Reactome | PSMD8 [nucleoplasm]

PSMD8 [nucleoplasm]

Stable Identifier

R-HSA-174318

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

26S proteasome non-ATPase regulatory subunit 8, 26S proteasome regulatory subunit S14, p31

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        PSMD8 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P48556 PSMD8

Gene Names

PSMD8

Chain

chain:1-350

Reference Genes

BioGPS Gene:5714 PSMD8

COSMIC (genes):PSMD8 PSMD8

CTD Gene:5714 PSMD8

dbSNP Gene:5714 PSMD8

ENSEMBL:ENSG00000099341.12 PSMD8

HGNC:9566 PSMD8

KEGG Gene (Homo sapiens):5714 PSMD8

Monarch:5714 PSMD8

NCBI Gene:5714 PSMD8

OMIM:617844 PSMD8

Reference Transcript

RefSeq:NM_002812.4 PSMD8

Other Identifiers

0002030041

11732145_a_at

11732146_x_at

1312_at

16861704

200820_PM_at

200820_at

2436669

32584_at

3832385

3832386

3832389

3832390

3832391

3832393

3832397

3832399

3832400

3832401

5714

8028380

D38047_at

GE57181

GO:0000502

GO:0005515

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005838

GO:0006508

GO:0008541

GO:0022624

GO:0030163

GO:0032991

GO:0043161

GO:0043226

HMNXSV003019807

ILMN_1733256

PH_hs_0004526

PH_hs_0031341

TC19000527.hg

g4506232_3p_at

Participates

as a component of

26S proteasome [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PSMD8 [cytosol]

Inferred To

psmD8-2 [nucleoplasm] (Dictyostelium discoideum)

rpn-12 [nucleoplasm] (Caenorhabditis elegans)

zgc:86762 [nucleoplasm] (Danio rerio)

PSMD8 [nucleoplasm] (Bos taurus)

PSMD8 [nucleoplasm] (Sus scrofa)

Ghost homologue of PSMD8 [nucleoplasm] (Canis familiaris)

Ghost homologue of PSMD8 [nucleoplasm] (Gallus gallus)

Ghost homologue of PSMD8 [nucleoplasm] (Xenopus tropicalis)

Psmd8 [nucleoplasm] (Mus musculus)

Psmd8 [nucleoplasm] (Rattus norvegicus)

Rpn12 [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_002803.2

OpenTargets

ENSG00000099341

GeneCards

P48556

HPA

ENSG00000099341-PSMD8

Ensembl

ENSP00000215071, ENST00000215071, ENSG00000099341

PRO

P48556

Pharos - Targets

P48556

PDB

5L4K, 5VGZ, 6MSK, 5VFR, 5VFT, 6WJN, 5VFS, 5T0I, 5VHS, 6MSH, 5VFP, 5T0J, 6WJD, 5VFQ, 6MSJ, 5GJQ, 5VHI, 5T0G, 6MSD, 5T0H, 5GJR, 6MSG, 5VHF, 6MSB, 5LN3, 5T0C, 5VHH, 5M32, 5VFU

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.669	4
UniProt:O00487 PSMD14	5	PSMD14 [secretory granule lumen] (R-HSA-6800926) PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [cytosol] (R-HSA-68722)	0.564	2
UniProt:Q16186 ADRM1	1	ADRM1 [cytosol] (R-HSA-5665939)	0.527	3
UniProt:P0DTC5 M	10	M [plasma membrane] (R-COV-9755780) N-glycan M [virion membrane] (R-COV-9694385) M [virion membrane] (R-COV-9694320) M [endocytic vesicle membrane] (R-COV-9694563) N-glycan M [endocytic vesicle membrane] (R-COV-9694738) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694439) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694446) M [endoplasmic reticulum membrane] (R-COV-9767620) nascent M [endoplasmic reticulum lumen] (R-COV-9694279) N-glycan M [endoplasmic reticulum membrane] (R-COV-9694684)	0.527	2
UniProt:Q8N3I7 BBS5	1	BBS5 [cytosol] (R-HSA-5617633)	0.508	2