Reactome | GGC-RAB5C [clathrin-coated endocytic vesicle membrane]

GGC-RAB5C [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-HSA-8871129

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

Ras-related protein Rab-5C, RAB5C_HUMAN

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        GGC-RAB5:GDP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        GGC-RAB5:GDP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        GGC-RAB5 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        GGC-RAB5C [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        GGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        GGC-RAB5:GTP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        GGC-RAB5 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        GGC-RAB5C [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dissociation of clathrin-associated proteins (Homo sapiens)
      - GGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        GGC-RAB5:GTP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        GGC-RAB5 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        GGC-RAB5C [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        GGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        GGC-RAB5:GTP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        GGC-RAB5 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        GGC-RAB5C [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
      - GGC-RAB5:GDP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        GGC-RAB5:GDP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        GGC-RAB5 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        GGC-RAB5C [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        GGC-RAB5:GDP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        GGC-RAB5:GDP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        GGC-RAB5 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        GGC-RAB5C [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P51148 RAB5C

Gene Names

RAB5C, RABL

Chain

chain:1-216

Reference Genes

BioGPS Gene:5878 RAB5C

COSMIC (genes):RAB5C RAB5C

CTD Gene:5878 RAB5C

dbSNP Gene:5878 RAB5C

ENSEMBL:ENSG00000108774 RAB5C

ENSEMBL_homo_sapiens_GENE:ENSG00000108774.15 RAB5C

HGNC:9785 RAB5C

KEGG Gene (Homo sapiens):5878 RAB5C

Monarch:5878 RAB5C

NCBI Gene:5878 RAB5C

OMIM:604037 RAB5C

UCSC:P51148 RAB5C

Reference Transcript

Other Identifiers

11725589_s_at

11739019_x_at

11753521_a_at

16845039

201140_PM_s_at

201140_s_at

201156_PM_s_at

201156_s_at

3295097

34836_at

3757665

3757666

3757667

3757670

3757672

3757673

3757675

3757676

3757684

5878

8015545

A_23_P107211

A_23_P107214

GE81414

GO:0000166

GO:0003824

GO:0003924

GO:0003925

GO:0005515

GO:0005525

GO:0005576

GO:0005615

GO:0005764

GO:0005765

GO:0005768

GO:0005773

GO:0005811

GO:0005886

GO:0006886

GO:0006897

GO:0012505

GO:0015031

GO:0016020

GO:0016192

GO:0016787

GO:0019003

GO:0031410

GO:0031901

GO:0035577

GO:0042470

GO:0043226

GO:0048227

GO:0070062

GO:0098772

HMNXSV003010354

HMNXSV003047120

Hs.479.0.A1_3p_a_at

ILMN_1769665

ILMN_2399140

TC17001525.hg

g4759019_3p_a_at

Participates

as a candidate of

GGC-RAB5 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Other forms of this molecule

RAB5C [azurophil granule membrane]

RAB5C [plasma membrane]

GGC-RAB5C [macropinosome membrane]

RAB5C [cytosol]

GGC-RAB5C [cytosol]

GGC-RAB5C [early endosome membrane]

RAB5C [early endosome membrane]

RAB5C [cytoplasmic vesicle membrane]

RAB5C [Golgi membrane]

Inferred To

GGC-RAB5C [clathrin-coated endocytic vesicle membrane] (Canis familiaris)

GGC-RAB5C [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)

GGC-RAB5C [clathrin-coated endocytic vesicle membrane] (Gallus gallus)

GGC-RAB5C [clathrin-coated endocytic vesicle membrane] (Mus musculus)

GGC-RAB5C [clathrin-coated endocytic vesicle membrane] (Schizosaccharomyces pombe)

Rab5c [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

rab-5 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)

Modified Residues

Name

S-geranylgeranyl-L-cysteine at 213

Coordinate

213

PsiMod Name

S-geranylgeranyl-L-cysteine [MOD:00113]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine.

Name

S-geranylgeranyl-L-cysteine at 214

Coordinate

214

PsiMod Name

S-geranylgeranyl-L-cysteine [MOD:00113]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine.

Cross References

RefSeq

XP_011523393.1, NP_004574.2, NP_958842.1, XP_011523392.1, NP_001238968.1

OpenTargets

ENSG00000108774

GeneCards

P51148

HPA

ENSG00000108774-RAB5C

Ensembl

ENSP00000377440, ENST00000393860, ENSP00000447053, ENSP00000345689, ENSG00000108774, ENST00000346213, ENST00000547517

PRO

P51148

Pharos - Targets

P51148

PDB

4KYI

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P20339 RAB5A	7	GGC-RAB5A [clathrin-coated endocytic vesicle membrane] (R-HSA-8871125) GGC-RAB5A [early endosome membrane] (R-HSA-8875323) GGC-RAB5A [cytosol] (R-HSA-8870432) RAB5A [early endosome membrane] (R-HSA-2130175) RAB5A [cytosol] (R-HSA-2201187) GGC-RAB5A [macropinosome membrane] (R-HSA-9837697) RAB5A [endosome membrane] (R-HSA-452257)	0.744	5
UniProt:Q9UH99 SUN2	1	SUN2 [nuclear envelope] (R-HSA-912382)	0.744	5
UniProt:P24386 CHM	1	CHM [cytosol] (R-HSA-6801097)	0.643	4
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	5
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	9