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TMED10 [Golgi membrane]
Stable Identifier
R-HSA-6808801
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi membrane
Synonyms
p23
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
COPI vesicle uncoating (Homo sapiens)
ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [Golgi membrane] (Homo sapiens)
TMED2:TMED10 tetramer [Golgi membrane] (Homo sapiens)
TMED10 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [Golgi membrane] (Homo sapiens)
TMED2:TMED10 tetramer [Golgi membrane] (Homo sapiens)
TMED10 [Golgi membrane] (Homo sapiens)
p24 dimers [Golgi membrane] (Homo sapiens)
TMED10 dimer [Golgi membrane] (Homo sapiens)
TMED10 [Golgi membrane] (Homo sapiens)
p24 dimers [Golgi membrane] (Homo sapiens)
TMED10 dimer [Golgi membrane] (Homo sapiens)
TMED10 [Golgi membrane] (Homo sapiens)
Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [Golgi membrane] (Homo sapiens)
TMED2:TMED10 tetramer [Golgi membrane] (Homo sapiens)
TMED10 [Golgi membrane] (Homo sapiens)
p24 dimers [Golgi membrane] (Homo sapiens)
TMED10 dimer [Golgi membrane] (Homo sapiens)
TMED10 [Golgi membrane] (Homo sapiens)
cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [Golgi membrane] (Homo sapiens)
TMED2:TMED10 tetramer [Golgi membrane] (Homo sapiens)
TMED10 [Golgi membrane] (Homo sapiens)
p24 dimers [Golgi membrane] (Homo sapiens)
TMED10 dimer [Golgi membrane] (Homo sapiens)
TMED10 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [Golgi membrane] (Homo sapiens)
TMED2:TMED10 tetramer [Golgi membrane] (Homo sapiens)
TMED10 [Golgi membrane] (Homo sapiens)
p24 dimers [Golgi membrane] (Homo sapiens)
TMED10 dimer [Golgi membrane] (Homo sapiens)
TMED10 [Golgi membrane] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
COPI vesicle uncoating (Homo sapiens)
ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [Golgi membrane] (Homo sapiens)
TMED2:TMED10 tetramer [Golgi membrane] (Homo sapiens)
TMED10 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [Golgi membrane] (Homo sapiens)
TMED2:TMED10 tetramer [Golgi membrane] (Homo sapiens)
TMED10 [Golgi membrane] (Homo sapiens)
p24 dimers [Golgi membrane] (Homo sapiens)
TMED10 dimer [Golgi membrane] (Homo sapiens)
TMED10 [Golgi membrane] (Homo sapiens)
p24 dimers [Golgi membrane] (Homo sapiens)
TMED10 dimer [Golgi membrane] (Homo sapiens)
TMED10 [Golgi membrane] (Homo sapiens)
Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [Golgi membrane] (Homo sapiens)
TMED2:TMED10 tetramer [Golgi membrane] (Homo sapiens)
TMED10 [Golgi membrane] (Homo sapiens)
p24 dimers [Golgi membrane] (Homo sapiens)
TMED10 dimer [Golgi membrane] (Homo sapiens)
TMED10 [Golgi membrane] (Homo sapiens)
cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [Golgi membrane] (Homo sapiens)
TMED2:TMED10 tetramer [Golgi membrane] (Homo sapiens)
TMED10 [Golgi membrane] (Homo sapiens)
p24 dimers [Golgi membrane] (Homo sapiens)
TMED10 dimer [Golgi membrane] (Homo sapiens)
TMED10 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [Golgi membrane] (Homo sapiens)
TMED2:TMED10 tetramer [Golgi membrane] (Homo sapiens)
TMED10 [Golgi membrane] (Homo sapiens)
p24 dimers [Golgi membrane] (Homo sapiens)
TMED10 dimer [Golgi membrane] (Homo sapiens)
TMED10 [Golgi membrane] (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Golgi-to-ER retrograde transport (Homo sapiens)
COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Homo sapiens)
Golgi-to-ER cargo [Golgi membrane] (Homo sapiens)
SURF4:p24 complex [Golgi membrane] (Homo sapiens)
TMED10 dimer [Golgi membrane] (Homo sapiens)
TMED10 [Golgi membrane] (Homo sapiens)
RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo [Golgi membrane] (Homo sapiens)
Golgi-to-ER cargo [Golgi membrane] (Homo sapiens)
SURF4:p24 complex [Golgi membrane] (Homo sapiens)
TMED10 dimer [Golgi membrane] (Homo sapiens)
TMED10 [Golgi membrane] (Homo sapiens)
