Reactome | p-Y419-SRC [nucleoplasm]

p-Y419-SRC [nucleoplasm]

Stable Identifier

R-HSA-8937690

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

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General

Active SRC can be found in the nucleus (Paladino et al. 2016). Myristoylation negatively affects SRC nuclear localization (David-Pfeuty et al. 1993).

Literature References

PubMed ID	Title	Journal	Year
7691845	Differential localization patterns of myristoylated and nonmyristoylated c-Src proteins in interphase and mitotic c-Src overexpresser cells Bagrodia, S, Shalloway, D, David-Pfeuty, T	J. Cell. Sci.	1993
26695438	A novel nuclear Src and p300 signaling axis controls migratory and invasive behavior in pancreatic cancer Yue, P, Acoba, J, Turkson, J, Rosser, CJ, Furuya, H, Paladino, D	Oncotarget	2016

External Reference Information

External Reference

UniProt:P12931 SRC

Gene Names

SRC, SRC1

Chain

initiator methionine:, chain:2-536

Reference Genes

BioGPS Gene:6714 SRC

COSMIC (genes):SRC SRC

CTD Gene:6714 SRC

dbSNP Gene:6714 SRC

ENSEMBL:ENSG00000197122 SRC

ENSEMBL_homo_sapiens_GENE:ENSG00000197122.13 SRC

ENSEMBL_homo_sapiens_GENE:ENSG00000291971.1 SRC

HGNC:11283 SRC

KEGG Gene (Homo sapiens):6714 SRC

Monarch:6714 SRC

NCBI Gene:6714 SRC

OMIM:190090 SRC

UCSC:P12931 SRC

Reference Transcript

Other Identifiers

11723135_s_at

11723136_x_at

1558211_PM_s_at

1558211_s_at

16913413

1938_at

213324_PM_at

213324_at

221284_PM_s_at

221284_s_at

3884193

3884196

3884198

3884199

3884200

3884202

3884203

3884207

3884209

3884210

3884214

3884215

3884216

3884221

3884223

3884227

3884228

3884229

38904_at

6714

8062377

A_14_P111562

A_23_P308603

GE81507

GO:0000166

GO:0001545

GO:0001819

GO:0002102

GO:0002223

GO:0002376

GO:0002862

GO:0003013

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0005080

GO:0005102

GO:0005158

GO:0005178

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005743

GO:0005764

GO:0005768

GO:0005770

GO:0005773

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0005901

GO:0005925

GO:0005975

GO:0006468

GO:0006914

GO:0006954

GO:0007010

GO:0007049

GO:0007155

GO:0007165

GO:0007172

GO:0007173

GO:0007179

GO:0007229

GO:0007283

GO:0007611

GO:0008284

GO:0009410

GO:0009612

GO:0010447

GO:0010628

GO:0010629

GO:0010632

GO:0010634

GO:0010907

GO:0010954

GO:0012501

GO:0014856

GO:0014911

GO:0016004

GO:0016020

GO:0016192

GO:0016236

GO:0016301

GO:0016310

GO:0016477

GO:0016740

GO:0018108

GO:0019899

GO:0019901

GO:0019904

GO:0020037

GO:0022407

GO:0022414

GO:0023052

GO:0030054

GO:0030154

GO:0030168

GO:0030331

GO:0030900

GO:0031234

GO:0031295

GO:0031333

GO:0031410

GO:0031648

GO:0031667

GO:0032200

GO:0032211

GO:0032587

GO:0032869

GO:0033146

GO:0033625

GO:0034139

