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PTGES3 [nucleoplasm]
Stable Identifier
R-HSA-5082403
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Prostaglandin E synthase 3, cPGES
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to heat stress (Homo sapiens)
HSF1 activation (Homo sapiens)
Dissociation of HSF1:HSP90 complex in the nucleus (Homo sapiens)
HSF1:HSP90:PTGES3 [nucleoplasm] (Homo sapiens)
PTGES3 [nucleoplasm] (Homo sapiens)
PTGES3 [nucleoplasm] (Homo sapiens)
HSF1-dependent transactivation (Homo sapiens)
Attenuation phase (Homo sapiens)
HSP90:FKBP4:PTGES3 binds HSF1 trimer (Homo sapiens)
HSF1 trimer:HSP90:FKBP4:PTGES3 [nucleoplasm] (Homo sapiens)
PTGES3 [nucleoplasm] (Homo sapiens)
HSP90:FKBP4:PTGES3 [nucleoplasm] (Homo sapiens)
PTGES3 [nucleoplasm] (Homo sapiens)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Homo sapiens)
ATP hydrolysis by HSP90 (Homo sapiens)
HSP90 complexes [nucleoplasm] (Homo sapiens)
HSP90:ATP:PTGES3:FKBP52:AR:Androgens [nucleoplasm] (Homo sapiens)
PTGES3 [nucleoplasm] (Homo sapiens)
HSP90:ATP:PTGES3:FKBP52:NR3C1:NR3C1 ligands [nucleoplasm] (Homo sapiens)
PTGES3 [nucleoplasm] (Homo sapiens)
HSP90:ATP:PTGES3:FKBP52:NR3C2:NR3C2 ligands [nucleoplasm] (Homo sapiens)
PTGES3 [nucleoplasm] (Homo sapiens)
HSP90:ATP:PTGES3:FKBP52:PGR:P4 [nucleoplasm] (Homo sapiens)
PTGES3 [nucleoplasm] (Homo sapiens)
PTGES3 [nucleoplasm] (Homo sapiens)
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Homo sapiens)
HSP90:ATP:PTGES3:FKBP52:AR:Androgens [nucleoplasm] (Homo sapiens)
PTGES3 [nucleoplasm] (Homo sapiens)
HSP90:ATP:PTGES3:FKBP52:NR3C1:NR3C1 ligands [nucleoplasm] (Homo sapiens)
PTGES3 [nucleoplasm] (Homo sapiens)
HSP90:ATP:PTGES3:FKBP52:NR3C2:NR3C2 ligands [nucleoplasm] (Homo sapiens)
PTGES3 [nucleoplasm] (Homo sapiens)
HSP90:ATP:PTGES3:FKBP52:PGR:P4 [nucleoplasm] (Homo sapiens)
PTGES3 [nucleoplasm] (Homo sapiens)
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
Aryl hydrocarbon receptor signalling (Homo sapiens)
AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Homo sapiens)
2xHSP90AB1:AIP:PTGES3 [nucleoplasm] (Homo sapiens)
PTGES3 [nucleoplasm] (Homo sapiens)
AHR:TCDD:2xHSP90AB1:AIP:PTGES3 [nucleoplasm] (Homo sapiens)
AHR:2xHSP90AB1:AIP:PTGES3 [nucleoplasm] (Homo sapiens)
PTGES3 [nucleoplasm] (Homo sapiens)
AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Homo sapiens)
AHR:TCDD:2xHSP90AB1:AIP:PTGES3 [nucleoplasm] (Homo sapiens)
AHR:2xHSP90AB1:AIP:PTGES3 [nucleoplasm] (Homo sapiens)
PTGES3 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
ESR1 binds ESR1 agonists (Homo sapiens)
ESR1:ESR1 agonists [nucleoplasm] (Homo sapiens)
ESR1:chaperone complex [nucleoplasm] (Homo sapiens)
PTGES3 [nucleoplasm] (Homo sapiens)
ESR1:chaperone complex [nucleoplasm] (Homo sapiens)
PTGES3 [nucleoplasm] (Homo sapiens)
ESR1 binds ESR1 antagonists (Homo sapiens)
ESR1:ESR1 antagonists [nucleoplasm] (Homo sapiens)
ESR1:chaperone complex [nucleoplasm] (Homo sapiens)
PTGES3 [nucleoplasm] (Homo sapiens)
ESR1:chaperone complex [nucleoplasm] (Homo sapiens)
PTGES3 [nucleoplasm] (Homo sapiens)
