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KPNB1 [ficolin-1-rich granule lumen]
Stable Identifier
R-HSA-6800978
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
ficolin-1-rich granule lumen
Synonyms
Importin beta-1, Karyopherin beta
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of ficolin-rich granule lumen proteins (Homo sapiens)
Ficolin-rich granule lumen proteins [ficolin-1-rich granule lumen] (Homo sapiens)
KPNB1 [ficolin-1-rich granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14974 KPNB1
Gene Names
KPNB1, NTF97
Chain
chain:1-876
Reference Genes
BioGPS Gene:3837 KPNB1
COSMIC (genes):KPNB1 KPNB1
CTD Gene:3837 KPNB1
dbSNP Gene:3837 KPNB1
ENSEMBL:ENSG00000108424 KPNB1
HGNC:6400 KPNB1
KEGG:hsa:3837 KPNB1
Monarch:3837 KPNB1
NCBI Gene:3837 KPNB1
OMIM:602738 KPNB1
UCSC:Q14974 KPNB1
Reference Transcript
RefSeq:NM_001276453.1 KPNB1
RefSeq:NM_002265.5 KPNB1
Participates
as a member of
Ficolin-rich granule lumen proteins [ficolin-1-rich granule lumen] (Homo sapiens)
Other forms of this molecule
KPNB1 [cytosol]
KPNB1 [nucleoplasm]
KPNB1 [extracellular region]
KPNB1 [specific granule lumen]
Inferred To
KPNB1 [ficolin-1-rich granule lumen]
(Bos taurus)
KPNB1 [ficolin-1-rich granule lumen]
(Canis familiaris)
KPNB1 [ficolin-1-rich granule lumen]
(Gallus gallus)
KPNB1 [ficolin-1-rich granule lumen]
(Plasmodium falciparum)
KPNB1 [ficolin-1-rich granule lumen]
(Sus scrofa)
kap95 [ficolin-1-rich granule lumen]
(Schizosaccharomyces pombe)
kpnb1 [ficolin-1-rich granule lumen]
(Xenopus tropicalis)
Fs(2)Ket [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
Kpnb1 [ficolin-1-rich granule lumen]
(Mus musculus)
Kpnb1 [ficolin-1-rich granule lumen]
(Rattus norvegicus)
KAP95 [ficolin-1-rich granule lumen]
(Saccharomyces cerevisiae)
imb-1 [ficolin-1-rich granule lumen]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001263382.1
,
NP_002256.2
OpenTargets
ENSG00000108424
ENSEMBL
ENST00000290158
,
ENSP00000464042
,
ENST00000535458
,
ENSP00000290158
,
ENST00000583648
,
ENSP00000438964
,
ENST00000540627
,
ENSG00000108424
,
ENSP00000438253
GeneCards
KPNB1
HPA
ENSG00000108424-KPNB1
PRO
Q14974
Pharos - Targets
Q14974
GlyGen
Q14974
HMDB Protein
HMDBP08462
PDB
1QGK
,
6N88
,
3LWW
,
8GCN
,
1F59
,
1O6P
,
3W5K
,
1O6O
,
1IBR
,
2Q5D
,
6N89
,
2QNA
,
1QGR
,
2P8Q
,
1M5N
Interactors (58)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P52292 KPNA2
2
KPNA2 [cytosol]
(R-HSA-205976)
KPNA2 [nucleoplasm]
(R-HSA-206045)
0.935
14
UniProt:P49790 NUP153
1
NUP153 [nucleoplasm]
(R-HSA-157695)
0.821
9
UniProt:O00629 KPNA4
2
KPNA4 [cytosol]
(R-HSA-1176066)
KPNA4 [nucleoplasm]
(R-HSA-1176058)
0.8
6
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.774
24
UniProt:P52294 KPNA1
2
KPNA1 [cytosol]
(R-HSA-180612)
KPNA1 [nucleoplasm]
(R-HSA-188865)
0.759
5
UniProt:Q15398 DLGAP5
1
DLGAP5 [cytosol]
(R-HSA-264452)
0.725
5
UniProt:P62826 RAN
2
RAN [cytosol]
(R-HSA-165540)
RAN [nucleoplasm]
(R-HSA-165528)
0.725
6
UniProt:O60684 KPNA6
2
KPNA6 [nucleoplasm]
(R-HSA-9734665)
KPNA6 [cytosol]
(R-HSA-9734672)
0.688
4
UniProt:O00505 KPNA3
2
KPNA3 [nucleoplasm]
(R-HSA-1176061)
