Reactome | RAD23B [cytosol]

RAD23B [cytosol]

Stable Identifier

R-HSA-8850589

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

HR23B, RAD23B homolog protein, UV excision repair protein RAD23 homolog B (HHR23B) (XP-C repair complementing complex 58 kDa protein) (P58), RAD23 homolog B (S. cerevisiae), XP-C repair complementing complex 58 kDa protein, P58 , UV excision repair protein RAD23 homolog B, HHR23B, P58

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P54727 RAD23B

Gene Names

RAD23B

Chain

chain:1-409

Reference Genes

BioGPS Gene:5887 RAD23B

COSMIC (genes):RAD23B RAD23B

CTD Gene:5887 RAD23B

dbSNP Gene:5887 RAD23B

ENSEMBL:ENSG00000119318 RAD23B

ENSEMBL_homo_sapiens_GENE:ENSG00000119318.13 RAD23B

HGNC:9813 RAD23B

KEGG Gene (Homo sapiens):5887 RAD23B

Monarch:5887 RAD23B

NCBI Gene:5887 RAD23B

OMIM:600062 RAD23B

UCSC:P54727 RAD23B

Reference Transcript

Other Identifiers

11731506_a_at

11745206_x_at

11745264_a_at

11754276_a_at

11758199_s_at

17087933

1874_at

201222_PM_s_at

201222_s_at

201223_PM_s_at

201223_s_at

223598_PM_at

223598_at

2613185

2613190

3183761

3183762

3183763

3183764

3183765

3183766

3183767

3183768

3183769

3183770

3183771

3183784

3183787

3183791

3183792

3183795

3183796

3183797

3183798

3183799

3183800

3183801

3183802

3183803

3183804

3183805

3183806

5887

8157125

81704_at

A_14_P120295

A_14_P120778

A_19_P00811441

A_23_P255273

A_24_P398092

A_24_P406664

A_33_P3312039

D21090_at

GE57109

GO:0000502

GO:0000976

GO:0000978

GO:0003677

GO:0003684

GO:0003697

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006281

GO:0006289

GO:0006974

GO:0007283

GO:0022414

GO:0030163

GO:0031593

GO:0032434

GO:0043130

GO:0043161

GO:0043226

GO:0048568

GO:0048856

GO:0061629

GO:0070628

GO:0071942

GO:0098761

GO:0140299

GO:0140612

HMNXSV003009107

Hs.178658.0.S1_3p_a_at

ILMN_1722662

PH_hs_0022747

PH_hs_0031911

TC09000545.hg

g4506386_3p_a_at

g9799079_3p_at

Participates

as a component of

Deglycosylation complex [endoplasmic reticulum membrane] (Homo sapiens)

Other forms of this molecule

RAD23B [nucleoplasm]

Inferred To

Ghost homologue of RAD23B [cytosol] (Sus scrofa)

Rad23 [cytosol] (Drosophila melanogaster)

RAD23B [cytosol] (Bos taurus)

RAD23B [cytosol] (Canis familiaris)

RAD23B [cytosol] (Gallus gallus)

rad-23 [cytosol] (Caenorhabditis elegans)

rad23ab [cytosol] (Danio rerio)

Dmel\CG10694 [cytosol] (Drosophila melanogaster)

Rad23b [cytosol] (Mus musculus)

Rad23b [cytosol] (Rattus norvegicus)

Homologues of RAD23B [cytosol] (Drosophila melanogaster)

rad23b [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001231653.1, NP_002865.1

OpenTargets

ENSG00000119318

HPA

ENSG00000119318-RAD23B

GeneCards

P54727

Ensembl

ENSP00000405623, ENST00000358015, ENSP00000350708, ENSG00000119318, ENST00000416373

PRO

P54727

Pharos - Targets

P54727

HMDB Protein

HMDBP12795

PDB

1P1A, 1UEL, 8EBS, 8EBV, 8EBW, 1PVE

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q01831 XPC	5	XPC [nucleoplasm] (R-HSA-67441) Ub-XPC [nucleoplasm] (R-HSA-6782944) Ub,SUMO-XPC [nucleoplasm] (R-HSA-6790460) Ub,SUMO,K63polyUb-XPC [nucleoplasm] (R-HSA-6790522) monoSUMO1-K655-XPC [nucleoplasm] (R-HSA-4570458)	0.869	14
UniProt:P55036 PSMD4	1	PSMD4 [cytosol] (R-HSA-68800)	0.856	11
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130)	0.683	5
UniProt:P41208 CETN2	3	CETN2 [cytosol] (R-HSA-380298) CETN2 [nucleoplasm] (R-HSA-4570490) polySUMO2,3-CETN2 [nucleoplasm] (R-HSA-4570486)	0.671	6
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-215-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783002) Ub-63-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783148) Ub-139-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783012) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070)	0.666	5
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.601	4
UniProt:P35998 PSMC2	5	PSMC2 [secretory granule lumen] (R-HSA-6800994) PSMC2 [extracellular region] (R-HSA-6806472) PSMC2 [ficolin-1-rich granule lumen] (R-HSA-6800421) PSMC2 [nucleoplasm] (R-HSA-174332) PSMC2 [cytosol] (R-HSA-68771)	0.564	2
UniProt:Q92681 RSC1A1	1	RSC1A1 [plasma membrane] (R-HSA-5216133)	0.556	3
UniProt:Q9UHC7 MKRN1	2	MKRN1 [cytosol] (R-HSA-976042) p-S109-MKRN1 [cytosol] (R-HSA-8948758)	0.556	3
UniProt:P60896 SEM1	2	SEM1 [nucleoplasm] (R-HSA-8866665) SEM1 [cytosol] (R-HSA-8866674)	0.527	3
UniProt:P24610	1	Pax3 [nucleoplasm] (R-MMU-5603237)	0.499	4
UniProt:P53350 PLK1	4	PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [cytosol] (R-HSA-164603)	0.489	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	10

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