Reactome | PSMD8 [nucleoplasm]

PSMD8 [nucleoplasm]

Stable Identifier

R-HSA-174318

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

26S proteasome non-ATPase regulatory subunit 8, 26S proteasome regulatory subunit S14, p31

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - G1/S DNA Damage Checkpoints (Homo sapiens)
    - p53-Independent G1/S DNA Damage Checkpoint (Homo sapiens)
      - Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A (Homo sapiens)
        
        Proteolytic degradation of ubiquitinated-Cdc25A (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        PSMD8 [nucleoplasm] (Homo sapiens)
- Cell Cycle, Mitotic (Homo sapiens)
  - Mitotic G1 phase and G1/S transition (Homo sapiens)
    - G1/S Transition (Homo sapiens)
      - Cyclin E associated events during G1/S transition (Homo sapiens)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        PSMD8 [nucleoplasm] (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        PSMD8 [nucleoplasm] (Homo sapiens)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
        
        Degradation of multiubiquitinated Cdh1 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        PSMD8 [nucleoplasm] (Homo sapiens)
  - S Phase (Homo sapiens)
    - Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
      - SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        PSMD8 [nucleoplasm] (Homo sapiens)

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        PSMD8 [nucleoplasm] (Homo sapiens)

Developmental Biology (Homo sapiens)

- Gastrulation (Homo sapiens)
  - Formation of paraxial mesoderm (Homo sapiens)
    - Somitogenesis (Homo sapiens)
      - RIPPLY2 binds TBX6 and recruits the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        PSMD8 [nucleoplasm] (Homo sapiens)
        
        TBX6:RIPPLY2:26S proteasome [nucleoplasm] (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        PSMD8 [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX2 (Homo sapiens)
      - Regulation of RUNX2 expression and activity (Homo sapiens)
        
        26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        PSMD8 [nucleoplasm] (Homo sapiens)
    - Transcriptional regulation by RUNX3 (Homo sapiens)
      - Regulation of RUNX3 expression and activity (Homo sapiens)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        PSMD8 [nucleoplasm] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Hedgehog (Homo sapiens)
  - Hedgehog 'on' state (Homo sapiens)
    - GLI2,3 are degraded by the proteasome (Homo sapiens)
      - 26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        PSMD8 [nucleoplasm] (Homo sapiens)
- Signaling by NOTCH (Homo sapiens)
  - Signaling by NOTCH4 (Homo sapiens)
    - Negative regulation of NOTCH4 signaling (Homo sapiens)
      - Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        PSMD8 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P48556 PSMD8

Gene Names

PSMD8

Chain

chain:1-350

Reference Genes

BioGPS Gene:5714 PSMD8

COSMIC (genes):PSMD8 PSMD8

CTD Gene:5714 PSMD8

dbSNP Gene:5714 PSMD8

ENSEMBL:ENSG00000099341 PSMD8

HGNC:9566 PSMD8

KEGG:hsa:5714 PSMD8

Monarch:5714 PSMD8

NCBI Gene:5714 PSMD8

OMIM:617844 PSMD8

UCSC:P48556 PSMD8

Reference Transcript

RefSeq:NM_002812.5 PSMD8

Other Identifiers

11732145_a_at

11732146_x_at

11761486_a_at

1312_at

16861704

200820_PM_at

200820_at

2436669

32584_at

3832384

3832385

3832386

3832387

3832388

3832389

3832390

3832391

3832392

3832393

3832394

3832395

3832396

3832397

3832398

3832399

3832400

3832401

5714

8028380

A_14_P131224

A_23_P67466

D38047_at

GE57181

GO:0000502

GO:0005515

GO:0005634

GO:0005654

GO:0005829

GO:0005838

GO:0006508

GO:0008541

GO:0022624

GO:0030163

GO:0043161

GO:0043226

HMNXSV003019807

ILMN_1733256

PH_hs_0004526

PH_hs_0031341

TC19000527.hg

g4506232_3p_at

Participates

as a component of

19S RP lid [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PSMD8 [cytosol]

Inferred To

rpn-12 [nucleoplasm] (Caenorhabditis elegans)

RPN12 [nucleoplasm] (Saccharomyces cerevisiae)

PSMD8 [nucleoplasm] (Bos taurus)

PSMD8 [nucleoplasm] (Canis familiaris)

PSMD8 [nucleoplasm] (Sus scrofa)

psmD8-1; psmD8-2 [nucleoplasm] (Dictyostelium discoideum)

psmd8 [nucleoplasm] (Danio rerio)

psmd8 [nucleoplasm] (Xenopus tropicalis)

Ghost homologue of PSMD8 [nucleoplasm] (Gallus gallus)

Psmd8 [nucleoplasm] (Mus musculus)

Psmd8 [nucleoplasm] (Rattus norvegicus)

