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What is Reactome ?
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Team
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Our Logo
License Agreement
Privacy Notice
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Table of Contents
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JUP [cytosol]
Stable Identifier
R-HSA-201598
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Junction plakoglobin
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 binds effectors at the plasma membrane (Homo sapiens)
CDC42 effectors [cytosol] (Homo sapiens)
JUP [cytosol] (Homo sapiens)
CDC42:GTP:CDC42 effectors [plasma membrane] (Homo sapiens)
CDC42 effectors [cytosol] (Homo sapiens)
JUP [cytosol] (Homo sapiens)
RHOA GTPase cycle (Homo sapiens)
RHOA binds effectors at the plasma membrane (Homo sapiens)
RHOA plasma membrane effectors [cytosol] (Homo sapiens)
JUP [cytosol] (Homo sapiens)
RHOA:GTP:cytosolic RHOA effectors [plasma membrane] (Homo sapiens)
RHOA plasma membrane effectors [cytosol] (Homo sapiens)
JUP [cytosol] (Homo sapiens)
RHOB GTPase cycle (Homo sapiens)
RHOB binds effectors at the plasma membrane (Homo sapiens)
RHOB effectors (plasma membrane) [cytosol] (Homo sapiens)
JUP [cytosol] (Homo sapiens)
RHOB:GTP:cytosolic RHOB effectors [plasma membrane] (Homo sapiens)
RHOB effectors (plasma membrane) [cytosol] (Homo sapiens)
JUP [cytosol] (Homo sapiens)
RHOC GTPase cycle (Homo sapiens)
RHOC binds effectors at the plasma membrane (Homo sapiens)
RHOC effectors [cytosol] (Homo sapiens)
JUP [cytosol] (Homo sapiens)
RHOC:GTP:RHOC effectors [plasma membrane] (Homo sapiens)
RHOC effectors [cytosol] (Homo sapiens)
JUP [cytosol] (Homo sapiens)
RHOH GTPase cycle (Homo sapiens)
RHOH binds effectors at the plasma membrane (Homo sapiens)
RHOH effectors [cytosol] (Homo sapiens)
JUP [cytosol] (Homo sapiens)
RHOH:GTP:RHOH effectors [plasma membrane] (Homo sapiens)
RHOH effectors [cytosol] (Homo sapiens)
JUP [cytosol] (Homo sapiens)
RHOJ GTPase cycle (Homo sapiens)
RHOJ binds effectors at the plasma membrane (Homo sapiens)
RHOJ effectors [cytosol] (Homo sapiens)
JUP [cytosol] (Homo sapiens)
RHOJ:GTP:RHOJ effectors [plasma membrane] (Homo sapiens)
RHOJ effectors [cytosol] (Homo sapiens)
JUP [cytosol] (Homo sapiens)
RHOQ GTPase cycle (Homo sapiens)
RHOQ binds effectors at the plasma membrane (Homo sapiens)
RHOQ effectors [cytosol] (Homo sapiens)
JUP [cytosol] (Homo sapiens)
RHOQ:GTP:RHOQ effectors [plasma membrane] (Homo sapiens)
RHOQ effectors [cytosol] (Homo sapiens)
JUP [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P14923 JUP
Gene Names
JUP, CTNNG, DP3
Chain
chain:1-745
Reference Genes
BioGPS Gene:3728 JUP
COSMIC (genes):JUP JUP
CTD Gene:3728 JUP
dbSNP Gene:3728 JUP
ENSEMBL:ENSG00000173801 JUP
HGNC:6207 JUP
KEGG Gene (Homo sapiens):3728 JUP
