Reactome | p-S2152-FLNA [cytosol]

p-S2152-FLNA [cytosol]

Stable Identifier

R-HSA-5669246

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases activate PAKs (Homo sapiens)
        
        PAK1 phosphorylates FLNA (Homo sapiens)
        
        p-S2152-FLNA [cytosol] (Homo sapiens)
        
        p-S2152-FLNA [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P21333 FLNA

Gene Names

FLNA, FLN, FLN1

Chain

initiator methionine:1, chain:2-2647

Reference Genes

BioGPS Gene:2316 FLNA

COSMIC (genes):FLNA FLNA

CTD Gene:2316 FLNA

dbSNP Gene:2316 FLNA

ENSEMBL:ENSG00000196924 FLNA

HGNC:3754 FLNA

KEGG Gene (Homo sapiens):2316 FLNA

Monarch:2316 FLNA

NCBI Gene:2316 FLNA

OMIM:300017 FLNA

UCSC:P21333 FLNA

Reference Transcript

Other Identifiers

0005890025

11715425_x_at

11746880_x_at

11752142_a_at

17115505

200859_x_at

213746_s_at

214752_x_at

2316

32749_s_at

32750_r_at

4027177

4027178

4027179

4027180

4027182

4027185

4027189

4027190

4027192

4027194

4027196

4027198

4027199

4027201

4027202

4027203

4027205

4027207

4027208

4027209

4027210

4027215

4027216

4027217

4027220

4027221

4027223

4027225

4027226

4027227

4027229

4027230

4027231

4027232

4027233

4027235

4027236

4027238

4027239

4027241

4027242

4027243

4027244

4027245

4027246

4027247

4027248

4027250

4027252

4027256

4027257

4027259

75220_s_at

8176026

89945_s_at

A_33_P3366120

A_33_P3408711

GE61113

GO:0000003

GO:0000278

GO:0000902

GO:0001525

GO:0001664

GO:0001837

GO:0001974

GO:0002376

GO:0002576

GO:0003007

GO:0003013

GO:0003674

GO:0003723

GO:0003779

GO:0005080

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005694

GO:0005730

GO:0005737

GO:0005794

GO:0005802

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0005903

GO:0005911

GO:0005925

GO:0005938

GO:0006464

GO:0006810

GO:0006913

GO:0006950

GO:0007010

GO:0007049

GO:0007155

GO:0007165

GO:0007195

GO:0007267

GO:0008092

GO:0008134

GO:0008150

GO:0008219

GO:0008283

GO:0009056

GO:0009058

GO:0010977

GO:0015031

GO:0015459

GO:0015629

GO:0016020

GO:0016192

GO:0016479

GO:0019899

GO:0019900

GO:0021943

GO:0021987

GO:0022607

GO:0030018

GO:0030030

GO:0030036

GO:0030154

GO:0030168

GO:0030334

GO:0030426

GO:0030863

GO:0031267

GO:0031523

GO:0031532

GO:0031852

GO:0032231

GO:0032233

GO:0032432

GO:0032991

GO:0034329

GO:0034330

GO:0034394

GO:0034641

GO:0034988

GO:0040011

GO:0042177

GO:0042307

GO:0042789

GO:0042803

GO:0042995

GO:0043025

GO:0043066

GO:0043113

GO:0043123

GO:0043198

GO:0043204

GO:0043226

GO:0043433

GO:0044295

GO:0044319

GO:0044325

GO:0044877

GO:0045022

GO:0045184

GO:0045216

GO:0045296

GO:0046332

GO:0048471

GO:0048646

GO:0048680

GO:0048856

GO:0048870

GO:0050808

GO:0050821

GO:0051015

GO:0051020

GO:0051220

GO:0051607

GO:0051764

GO:0055085

GO:0060271

GO:0070062

GO:0070527

GO:0071526

GO:0072659

GO:0090042

GO:0090307

GO:0097368

GO:0097440

GO:0098794

GO:0098978

GO:0140014

GO:1900026

GO:1901381

GO:1902396

GO:1905000

GO:1905031

GO:2000179

GO:2001046

GO:2001224

HMNXSV003030321

Hs.195464.1.A1_3p_a_at

ILMN_1687335

PH_hs_0011552

TC0X001530.hg

X53416_at

Participates

as a component of

p-S2152-FLNA [cytosol] (Homo sapiens)

Other forms of this molecule

FLNA [extracellular region]

FLNA [cytosol]

Inferred To

Homologues of p-S2152-FLNA [cytosol] (Danio rerio)

phospho-Flna [cytosol] (Mus musculus)

phospho-Flna [cytosol] (Rattus norvegicus)

phospho-cher [cytosol] (Drosophila melanogaster)

phospho-p-S2152-FLNA [cytosol] (Sus scrofa)

phospho-flna [cytosol] (Danio rerio)

phospho-FLNA [cytosol] (Canis familiaris)

phospho-fln-1 [cytosol] (Caenorhabditis elegans)

