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GPI-CD59 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-5689453
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPII-mediated vesicle transport (Homo sapiens)
Inner coat assembly and cargo binding (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59 [endoplasmic reticulum membrane] (Homo sapiens)
Loss of SAR1B GTPase (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59 [endoplasmic reticulum membrane] (Homo sapiens)
SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59 [endoplasmic reticulum membrane] (Homo sapiens)
SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59 [endoplasmic reticulum membrane] (Homo sapiens)
Vesicle budding (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59 [endoplasmic reticulum membrane] (Homo sapiens)
Cargo concentration in the ER (Homo sapiens)
Inner coat assembly and cargo binding (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59 [endoplasmic reticulum membrane] (Homo sapiens)
TMED2:TMED10 tetramer binds GPI anchored proteins (Homo sapiens)
GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59 [endoplasmic reticulum membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59 [endoplasmic reticulum membrane] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPII-mediated vesicle transport (Homo sapiens)
Inner coat assembly and cargo binding (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59 [endoplasmic reticulum membrane] (Homo sapiens)
Loss of SAR1B GTPase (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59 [endoplasmic reticulum membrane] (Homo sapiens)
SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59 [endoplasmic reticulum membrane] (Homo sapiens)
SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59 [endoplasmic reticulum membrane] (Homo sapiens)
Vesicle budding (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59 [endoplasmic reticulum membrane] (Homo sapiens)
Cargo concentration in the ER (Homo sapiens)
Inner coat assembly and cargo binding (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59 [endoplasmic reticulum membrane] (Homo sapiens)
TMED2:TMED10 tetramer binds GPI anchored proteins (Homo sapiens)
GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59 [endoplasmic reticulum membrane] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
GPI-CD59 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P13987 CD59
Gene Names
CD59, MIC11, MIN1, MIN2, MIN3, MSK21
Chain
signal peptide:1-25, chain:26-102, propeptide:103-128
Reference Genes
BioGPS Gene:966 CD59
COSMIC (genes):CD59 CD59
CTD Gene:966 CD59
dbSNP Gene:966 CD59
ENSEMBL:ENSG00000085063 CD59
HGNC:1689 CD59
KEGG:hsa:966 CD59
Monarch:966 CD59
NCBI Gene:966 CD59
OMIM:107271 CD59
UCSC:P13987 CD59
Reference Transcript
RefSeq:NM_000611.5 CD59
RefSeq:NM_001127223.1 CD59
RefSeq:NM_001127227.1 CD59
RefSeq:NM_001127225.1 CD59
RefSeq:NM_203331.2 CD59
RefSeq:NM_001127226.1 CD59
RefSeq:NM_203329.2 CD59
RefSeq:NM_203330.2 CD59
Other Identifiers
11718100_s_at
11718101_at
11718102_at
11757306_s_at
16737194
16737200
200983_PM_x_at
200983_x_at
200984_PM_s_at
200984_s_at
200985_PM_s_at
200985_s_at
212463_PM_at
212463_at
228748_PM_at
228748_at
3368706
3368708
3368709
3368710
3368711
3368712
3368713
3368714
3368715
3368716
3368717
3368718
3368719
3368720
3368721
3368722
3368723
3368724
3368725
3368726
3368727
3368728
3368729
3368730
3368732
3368734
3368735
3368737
3368738
3368739
3368740
3368741
3368742
3368743
3368745
3368746
3368747
39170_at
39351_at
62133_at
7947425
966
A_23_P75523
A_24_P141481
A_24_P639441
A_24_P784765
A_33_P3409746
GE56215
GE79480
GE88415
GO:0000139
GO:0001848
GO:0001971
GO:0005515
GO:0005576
GO:0005615
GO:0005789
GO:0005886
GO:0005925
GO:0007166
GO:0007596
GO:0009897
GO:0009986
GO:0012507
GO:0016020
GO:0030133
GO:0030449
GO:0031410
GO:0031982
GO:0033116
GO:0035579
GO:0043226
GO:0070062
GO:0070821
GO:0098552
GO:1903659
HMNXSV003026907
HMNXSV003054760
Hs.119663.0.S1_3p_a_at
Hs.119663.0.S2_3p_a_at
Hs.293774.0.A1_3p_at
Hs.99766.0.S1_3p_at
ILMN_1669659
ILMN_1724789
ILMN_2333687
M84349_at
PH_hs_0014290
TC11001540.hg
TC11003112.hg
TC11003113.hg
g10835164_3p_a_at
Participates
as a member of
GPI-CD59, GPI-FOLR1 [endoplasmic reticulum membrane] (Homo sapiens)
Other forms of this molecule
CD59 [plasma membrane]
CD59 [specific granule membrane]
CD59 [tertiary granule membrane]
GPI-CD59 [ER to Golgi transport vesicle membrane]
GPI-CD59 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GPI-CD59 [transport vesicle]
GPI-CD59 [Golgi membrane]
Inferred To
CD59 [endoplasmic reticulum membrane]
(Bos taurus)
CD59 [endoplasmic reticulum membrane]
(Canis familiaris)
CD59 [endoplasmic reticulum membrane]
(Sus scrofa)
Cd59b [endoplasmic reticulum membrane]
(Mus musculus)
Cd59 [endoplasmic reticulum membrane]
(Rattus norvegicus)
GPI-CD59 [endoplasmic reticulum membrane]
(Gallus gallus)
Modified Residues
Name
L-asparagine amide (GPI-anchor amidated amino acid carboxyl end residue(1−)) at 102
Coordinate
102
Modification
GPI-anchor amidated amino acid carboxyl end residue(1−)
PsiMod Name
L-asparagine amide
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to L-asparagine amide.
Cross References
RefSeq
NP_000602.1
,
NP_001120699.1
,
NP_001120698.1
,
NP_976076.1
,
NP_001120695.1
,
NP_001120697.1
,
NP_976075.1
,
NP_976074.1
OpenTargets
ENSG00000085063
ENSEMBL
ENSP00000498879
,
ENST00000445143
,
ENST00000415002
,
ENSP00000494884
,
ENSP00000379191
,
ENST00000642928
,
ENSP00000410182
,
ENST00000395850
,
ENST00000527577
,
ENSP00000432942
,
ENSP00000340210
,
ENSP00000498448
,
ENSP00000404822
,
ENST00000651785
,
ENSP00000403511
,
ENST00000652678
,
ENST00000437761
,
ENST00000351554
HPA
ENSG00000085063-CD59
PRO
P13987
Pharos - Targets
P13987
GlyGen
P13987
Orphanet
CD59
PDB
1CDQ
,
2UWR
,
2UX2
,
2OFS
,
1ERG
,
5IMT
,
4BIK
,
6ZD0
,
1ERH
,
8B0G
,
1CDS
,
1CDR
,
8B0H
,
8B0F
,
2J8B
,
5IMY
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
10
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.643
9
UniProt:O35587 TMEDA
0.576
5
UniProt:Q15363 TMED2
5
TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-1911531)
TMED2 [endoplasmic reticulum membrane]
(R-HSA-5689480)
TMED2 [ER to Golgi transport vesicle membrane]
(R-HSA-5689847)
TMED2 [transport vesicle]
(R-HSA-6808806)
TMED2 [Golgi membrane]
(R-HSA-6808804)
0.576
4
IntAct:EBI-25865403 EHD27213144
0.556
3
UniProt:Q5JX71 F209A
0.556
3
UniProt:Q778I9 Q778I9
0.537
4
UniProt:Q86T26 TM11B
0.527
2
UniProt:Q01415 GALK2
0.527
2
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