GO:0034330

GO:0034332

GO:0034446

GO:0034614

GO:0035306

GO:0035331

GO:0035556

GO:0035635

GO:0036035

GO:0036120

GO:0036211

GO:0038096

GO:0038128

GO:0038166

GO:0042060

GO:0042169

GO:0042476

GO:0042542

GO:0043025

GO:0043065

GO:0043066

GO:0043114

GO:0043149

GO:0043154

GO:0043226

GO:0043274

GO:0044294

GO:0044325

GO:0044877

GO:0045056

GO:0045087

GO:0045121

GO:0045124

GO:0045296

GO:0045453

GO:0045747

GO:0045780

GO:0045785

GO:0046579

GO:0046628

GO:0046777

GO:0046875

GO:0048008

GO:0048010

GO:0048011

GO:0048013

GO:0048041

GO:0048471

GO:0048477

GO:0048856

GO:0048870

GO:0050731

GO:0050839

GO:0050847

GO:0050877

GO:0050900

GO:0051057

GO:0051117

GO:0051219

GO:0051222

GO:0051385

GO:0051450

GO:0051602

GO:0051604

GO:0051895

GO:0051897

GO:0051902

GO:0051974

GO:0060065

GO:0060444

GO:0060491

GO:0060576

GO:0065003

GO:0070062

GO:0070102

GO:0070161

GO:0070301

GO:0070374

GO:0070542

GO:0070555

GO:0070700

GO:0071222

GO:0071253

GO:0071375

GO:0071393

GO:0071398

GO:0071456

GO:0071498

GO:0071560

GO:0071803

GO:0071897

GO:0071902

GO:0086091

GO:0090263

GO:0097060

GO:0097110

GO:0098542

GO:0098609

GO:0098772

GO:0098978

GO:0099091

GO:0140096

GO:1900182

GO:1902533

GO:1902737

GO:1903997

GO:1904263

GO:1904385

GO:1904707

GO:1990646

GO:2000256

GO:2000386

GO:2000394

GO:2000588

GO:2000641

GO:2000811

GO:2001237

GO:2001243

GO:2001286

HMNXSV003035331

Hs.198298.0.S1_3p_at

Hs2.383588.1.A1_3p_s_at

ILMN_1685898

ILMN_1729987

K03218_at

PH_hs_0033377

TC20000273.hg

TC20001205.hg

g4885608_3p_a_at

Participates

as an input of

RUNX1 binds SRC (Homo sapiens)

as an output of

SRC phosphorylates RUNX1 (Homo sapiens)

as a component of

p-Y419-SRC:RUNX1 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

SRC [cytosol]

p-Y419-SRC [cytosol]

MyrG-SRC [plasma membrane]

MyrG,p-Y530-SRC [plasma membrane]

MyrG-p-Y419-SRC [plasma membrane]

Modified Residues

Name

O4'-phospho-L-tyrosine at 419

Coordinate

419

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_011527315.1, XP_016883514.1, NP_005408.1, NP_938033.1, XP_016883513.1, XP_016883515.1, XP_016883516.1

ZINC - World Drugs

SRC_HUMAN

Guide to Pharmacology - Targets

2206

OpenTargets

ENSG00000197122

ZINC - FDA approved

SRC_HUMAN

ZINC - Substances

SRC_HUMAN

ZINC target

P12931

ZINC - Biogenic

SRC_HUMAN

PRO

P12931

PDB

6E6E, 1O4G, 4F5B, 1O4R, 1O4A, 1O4K, 6EHJ, 2BDF, 1SHD, 1HCS, 3ZMQ, 1A09, 2BDJ, 1O41, 1YOJ, 6ATE, 4MXO, 1O4I, 1O4P, 3ZMP, 1A1E, 1O4L, 1O4F, 4HXJ, 8GWH, 1KSW, 7T1U, 1O4Q, 1O49, 1YI6, 4F5A, 1A07, 1YOL, 2SRC, 1O4J, 6C4S, 4MXZ, 1O4N, 1Y57, 1A1C, 1O4D, 1O47, 1YOM, 7NG7, 4F59, 1O44, 1O4H, 8JF3, 4MXY, 1O4E, 1O48, 1O4B, 1HCT, 1O4O, 7OTE, 4MXX, 1O45, 1FMK, 1A08, 1A1A, 1O4M, 4K11, 1O42, 1O4C, 2H8H, 1O46, 7YQE, 8HAQ, 1A1B, 3VRO, 1O43