Monarch:3728 JUP
NCBI Gene:3728 JUP
OMIM:173325 JUP
UCSC:P14923 JUP
Reference Transcript
RefSeq:XM_011524756.1 JUP
RefSeq:NM_002230.2 JUP
RefSeq:XM_006721875.1 JUP
RefSeq:XM_006721874.2 JUP
RefSeq:XM_017024590.1 JUP
RefSeq:XM_011524755.1 JUP
RefSeq:NM_021991.2 JUP
RefSeq:XM_006721878.1 JUP
RefSeq:XM_011524757.2 JUP
RefSeq:XM_006721873.2 JUP
RefSeq:XM_011524753.2 JUP
RefSeq:XM_011524758.1 JUP
Other Identifiers
0004560338
0006450064
11716343_a_at
16844872
201015_s_at
2047_s_at
3728
3757331
3757332
3757333
3757334
3757335
3757336
3757337
3757338
3757339
3757341
3757343
3757344
3757346
3757348
3757349
3757351
3757352
3757353
3757354
3757355
3757356
3757357
3757358
3757359
3757361
3757366
3757370
3757371
8015412
A_23_P501822
GE60426
GO:0001533
GO:0001954
GO:0002159
GO:0002376
GO:0003013
GO:0003674
GO:0003713
GO:0005198
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005737
GO:0005829
GO:0005856
GO:0005882
GO:0005886
GO:0005911
GO:0005912
GO:0005915
GO:0005916
GO:0005925
GO:0006810
GO:0006913
GO:0007155
GO:0007165
GO:0007267
GO:0008134
GO:0008150
GO:0008219
GO:0008283
GO:0009058
GO:0009898
GO:0014704
GO:0015031
GO:0015629
GO:0016020
GO:0016192
GO:0016327
GO:0016328
GO:0016342
GO:0016477
GO:0019899
GO:0019901
GO:0019903
GO:0022607
GO:0030018
GO:0030054
GO:0030057
GO:0030154
GO:0030674
GO:0031410
GO:0031424
GO:0032991
GO:0032993
GO:0034330
GO:0034332
GO:0034641
GO:0035257
GO:0035580
GO:0040011
GO:0042127
GO:0042307
GO:0042803
GO:0043226
GO:0043312
GO:0043537
GO:0043588
GO:0044877
GO:0045294
GO:0045296
GO:0045766
GO:0045944
GO:0048646
GO:0048856
GO:0048870
GO:0050839
GO:0050982
GO:0051091
GO:0070062
GO:0070268
GO:0071603
GO:0071665
GO:0071681
GO:0072659
GO:0086073
GO:0086083
GO:0086091
GO:0090263
GO:0098609
GO:0098911
GO:0106006
GO:1904813
HMNXSV003035004
ILMN_1733811
ILMN_1741970
ILMN_2366864
PH_hs_0000315
TC17002907.hg
Z68228_s_at
g12056467_3p_a_at
Participates
as a candidate of
CDC42 effectors [cytosol] (Homo sapiens)
RHOA plasma membrane effectors [cytosol] (Homo sapiens)
RHOB effectors (plasma membrane) [cytosol] (Homo sapiens)
RHOC effectors [cytosol] (Homo sapiens)
RHOH effectors [cytosol] (Homo sapiens)
RHOJ effectors [cytosol] (Homo sapiens)
RHOQ effectors [cytosol] (Homo sapiens)
Other forms of this molecule
JUP [cornified envelope]
JUP [specific granule lumen]
JUP [extracellular region]
JUP [ficolin-1-rich granule lumen]
JUP [plasma membrane]
Inferred To
JUP [cytosol]
(Canis familiaris)
JUP [cytosol]
(Gallus gallus)
JUP [cytosol]
(Sus scrofa)
Jup [cytosol]
(Mus musculus)
Jup [cytosol]
(Rattus norvegicus)
jupa [cytosol]
(Danio rerio)
wrm-1 [cytosol]
(Caenorhabditis elegans)
arm [cytosol]
(Drosophila melanogaster)
Homologues of JUP [cytosol]
(Caenorhabditis elegans)
bar-1 [cytosol]
(Caenorhabditis elegans)
hmp-2 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
XP_006721937.1
,
XP_006721938.1
,
