Reactome | PSMB1 [extracellular region]

PSMB1 [extracellular region]

Stable Identifier

R-HSA-6806477

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Proteasome subunit beta type 1 , Proteasome component C5, Macropain subunit C5, Multicatalytic endopeptidase complex subunit C5, Proteasome gamma chain

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P20618 PSMB1

Gene Names

PSMB1, PSC5

Chain

propeptide:1-28, chain:29-241

Reference Genes

BioGPS Gene:5689 PSMB1

COSMIC (genes):PSMB1 PSMB1

CTD Gene:5689 PSMB1

dbSNP Gene:5689 PSMB1

ENSEMBL:ENSG00000008018 PSMB1

ENSEMBL_homo_sapiens_GENE:ENSG00000008018.9 PSMB1

HGNC:9537 PSMB1

KEGG Gene (Homo sapiens):5689 PSMB1

Monarch:5689 PSMB1

NCBI Gene:5689 PSMB1

OMIM:602017 PSMB1

UCSC:P20618 PSMB1

Reference Transcript

RefSeq:NM_002793.3 PSMB1

Other Identifiers

11715943_x_at

11754482_a_at

1447_at

17026002

200876_PM_s_at

200876_s_at

214288_PM_s_at

214288_s_at

2986503

2986504

2986506

2986510

2986511

2986514

2986515

2986521

2986522

5689

8130952

A_23_P156531

A_24_P233570

D00761_at

GE79695

GO:0000502

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005839

GO:0019774

GO:0030163

GO:0031410

GO:0034774

GO:0043161

GO:0043226

GO:0051603

GO:0070062

GO:1904813

HMNXSV003007545

ILMN_1789176

PH_hs_0023954

TC06002343.hg

g4506192_3p_a_at

Participates

as a member of

Other forms of this molecule

PSMB1 [secretory granule lumen]

PSMB1 [ficolin-1-rich granule lumen]

PSMB1 [nucleoplasm]

PSMB1 [cytosol]

Inferred To

pam1 [extracellular region] (Schizosaccharomyces pombe)

psmb1 [extracellular region] (Danio rerio)

psmb1 [extracellular region] (Xenopus tropicalis)

Psmb1 [extracellular region] (Mus musculus)

Psmb1 [extracellular region] (Rattus norvegicus)

PSMB1 [extracellular region] (Bos taurus)

PSMB1 [extracellular region] (Canis familiaris)

PSMB1 [extracellular region] (Gallus gallus)

PSMB1 [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_002784.1

ZINC - World Drugs

PSB1_HUMAN

Guide to Pharmacology - Targets

2404

OpenTargets

ENSG00000008018

ZINC - FDA approved

PSB1_HUMAN

ZINC - Substances

PSB1_HUMAN

ZINC target

P20618

PRO

P20618

PDB

7V5M, 5LEX, 7QYB, 6MSJ, 5L60, 5GJQ, 5L5P, 7NAP, 8CVR, 8UD9, 8BZL, 5L5E, 7NAN, 6MSG, 6XMJ, 7W3A, 7W3B, 5L5H, 5L4G, 7QXN, 6MSD, 6KWY, 7W3I, 8CVT, 6R70, 5L5J, 7B12, 6WJN, 7QYA, 7W39, 8QYS, 7QXW, 7QXU, 5LEZ, 5T0H, 5LE5, 5LF0, 7W3H, 7W37, 4R3O, 7W3C, 5VFU, 7W3M, 5LF7, 5L5R, 7W3F, 5L5Q, 7W3K, 8QZ9, 5VFS, 4R67, 5LN3, 6AVO, 5VFP, 7NAQ, 5LF1, 5VFR, 7PG9, 7NAO, 5T0G, 5L5Y, 7QY7, 6MSK, 7V5G, 5VFO, 5L5B, 8CXB, 6RGQ, 5L5F, 6MSE, 5M32, 5T0C, 5GJR, 5L61, 5L64, 6MSB, 5L5I, 5M2B, 5L5T, 5L5S, 5L5W, 7W38, 8QYO, 5T0J, 8CVS, 5VFQ, 5L5V, 8QYN, 5L5D, 7LXV, 7W3G, 7QXX, 5LEY, 6WJD, 5T0I, 5L5O, 5L5X, 5LF6, 5L62, 7NHT, 7QXP, 6REY, 6MSH, 5A0Q, 7AWE, 5L5Z, 5L5U, 5LF3, 7W3J, 6E5B, 5LF4, 5L63, 5VFT

ZINC - Investigational

PSB1_HUMAN

GeneCards

P20618

HPA

ENSG00000008018-PSMB1

Ensembl

ENSP00000262193, ENSG00000008018, ENST00000262193

Pharos - Targets

P20618

ZINC - Predictions - Purchasable

PSB1_HUMAN

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.795	8
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.781	7
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	7
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.643	4
UniProt:Q9UL46 PSME2	2	PSME2 [cytosol] (R-HSA-68814) PSME2 [nucleoplasm] (R-HSA-174350)	0.643	5
UniProt:P62333 PSMC6	2	PSMC6 [nucleoplasm] (R-HSA-174319) PSMC6 [cytosol] (R-HSA-68783)	0.638	3
UniProt:Q9H0E2 TOLLIP	4	TOLLIP [cytosol] (R-HSA-446885) TOLLIP [azurophil granule lumen] (R-HSA-6799709) TOLLIP [extracellular region] (R-HSA-6800448) TOLLIP [specific granule lumen] (R-HSA-6799719)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q96BZ8 LENG1	1	LENG1 [nucleoplasm] (R-HSA-9769590)	0.556	3
UniProt:P84022 SMAD3	20	Ub-SMAD3 [cytosol] (R-HSA-6782830) p-S423,S425-SMAD3 D258N [cytosol] (R-HSA-3315470) p-S423,S425-SMAD3 R268C [cytosol] (R-HSA-3315075) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080) SMAD3 Q316* [cytosol] (R-HSA-9668765) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 S425C [cytosol] (R-HSA-3308499) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 [nucleoplasm] (R-HSA-206150) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471)	0.556	3
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.556	3
UniProt:Q9P2X3 IMPACT	1	IMPACT [cytosol] (R-HSA-9634678)	0.556	3
UniProt:P49821 NDUFV1	1	NDUFV1 [mitochondrial inner membrane] (R-HSA-163926)	0.556	3
UniProt:Q96CA5 BIRC7	1	BIRC7 [cytosol] (R-HSA-50855)	0.556	5
UniProt:Q9HBZ2 ARNT2	1	ARNT2 [nucleoplasm] (R-HSA-8936838)	0.556	3
UniProt:Q9HAP6 LIN7B	2	LIN7B [plasma membrane] (R-HSA-5216107) LIN7B [transport vesicle membrane] (R-HSA-9610415)	0.556	3
UniProt:P23025 XPA	1	XPA [nucleoplasm] (R-HSA-67437)	0.556	3
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.556	5
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	8

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