ZINC - Investigational

SRC_HUMAN

ZINC - Metabolites

SRC_HUMAN

IntEnz

2.7.10.2

GeneCards

P12931

HPA

ENSG00000197122-SRC

Ensembl

ENSG00000197122, ENST00000358208, ENSP00000509325, ENSP00000508666, ENST00000373558, ENSP00000362659, ENST00000692112, ENSP00000362668, ENSP00000350941, ENSP00000362680, ENST00000373578, ENST00000692423, ENST00000373567

Pharos - Targets

P12931

Orphanet

25273

ZINC - Predictions - Purchasable

SRC_HUMAN

Interactors (76)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P18031 PTPN1	2	PTPN1 [cytosol] (R-HSA-210625) PTPN1 [endosome membrane] (R-HSA-9815895)	0.937	14
UniProt:Q05397 PTK2	11	pY-PTK2 [cytosol] (R-HSA-9632393) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) PTK2(773-1052) [cytosol] (R-HSA-202829) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2 [cytosol] (R-HSA-201621) p-Y397-PTK2 [cytosol] (R-HSA-354068) p-6Y-PTK2 [cytosol] (R-HSA-354128)	0.924	9
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.9	9
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.848	12
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637)	0.845	8
UniProt:Q9H5V8 CDCP1			0.793	5
UniProt:P08581 MET	7	p-Y1234,Y1235,Y1356-MET [plasma membrane] (R-HSA-6807014) p-Y1349,Y1356-MET [plasma membrane] (R-HSA-6807032) MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-8875181) MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (R-HSA-8875180) p-Y1003,4Y-MET [plasma membrane] (R-HSA-8874689) MET [plasma membrane] (R-HSA-419603) p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-6806973)	0.787	7
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.779	7
UniProt:P35968 KDR	5	p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane] (R-HSA-9673636) VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) fusion [plasma membrane] (R-HSA-9673613) p-Y801,Y1054,Y1175-KDR [plasma membrane] (R-HSA-9860484) VEGFR2 [plasma membrane] (R-HSA-195382) p-6Y-VEGFR2 [plasma membrane] (R-HSA-4420103)	0.77	6
UniProt:Q13444 ADAM15	1	ADAM15 [plasma membrane] (R-HSA-708329)	0.75	4
UniProt:P15941 MUC1	19	MUC1(24-1255) [plasma membrane] (R-HSA-6793976) Core 8 (MUC1) [Golgi lumen] (R-HSA-1462219) Core 2S (MUC1) [Golgi lumen] (R-HSA-6786333) Core 5 (MUC1) [Golgi lumen] (R-HSA-1462231) Core 4 (MUC1) [Golgi lumen] (R-HSA-1462154) Core 3 (MUC1) [Golgi lumen] (R-HSA-1462068) Core 7 (MUC1) [Golgi lumen] (R-HSA-1462105) extended Core 6 (MUC1) [Golgi lumen] (R-HSA-1967019) Core 6 (MUC1) [Golgi lumen] (R-HSA-1462085) MUC1(24-1255) [Golgi lumen] (R-HSA-913611) Disialyl T-antigen (MUC1) [Golgi lumen] (R-HSA-1463518) Sialyl T-antigen (MUC1) [Golgi lumen] (R-HSA-1463531) Sialyl-2,3 T-antigen (MUC1) [Golgi lumen] (R-HSA-1463483) T-antigen (MUC1) [Golgi lumen] (R-HSA-1462359) Sialyl Tn antigen (MUC1) [Golgi lumen] (R-HSA-1463526) GalNAc-MUC1(24-1255) [Golgi lumen] (R-HSA-913642) Core 2a (MUC1) [Golgi lumen] (R-HSA-6784286) Core 2 (MUC1) [Golgi lumen] (R-HSA-1462167) GalNAc-MUC1(24-1255) [plasma membrane] (R-HSA-8858449)	0.748	5