KPNA3 [cytosol]
(R-HSA-1176070)
0.688
4
UniProt:Q2NL82 TSR1
2
TSR1 [nucleoplasm]
(R-HSA-6791574)
TSR1 [cytosol]
(R-HSA-6791570)
0.643
5
UniProt:P18754 RCC1
2
RCC1 [chromosome]
(R-HSA-9668547)
RCC1 [nucleoplasm]
(R-HSA-180690)
0.643
3
UniProt:Q9UKX7 NUP50
1
NUP50 [nucleoplasm]
(R-HSA-157740)
0.643
4
UniProt:P03101 VL1
0.623
2
UniProt:P14907
1
NSP1 [nuclear envelope]
(R-SCE-157713)
0.623
2
UniProt:P51178 PLCD1
1
PLCD1 [plasma membrane]
(R-HSA-2023880)
0.602
4
UniProt:P04620 REV
0.576
3
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.569
11
UniProt:P04626 ERBB2
20
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 Y772_A775dup [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
0.567
14
UniProt:Q9ERU9 Ranbp2
5
Ranbp2 [nuclear envelope]
(R-MMU-4551720)
Ranbp2 [nuclear envelope]
(R-MMU-4551599)
Ranbp2 [nuclear envelope]
(R-MMU-5228524)
Ranbp2 [nuclear envelope]
(R-MMU-2993756)
Ranbp2 [cytosol]
(R-MMU-157703)
0.564
2
UniProt:P63279 UBE2I
9
monoSUMO1-K14-UBE2I [nucleoplasm]
(R-HSA-4085358)
UBE2I [nuclear envelope]
(R-HSA-4655408)
SUMO3-C93-UBE2I [nucleoplasm]
(R-HSA-3730629)
UBE2I [nucleoplasm]
(R-HSA-912481)
SUMO1-C93-UBE2I [nucleoplasm]
(R-HSA-3730617)
SUMO2-C93-UBE2I [nucleoplasm]
(R-HSA-3730619)
SUMO1-C93-UBE2I [cytosol]
(R-HSA-4656909)
UBE2I [cytosol]
(R-HSA-4655342)
SUMO2-C93-UBE2I [cytosol]
(R-HSA-4656944)
0.527
3
UniProt:P46060 RANGAP1
3
RANGAP1 [cytosol]
(R-HSA-376255)
monoSUMO1-K524-RANGAP1 [nuclear envelope]
(R-HSA-3000416)
RANGAP1 [nuclear envelope]
(R-HSA-167661)
0.527
2
UniProt:Q69YH5 CDCA2
0.527
2
UniProt:Q09161 NCBP1
2
NCBP1 [nucleoplasm]
(R-HSA-51469)
NCBP1 [cytosol]
(R-HSA-162459)
0.527
6
UniProt:Q96HA1 POM121
1
POM121 [nuclear envelope]
(R-HSA-157747)
0.527
2
UniProt:O95373 IPO7
0.527
3
UniProt:P43487 RANBP1
1
RANBP1 [nuclear envelope]
(R-HSA-167651)
0.527
3
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
3
UniProt:Q9BW19 KIFC1
1
KIFC1 [cytosol]
(R-HSA-990500)
0.527
2
UniProt:P49792 RANBP2
6
RANBP2 [cytosol]
(R-HSA-157703)
RANBP2(1-867)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9702002)
RANBP2(1-867)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9718443)
RANBP2 [nuclear envelope]
(R-HSA-2993756)
monoSUMO1-K2592,K2650,K2723-RANBP2 [nuclear envelope]
(R-HSA-4551599)
polySUMO2-K2652,K2725-RANBP2 [nuclear envelope]
(R-HSA-4551720)
0.527
2
UniProt:P63165 SUMO1
11
lysyl-G97-SUMO1 [nucleoplasm]
(R-HSA-9761562)
SUMO1(2-101) [nucleoplasm]
(R-HSA-2990831)
SUMO1 [nucleoplasm]
(R-HSA-877304)
UBA2-G97-SUMO1 [nucleoplasm]
(R-HSA-3730616)
UBE2I-G97-SUMO1 [nucleoplasm]
(R-HSA-3730622)
lysyl-G97-SUMO1 [cytosol]
(R-HSA-9762266)
lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-9762380)
UBE2I-G97-SUMO1 [cytosol]
(R-HSA-4656941)
lysyl-G97-SUMO1 [viral capsid]
(R-HSA-9762386)
lysyl-G97-SUMO1 [nucleolus]
(R-HSA-9762385)
lysyl-G97-SUMO1 [plasma membrane]
(R-HSA-9762382)
0.527
2
UniProt:Q9NPC8 SIX2
1
SIX2 [nucleoplasm]
(R-HSA-9831037)
0.527
3
UniProt:Q9BXS6 NUSAP
0.527
2
UniProt:O15355 PPM1G
0.527
2
UniProt:Q8N1F7 NUP93
2
NUP93 [nuclear envelope]
(R-HSA-157749)
NUP93 [cytosol]
(R-HSA-9634167)
0.527
2
UniProt:Q86VU5 CMTD1
0.527
2
