Reactome | GLS [mitochondrial matrix]

GLS [mitochondrial matrix]

Stable Identifier

R-HSA-70607

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

glutaminase, Glutaminase, kidney isoform, mitochondrial precursor

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Metabolic Genes (Homo sapiens)
        
        glutamine + H2O => glutamate + NH4+ (GLS) (Homo sapiens)
        
        GLS dimers [mitochondrial matrix] (Homo sapiens)
        
        GLS dimer [mitochondrial matrix] (Homo sapiens)
        
        GLS [mitochondrial matrix] (Homo sapiens)

External Reference Information

External Reference

UniProt:O94925 GLS

Gene Names

GLS, GLS1, KIAA0838

Chain

transit peptide:1-54, chain:55-669, chain:73-669

Reference Genes

BioGPS Gene:2744 GLS

COSMIC (genes):GLS GLS

CTD Gene:2744 GLS

dbSNP Gene:2744 GLS

ENSEMBL:ENSG00000115419 GLS

HGNC:4331 GLS

KEGG:hsa:2744 GLS

Monarch:2744 GLS

NCBI Gene:2744 GLS

OMIM:138280 GLS

UCSC:O94925 GLS

Reference Transcript

Other Identifiers

11743151_a_at

11748367_a_at

11759440_at

11760037_a_at

11760038_a_at

11760989_at

11763320_x_at

11763693_a_at

11763694_a_at

16888865

203157_PM_s_at

203157_s_at

203158_PM_s_at

203158_s_at

203159_PM_at

203159_at

211414_PM_at

211414_at

221510_3p_s_at

221510_PM_s_at

221510_s_at

223079_PM_s_at

223079_s_at

244796_PM_at

244796_at

2520292

2520293

2520294

2520295

2520296

2520297

2520298

2520304

2520305

2520306

2520307

2520308

2520309

2520311

2520313

2520316

2520317

2520318

2520319

2520320

2520324

2520325

2520326

2520327

2520328

2520329

2520330

2520332

2520333

2520334

2520335

2520337

2520338

2520341

2520342

2520343

2520344

2520345

2520346

2520347

2520348

2520349

2520350

2520351

2520361

2520363

2520364

2520370

2520371

2520373

2744

34719_at

43839_f_at

54799_at

57270_f_at

65484_f_at

8047097

A_23_P308800

A_23_P39766

A_33_P3267356

A_33_P3379916

GE529409

GE62298

GE63024

GE712340

GO:0001967

GO:0002087

GO:0003824

GO:0004359

GO:0005515

GO:0005737

GO:0005739

GO:0005759

GO:0005829

GO:0006520

GO:0006537

GO:0006541

GO:0006543

GO:0007268

GO:0016787

GO:0023052

GO:0043226

GO:0045202

GO:0050877

GO:0051289

GO:0065003

GO:0090461

HMNXSV003013323

HMNXSV003015315

HMNXSV003049315

Hs.239189.1.S1_3p_a_at

Hs.297425.0.A1_3p_at

ILMN_2188722

PH_hs_0022414

PH_hs_0039225

RNA147301|p0405_imsncRNA820

g4240164_3p_a_at

g5690371_3p_a_at

g5690371_3p_x_at

g6002672_3p_a_at

g6002675_3p_at

g6002675_3p_x_at

g7662327_3p_at

Participates

as a component of

GLS dimer [mitochondrial matrix] (Homo sapiens)

Inferred To

Homologues of GLS [mitochondrial matrix] (Caenorhabditis elegans)

glna-1 [mitochondrial matrix] (Caenorhabditis elegans)

GLS [mitochondrial matrix] (Bos taurus)

GLS [mitochondrial matrix] (Caenorhabditis elegans)

GLS [mitochondrial matrix] (Canis familiaris)

GLS [mitochondrial matrix] (Drosophila melanogaster)

GLS [mitochondrial matrix] (Gallus gallus)

GLS [mitochondrial matrix] (Mus musculus)

GLS [mitochondrial matrix] (Rattus norvegicus)

GLS [mitochondrial matrix] (Sus scrofa)

Cross References

RefSeq

NP_055720.3, NP_001243239.1

Guide to Pharmacology - Targets

2891

OpenTargets

ENSG00000115419

ENSEMBL

ENSP00000340689, ENST00000320717, ENSP00000317379, ENST00000338435

ZINC target

O94925

PRO

O94925

GlyGen

O94925

PDB

3CZD, 8JUB, 5JYP, 6LOX, 8JUE, 6UJG, 6UME, 3VOZ, 3VOY, 3VP3, 3VP1, 5HL1, 8BSK, 5I94, 6UJM, 8SZJ, 6UK6, 7REN, 3UNW, 8BSN, 4O7D, 5FI7, 6UKB, 5FI2, 6ULA, 5WJ6, 7SBN, 6UL9, 7SBM, 5D3O, 5JYO, 6UMD, 8GWR, 6UMF, 6UMC, 3VP4, 3VP2, 3VP0, 5U0J, 5U0I, 5UQE, 8BSL, 3UO9, 8BSM, 8IMB, 8IMA, 5FI6, 7RGG, 6ULJ

IntEnz

3.5.1.2

HPA

ENSG00000115419-GLS

Pharos - Targets

O94925

Orphanet

GLS

HMDB Protein

HMDBP00680

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	5