UniProt:P18433 PTPRA	1	PTPRA [plasma membrane] (R-HSA-388755)	0.734	5
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.708	6
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.708	11
UniProt:P56945 BCAR1	4	p-Y-BCAR1 [cytosol] (R-HSA-372645) p-Y12-BCAR1 [cytosol] (R-HSA-5218739) p-Y165,Y664-BCAR1 [cytosol] (R-HSA-8848723) BCAR1 [cytosol] (R-HSA-201625)	0.688	3
UniProt:Q01973 ROR1	2	ROR1 [clathrin-coated endocytic vesicle membrane] (R-HSA-5140727) ROR1 [plasma membrane] (R-HSA-197814)	0.682	9
UniProt:P06241 FYN	6	p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y531-FYN [cytosol] (R-HSA-391819) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) FYN [cytosol] (R-HSA-200917)	0.669	5
UniProt:P07948 LYN	7	MyrG2-PalmC3-LYN [lysosomal membrane] (R-HSA-9707903) MyrG2-PalmC3-LYN [endocytic vesicle membrane] (R-HSA-9705728) LYN [plasma membrane] (R-HSA-197943) p-Y397-LYN [cytosol] (R-HSA-8942608) p-Y397-LYN [plasma membrane] (R-HSA-2454229) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875) LYN [cytosol] (R-HSA-354251)	0.669	4
UniProt:P07900 HSP90AA1	8	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.669	3
UniProt:Q9H204 MED28	1	MED28 [nucleoplasm] (R-HSA-6804546)	0.656	3
UniProt:Q8WUM4 PDCD6IP	1	PDCD6IP [cytosol] (R-HSA-917717)	0.653	7
UniProt:P55196 AFDN			0.65	7
UniProt:Q14289 PTK2B	3	p-Y-PTK2B [cytosol] (R-HSA-508515) PTK2B [cytosol] (R-HSA-390932) PTK2B [cytosol] (R-HSA-5218721)	0.643	3
UniProt:P49407 ARRB1	6	ARRB1 [cytosol] (R-HSA-264470) PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [endocytic vesicle membrane] (R-HSA-9910882) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.623	3
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.621	3
UniProt:P07550 ADRB2	5	pS-ADRB2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869143) ADRB2 [endosome membrane] (R-HSA-6783036) PolyUb-ADRB2 [endosome membrane] (R-HSA-6783066) pS-ADRB2 [plasma membrane] (R-HSA-8852158) ADRB2 [plasma membrane] (R-HSA-390647)	0.611	3
UniProt:Q9ULH1 ASAP1	1	ASAP1 [cytosol] (R-HSA-5620905)	0.609	3
UniProt:P35326 SPRR2A	2	SPRR2A [cornified envelope] (R-HSA-8934850) SPRR2A [cytosol] (R-HSA-6810863)	0.602	3
UniProt:Q62884 Q62884			0.602	3
UniProt:P61978 HNRNPK	2	polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532) HNRNPK [nucleoplasm] (R-HSA-71945)	0.593	6
UniProt:Q68CZ2 TNS3	1	TNS3 [cytosol] (R-HSA-8875524)	0.591	13
UniProt:P27635 RPL10	1	RPL10 [cytosol] (R-HSA-72402)	0.591	6
UniProt:P16284 PECAM1	5	PECAM1 [platelet alpha granule membrane] (R-HSA-61489) PECAM1 [plasma membrane] (R-HSA-114686) PECAM1 [secretory granule membrane] (R-HSA-6804778) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) p-Y713-PECAM1 [plasma membrane] (R-HSA-9860772)	0.59	3
UniProt:P00519 ABL1	6	p-Y393-ABL1 [cytosol] (R-HSA-9865161) p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) ABL1 [cytosol] (R-HSA-375987) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610) ABL1 [nucleoplasm] (R-HSA-5686579) p-S456-ABL1 [nucleoplasm] (R-HSA-5686576)	0.589	2
