Reactome | PSME1 [cytosol]

PSME1 [cytosol]

Stable Identifier

R-HSA-68812

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Proteasome activator complex subunit 1, Proteasome activator 28-alpha subunit, PA28alpha, PA28a, Activator of multicatalytic protease subunit 1, 11S regulator complex alpha subunit, REG-alpha, Interferon gamma up-regulated I-5111 protein, IGUP I-5111

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q06323 PSME1

Gene Names

PSME1, IFI5111

Chain

chain:1-249

Reference Genes

BioGPS Gene:5720 PSME1

COSMIC (genes):PSME1 PSME1

CTD Gene:5720 PSME1

dbSNP Gene:5720 PSME1

ENSEMBL:ENSG00000092010 PSME1

HGNC:9568 PSME1

Monarch:5720 PSME1

NCBI Gene:5720 PSME1

OMIM:600654 PSME1

UCSC:Q06323 PSME1

Reference Transcript

Other Identifiers

11726579_a_at

11726580_x_at

11733370_a_at

1558938_PM_at

1558938_at

16782615

16782637

200814_PM_at

200814_at

3529610

3529611

3529612

3529617

3529618

3529619

3529620

3529621

3529622

3529623

3529624

3529625

3529626

3529627

3529629

3529630

3529631

3529632

3529633

3529634

3529635

3529636

3529637

3529638

3529639

3529640

3529641

3529642

3529643

3529644

3529646

36600_at

5720

57219_at

57221_g_at

7973564

A_14_P135866

A_23_P151610

A_23_P151614

GE61303

GO:0000502

GO:0002376

GO:0005515

GO:0005654

GO:0005737

GO:0005829

GO:0008537

GO:0019884

GO:0043226

GO:0061133

GO:0061136

GO:0070062

GO:0098772

GO:2000045

HMNXSV003020760

ILMN_1726698

ILMN_1806017

L07633_at

PH_hs_0004316

PH_hs_0035453

TC14000159.hg

TC14000160.hg

TC14001606.hg

g5453989_3p_at

Participates

as an input of

Formation of the PA28-alpha-beta regulatory particle (Homo sapiens)

as a component of

PA28-alpha-beta heteroheptamer [cytosol] (Homo sapiens)

Inferred To

psme-3 [cytosol] (Caenorhabditis elegans)

psmE3 [cytosol] (Dictyostelium discoideum)

PSME1 [cytosol] (Bos taurus)

PSME1 [cytosol] (Canis familiaris)

PSME1 [cytosol] (Plasmodium falciparum)

PSME1 [cytosol] (Sus scrofa)

Psme1 [cytosol] (Mus musculus)

Psme1 [cytosol] (Rattus norvegicus)

psme1 [cytosol] (Danio rerio)

psme1 [cytosol] (Xenopus tropicalis)

REG [cytosol] (Drosophila melanogaster)

Cross References

OpenTargets

ENSG00000092010

ENSEMBL

ENST00000382708, ENSP00000493882, ENSP00000206451, ENSP00000495095, ENST00000646132, ENSP00000453976, ENST00000643169, ENSP00000496083, ENST00000206451, ENST00000561435, ENSP00000372155, ENST00000645537

