Reactome | TPR [nucleoplasm]

TPR [nucleoplasm]

Stable Identifier

R-HSA-157692

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Tpr

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P12270 TPR

Gene Names

TPR

Chain

initiator methionine:, chain:2-2363

Reference Genes

BioGPS Gene:7175 TPR

COSMIC (genes):TPR TPR

CTD Gene:7175 TPR

dbSNP Gene:7175 TPR

ENSEMBL:ENSG00000047410 TPR

HGNC:12017 TPR

KEGG:hsa:7175 TPR

Monarch:7175 TPR

NCBI Gene:7175 TPR

OMIM:189940 TPR

UCSC:P12270 TPR

Reference Transcript

RefSeq:NM_003292.2 TPR

Other Identifiers

11727481_at

11727482_a_at

11727483_a_at

11727484_a_at

11727485_at

1557227_PM_s_at

1557227_s_at

16697299

201730_PM_s_at

201730_s_at

201731_PM_s_at

201731_s_at

215220_PM_s_at

215220_s_at

228709_PM_at

228709_at

2448233

2448234

2448235

2448236

2448237

2448238

2448239

2448240

2448241

2448244

2448247

2448248

2448249

2448251

2448252

2448254

2448255

2448256

2448257

2448259

2448260

2448261

2448262

2448264

2448265

2448266

2448267

2448268

2448269

2448270

2448271

2448272

2448273

2448274

2448275

2448276

2448277

2448278

2448279

2448280

2448281

2448282

2448283

2448284

2448285

2448286

2448287

2448288

2448289

2448290

2448291

2448292

2448293

2448294

2448295

2448296

2448297

2448298

2448300

2448301

2448302

2448303

2448305

2448307

2448308

2448309

2448310

2448311

2448312

2448313

2448314

2448315

2448316

2448317

2448318

2448319

2448320

2448321

2448322

421_at

7175

75951_r_at

7922912

A_23_P45875

A_24_P179611

A_33_P3361771

GE59926

GE903194

GO:0000122

GO:0000775

GO:0000776

GO:0003682

GO:0003723

GO:0003729

GO:0005198

GO:0005515

GO:0005634

GO:0005635

GO:0005643

GO:0005654

GO:0005694

GO:0005737

GO:0005819

GO:0005856

GO:0005868

GO:0006355

GO:0006404

GO:0006405

GO:0006406

GO:0006606

GO:0006886

GO:0006913

GO:0006999

GO:0007094

GO:0008092

GO:0010965

GO:0015031

GO:0015631

GO:0016020

GO:0017056

GO:0031072

GO:0031453

GO:0031965

GO:0031990

GO:0032880

GO:0034399

GO:0034605

GO:0035457

GO:0042307

GO:0042405

GO:0042803

GO:0043226

GO:0044615

GO:0045947

GO:0046827

GO:0046832

GO:0051019

GO:0051028

GO:0051301

GO:0070840

GO:0070849

GO:0072686

GO:0090267

GO:0090316

GO:1901673

HMNXSV003017559

Hs.169750.0.S1_3p_a_at

Hs.218791.1.A1_3p_at

Hs.306642.0.S1_3p_s_at

Hs2.433856.1.S1_3p_s_at

ILMN_1730999

PH_hs_0022811

TC01003636.hg

TC01005999.hg

X66397_at

g4507658_3p_a_at

Participates

as a component of

Other forms of this molecule

TPR M489P [nucleoplasm]

TPR L458P [nucleoplasm]

TPR(2-629)-p-7Y-ALK(1058-1620) fusion [cytosol]

TPR(2-629)-ALK(1058-1620) fusion [cytosol]

Inferred To

Tpr [nucleoplasm] (Mus musculus)

Tpr [nucleoplasm] (Rattus norvegicus)

Ghost homologue of TPR [nucleoplasm] (Bos taurus)

Mgtor [nucleoplasm] (Drosophila melanogaster)

nup211 [nucleoplasm] (Schizosaccharomyces pombe)

TPR [nucleoplasm] (Canis familiaris)

TPR [nucleoplasm] (Gallus gallus)

TPR [nucleoplasm] (Sus scrofa)

npp-21 [nucleoplasm] (Caenorhabditis elegans)

MLP1 [nucleoplasm] (Saccharomyces cerevisiae)

tpr [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_003283.2

ENSEMBL

ENSP00000356448, ENST00000367478, ENSP00000483425, ENSG00000047410, ENST00000613151

OpenTargets

ENSG00000047410

GeneCards

TPR

HPA

ENSG00000047410-TPR

PRO

P12270

Pharos - Targets

P12270

GlyGen

P12270

Orphanet

TPR

PDB

5TO6, 5TO7, 5TVB, 5TO5

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Z1B5	1	Mad2l1 [cytosol] (R-MMU-141400)	0.564	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:Q9Y6D9 MAD1L1	1	MAD1L1 [cytosol] (R-HSA-141433)	0.524	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	7
UniProt:Q12906 ILF3	3	ILF3 [nucleoplasm] (R-HSA-9760401) ILF3 [cytosol] (R-HSA-450564) p-T188,T315-ILF3 [cytosol] (R-HSA-9836381)	0.483	2

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