XP_006721936.1
,
NP_002221.1
,
XP_011523060.1
,
XP_011523055.1
,
XP_011523058.1
,
XP_006721941.1
,
XP_011523057.1
,
XP_011523059.1
,
XP_016880079.1
,
NP_068831.1
OpenTargets
ENSG00000173801
GeneCards
P14923
HPA
ENSG00000173801-JUP
Ensembl
ENSP00000377507
,
ENSP00000311113
,
ENSP00000377508
,
ENSG00000173801
,
ENST00000393931
,
ENST00000310706
,
ENST00000393930
PRO
P14923
Orphanet
16283
PDB
3IFQ
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14192 FHL2
1
FHL2 [nucleoplasm]
(R-HSA-561161)
0.781
7
UniProt:Q9NSA3 CTNNBIP1
1
CTNNBIP1 [nucleoplasm]
(R-HSA-3772388)
0.749
5
UniProt:O15169 AXIN1
11
AXIN1 Y346* [cytosol]
(R-HSA-4839753)
AXIN1 L396M [cytosol]
(R-HSA-5251503)
AXIN1 E406* [cytosol]
(R-HSA-5251500)
AXIN1 W247* [cytosol]
(R-HSA-5251512)
AXIN1 P354L [cytosol]
(R-HSA-5251511)
AXIN1 P255S [cytosol]
(R-HSA-5251505)
ub-AXIN1 [cytosol]
(R-HSA-4641133)
AXIN1 [cytosol]
(R-HSA-195249)
p-T519,S524,S531-AXIN1 [cytosol]
(R-HSA-206040)
RibC-AXIN1 [cytosol]
(R-HSA-3640841)
Ub-RibC-AXIN1 [cytosol]
(R-HSA-3640864)
0.666
4
UniProt:P25054 APC
86
APC C1410* [cytosol]
(R-HSA-9666925)
APC R213* [cytosol]
(R-HSA-9666924)
APC K1310* [cytosol]
(R-HSA-9666926)
APC R499* [cytosol]
(R-HSA-9666927)
APC R1450* [cytosol]
(R-HSA-5251499)
APC G1357* [cytosol]
(R-HSA-9666940)
APC L1488* [cytosol]
(R-HSA-9666941)
APC S1400* [cytosol]
(R-HSA-9666942)
APC S1346* [cytosol]
(R-HSA-9666943)
APC R405* [cytosol]
(R-HSA-9666936)
APC S1281* [cytosol]
(R-HSA-9666937)
APC E1573* [cytosol]
(R-HSA-9666938)
APC R805* [cytosol]
(R-HSA-9666939)
APC R1386* [cytosol]
(R-HSA-9666932)
APC S1327* [cytosol]
(R-HSA-9666933)
APC E1209* [cytosol]
(R-HSA-9666934)
APC Q1469* [cytosol]
(R-HSA-9666935)
APC R564* [cytosol]
(R-HSA-9666928)
APC E1536* [cytosol]
(R-HSA-9666929)
APC G1288* [cytosol]
(R-HSA-9666930)
APC G1312* [cytosol]
(R-HSA-9666931)
APC R283* [cytosol]
(R-HSA-9666988)
APC Q1367* [cytosol]
(R-HSA-9666989)
APC E1353* [cytosol]
(R-HSA-9666990)
APC R332* [cytosol]
(R-HSA-9666991)
APC K993* [cytosol]
(R-HSA-9666984)
APC R876* [cytosol]
(R-HSA-9666985)
APC R302* [cytosol]
(R-HSA-9666986)
APC E1309* [cytosol]
(R-HSA-9666987)
APC Y935* [cytosol]
(R-HSA-9666980)
APC E1286* [cytosol]
(R-HSA-9666981)
APC Q1378* [cytosol]
(R-HSA-9666982)
APC R554* [cytosol]
(R-HSA-9666983)
APC S1356* [cytosol]
(R-HSA-9666976)
APC R232* [cytosol]
(R-HSA-9666977)
APC E1379* [cytosol]
(R-HSA-9666978)
APC E984* [cytosol]
(R-HSA-9666979)
APC R1114* [cytosol]
(R-HSA-9666996)
APC S1282* [cytosol]
(R-HSA-9666997)
APC Q1328* [cytosol]
(R-HSA-9666998)
APC E1295* [cytosol]
(R-HSA-9666992)
APC E1151* [cytosol]
(R-HSA-9666993)
APC E1322* [cytosol]
(R-HSA-9666994)
APC E1345* [cytosol]
(R-HSA-9666995)
APC K1308* [cytosol]
(R-HSA-9666956)
APC S1344* [cytosol]
(R-HSA-9666957)
APC E1577* [cytosol]
(R-HSA-9666958)
APC Q1127* [cytosol]
(R-HSA-9666959)
APC E1464* [cytosol]
(R-HSA-9666952)
