Reactome | RAB5B [early endosome membrane]

RAB5B [early endosome membrane]

Stable Identifier

R-HSA-2029080

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

early endosome membrane

Synonyms

Ras-related protein Rab-5B, RAB5B_HUMAN

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Rab regulation of trafficking (Homo sapiens)
    - TBC/RABGAPs (Homo sapiens)
      - TBC1D3 associates with RAB5 (Homo sapiens)
        
        GGA1,2,3:RAB5:GTP:RABGEF1 [early endosome membrane] (Homo sapiens)
        
        RAB5:GTP [early endosome membrane] (Homo sapiens)
        
        RAB5B:GTP [early endosome membrane] (Homo sapiens)
        
        RAB5B [early endosome membrane] (Homo sapiens)
        
        TBC1D3:GGA:RAB5:GTP:RABGEF1 [early endosome membrane] (Homo sapiens)
        
        GGA1,2,3:RAB5:GTP:RABGEF1 [early endosome membrane] (Homo sapiens)
        
        RAB5:GTP [early endosome membrane] (Homo sapiens)
        
        RAB5B:GTP [early endosome membrane] (Homo sapiens)
        
        RAB5B [early endosome membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P61020 RAB5B

Gene Names

RAB5B

Chain

initiator methionine:, chain:2-215

Reference Genes

BioGPS Gene:5869 RAB5B

COSMIC (genes):RAB5B RAB5B

CTD Gene:5869 RAB5B

dbSNP Gene:5869 RAB5B

ENSEMBL:ENSG00000111540 RAB5B

HGNC:9784 RAB5B

KEGG:hsa:5869 RAB5B

Monarch:5869 RAB5B

NCBI Gene:5869 RAB5B

OMIM:179514 RAB5B

UCSC:P61020 RAB5B

Reference Transcript

Other Identifiers

11717194_a_at

11717195_a_at

11751177_a_at

1221_at

16752322

201276_PM_at

201276_at

3417033

3417034

3417162

3417163

3417164

3417165

3417166

3417167

3417168

3417169

3417170

3417171

3417172

3417173

3417174

3417175

3417176

3417177

3417178

3417179

3417185

3417186

3417187

3417197

3417198

3417200

3635211

37362_at

5869

7956088

A_23_P410998

GE59798

GO:0000166

GO:0002376

GO:0003824

GO:0003924

GO:0003925

GO:0005515

GO:0005525

GO:0005768

GO:0005769

GO:0005886

GO:0006886

GO:0006897

GO:0007032

GO:0012505

GO:0015031

GO:0016020

GO:0016192

GO:0016787

GO:0019003

GO:0019882

GO:0030100

GO:0030139

GO:0030667

GO:0030672

GO:0030742

GO:0031410

GO:0031901

GO:0042470

GO:0043226

GO:0043231

GO:0048227

GO:0070062

GO:0098772

HMNXSV003020201

ILMN_1710682

ILMN_1752582

PH_hs_0004481

TC12000497.hg

X54871_at

g12006052_3p_at

g12006052_3p_x_at

Participates

as a component of

RAB5B:GTP [early endosome membrane] (Homo sapiens)

Other forms of this molecule

GGC-RAB5B [clathrin-coated endocytic vesicle membrane]

GGC-RAB5B [early endosome membrane]

GGC-RAB5B [cytosol]

RAB5B [cytosol]

GGC-RAB5B [macropinosome membrane]

RAB5B [plasma membrane]

RAB5B [secretory granule membrane]

Inferred To

rab-5 [early endosome membrane] (Caenorhabditis elegans)

RAB5B [early endosome membrane] (Gallus gallus)

RAB5B [early endosome membrane] (Sus scrofa)

RAB5A [early endosome membrane] (Drosophila melanogaster)

Cross References

ENSEMBL

ENSP00000391319, ENST00000360299, ENST00000448789, ENSP00000353444, ENSP00000450168, ENST00000553116

OpenTargets

ENSG00000111540

IntEnz

3.6.5.2

HPA

ENSG00000111540-RAB5B

PRO

P61020

Pharos - Targets

P61020

GlyGen

P61020

HMDB Protein

HMDBP08511

PDB

2HEI

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.761	9
GTP [ChEBI:15996]	7	GTP [cilium] (R-ALL-5617813) GTP [early endosome membrane] (R-ALL-2130170) GTP [lysosomal membrane] (R-ALL-2213216) GTP [platelet dense granule lumen] (R-ALL-114625) GTP [cytoplasmic vesicle membrane] (R-ALL-1996291) GTP [ER to Golgi transport vesicle membrane] (R-ALL-983318) GTP [Golgi membrane] (R-ALL-1806221)	0.558	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q9Y324 FCF1	1	FCF1 [nucleoplasm] (R-HSA-6790672)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	9

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