granule lumen] (R-HSA-6800950)	0.527	2
UniProt:Q92542 NCSTN	3	NCSTN [endosome membrane] (R-HSA-9010085) NCSTN [azurophil granule membrane] (R-HSA-6799220) NCSTN [plasma membrane] (R-HSA-2534241)	0.527	2
UniProt:Q03518 TAP1	3	TAP1 [phagocytic vesicle membrane] (R-HSA-1236845) TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863953) TAP1 [endoplasmic reticulum membrane] (R-HSA-947474)	0.527	2
UniProt:Q86WK7 AMGO3			0.527	2
UniProt:Q7L1S5 CHST9			0.527	2
UniProt:O75477 ERLIN1	1	ERLIN1 [endoplasmic reticulum membrane] (R-HSA-8866518)	0.527	2
UniProt:Q9GZX3 CHST6	9	CHST6 R211W [Golgi membrane] (R-HSA-3656457) CHST6 L276P [Golgi membrane] (R-HSA-3656477) CHST6 K174R [Golgi membrane] (R-HSA-3656480) CHST6 [Golgi membrane] (R-HSA-1971537) CHST6 C102G [Golgi membrane] (R-HSA-3656470) CHST6 L200R [Golgi membrane] (R-HSA-3656454) CHST6 D203E [Golgi membrane] (R-HSA-3656437) CHST6 E274K [Golgi membrane] (R-HSA-3656420) CHST6 Y110C [Golgi membrane] (R-HSA-3656419)	0.527	2
UniProt:O75354 ENTPD6	1	ENTPD6 (77-484) [extracellular region] (R-HSA-8851464)	0.527	2
UniProt:P15812 CD1E			0.527	2
UniProt:Q9HB40 RISC			0.527	2
UniProt:P29016 CD1B	1	CD1B [plasma membrane] (R-HSA-197793)	0.527	3
UniProt:Q7KZN9 COX15	1	COX15 [mitochondrial inner membrane] (R-HSA-2995350)	0.527	2
UniProt:Q4G148 GXLT1			0.527	3
UniProt:Q8IZF4 AGRG5			0.527	2
UniProt:Q13724 MOGS	3	MOGS F652L [endoplasmic reticulum membrane] (R-HSA-4839779) MOGS R486T [endoplasmic reticulum membrane] (R-HSA-4839818) MOGS [endoplasmic reticulum membrane] (R-HSA-532676)	0.527	2
UniProt:Q13443 ADAM9	1	ADAM9 [plasma membrane] (R-HSA-708336)	0.527	2
UniProt:Q9H4B8 DPEP3			0.527	2
UniProt:Q08380 LGALS3BP	2	LGALS3BP [extracellular region] (R-HSA-8848882) LGALS3BP [platelet dense granule lumen] (R-HSA-8848916)	0.527	2
UniProt:Q8WXQ8 CBPA5			0.527	2
UniProt:P01019 AGT	7	AGT(36-41) [extracellular region] (R-HSA-2022355) AGT(35-41) [extracellular region] (R-HSA-2022354) AGT(34-40) [extracellular region] (R-HSA-2022351) AGT(34-42) [extracellular region] (R-HSA-2022348) AGT [extracellular region] (R-HSA-1998759) AGT(34-43) [extracellular region] (R-HSA-2022346) AGT(34-41) [extracellular region] (R-HSA-374187)	0.527	2
UniProt:Q13444 ADAM15	1	ADAM15 [plasma membrane] (R-HSA-708329)	0.527	2
UniProt:Q9H0U3 MAGT1	2	MAGT1 [azurophil granule membrane] (R-HSA-6799208) MAGT1 [plasma membrane] (R-HSA-4836523)	0.527	2
UniProt:P30101 PDIA3	3	PDIA3 [phagocytic vesicle] (R-HSA-1236870) PDIA3 [recycling endosome membrane] (R-HSA-8863849) PDIA3 [endoplasmic reticulum lumen] (R-HSA-901028)	0.527	2
UniProt:Q9H2A9 CHST8	1	CHST8 [Golgi membrane] (R-HSA-6786024)	0.527	3
UniProt:Q6PIU2 NCEH1	1	NCEH1 [endoplasmic reticulum membrane] (R-HSA-6813685)	0.527	2
UniProt:Q16288 NTRK3	6	NTRK3(32-495) [plasma membrane] (R-HSA-9603541) NTRK3(642-839) [cytosol] (R-HSA-9603540) NTRK3(496-641) [mitochondrial outer membrane] (R-HSA-9603557) NTRK3(496-641) [cytosol] (R-HSA-9603542) NTRK3 [plasma membrane] (R-HSA-6798240) p-5Y-NTRK3 [plasma membrane] (R-HSA-9034718)	0.527	2
UniProt:P21796 VDAC1	7	PolyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-6783079) VDAC1 [mitochondrial intermembrane space] (R-HSA-1267960) VDAC1 [mitochondrial outer membrane] (R-HSA-1267988) Ub-VDAC1 [mitochondrial outer membrane] (R-HSA-9834989) K48polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-5205624) K63polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-9834037) p-S65-Ub:VDAC1 [mitochondrial outer membrane] (R-HSA-9834991)	0.527	3
UniProt:Q9NPC4 A4GALT	1	A4GALT [Golgi membrane] (R-HSA-9846476)	0.527	3
UniProt:Q9Y2C2 UST	1	UST [Golgi membrane] (R-HSA-2022058)	0.527	3