UniProt:Q07666 KHDRBS1	3	p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm] (R-HSA-8848970) p-Y435,Y440,Y443-KHDRBS1 [cytosol] (R-HSA-8848995) KHDRBS1 [nucleoplasm] (R-HSA-8848941)	0.573	3
UniProt:P01112 HRAS	20	HRAS Q61R [plasma membrane] (R-HSA-6802458) HRAS Q61L [plasma membrane] (R-HSA-6802452) HRAS Q61K [plasma membrane] (R-HSA-6802442) HRAS G13R [plasma membrane] (R-HSA-6802368) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS G12C [plasma membrane] (R-HSA-9656561) HRAS [plasma membrane] (R-HSA-62717) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788)	0.571	2
UniProt:P34152 Ptk2	13	phospho-pY-PTK2 [cytosol] (R-MMU-9632393) phospho-p-6Y-PTK2 [cytosol] (R-MMU-354128) phospho-p-Y397-PTK2 [cytosol] (R-MMU-354068) PTK2 [cytosol] (R-MMU-201621) PTK2(1-772) [cytosol] (R-MMU-202827) PTK2(773-1052) [cytosol] (R-MMU-202829) phospho-p-6Y,S732-PTK2 [cytosol] (R-MMU-5218694) phospho-p-5Y,S732-PTK2 [cytosol] (R-MMU-5229006) phospho-p-5Y-PTK2 [cytosol] (R-MMU-5218711) Fak1 [cytosol] (R-MMU-3928448) p-Y428-FAK1 [cytosol] (R-MMU-3928397) phospho-p-Y194,Y397-PTK2 [cytosol] (R-MMU-8874600) phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-MMU-8874613)	0.564	2
UniProt:P68400 CSNK2A1	2	CSNK2A1 [nucleoplasm] (R-HSA-6805057) CSNK2A1 [cytosol] (R-HSA-201713)	0.564	2
UniProt:P32121 ARRB2	3	ARRB2 [cytosol] (R-HSA-416464) PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [endocytic vesicle membrane] (R-HSA-9910881)	0.564	2
linoleoyl-CoA [ChEBI:15530]	2	LA-CoA [endoplasmic reticulum lumen] (R-ALL-2046063) LIN-CoA [mitochondrial matrix] (R-ALL-77359)	0.558	2
ChEBI:15532 MYRISTOYL-COA			0.558	2
UniProt:O43184 ADAM12	1	ADAM12 [plasma membrane] (R-HSA-179792)	0.558	2
UniProt:Q8R5G7	1	Arap3 [cytosol] (R-MMU-195185)	0.558	3
UniProt:Q9BR61 ACBD6	1	ACBD6 [cytosol] (R-HSA-8848243)	0.558	4
UniProt:P27986-2 PIK3R1			0.556	3
UniProt:Q13829 TNFAIP1	1	TNFAIP1 [cytosol] (R-HSA-9696531)	0.556	3
UniProt:Q9UNY5 ZN232			0.556	3
UniProt:Q14693 LPIN1	3	p-S106-LPIN1 [nucleoplasm] (R-HSA-4419936) LPIN1 [nuclear envelope] (R-HSA-4419927) LPIN1 [endoplasmic reticulum membrane] (R-HSA-549157)	0.556	3
UniProt:Q9UIH9 KLF15	1	KLF15 [nucleoplasm] (R-HSA-8878735)	0.556	3
UniProt:O14796 SH2D1B	1	SH2D1B [cytosol] (R-HSA-5685187)	0.556	3
UniProt:Q13322-4 GRB10			0.556	3
UniProt:Q6XD76 ASCL4			0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	6
UniProt:Q15907 RAB11B	3	RAB11B [recycling endosome membrane] (R-HSA-8854762) GGC-RAB11B [cytosol] (R-HSA-8873766) RAB11B [cytosol] (R-HSA-8873671)	0.556	3
UniProt:O60880 SH2D1A	1	SH2D1A [cytosol] (R-HSA-5685108)	0.556	3
UniProt:Q14457 BECN1	4	K63polyUb-BECN1 [cytosol] (R-HSA-6782989) ISG15-K-BECN1 [cytosol] (R-HSA-9853030) p-S15-BECN1 [cytosol] (R-HSA-5682391) BECN1 [cytosol] (R-HSA-1632841)	0.556	3
UniProt:Q9BU70 TRMO			0.547	2
UniProt:P97288	1	Htr4 [plasma membrane] (R-MMU-391008)	0.544	2