UniProt:Q00839 HNRNPU
1
HNRNPU [nucleoplasm]
(R-HSA-71953)
0.527
3
UniProt:P61769 B2M
11
B2M(21-119) [plasma membrane]
(R-HSA-167743)
B2M(21-119) [endoplasmic reticulum lumen]
(R-HSA-983063)
B2M(21-119) [tertiary granule lumen]
(R-HSA-6800179)
B2M(21-119) [extracellular region]
(R-HSA-1302721)
B2M(21-119) [specific granule lumen]
(R-HSA-6806144)
B2M(21-119) [early endosome lumen]
(R-HSA-1236827)
B2M(21-119) [phagocytic vesicle membrane]
(R-HSA-1236891)
B2M(21-119) [recycling endosome membrane]
(R-HSA-8863880)
B2M(21-119) [ER to Golgi transport vesicle membrane]
(R-HSA-983378)
B2M(21-119) [Golgi membrane]
(R-HSA-983403)
B2M(21-119) [early endosome membrane]
(R-HSA-182298)
0.527
4
UniProt:O15297 PPM1D
1
PPM1D [nucleoplasm]
(R-HSA-2562518)
0.527
2
UniProt:Q5SSJ5 HP1B3
0.527
2
UniProt:A8CG34 POM121C
1
POM121C [nuclear envelope]
(R-HSA-6805165)
0.527
2
UniProt:Q8K4J6
3
Mrtfa [nucleoplasm]
(R-MMU-3900216)
Mrtfa [nucleoplasm]
(R-MMU-3900220)
Mrtfa [cytosol]
(R-MMU-5665975)
0.525
2
UniProt:Q16637-3 SMN1
0.524
5
UniProt:P27105 STOM
4
STOM [tertiary granule membrane]
(R-HSA-6800960)
STOM [plasma membrane]
(R-HSA-6806258)
STOM [specific granule membrane]
(R-HSA-6799569)
STOM [azurophil granule membrane]
(R-HSA-6800997)
0.508
2
UniProt:Q15077 P2RY6
1
P2RY6 [plasma membrane]
(R-HSA-417924)
0.499
4
UniProt:B3CRR2 B3CRR2
0.499
2
UniProt:Q9WMX2 POLG
0.499
2
UniProt:F5H1C8 F5H1C8
0.499
2
UniProt:Q9Y275 TNFSF13B
1
sBAFF [extracellular region]
(R-HSA-5676541)
0.499
2
UniProt:Q99558 MAP3K14
5
Active NIK [cytosol]
(R-HSA-5607646)
MAP3K14 [cytosol]
(R-HSA-168189)
p-MAP3K14 [cytosol]
(R-HSA-168187)
K48polyUb-NIK [cytosol]
(R-HSA-5668525)
p-T559-MAP3K14 [cytosol]
(R-HSA-5668531)
0.499
2
UniProt:P04233 CD74
13
CD74 [plasma membrane]
(R-HSA-2130666)
CD74 [lysosomal membrane]
(R-HSA-2130320)
CD74(1-176) [lysosomal membrane]
(R-HSA-2130602)
CD74 [endocytic vesicle membrane]
(R-HSA-2130460)
CD74 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130522)
CD74 [transport vesicle membrane]
(R-HSA-2130624)
CD74 [trans-Golgi network membrane]
(R-HSA-2130493)
CD74 [Golgi membrane]
(R-HSA-2214388)
CD74 [ER to Golgi transport vesicle membrane]
(R-HSA-2130456)
CD74 [lumenal side of endoplasmic reticulum membrane]
(R-HSA-1181241)
CD74(1-117) [lysosomal membrane]
(R-HSA-2130632)
CD74(81-104) [lysosomal membrane]
(R-HSA-2130446)
CD74(81-104) [lysosomal lumen]
(R-HSA-2213220)
0.499
2
UniProt:Q9H1C4 UNC93B1
4
UNC93B1 [Golgi membrane]
(R-HSA-1679064)
UNC93B1 [endoplasmic reticulum membrane]
(R-HSA-1678930)
UNC93B1 P345Pfs*103 [endoplasmic reticulum membrane]
(R-HSA-9628866)
UNC93B1 L230Afs*188 [endoplasmic reticulum membrane]
(R-HSA-9628869)
0.499
2
UniProt:Q4G0J3 LARP7
0.483
2
UniProt:P07910 HNRNPC
3
HNRNPC [nucleoplasm]
(R-HSA-71933)
SUMO1-K250-HNRNPC [nucleoplasm]
(R-HSA-4570543)
HNRNPC [cytosol]
(R-HSA-9715136)
0.483
2
UniProt:Q9NR30 DDX21
1
DDX21 [nucleoplasm]
(R-HSA-5250652)
0.483
2
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE
0.462
2
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE
0.462
2
UniProt:Q8IUH3 RBM45
0.462
2
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