Modified Residues

Name

O-phospho-L-serine at 2152

Coordinate

2152

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001104026.1, NP_001447.2

OpenTargets

ENSG00000196924

HPA

ENSG00000196924-FLNA

GeneCards

P21333

Ensembl

ENSP00000416926, ENSP00000353467, ENSG00000196924, ENST00000369850, ENST00000360319, ENST00000422373, ENSP00000358866

PRO

P21333

Pharos - Targets

P21333

GlyGen

P21333

Orphanet

16058

PDB

2K7Q, 2JF1, 6D8C, 2BRQ, 2K7P, 3HOP, 2K3T, 3RGH, 2MTP, 2BP3, 6EW1, 3CNK, 2WFN, 3HOR, 2J3S, 3HOC, 3ISW, 4P3W, 2AAV, 4M9P, 2W0P, 5XR1

Interactors (28)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05556 ITGB1	2	ITGB1 [endosome membrane] (R-HSA-9611157) ITGB1 [plasma membrane] (R-HSA-57596)	0.819	6
UniProt:P26010 ITGB7	1	ITGB7 [plasma membrane] (R-HSA-3006427)	0.737	7
UniProt:O95067 CCNB2	1	CCNB2 [cytosol] (R-HSA-68897)	0.679	8
UniProt:Q8N264 ARHGAP24	1	ARHGAP24 [cytosol] (R-HSA-2976578)	0.639	6
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.615	3
UniProt:P05106 ITGB3	3	p-T779-ITGB3 [plasma membrane] (R-HSA-432107) ITGB3 [plasma membrane] (R-HSA-57600) ITGB3(27-?) [platelet alpha granule membrane] (R-HSA-114512)	0.611	3
UniProt:P08514-1 ITGA2B			0.611	3
UniProt:Q12948 FOXC1			0.61	8
UniProt:P35372 OPRM1	1	OPRM1 [plasma membrane] (R-HSA-60951)	0.602	5
UniProt:P03372 ESR1	8	Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [cytosol] (R-HSA-9020968) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) PalmS-ESR1 [cytosol] (R-HSA-9020974) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302)	0.597	3
UniProt:Q86SQ0 PHLB2			0.564	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.564	2
UniProt:P26010-1 ITGB7			0.558	2
UniProt:O14786 NRP1	1	NRP1 [plasma membrane] (R-HSA-3008773)	0.558	2
UniProt:P26583 HMGB2	1	HMGB2 [nucleoplasm] (R-HSA-266211)	0.547	2
UniProt:P49286 MTNR1B	1	MTNR1B [plasma membrane] (R-HSA-419349)	0.547	2
UniProt:O75369 FLNB	1	FLNB [cytosol] (R-HSA-354163)	0.543	5
UniProt:Q99759 MAP3K3	1	MAP3K3 [cytosol] (R-HSA-507725)	0.536	2
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.536	3
UniProt:P07228 ITGB1	1	Integrin beta-1 [plasma membrane] (R-GGA-2467444)	0.527	2
UniProt:Q9BYB0 SHANK3	1	SHANK3 [cytosol] (R-HSA-6794277)	0.508	2
UniProt:P49768 PSEN1	6	PSEN1(299-467) [plasma membrane] (R-HSA-2534245) PSEN1(1-298) [azurophil granule membrane] (R-HSA-6799209) PSEN1(1-298) [plasma membrane] (R-HSA-2534298) PSEN1(1-467) [plasma membrane] (R-HSA-201606) PSEN1(299-467) [azurophil granule membrane] (R-HSA-6799234) PSEN1(1-467) [azurophil granule membrane] (R-HSA-6799235)	0.508	2
UniProt:P51114 FXR1	2	p-FXR1-BRAF fusion [cytosol] (R-HSA-6802530) FXR1-BRAF fusion [cytosol] (R-HSA-6802326)	0.508	2
UniProt:P49810 PSEN2	2	PSEN2(1-297) [plasma membrane] (R-HSA-201599) PSEN2(298-448) [plasma membrane] (R-HSA-9013329)	0.508	2
UniProt:Q9WMX2-PRO_0000037548			0.463	6
UniProt:Q9WMX2-PRO_0000037551			0.463	6
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [ChEBI:18348]	6	PI(4,5)P2 [early endosome membrane] (R-ALL-8849966) PI(4,5)P2 [endoplasmic reticulum membrane] (R-ALL-2023856) PI(4,5)P2 [nucleoplasm] (R-ALL-6810412) PI(4,5)P2 [cytoplasmic vesicle membrane] (R-ALL-8874467) PI(4,5)P2 [plasma membrane] (R-ALL-179856) PI(4,5)P2 [Golgi membrane] (R-ALL-1806165)	0.462	2
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate [ChEBI:16851]	7	PI(3,5)P2 [early endosome membrane] (R-ALL-1806205) PI(3,5)P2 [late endosome membrane] (R-ALL-1806289) PI(3,5)P2 [endoplasmic reticulum membrane] (R-ALL-6809774) PI(3,5)P2 [lysosomal membrane] (R-ALL-5334668) PI(3,5)P2 [phagophore assembly site membrane] (R-ALL-5692959) PI(3,5)P2 [plasma membrane] (R-ALL-1806224) PI(3,5)P2 [Golgi membrane] (R-ALL-1806290)	0.462	2

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