UniProt:O14672 ADAM10	6	ADAM10(215-824) [plasma membrane] (R-HSA-179885) ADAM10 [plasma membrane] (R-HSA-157237) ADAM10 [endoplasmic reticulum lumen] (R-HSA-8956768) p-ADAM10 [endoplasmic reticulum lumen] (R-HSA-8956999) ADAM10 [tertiary granule membrane] (R-HSA-6800992) ADAM10 [specific granule membrane] (R-HSA-6799566)	0.544	3
UniProt:P25962	1	Adrb3 [plasma membrane] (R-MMU-390623)	0.544	2
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.544	2
UniProt:P40763 STAT3	12	Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [nucleoplasm] (R-HSA-8983188) p-STAT3 [cytosol] (R-HSA-8982823) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705-STAT3 [cytosol] (R-HSA-8983130) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-914048) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.527	5
UniProt:P05023 ATP1A1	1	ATP1A1 [plasma membrane] (R-HSA-936850)	0.527	5
UniProt:P49023 PXN	4	p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [plasma membrane] (R-HSA-180493) PXN [cytosol] (R-HSA-210014) p-Y31,Y118-PXN [cytosol] (R-HSA-5218693)	0.527	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.527	2
UniProt:P19367 HK1	4	HK1 T680S [cytosol] (R-HSA-5621880) HK1 H577_C672del [cytosol] (R-HSA-5621873) HK1 L529S [cytosol] (R-HSA-5621861) HK1 [cytosol] (R-HSA-70395)	0.524	2
UniProt:Q13177 PAK2	11	p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524) PAK2(1-524) [plasma membrane] (R-HSA-164946) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2 [cytosol] (R-HSA-211604) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653)	0.524	2
UniProt:P12814 ACTN1	3	ACTN1 [cytosol] (R-HSA-354096) ACTN1 [platelet alpha granule lumen] (R-HSA-349724) ACTN1 [extracellular region] (R-HSA-349722)	0.524	2
UniProt:Q9H3S7 PTPN23	1	PTPN23 [nucleoplasm] (R-HSA-9008924)	0.499	2
UniProt:Q9Y6K9 IKBKG	12	IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG [nucleoplasm] (R-HSA-4755413) K63polyUb-IKBKG [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397) IKBKG [cytosol] (R-HSA-168108)	0.499	3
ChEBI:39112 BOSUTINIB			0.499	2
ChEBI:45783 IMATINIB			0.499	2
UniProt:P12830 CDH1	8	CDH1(732-882) [plasma membrane] (R-HSA-3827997) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(701-882) [extracellular region] (R-HSA-2534158) Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) CDH1(155-750) [plasma membrane] (R-HSA-202940) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(155-882) [plasma membrane] (R-HSA-198003)	0.499	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	4
UniProt:O15455 TLR3	6	TLR3 E746* [endosome membrane] (R-HSA-5602730) TLR3 P554S [endosome membrane] (R-HSA-5602428) TLR3 [endoplasmic reticulum membrane] (R-HSA-1679057) TLR3 [endolysosome membrane] (R-HSA-167941) TLR3 [Golgi membrane] (R-HSA-1678955) TLR3 [endosome membrane] (R-HSA-2000341)	0.463	2
UniProt:P23743 DGKA	1	DGKA [plasma membrane] (R-HSA-426056)	0.462	2

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