Reactome | UBE3A [cytosol]

UBE3A [cytosol]

Stable Identifier

R-HSA-976028

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ubiquitin-protein ligase E3A, UBE3A_HUMAN

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
19325566	E6AP promotes the degradation of the PML tumor suppressor Jiang, YH, Berger, M, Grossman, T, Matentzoglu, K, Muller, S, Louria-Hayon, I, Haupt, S, Scheffner, M, Silberman, I, Levav-Cohen, Y, Alsheich-Bartok, O, Haupt, Y	Cell Death Differ.	2009

External Reference Information

External Reference

UniProt:Q05086 UBE3A

Gene Names

UBE3A, E6AP, EPVE6AP, HPVE6A

Chain

chain:1-875

Reference Genes

BioGPS Gene:7337 UBE3A

COSMIC (genes):UBE3A UBE3A

CTD Gene:7337 UBE3A

dbSNP Gene:7337 UBE3A

ENSEMBL:ENSG00000114062 UBE3A

HGNC:12496 UBE3A

KEGG:hsa:7337 UBE3A

Monarch:7337 UBE3A

NCBI Gene:7337 UBE3A

OMIM:601623 UBE3A

UCSC:Q05086 UBE3A

Reference Transcript

Participates

as a candidate of

E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)

Inferred To

HUL4 [cytosol] (Saccharomyces cerevisiae)

UBE3A [cytosol] (Bos taurus)

UBE3A [cytosol] (Canis familiaris)

UBE3A [cytosol] (Gallus gallus)

UBE3A [cytosol] (Sus scrofa)

Ube3a [cytosol] (Drosophila melanogaster)

Ube3a [cytosol] (Mus musculus)

Ube3a [cytosol] (Rattus norvegicus)

mug30 [cytosol] (Schizosaccharomyces pombe)

ube3a [cytosol] (Danio rerio)

ube3a [cytosol] (Dictyostelium discoideum)

Cross References

OpenTargets

ENSG00000114062

ENSEMBL

ENSP00000490557, ENST00000650110, ENSP00000411258, ENSP00000490258, ENSP00000457771, ENST00000438097, ENST00000649550, ENST00000637886, ENSP00000486349, ENSP00000490111, ENST00000638011, ENSP00000497594, ENSP00000401265, ENST00000638155, ENSP00000497572, ENST00000566215, ENSG00000114062, ENST00000648336, ENST00000428984, ENSP00000497549, ENST00000630424

HPA

ENSG00000114062-UBE3A

GeneCards

UBE3A

PRO

Q05086

Pharos - Targets

Q05086

Orphanet

UBE3A

GlyGen

Q05086

HMDB Protein

HMDBP09313

PDB

1EQX, 2KR1, 8JRR, 8JRP, 1C4Z, 1D5F, 6SLM, 4XR8, 8R1F, 4GIZ, 7QPB, 8GCR, 8ENP, 8R1G, 8JRQ, 6TGK, 8JRN, 6SJV, 8JRO, 8EPT, 6U19, 7Q41

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.77	6
UniProt:P55036 PSMD4	1	PSMD4 [cytosol] (R-HSA-68800)	0.728	5
UniProt:Q14566 MCM6	1	MCM6 [nucleoplasm] (R-HSA-68553)	0.608	6
UniProt:Q16611 BAK1	2	BAK1 activated [mitochondrial outer membrane] (R-HSA-50690) BAK1 [mitochondrial outer membrane] (R-HSA-139896)	0.544	2
UniProt:Q08J23 NSUN2	1	NSUN2 [nucleoplasm] (R-HSA-6782382)	0.499	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	7
UniProt:Q06413 MEF2C	3	MEF2C [nucleoplasm] (R-HSA-199938) p-S396-MEF2C [nucleoplasm] (R-HSA-199942) p-T293,T300,S387-MEF2C [nucleoplasm] (R-HSA-448838)	0.463	3

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