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PSMD8 [nucleoplasm]
Stable Identifier
R-HSA-174318
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
26S proteasome non-ATPase regulatory subunit 8, 26S proteasome regulatory subunit S14, p31
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD8 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD8 [nucleoplasm] (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD8 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD8 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD8 [nucleoplasm] (Homo sapiens)
Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD8 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD8 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD8 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD8 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P48556 PSMD8
Gene Names
PSMD8
Chain
chain:1-350
Reference Genes
BioGPS Gene:5714 PSMD8
COSMIC (genes):PSMD8 PSMD8
CTD Gene:5714 PSMD8
dbSNP Gene:5714 PSMD8
ENSEMBL:ENSG00000099341 PSMD8
HGNC:9566 PSMD8
KEGG Gene (Homo sapiens):5714 PSMD8
Monarch:5714 PSMD8
NCBI Gene:5714 PSMD8
OMIM:617844 PSMD8
Reference Transcript
RefSeq:NM_002812.4 PSMD8
Other Identifiers
0002030041
11732145_a_at
11732146_x_at
1312_at
16861704
200820_at
2436669
32584_at
3832385
3832386
3832389
3832390
3832391
3832393
3832397
3832399
3832400
3832401
5714
8028380
A_23_P67466
D38047_at
GE57181
GO:0000165
GO:0000209
GO:0000278
GO:0000502
GO:0002223
GO:0002376
GO:0002479
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005838
GO:0006464
GO:0006508
GO:0006520
GO:0006521
GO:0006810
GO:0006950
GO:0007049
GO:0007165
GO:0007267
GO:0008150
GO:0008541
GO:0009056
GO:0009058
GO:0010972
GO:0016579
GO:0022624
GO:0030154
GO:0031145
GO:0031146
GO:0032991
GO:0033209
GO:0034641
GO:0034655
GO:0038061
GO:0038095
GO:0043161
GO:0043226
GO:0043488
GO:0043687
GO:0044281
GO:0048856
GO:0050852
GO:0055085
GO:0060071
GO:0061418
GO:0070498
GO:0090090
GO:0090263
GO:1901990
GO:1902036
ILMN_1733256
PH_hs_0004526
PH_hs_0031341
TC19000527.hg
g4506232_3p_at
Participant Of
hasComponent
26S proteasome [nucleoplasm]
Other forms of this molecule
PSMD8 [cytosol]
Inferred To
psmD8-2 [nucleoplasm] (Dictyostelium discoideum)
rpn-12 [nucleoplasm] (Caenorhabditis elegans)
PSMD8 [nucleoplasm] (Canis familiaris)
PSMD8 [nucleoplasm] (Sus scrofa)
psmd8 [nucleoplasm] (Danio rerio)
psmd8 [nucleoplasm] (Xenopus tropicalis)
Psmd8 [nucleoplasm] (Mus musculus)
Psmd8 [nucleoplasm] (Rattus norvegicus)
Rpn12 [nucleoplasm] (Drosophila melanogaster)
Cross References
RefSeq
NP_002803.2
Target Pathogen
5b354852be737e166372e892
OpenTargets
ENSG00000099341
GeneCards
P48556
HPA
ENSG00000099341-PSMD8
Ensembl
ENSP00000481136
,
ENSP00000215071
,
ENST00000620216
,
ENST00000215071
,
ENSG00000099341
PRO
P48556
PDB
5VHF
,
5VFT
,
5M32
,
5VFU
,
5GJQ
,
6MSB
,
5VFS
,
5VFR
,
5LN3
,
6MSK
,
5VGZ
,
5T0C
,
5VFQ
,
5T0I
,
5VFP
,
5T0J
,
6MSJ
,
5L4K
,
5VHS
,
6MSH
,
5T0H
,
5VHI
,
5T0G
,
6MSD
,
5GJR
,
5VHH
,
6MSG
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [nucleoplasm]
(R-HSA-5689584)
UCHL5 [cytosol]
(R-HSA-1629778)
0.669
4
UniProt:O00487 PSMD14
5
PSMD14 [extracellular region]
(R-HSA-6806511)
PSMD14 [ficolin-1-rich granule lumen]
(R-HSA-6800419)
PSMD14 [secretory granule lumen]
(R-HSA-6800926)
PSMD14 [nucleoplasm]
(R-HSA-174329)
PSMD14 [cytosol]
(R-HSA-68722)
0.564
2
UniProt:P0DTC5 M
8
N-glycan M [endocytic vesicle membrane]
(R-COV-9694738)
M [endocytic vesicle membrane]
(R-COV-9694563)
N-glycan M [endoplasmic reticulum membrane]
(R-COV-9694684)
nascent M [endoplasmic reticulum lumen]
(R-COV-9694279)
N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9694446)
M [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9694439)
M [virion membrane]
(R-COV-9694320)
N-glycan M [virion membrane]
(R-COV-9694385)
0.527
2
UniProt:Q16186 ADRM1
1
ADRM1 [cytosol]
(R-HSA-5665939)
0.527
3
UniProt:Q8N3I7 BBS5
1
BBS5 [cytosol]
(R-HSA-5617633)
0.508
2
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