Reactome | PSMD8 [nucleoplasm]

PSMD8 [nucleoplasm]

Stable Identifier

R-HSA-174318

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

26S proteasome non-ATPase regulatory subunit 8, 26S proteasome regulatory subunit S14, p31

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P48556 PSMD8

Gene Names

PSMD8

Chain

chain:1-350

Reference Genes

BioGPS Gene:5714 PSMD8

COSMIC (genes):PSMD8 PSMD8

CTD Gene:5714 PSMD8

dbSNP Gene:5714 PSMD8

ENSEMBL:ENSG00000099341 PSMD8

HGNC:9566 PSMD8

KEGG Gene (Homo sapiens):5714 PSMD8

Monarch:5714 PSMD8

NCBI Gene:5714 PSMD8

OMIM:617844 PSMD8

Reference Transcript

RefSeq:NM_002812.4 PSMD8

Other Identifiers

0002030041

11732145_a_at

11732146_x_at

1312_at

16861704

200820_at

2436669

32584_at

3832385

3832386

3832389

3832390

3832391

3832393

3832397

3832399

3832400

3832401

5714

8028380

A_23_P67466

D38047_at

GE57181

GO:0000165

GO:0000209

GO:0000278

GO:0000502

GO:0002223

GO:0002376

GO:0002479

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005838

GO:0006464

GO:0006508

GO:0006520

GO:0006521

GO:0006810

GO:0006950

GO:0007049

GO:0007165

GO:0007267

GO:0008150

GO:0008541

GO:0009056

GO:0009058

GO:0010972

GO:0016579

GO:0022624

GO:0030154

GO:0031145

GO:0031146

GO:0032991

GO:0033209

GO:0034641

GO:0034655

GO:0038061

GO:0038095

GO:0043161

GO:0043226

GO:0043488

GO:0043687

GO:0044281

GO:0048856

GO:0050852

GO:0055085

GO:0060071

GO:0061418

GO:0070498

GO:0090090

GO:0090263

GO:1901990

GO:1902036

ILMN_1733256

PH_hs_0004526

PH_hs_0031341

TC19000527.hg

g4506232_3p_at

Participant Of

hasComponent

26S proteasome [nucleoplasm]

Other forms of this molecule

PSMD8 [cytosol]

Inferred To

psmD8-2 [nucleoplasm] (Dictyostelium discoideum)

rpn-12 [nucleoplasm] (Caenorhabditis elegans)

PSMD8 [nucleoplasm] (Canis familiaris)

PSMD8 [nucleoplasm] (Sus scrofa)

psmd8 [nucleoplasm] (Danio rerio)

psmd8 [nucleoplasm] (Xenopus tropicalis)

Psmd8 [nucleoplasm] (Mus musculus)

Psmd8 [nucleoplasm] (Rattus norvegicus)

Rpn12 [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_002803.2

Target Pathogen

5b354852be737e166372e892

OpenTargets

ENSG00000099341

GeneCards

P48556

HPA

ENSG00000099341-PSMD8

Ensembl

ENSP00000481136, ENSP00000215071, ENST00000620216, ENST00000215071, ENSG00000099341

PRO

P48556

PDB

5VHF, 5VFT, 5M32, 5VFU, 5GJQ, 6MSB, 5VFS, 5VFR, 5LN3, 6MSK, 5VGZ, 5T0C, 5VFQ, 5T0I, 5VFP, 5T0J, 6MSJ, 5L4K, 5VHS, 6MSH, 5T0H, 5VHI, 5T0G, 6MSD, 5GJR, 5VHH, 6MSG

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [nucleoplasm] (R-HSA-5689584) UCHL5 [cytosol] (R-HSA-1629778)	0.669	4
UniProt:O00487 PSMD14	5	PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419) PSMD14 [secretory granule lumen] (R-HSA-6800926) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [cytosol] (R-HSA-68722)	0.564	2
UniProt:P0DTC5 M	8	N-glycan M [endocytic vesicle membrane] (R-COV-9694738) M [endocytic vesicle membrane] (R-COV-9694563) N-glycan M [endoplasmic reticulum membrane] (R-COV-9694684) nascent M [endoplasmic reticulum lumen] (R-COV-9694279) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694446) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694439) M [virion membrane] (R-COV-9694320) N-glycan M [virion membrane] (R-COV-9694385)	0.527	2
UniProt:Q16186 ADRM1	1	ADRM1 [cytosol] (R-HSA-5665939)	0.527	3
UniProt:Q8N3I7 BBS5	1	BBS5 [cytosol] (R-HSA-5617633)	0.508	2