HPA

ENSG00000092010-PSME1

PRO

Q06323

Pharos - Targets

Q06323

GlyGen

Q06323

PDB

7DR6, 7DRW, 7NAP, 7NAO, 1AVO, 8CXB

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UL46 PSME2	2	PSME2 [nucleoplasm] (R-HSA-174350) PSME2 [cytosol] (R-HSA-68814)	0.801	10
UniProt:P49721 PSMB2	2	PSMB2 [cytosol] (R-HSA-68744) PSMB2 [nucleoplasm] (R-HSA-174335)	0.725	5
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.718	9
UniProt:Q99436 PSMB7	7	PSMB7 [cytosol] (R-HSA-68759) PSMB7 [nucleoplasm] (R-HSA-174331) PSMB7 [secretory granule lumen] (R-HSA-6803279) PSMB7 [extracellular region] (R-HSA-6806449) PSMB7 [ficolin-1-rich granule lumen] (R-HSA-6803312) pro-PSMB7 [cytosol] (R-HSA-9908145) PSMB7(1-43) [cytosol] (R-HSA-9908129)	0.643	4
UniProt:P28070 PSMB4	4	PSMB4 [cytosol] (R-HSA-68750) PSMB4 [nucleoplasm] (R-HSA-174343) pro-PSMB4 [cytosol] (R-HSA-9908138) PSMB4(1-45) [cytosol] (R-HSA-9908122)	0.643	4
UniProt:P28065 PSMB9	3	pro-PSMB9 [cytosol] (R-HSA-9908136) PSMB9 [cytosol] (R-HSA-68765) PSMB9(1-20) [cytosol] (R-HSA-9908132)	0.643	5
UniProt:Q969U7 PSMG2	1	PSMG2 [cytosol] (R-HSA-9908053)	0.643	3
UniProt:P20618 PSMB1	7	PSMB1 [cytosol] (R-HSA-68738) PSMB1 [nucleoplasm] (R-HSA-174347) PSMB1 [secretory granule lumen] (R-HSA-6803287) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340) pro-PSMB1 [cytosol] (R-HSA-9908139) PSMB1(1-28) [cytosol] (R-HSA-9908143)	0.643	5
UniProt:P49720 PSMB3	2	PSMB3 [cytosol] (R-HSA-68747) PSMB3 [nucleoplasm] (R-HSA-174341)	0.643	5
UniProt:Q14957 GRIN2C	3	GRIN2C [plasma membrane] (R-HSA-419560) GRIN2C [endoplasmic reticulum membrane] (R-HSA-9609761) p-Y-GRIN2C [plasma membrane] (R-HSA-9612189)	0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:Q5JTV8 TOR1AIP1	1	TOR1AIP1 [cytosol] (R-HSA-9715083)	0.556	3
UniProt:P06396 GSN	7	GSN [cytosol] (R-HSA-350275) GSN(28-403) [cytosol] (R-HSA-201618) GSN(404-782) [cytosol] (R-HSA-350272) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(200-270) [extracellular region] (R-HSA-976940)	0.556	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:Q8WXH2 JPH3			0.556	3
UniProt:Q9Y649 Q9Y649			0.556	3
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) p-6Y-FGFR3 A391E [plasma membrane] (R-HSA-2065835) p-6Y-FGFR3 K650T [plasma membrane] (R-HSA-2032966) p-6Y-FGFR3 G382D [plasma membrane] (R-HSA-2032950) p-6Y-FGFR3 G380R [plasma membrane] (R-HSA-2032946) p-6Y-FGFR3 K650M [plasma membrane] (R-HSA-2032959)	0.556	3
UniProt:Q06323 PSME1	1	PSME1 [cytosol] (R-HSA-68812)	0.553	2
UniProt:P25787 PSMA2	5	PSMA2 [cytosol] (R-HSA-68726) PSMA2 [nucleoplasm] (R-HSA-174345) PSMA2 [secretory granule lumen] (R-HSA-6803329) PSMA2 [extracellular region] (R-HSA-6806506) PSMA2 [ficolin-1-rich granule lumen] (R-HSA-6803285)	0.527	4
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	5
UniProt:P28066 PSMA5	5	PSMA5 [cytosol] (R-HSA-68732) PSMA5 [nucleoplasm] (R-HSA-174340) PSMA5 [secretory granule lumen] (R-HSA-6803316) PSMA5 [extracellular region] (R-HSA-6806459) PSMA5 [ficolin-1-rich granule lumen] (R-HSA-6803328)	0.527	5
UniProt:O14818 PSMA7	2	PSMA7 [nucleoplasm] (R-HSA-174351) PSMA7 [cytosol] (R-HSA-68736)	0.527	2
UniProt:P60896 SEM1	2	SEM1 [cytosol] (R-HSA-8866674) SEM1 [nucleoplasm] (R-HSA-8866665)	0.527	2
UniProt:P40313 CTRL	1	pro-CTRL [zymogen granule] (R-HSA-9922800)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	4

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