Reactome | BLVRA [cytosol]

BLVRA [cytosol]

Stable Identifier

R-HSA-189390

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Biliverdin reductase A, BIEA_HUMAN

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - Cytoprotection by HMOX1 (Homo sapiens)
      - BLVRA:Zn2+, BLVRB reduce BV to BIL (Homo sapiens)
        
        BLVRA:Zn2+,BLVRB [cytosol] (Homo sapiens)
        
        BLVRA:Zn2+ [cytosol] (Homo sapiens)
        
        BLVRA [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P53004 BLVRA

Gene Names

BLVRA, BLVR, BVR

Chain

propeptide:1-2, chain:3-296

Reference Genes

BioGPS Gene:644 BLVRA

COSMIC (genes):BLVRA BLVRA

CTD Gene:644 BLVRA

dbSNP Gene:644 BLVRA

ENSEMBL:ENSG00000106605 BLVRA

ENSEMBL:ENSG00000106605.11 BLVRA

HGNC:1062 BLVRA

KEGG Gene (Homo sapiens):644 BLVRA

Monarch:644 BLVRA

NCBI Gene:644 BLVRA

OMIM:109750 BLVRA

UCSC:P53004 BLVRA

Reference Transcript

Other Identifiers

11738906_a_at

17045555

203771_3p_s_at

203771_PM_s_at

203771_s_at

203773_PM_x_at

203773_x_at

211729_PM_x_at

211729_x_at

2999553

2999566

2999568

2999571

2999573

2999576

2999577

2999578

32618_at

644

8132515

A_23_P71148

GE60160

GO:0000166

GO:0003824

GO:0004074

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005829

GO:0008270

GO:0016491

GO:0042167

GO:0043226

GO:0046872

GO:0070062

GO:0106276

GO:0106277

HMNXSV003046575

Hs.81029.0.A1_3p_s_at

ILMN_1691436

PH_hs_0025429

TC07000267.hg

U34877_at

g4502416_3p_s_at

Participates

as a component of

BLVRA:Zn2+ [cytosol] (Homo sapiens)

Inferred To

BLVRA [cytosol] (Bos taurus)

BLVRA [cytosol] (Canis familiaris)

BLVRA [cytosol] (Danio rerio)

BLVRA [cytosol] (Gallus gallus)

BLVRA [cytosol] (Mus musculus)

BLVRA [cytosol] (Rattus norvegicus)

BLVRA [cytosol] (Sus scrofa)

BLVRA [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

XP_011513776.1, NP_000703.2, NP_001240752.1, XP_016868009.1

OpenTargets

ENSG00000106605

IntEnz

1.3.1.24

HPA

ENSG00000106605-BLVRA

GeneCards

P53004

Ensembl

ENST00000265523, ENSP00000265523, ENSG00000106605, ENST00000402924, ENSP00000385757

PRO

P53004

Pharos - Targets

P53004

Orphanet

20549

HMDB Protein

HMDBP00700

PDB

2H63

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P28482 MAPK1	18	MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293) MAPK1 [azurophil granule lumen] (R-HSA-6799225) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) p-T185-MAPK1 [cytosol] (R-HSA-9635773) MAPK1 [nucleoplasm] (R-HSA-199960) MAPK1 [cytosol] (R-HSA-59282) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354)	0.499	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	4

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