ESTG binds ESR1:chaperone complex (Homo sapiens)
ESR1:chaperone complex [nucleoplasm] (Homo sapiens)
PTGES3 [nucleoplasm] (Homo sapiens)
ESTG:ESR1:chaperone complex [nucleoplasm] (Homo sapiens)
ESR1:chaperone complex [nucleoplasm] (Homo sapiens)
PTGES3 [nucleoplasm] (Homo sapiens)
ESTG binds ESR2:chaperone complex (Homo sapiens)
ESR2:chaperone complex [nucleoplasm] (Homo sapiens)
PTGES3 [nucleoplasm] (Homo sapiens)
ESTG:ESR2:chaperone complex [nucleoplasm] (Homo sapiens)
ESR2:chaperone complex [nucleoplasm] (Homo sapiens)
PTGES3 [nucleoplasm] (Homo sapiens)
Estrogen-dependent gene expression (Homo sapiens)
Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Homo sapiens)
HSP90:ATP:PTGES3:FKBP52:PGR:P4 [nucleoplasm] (Homo sapiens)
PTGES3 [nucleoplasm] (Homo sapiens)
PTGES3 [nucleoplasm] (Homo sapiens)
Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 (Homo sapiens)
ESR1:chaperone complex [nucleoplasm] (Homo sapiens)
PTGES3 [nucleoplasm] (Homo sapiens)
PTGES3 [nucleoplasm] (Homo sapiens)
HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex (Homo sapiens)
ESR:ESTG:chaperone complex [nucleoplasm] (Homo sapiens)
ESTG:ESR1:chaperone complex [nucleoplasm] (Homo sapiens)
ESR1:chaperone complex [nucleoplasm] (Homo sapiens)
PTGES3 [nucleoplasm] (Homo sapiens)
ESTG:ESR2:chaperone complex [nucleoplasm] (Homo sapiens)
ESR2:chaperone complex [nucleoplasm] (Homo sapiens)
PTGES3 [nucleoplasm] (Homo sapiens)
PTGES3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15185 PTGES3
Gene Names
PTGES3, P23, TEBP
Chain
chain:1-160
Reference Genes
BioGPS Gene:10728 PTGES3
COSMIC (genes):PTGES3 PTGES3
CTD Gene:10728 PTGES3
dbSNP Gene:10728 PTGES3
ENSEMBL:ENSG00000110958 PTGES3
HGNC:16049 PTGES3
KEGG Gene (Homo sapiens):10728 PTGES3
Monarch:10728 PTGES3
NCBI Gene:10728 PTGES3
OMIM:607061 PTGES3
UCSC:Q15185 PTGES3
Reference Transcript
RefSeq:NM_006601.6 PTGES3
RefSeq:NM_001282603.1 PTGES3
RefSeq:NM_001282605.1 PTGES3
RefSeq:NM_001282602.1 PTGES3
RefSeq:NM_001282604.1 PTGES3
RefSeq:NM_001282601.1 PTGES3
Other Identifiers
0000450193
10728
11743372_s_at
11747662_x_at
11751818_x_at
11753366_x_at
16766283
200627_PM_at
200627_at
2421920
2421921
2473546
2793347
3163060
32548_at
3458058
3458059
3458060
3458061
3458065
3458070
3458073
3458076
3458078
3458092
7964250
GE79257
GO:0000723
GO:0000781
GO:0001516
GO:0003674
GO:0003720
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005697
GO:0005737
GO:0005829
GO:0005975
GO:0005978
GO:0006091
GO:0006259
GO:0006457
GO:0006629
GO:0006631
GO:0006633
GO:0006693
GO:0007004
GO:0007165
GO:0008150
GO:0008283
GO:0009058
GO:0016779
GO:0016853
GO:0019371
GO:0019899
GO:0022607
GO:0022618
GO:0032991
GO:0034641
GO:0042327
GO:0042921
GO:0043226
GO:0043588
GO:0044281
GO:0048856
GO:0050220
GO:0050821
GO:0051082
GO:0051085
GO:0051087
GO:0051131
GO:0051276
GO:0051879
GO:0051973
GO:0060430
GO:0065003
GO:0070182
GO:0101031
GO:1905323
HMNXSV003016817
HMNXSV003057078
ILMN_1667916
ILMN_1719749
ILMN_1752566
L24804_at
TC12001612.hg
TC12002910.hg
g12804292_3p_at
g12804292_3p_x_at
Participates
as an output of
Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Homo sapiens)
Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 (Homo sapiens)
ATP hydrolysis by HSP90 (Homo sapiens)
Dissociation of HSF1:HSP90 complex in the nucleus (Homo sapiens)
HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex (Homo sapiens)
as a component of
2xHSP90AB1:AIP:PTGES3 [nucleoplasm] (Homo sapiens)
AHR:2xHSP90AB1:AIP:PTGES3 [nucleoplasm] (Homo sapiens)
HSP90:ATP:PTGES3:FKBP52:NR3C2:NR3C2 ligands [nucleoplasm] (Homo sapiens)
HSP90:ATP:PTGES3:FKBP52:NR3C1:NR3C1 ligands [nucleoplasm] (Homo sapiens)
HSP90:ATP:PTGES3:FKBP52:AR:Androgens [nucleoplasm] (Homo sapiens)
HSP90:ATP:PTGES3:FKBP52:PGR:P4 [nucleoplasm] (Homo sapiens)
HSF1:HSP90:PTGES3 [nucleoplasm] (Homo sapiens)
HSF1 trimer:HSP90:FKBP4:PTGES3 [nucleoplasm] (Homo sapiens)
HSP90:FKBP4:PTGES3 [nucleoplasm] (Homo sapiens)
ESR1:chaperone complex [nucleoplasm] (Homo sapiens)
ESR2:chaperone complex [nucleoplasm] (Homo sapiens)
Other forms of this molecule
PTGES3 [cytosol]
Inferred To
ptges3a [nucleoplasm]
(Danio rerio)
Ghost homologue of PTGES3 [nucleoplasm]
(Canis familiaris)
wos2 [nucleoplasm]
(Schizosaccharomyces pombe)
PTGES3 [nucleoplasm]
(Bos taurus)
PTGES3 [nucleoplasm]
(Dictyostelium discoideum)
PTGES3 [nucleoplasm]
(Drosophila melanogaster)
PTGES3 [nucleoplasm]
(Gallus gallus)
PTGES3 [nucleoplasm]
(Plasmodium falciparum)
PTGES3 [nucleoplasm]
(Sus scrofa)
Ptges3 [nucleoplasm]
(Mus musculus)
Ptges3 [nucleoplasm]
(Rattus norvegicus)
SBA1 [nucleoplasm]
(Saccharomyces cerevisiae)
daf-41 [nucleoplasm]
(Caenorhabditis elegans)
ptges3 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001269534.1
,
NP_001269530.1
,
NP_001269533.1
,
NP_001269532.1
,
NP_001269531.1
,
NP_006592.3
Guide to Pharmacology - Targets
1379
OpenTargets
ENSG00000110958
HPA
ENSG00000110958-PTGES3
GeneCards
Q15185
Ensembl
ENST00000436399
,
ENST00000414274
,
ENSP00000402385
,
ENSP00000414892
,
ENSP00000262033
,
ENST00000262033
,
ENST00000448157
,
ENSP00000405299
,
ENSG00000110958
PRO
Q15185
Pharos - Targets
Q15185
PDB
7L7I
,
7L7J
,
1EJF
HMDB Protein
HMDBP10674
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P07900 HSP90AA1
8
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
0.756
6
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.744
4
UniProt:Q9NRG4 SMYD2
1
SMYD2 [nucleoplasm]
(R-HSA-3222233)
0.564
2
UniProt:P53041 PPP5C
2
PPP5C [nucleoplasm]
(R-HSA-5683410)
PPP5C [cytosol]
(R-HSA-5675402)
0.527
2
UniProt:Q9Y463 DYR1B
0.527
2
UniProt:O14654 IRS4
2
p-Y-IRS4 [plasma membrane]
(R-HSA-2424302)
IRS4 [plasma membrane]
(R-HSA-2424297)
0.499
2
UniProt:Q9UKV8 AGO2
2
EIF2C2 [nucleoplasm]
(R-HSA-5578701)
AGO2 [cytosol]
(R-HSA-209723)
0.499
3
UniProt:P05919 vpu
6
VPU (P05919) protein [extracellular region]
(R-HIV-175522)
VPU (P05919) protein [cytosol]
(R-HIV-173223)
VPU (P05919) protein [nucleoplasm]
(R-HIV-175200)
VPU (P05919) [endoplasmic reticulum membrane]
(R-HIV-180550)
VPU (P05919) [Golgi membrane]
(R-HIV-3149439)
VPU (P05919) [plasma membrane]
(R-HIV-3149423)
0.462
2
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