APC E1317* [cytosol]
(R-HSA-9666953)
APC G1309Dfs*4 [cytosol]
(R-HSA-4791251)
APC W1049* [cytosol]
(R-HSA-9666954)
APC Q1429* [cytosol]
(R-HSA-9666955)
APC L1564* [cytosol]
(R-HSA-9666948)
APC Q1294* [cytosol]
(R-HSA-9666949)
APC K1363* [cytosol]
(R-HSA-9666950)
APC E1408* [cytosol]
(R-HSA-9666951)
APC E1284* [cytosol]
(R-HSA-9666944)
APC E1374* [cytosol]
(R-HSA-9666945)
APC Q767* [cytosol]
(R-HSA-9666946)
APC E941* [cytosol]
(R-HSA-9666947)
APC Q1303* [cytosol]
(R-HSA-9666972)
APC S943* [cytosol]
(R-HSA-9666973)
APC E1306* [cytosol]
(R-HSA-9666975)
APC S895* [cytosol]
(R-HSA-9666969)
APC S1315* [cytosol]
(R-HSA-9666970)
APC G1412* [cytosol]
(R-HSA-9666971)
APC Y1376* [cytosol]
(R-HSA-9666964)
APC Q886* [cytosol]
(R-HSA-9666965)
APC S1392* [cytosol]
(R-HSA-9666966)
APC S1539* [cytosol]
(R-HSA-9666967)
APC E1451* [cytosol]
(R-HSA-9666960)
APC E1397* [cytosol]
(R-HSA-9666961)
APC Q1406* [cytosol]
(R-HSA-9666962)
APC E1544* [cytosol]
(R-HSA-9666963)
APC F1197* [cytosol]
(R-HSA-5246655)
APC Q1338* [cytosol]
(R-HSA-5246654)
APC S811* [cytosol]
(R-HSA-5246652)
APC I1417 fs*2 [cytosol]
(R-HSA-5246651)
APC E1554* [cytosol]
(R-HSA-5246648)
p-ub-APC [cytosol]
(R-HSA-3009421)
K63polyUb-APC [cytosol]
(R-HSA-5246690)
APC [nucleoplasm]
(R-HSA-3361755)
APC(1-777) [cytosol]
(R-HSA-2976014)
APC(778-2843) [cytosol]
(R-HSA-2976013)
APC [cytosol]
(R-HSA-2976015)
0.64
3
UniProt:P35222 CTNNB1
33
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
Ub-K,p-Y-CTNNB1 [cytosol]
(R-HSA-8877006)
p-Y-CTNNB1 [cytosol]
(R-HSA-8876940)
p-S552-CTNNB1 [nucleoplasm]
(R-HSA-3134926)
p-S552-CTNNB1 [cytosol]
(R-HSA-3134933)
CTNNB1 [plasma membrane]
(R-HSA-9038440)
p-S45 CTNNB1 [cytosol]
(R-HSA-8942363)
p-T41,S45 CTNNB1 [cytosol]
(R-HSA-8942367)
p-S37,T41,S45, CTNNB1 [cytosol]
(R-HSA-8942369)
p-S33,S37,T41,S45 CTNNB1 [cytosol]
(R-HSA-8942374)
CTNNB1(116-376) [cytosol]
(R-HSA-202950)
CTNNB1(1-115) [cytosol]
(R-HSA-202930)
CTNNB1 [cytosol]
(R-HSA-448839)
CTNNB1 [nucleoplasm]
(R-HSA-3451168)
0.615
3
UniProt:P16284 PECAM1
4
p-Y663,Y686-PECAM1(27-?) [plasma membrane]
(R-HSA-210007)
PECAM1 [plasma membrane]
(R-HSA-114686)
PECAM1 [secretory granule membrane]
(R-HSA-6804778)
PECAM1 [platelet alpha granule membrane]
(R-HSA-61489)
0.61
7
UniProt:P15924 DSP
4
DSP [ficolin-1-rich granule membrane]
(R-HSA-6801396)
DSP [cornified envelope]
(R-HSA-8847736)
DSP(?-?) [plasma membrane]
(R-HSA-351843)
DSP [plasma membrane]
(R-HSA-201580)
0.573
3
UniProt:P00533 EGFR
59
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
EGFR [endosome membrane]
(R-HSA-9611160)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.553
2
UniProt:P35221 CTNNA1
2
CTNNA1 [plasma membrane]
(R-HSA-191735)
CTNNA1 [cytosol]
(R-HSA-191697)
0.519
2
UniProt:P03372 ESR1
8
SUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.462
2
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