UniProt:Q9UHC6-1 CNTNAP2			0.499	2
UniProt:P41143 OPRD1	1	OPRD1 [plasma membrane] (R-HSA-374265)	0.499	2
UniProt:P11607	2	ATP2A2 [platelet dense tubular network membrane] (R-SSC-427903) ATP2A2 [endoplasmic reticulum membrane] (R-SSC-391962)	0.499	2
UniProt:P0C739 BNL2A			0.491	2
UniProt:O75976 CPD	3	CPD [Golgi membrane] (R-HSA-432675) CPD [cytoplasmic vesicle membrane] (R-HSA-432671) CPD [plasma membrane] (R-HSA-9715182)	0.483	2
UniProt:Q86Y07 VRK2	2	VRK2 [mitochondrial outer membrane] (R-HSA-9715102) VRK2 [endoplasmic reticulum membrane] (R-HSA-9714457)	0.483	3
UniProt:P51648 ALDH3A2	1	ALDH3A2 [cytosol] (R-HSA-9715204)	0.483	3
UniProt:Q9HCU5 PREB	1	PREB [endoplasmic reticulum membrane] (R-HSA-203984)	0.483	3
UniProt:O14579 COPE	4	COPE [endoplasmic reticulum membrane] (R-HSA-6810959) COPE [Golgi membrane] (R-HSA-6808743) COPE [transport vesicle] (R-HSA-6808745) COPE [cytosol] (R-HSA-199969)	0.483	3
UniProt:P52298 NCBP2	2	NCBP2 [nucleoplasm] (R-HSA-51463) NCBP2 [cytosol] (R-HSA-162458)	0.483	2
UniProt:O95292 VAPB	2	VAPB [endoplasmic reticulum membrane] (R-HSA-429718) VAPB [Golgi membrane] (R-HSA-9715115)	0.483	3
UniProt:O95573 ACSL3	2	ACSL3 [mitochondrial outer membrane] (R-HSA-9632656) ACSL3 [endoplasmic reticulum membrane] (R-HSA-548787)	0.483	3
UniProt:Q9P0I2 EMC3	1	EMC3 [endoplasmic reticulum membrane] (R-HSA-9714347)	0.483	3
UniProt:Q9H8Y8 GORASP2	2	GORASP2 [Golgi membrane] (R-HSA-2422385) p-T222,T225-GORASP2 [Golgi membrane] (R-HSA-2422965)	0.483	2
UniProt:O43865 AHCYL1	1	AHCYL1 [endoplasmic reticulum membrane] (R-HSA-5215973)	0.483	2
UniProt:Q6ZNB6 NFXL1			0.483	2
UniProt:P30530 AXL	2	p-Y779,Y821-AXL [plasma membrane] (R-HSA-5357460) AXL [plasma membrane] (R-HSA-197705)	0.483	2
UniProt:Q9BTX1 NDC1	1	NDC1 [nuclear envelope] (R-HSA-6805183)	0.483	3
UniProt:O43402 EMC8			0.483	2
UniProt:Q96A57 TM230			0.483	2
UniProt:Q9Y679 AUP1			0.483	2
UniProt:Q6NUS6 TCTN3	1	TCTN3 [ciliary membrane] (R-HSA-5626662)	0.483	3
UniProt:Q8N4V1 MMGT1	1	MMGT1 [Golgi membrane] (R-HSA-5216137)	0.483	3
UniProt:Q9NPA0 EMC7			0.483	3
UniProt:P11717 IGF2R	7	IGF2R [clathrin-coated endocytic vesicle membrane] (R-HSA-8869091) IGF2R [Golgi membrane] (R-HSA-434345) IGF2R [cytoplasmic vesicle membrane] (R-HSA-434213) IGF2R [transport vesicle] (R-HSA-6814609) IGF2R [trans-Golgi network membrane] (R-HSA-6814608) IGF2R [plasma membrane] (R-HSA-6806532) IGF2R [secretory granule membrane] (R-HSA-6803320)	0.483	2
UniProt:Q96S66 CLCC1			0.483	3
UniProt:Q5J8M3 EMC4			0.483	2
UniProt:P50402 EMD	4	EMD [nuclear envelope] (R-HSA-201573) EMD [cytosol] (R-HSA-9613988) EMD [endoplasmic reticulum membrane] (R-HSA-9613998) EMD [endosome membrane] (R-HSA-9715092)	0.483	3
UniProt:P21860 ERBB3			0.483	3
UniProt:Q15005 SPCS2	1	SPCS2 [endoplasmic reticulum membrane] (R-HSA-264996)	0.483	2
UniProt:Q13586 STIM1	1	STIM1 [endoplasmic reticulum membrane] (R-HSA-434675)	0.483	3
UniProt:P61009 SPCS3	1	SPCS3 [endoplasmic reticulum membrane] (R-HSA-264916)	0.483	2
UniProt:Q96A33 CCD47			0.483	4
UniProt:P04234 CD3D	3	CD3D [clathrin-coated endocytic vesicle membrane] (R-HSA-8869079) CD3D [plasma membrane] (R-HSA-198171) p-Y149,Y160-CD3D [plasma membrane] (R-HSA-202329)	0.483	2
UniProt:Q5JTV8 TOR1AIP1	1	TOR1AIP1 [cytosol] (R-HSA-9715083)	0.483	3
UniProt:Q4KMQ2 ANO6	3	ANO6 [specific granule membrane] (R-HSA-6799509) ANO6 [plasma membrane] (R-HSA-2684941) ANO6 [tertiary granule membrane] (R-HSA-6800903)	0.483	2
UniProt:Q8WVM8 SCFD1	1	SCFD1 [cytosol] (R-HSA-5688147)	0.483	3
UniProt:A0A0F6B1Q8 A0A0F6B1Q8			0.462	2
UniProt:P30050 RPL12	1	RPL12 [cytosol] (R-HSA-72408)	0.462	3

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