Rpn12 [nucleoplasm] (Drosophila melanogaster)

rpn12 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_002803.2

OpenTargets

ENSG00000099341

ENSEMBL

ENSP00000215071, ENST00000215071, ENSG00000099341

HPA

ENSG00000099341-PSMD8

GeneCards

PSMD8

PRO

P48556

Pharos - Targets

P48556

GlyGen

P48556

PDB

9E8G, 9E8K, 9E8I, 8USC, 5T0C, 7QYA, 5VFQ, 7QXU, 7W3G, 6MSH, 7W3I, 8JRI, 6WJN, 6MSG, 7QXW, 5L4K, 6WJD, 7W37, 9E8O, 7W38, 5VFS, 9E8Q, 8JRT, 6MSK, 5LN3, 5M32, 5T0G, 5T0J, 7W3K, 7W3M, 7QXP, 7QXN, 5GJQ, 5VHH, 9E8H, 9E8J, 8CVT, 5VHI, 7QYB, 8USB, 5VFR, 7W3H, 7W3J, 7W3B, 5VHF, 7W3A, 6MSB, 5VFU, 5VGZ, 5VFP, 5GJR, 7W39, 5VFT, 6MSJ, 5T0H, 5T0I, 5VHS, 8JTI, 9E8L, 9E8N, 7W3F, 6MSD, 7W3C, 7QY7, 7QXX

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.725	5
UniProt:Q16186 ADRM1	2	ADRM1 [cytosol] (R-HSA-5665939) ADRM1 [nucleoplasm] (R-HSA-9918361)	0.643	4
UniProt:Q16401 PSMD5	1	PSMD5 [cytosol] (R-HSA-68802)	0.643	4
UniProt:P51665 PSMD7	5	PSMD7 [cytosol] (R-HSA-68806) PSMD7 [nucleoplasm] (R-HSA-174309) PSMD7 [ficolin-1-rich granule lumen] (R-HSA-6800406) PSMD7 [extracellular region] (R-HSA-6806488) PSMD7 [secretory granule lumen] (R-HSA-6801008)	0.643	4
UniProt:P55036 PSMD4	1	PSMD4 [cytosol] (R-HSA-68800)	0.564	2
UniProt:Q9UNM6 PSMD13	5	PSMD13 [cytosol] (R-HSA-68794) PSMD13 [nucleoplasm] (R-HSA-174326) PSMD13 [ficolin-1-rich granule lumen] (R-HSA-6800413) PSMD13 [extracellular region] (R-HSA-6806469) PSMD13 [secretory granule lumen] (R-HSA-6800983)	0.564	3
UniProt:Q92529 SHC3	2	SHC3 [cytosol] (R-HSA-3006448) p-Y-SHC3 [cytosol] (R-HSA-3009043)	0.556	3
UniProt:P30041 PRDX6	3	PRDX6 [extracellular region] (R-HSA-6806198) PRDX6 [azurophil granule lumen] (R-HSA-6798744) PRDX6 [cytosol] (R-HSA-3343670)	0.556	3
UniProt:O00232 PSMD12	5	PSMD12 [cytosol] (R-HSA-68792) PSMD12 [nucleoplasm] (R-HSA-174339) PSMD12 [ficolin-1-rich granule lumen] (R-HSA-6800416) PSMD12 [extracellular region] (R-HSA-6806480) PSMD12 [secretory granule lumen] (R-HSA-6800934)	0.527	3
UniProt:P0DTC5 M	10	M [plasma membrane] (R-COV-9755780) N-glycan M [virion membrane] (R-COV-9694385) M [virion membrane] (R-COV-9694320) M [endocytic vesicle membrane] (R-COV-9694563) N-glycan M [endocytic vesicle membrane] (R-COV-9694738) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694439) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694446) M [endoplasmic reticulum membrane] (R-COV-9767620) nascent M [endoplasmic reticulum lumen] (R-COV-9694279) N-glycan M [endoplasmic reticulum membrane] (R-COV-9694684)	0.527	2
UniProt:P49720 PSMB3	2	PSMB3 [cytosol] (R-HSA-68747) PSMB3 [nucleoplasm] (R-HSA-174341)	0.527	3
UniProt:P43686 PSMC4	2	PSMC4 [cytosol] (R-HSA-68777) PSMC4 [nucleoplasm] (R-HSA-174315)	0.527	2
UniProt:P28065 PSMB9	3	PSMB9 [cytosol] (R-HSA-68765) pro-PSMB9 [cytosol] (R-HSA-9908136) PSMB9(1-20) [cytosol] (R-HSA-9908132)	0.527	2
UniProt:Q13200 PSMD2	5	PSMD2 [cytosol] (R-HSA-68796) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [secretory granule lumen] (R-HSA-6800919)	0.527	2
UniProt:O00487 PSMD14	5	PSMD14 [cytosol] (R-HSA-68722) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419) PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [secretory granule lumen] (R-HSA-6800926)	0.527	2
UniProt:O14641 DVL2	5	DVL2 [cytosol] (R-HSA-201694) ub-DVL2 [cytosol] (R-HSA-4652689) pp-DVL2 [cytosol] (R-HSA-3772398) p-DVL2 [cytosol] (R-HSA-201706) p-DVL2 [clathrin-coated endocytic vesicle] (R-HSA-5138444)	0.527	2
UniProt:O75832 PSMD10	1	PSMD10 [cytosol] (R-HSA-68788)	0.527	3
UniProt:Q53HC0 CCD92			0.527	3
UniProt:Q5JXX7 TMM31			0.527	2
UniProt:Q8N3I7 BBS5	1	BBS5 [cytosol] (R-HSA-5617633)	0.508	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	4

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