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PXLP-K279-GOT2 [mitochondrial matrix]
Stable Identifier
R-HSA-9608413
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
aspartate aminotransferase, mitochondrial, apoenzyme monomer, GOT2, glutamate oxaloacetate transaminase-2, Aspartate aminotransferase, mitochondrial precursor , Transaminase A
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Respiratory electron transport (Homo sapiens)
Malate-aspartate shuttle (Homo sapiens)
GOT2 transaminates OA and L-Glu (Homo sapiens)
GOT2 dimer [mitochondrial matrix] (Homo sapiens)
PXLP-K279-GOT2 [mitochondrial matrix] (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Aspartate and asparagine metabolism (Homo sapiens)
GOT2 dimer transaminates L-Asp (Homo sapiens)
GOT2 dimer [mitochondrial matrix] (Homo sapiens)
PXLP-K279-GOT2 [mitochondrial matrix] (Homo sapiens)
Glutamate and glutamine metabolism (Homo sapiens)
GOT2 transaminates OA and L-Glu (Homo sapiens)
GOT2 dimer [mitochondrial matrix] (Homo sapiens)
PXLP-K279-GOT2 [mitochondrial matrix] (Homo sapiens)
Glyoxylate metabolism and glycine degradation (Homo sapiens)
PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Homo sapiens)
GOT2 dimer [mitochondrial matrix] (Homo sapiens)
PXLP-K279-GOT2 [mitochondrial matrix] (Homo sapiens)
Sulfur amino acid metabolism (Homo sapiens)
Degradation of cysteine and homocysteine (Homo sapiens)
GOT2 dimer transfers amino group from L-Cys to 2OG to form 3MPYR and Glu (Homo sapiens)
GOT2 dimer [mitochondrial matrix] (Homo sapiens)
PXLP-K279-GOT2 [mitochondrial matrix] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
4052435
The primary structure of mitochondrial aspartate aminotransferase from human heart
Bossa, F
,
Maras, B
,
Barra, D
,
Pascarella, S
,
Angelaccio, S
,
Doonan, S
,
Martini, F
Biochim Biophys Acta
1985
External Reference Information
External Reference
UniProt:P00505 GOT2
Gene Names
GOT2, KYAT4
Chain
transit peptide:1-29, chain:30-430
Reference Genes
BioGPS Gene:2806 GOT2
COSMIC (genes):GOT2 GOT2
CTD Gene:2806 GOT2
dbSNP Gene:2806 GOT2
ENSEMBL:ENSG00000125166 GOT2
HGNC:4433 GOT2
KEGG:hsa:2806 GOT2
Monarch:2806 GOT2
NCBI Gene:2806 GOT2
OMIM:138150 GOT2
UCSC:P00505 GOT2
Reference Transcript
RefSeq:NM_002080.3 GOT2
RefSeq:NM_001286220.1 GOT2
Other Identifiers
11719115_a_at
11719116_a_at
11719117_x_at
11747589_a_at
11757959_s_at
16826985
200708_PM_at
200708_at
2444266
2806
3404426
3406653
3693838
3693839
3693840
3693841
3693843
3693845
3693846
3693847
3693848
3693849
3693850
3693851
3693853
3693854
3693855
3693856
3693857
3693862
3693863
40764_at
8001764
A_23_P106575
A_33_P3414482
GE57871
GO:0003723
GO:0003824
GO:0004069
GO:0005739
GO:0005759
GO:0005886
GO:0006103
GO:0006107
GO:0006520
GO:0006531
GO:0006532
GO:0006533
GO:0006536
GO:0006575
GO:0006869
GO:0008483
GO:0009058
GO:0015908
GO:0016212
GO:0016740
GO:0019470
GO:0019550
GO:0019551
GO:0030170
GO:0043226
GO:0045471
GO:0070062
GO:0097052
HMNXSV003016060
ILMN_1801348
M22632_at
PH_hs_0023753
TC16001158.hg
g4504068_3p_at
Participates
as a component of
GOT2 dimer [mitochondrial matrix] (Homo sapiens)
Inferred To
Homologues of PXLP-K279-GOT2 [mitochondrial matrix]
(Sus scrofa)
PXLP-Got2 [mitochondrial matrix]
(Rattus norvegicus)
Got2 [mitochondrial matrix]
(Drosophila melanogaster)
GOT2 [mitochondrial matrix]
(Canis familiaris)
PXLP-K279-GOT2 [mitochondrial matrix]
(Bos taurus)
PXLP-K279-GOT2 [mitochondrial matrix]
(Dictyostelium discoideum)
PXLP-K279-GOT2 [mitochondrial matrix]
(Gallus gallus)
PXLP-K279-GOT2 [mitochondrial matrix]
(Mus musculus)
PXLP-K279-GOT2 [mitochondrial matrix]
(Saccharomyces cerevisiae)
PXLP-K279-GOT2 [mitochondrial matrix]
(Schizosaccharomyces pombe)
PXLP-K279-GOT2 [mitochondrial matrix]
(Sus scrofa)
PXLP-K279-GOT2 [mitochondrial matrix]
(Xenopus tropicalis)
got-2.2 [mitochondrial matrix]
(Caenorhabditis elegans)
got2b [mitochondrial matrix]
(Danio rerio)
Modified Residues
Name
N6-pyridoxal phosphate-L-lysine at 279
Coordinate
279
PsiMod Name
N6-pyridoxal phosphate-L-lysine [MOD:00128]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-pyridoxal phosphate-L-lysine.
Cross References
RefSeq
NP_001273149.1
,
NP_002071.2
ENSEMBL
ENST00000434819
,
ENST00000245206
,
ENSP00000245206
,
ENSP00000394100
OpenTargets
ENSG00000125166
HPA
ENSG00000125166-GOT2
PRO
P00505
Pharos - Targets
P00505
GlyGen
P00505
HMDB Protein
HMDBP00284
PDB
5AX8
,
8SKR
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
5
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