p24 dimers [Golgi membrane] (Homo sapiens)
TMED10 dimer [Golgi membrane] (Homo sapiens)
TMED10 [Golgi membrane] (Homo sapiens)
p24 dimers [Golgi membrane] (Homo sapiens)
TMED10 dimer [Golgi membrane] (Homo sapiens)
TMED10 [Golgi membrane] (Homo sapiens)
ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Homo sapiens)
RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo [Golgi membrane] (Homo sapiens)
Golgi-to-ER cargo [Golgi membrane] (Homo sapiens)
SURF4:p24 complex [Golgi membrane] (Homo sapiens)
TMED10 dimer [Golgi membrane] (Homo sapiens)
TMED10 [Golgi membrane] (Homo sapiens)
p24 dimers [Golgi membrane] (Homo sapiens)
TMED10 dimer [Golgi membrane] (Homo sapiens)
TMED10 [Golgi membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49755 TMED10
Gene Names
TMED10, TMP21
Chain
signal peptide:1-31, chain:32-219
Reference Genes
BioGPS Gene:10972 TMED10
COSMIC (genes):TMED10 TMED10
CTD Gene:10972 TMED10
dbSNP Gene:10972 TMED10
ENSEMBL:ENSG00000170348 TMED10
ENSEMBL_homo_sapiens_GENE:ENSG00000170348.9 TMED10
HGNC:16998 TMED10
KEGG Gene (Homo sapiens):10972 TMED10
Monarch:10972 TMED10
NCBI Gene:10972 TMED10
OMIM:605406 TMED10
UCSC:P49755 TMED10
Reference Transcript
RefSeq:NM_006827.5 TMED10
Other Identifiers
10972
11715544_a_at
11715545_at
11756630_a_at
11757810_s_at
16794935
200929_PM_at
200929_at
212352_PM_s_at
212352_s_at
3120998
3120999
3572341
3572342
3572343
3572344
3572347
3572348
3572350
3572351
3572352
3572353
3572354
35754_at
36128_at
7980296
A_23_P14537
A_24_P917833
GE57759
GE57761
GO:0000139
GO:0005215
GO:0005515
GO:0005783
GO:0005789
GO:0005793
GO:0005794
GO:0005801
GO:0005886
GO:0006886
GO:0006888
GO:0006890
GO:0007030
GO:0008320
GO:0012507
GO:0015031
GO:0016020
GO:0016192
GO:0019905
GO:0030133
GO:0030134
GO:0030137
GO:0030140
GO:0030658
GO:0030667
GO:0031410
GO:0032732
GO:0033116
GO:0035459
GO:0035964
GO:0042470
GO:0042589
GO:0043226
GO:0045055
GO:0048199
GO:0048205
GO:0048208
GO:0050714
GO:0055085
GO:0061024
GO:0065003
GO:0070765
GO:0071806
GO:0106272
GO:0106273
GO:1902003
HMNXSV003052665
Hs.74137.2.S1_3p_a_at
ILMN_1736585
L40391_at
L40397_at
PH_hs_0033498
TC14001318.hg
U61734_s_at
g5803200_3p_at
Participates
as a component of
TMED2:TMED10 tetramer [Golgi membrane] (Homo sapiens)
TMED10 dimer [Golgi membrane] (Homo sapiens)
Other forms of this molecule
TMED10 [ER to Golgi transport vesicle membrane]
TMED10 [endoplasmic reticulum membrane]
TMED10 [endoplasmic reticulum-Golgi intermediate compartment membrane]
TMED10 [transport vesicle]
Inferred To
ERV25 [Golgi membrane]
(Saccharomyces cerevisiae)
erv25 [Golgi membrane]
(Schizosaccharomyces pombe)
bai [Golgi membrane]
(Drosophila melanogaster)
tmed-10 [Golgi membrane]
(Caenorhabditis elegans)
tmed10 [Golgi membrane]
(Xenopus tropicalis)
TMED10 [Golgi membrane]
(Bos taurus)
TMED10 [Golgi membrane]
(Canis familiaris)
TMED10 [Golgi membrane]
(Gallus gallus)
TMED10 [Golgi membrane]
(Sus scrofa)
Tmed10 [Golgi membrane]
(Mus musculus)
Tmed10 [Golgi membrane]
(Rattus norvegicus)
empD [Golgi membrane]
(Dictyostelium discoideum)
TMP21 [Golgi membrane]
(Danio rerio)
Cross References
RefSeq
NP_006818.3
OpenTargets
ENSG00000170348
HPA
ENSG00000170348-TMED10
GeneCards
P49755
Ensembl
ENST00000303575
,
ENSP00000303145
,
ENSG00000170348
PRO
P49755
Pharos - Targets
P49755
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15363 TMED2
5
TMED2 [ER to Golgi transport vesicle membrane]
(R-HSA-5689847)
TMED2 [endoplasmic reticulum membrane]
(R-HSA-5689480)
TMED2 [transport vesicle]
(R-HSA-6808806)
TMED2 [Golgi membrane]
(R-HSA-6808804)
TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-1911531)
0.832
7
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
10
UniProt:P04618 rev
3
REV (P04618) protein [extracellular region]
(R-HIV-174998)
REV (P04618) protein [nucleoplasm]
(R-HIV-175380)
REV (P04618) protein [cytosol]
(R-HIV-173267)
0.462
2
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